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B. Fredholm · SciRah

Researcher profile · Semantic Scholar

B. Fredholm

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B. Fredholm — researcher profile on SciRah

h-index: 110
Works: 650
Citations: 49K

Most-cited papers

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
B. Fredholm, A. IJzerman, K. Jacobson, J. Linden +1 more
2011Pharmacological Reviews1,325 citations Open access
Semantic Scholar
Adenosine receptors as drug targets — what are the challenges?
Jiang-Fan Chen, H. Eltzschig, B. Fredholm
2013Nature reviews. Drug discovery875 citations Open access
Semantic Scholar
Adenosine Signalling and Function in Glial Cells
Detlev Boison, Jiang-Fan Chen, B. Fredholm
2009Cell Death and Differentiation307 citations Open access
Semantic Scholar
Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens
M. Lazarus, Hai-Ying Shen, Y. Chérasse, Wei-Min Qu +9 more
2011Journal of Neuroscience297 citations Open access
Semantic Scholar
On the mechanism of action of theophylline and caffeine.
B. Fredholm
2009Acta Medica Scandinavica237 citations
Semantic Scholar
Adenosine receptors as drug targets
B. Fredholm
2010Experimental Cell Research217 citations Open access
Semantic Scholar
CX3CL1 Is Neuroprotective in Permanent Focal Cerebral Ischemia in Rodents
R. Cipriani, P. Villa, Giuseppina Chece, C. Lauro +7 more
2011Journal of Neuroscience190 citations Open access
Semantic Scholar
Adenosine and ATP receptors in the brain.
G. Burnstock, B. Fredholm, A. Verkhratsky
2011Current Topics in Medicinal Chemistry188 citations
Semantic Scholar
A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors.
S. Masino, Tianfu Li, Panos Theofilas, U. Sandau +5 more
2011Journal of Clinical Investigation158 citations Open access
Semantic Scholar
Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep
Y. Oishi, Zhi-Li Huang, B. Fredholm, Y. Urade +1 more
2008Proceedings of the National Academy of Sciences of the United States of America146 citations Open access
Semantic Scholar
The birth and postnatal development of purinergic signalling
G. Burnstock, B. Fredholm, R. North, A. Verkhratsky
2010Acta Physiologica135 citations
Semantic Scholar
Adenosine—a physiological or pathophysiological agent?
B. Fredholm
2013Journal of molecular medicine131 citations
Semantic Scholar
Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans
R. Figler, Guo-Quan Wang, S. Srinivasan, D. Jung +9 more
2011Diabetes129 citations Open access
Semantic Scholar
On the mechanism of relaxation of tracheal muscle by theophylline and other cyclic nucleotide phosphodiesterase inhibitors.
B. Fredholm, K. Brodin, Kjell Strandberg
2009Acta Pharmacologica et Toxicologica124 citations
Semantic Scholar
Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue-interactions with insulin.
Stina M. Johansson, E. Lindgren, Jiang Yang, A. Herling +1 more
2008European Journal of Pharmacology122 citations
Semantic Scholar
Adenosine A1 Receptors and Microglial Cells Mediate CX3CL1-Induced Protection of Hippocampal Neurons Against Glu-Induced Death
C. Lauro, R. Cipriani, M. Catalano, F. Trettel +7 more
2010Neuropsychopharmacology107 citations Open access
Semantic Scholar
Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.
Jiang Yang, Jiang-Fan Chen, B. Fredholm
2009American Journal of Physiology. Heart and Circulatory Physiology102 citations Open access
Semantic Scholar
Low, but not high, dose caffeine is a readily available probe for adenosine actions.
B. Fredholm, Jiang-Ning Yang, Yingqing Wang
2017Molecular Aspects of Medicine99 citations
Semantic Scholar
Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function
Firas M. Kara, V. Chitu, Jennifer E. Sloane, M. Axelrod +3 more
2010The FASEB Journal97 citations Open access
Semantic Scholar
Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage.
Olga Björklund, Ming-Mei Shang, I. Tonazzini, E. Daré +1 more
2008European Journal of Pharmacology93 citations
Semantic Scholar
Adenosine A1 Receptors (A1R) Regulate Bone Resorption II Adenosine A1R Blockade or Deletion Increases Bone Density and Prevents Ovariectomy-Induced Bone Loss
Firas M. Kara, S. Doty, A. Boskey, S. Goldring +3 more
2010Arthritis & Rheumatism88 citations Open access
Semantic Scholar
LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R).
L. Maggi, F. Trettel, Maria Scianni, C. Bertollini +3 more
2009Journal of Neuroimmunology82 citations
Semantic Scholar
Pharmacological targeting of adenosine receptor signaling.
M. Peleli, B. Fredholm, L. Sobrevia, M. Carlström
2017Molecular Aspects of Medicine75 citations Open access
Semantic Scholar
Adenosine and the regulation of metabolism and body temperature.
B. Fredholm, Stina M. Johansson, Yingqing Wang
2011Advances in Pharmacology68 citations
Semantic Scholar
The xanthine derivative 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine (HWA 285) enhances the actions of adenosine.
B. Fredholm, K. Lindström
2009Acta Pharmacologica et Toxicologica67 citations
Semantic Scholar
Notes on the history of caffeine use.
B. Fredholm
2011Handbook of Experimental Pharmacology62 citations
Semantic Scholar
Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells.
X. Hua, K. Chason, B. Fredholm, D. Deshpande +2 more
2008Journal of Allergy and Clinical Immunology60 citations Open access
Semantic Scholar
Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling.
Liqun Yu, Joana E. Coelho, Xiaoling Zhang, Yutao Fu +5 more
2009Physiological Genomics55 citations Open access
Semantic Scholar
In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress, and AMPK signaling in the liver
M. Peleli, M. Hezel, Christa Zollbrecht, A. E. G. Persson +4 more
2015Frontiers in Physiology51 citations Open access
Semantic Scholar
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors
Cristina Roseti, K. Martinello, S. Fucile, Vanessa Piccari +12 more
2008Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Adenosine and Sleep.
M. Lazarus, Jiang-Fan Chen, Zhi-Li Huang, Y. Urade +1 more
2017Handbook of Experimental Pharmacology47 citations
Semantic Scholar
Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses
Ting Yang, Xiang Gao, M. Sandberg, Christa Zollbrecht +10 more
2015Diabetologia47 citations Open access
Semantic Scholar
Absence of adenosine A1 receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin.
A. Salehi, Fariborz Parandeh, B. Fredholm, E. Grapengiesser +1 more
2009Life Science47 citations
Semantic Scholar
Deletion of adenosine A1 or A2A receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson’s disease
Danqing Xiao, J. Cassin, B. Healy, Thomas C. Burdett +3 more
2010Brain Research44 citations Open access
Semantic Scholar
Adenosine A3 receptors regulate heart rate, motor activity and body temperature
Jiang-Ning Yang, Yingqing Wang, P. García-Rovés, M. Björnholm +1 more
2010Acta Physiologica44 citations Open access
Semantic Scholar
CX3CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes.
S. Piccinin, S. Di Angelantonio, Alessio Piccioni, R. Volpini +5 more
2010Journal of Neuroimmunology44 citations
Semantic Scholar
High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases.
J. Sällström, M. Carlström, J. Olerud, B. Fredholm +3 more
2010American Journal of Physiology. Regulatory Integrative and Comparative Physiology43 citations
Semantic Scholar
Adenosine-dopamine interactions revealed in knockout mice
P. Salmi, K. Chergui, B. Fredholm
2007Journal of Molecular Neuroscience42 citations
Semantic Scholar
The effect of alkylxanthines and other phosphodiesterase inhibitors on adenosine-receptor mediated decrease in lipolysis and cyclic AMP accumulation in rat fat cells.
B. Fredholm, Eva Lindgren
2009Acta Pharmacologica et Toxicologica41 citations
Semantic Scholar
Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine.
Jiang Yang, Olga Björklund, Karin Lindström-Törnqvist, E. Lindgren +6 more
2009Journal of applied physiology40 citations Open access
Semantic Scholar
Perinatal Caffeine, Acting on Maternal Adenosine A1 Receptors, Causes Long-Lasting Behavioral Changes in Mouse Offspring
Olga Björklund, Johan Kahlström, P. Salmi, B. Fredholm
2008PLoS ONE40 citations Open access
Semantic Scholar
International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?
T. Kenakin, L. Agnati, M. Caron, B. Fredholm +6 more
2010Journal of Receptor and Signal Transduction Research39 citations
Semantic Scholar
The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration.
Olga Björklund, Johan Kahlström, P. Salmi, S. Ogren +4 more
2007Toxicology37 citations
Semantic Scholar
Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt–Induced Hypertension
Ting Yang, Christa Zollbrecht, Malin E. Winerdal, Z. Zhuge +11 more
2016Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease36 citations Open access
Semantic Scholar
Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice.
Olga Björklund, L. Halldner-Henriksson, Jiang-Ning Yang, T. Eriksson +3 more
2008Physiology and Behavior34 citations
Semantic Scholar
Effects of ethanol on human lymphocyte levels of cyclic AMP. In vitro: Potentiation of the response to isoproterenol, prostaglandin E2 or adenosine stimulation.
Sixtus Hynie, Fred Lanefelt, B. Fredholm
2009Acta Pharmacologica et Toxicologica33 citations
Semantic Scholar
Adenosine A1 receptors contribute to immune regulation after neonatal hypoxic ischemic brain injury
Max Winerdal, Malin E. Winerdal, Yingqing Wang, B. Fredholm +2 more
2016Purinergic Signalling Purinergic Signalling32 citations Open access
Semantic Scholar
Adenosine A2A receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC
Frank Brand, Athena M. Klutz, K. Jacobson, B. Fredholm +1 more
2008European Journal of Pharmacology31 citations Open access
Semantic Scholar
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
J. Sawynok, A. Reid, B. Fredholm
2008Neuroscience Letters31 citations
Semantic Scholar
Adenosine analogues stimulate cyclic AMP-accumulation in cultured neuroblastoma and glioma cells.
L. Elfman, Eva Lindgren, Erik Walum, B. Fredholm
2009Acta Pharmacologica et Toxicologica29 citations
Semantic Scholar

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