Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

J. van Loosdregt · SciRah

Researcher profile · Semantic Scholar

J. van Loosdregt

Share profile

J. van Loosdregt — researcher profile on SciRah

h-index: 26
Works: 74
Citations: 7,277

Most-cited papers

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
D. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, M. Abdellatif +496 more
2021Autophagy4,016 citations Open access
Semantic Scholar
Amphiregulin enhances regulatory T cell suppressive function via the epidermal growth factor receptor
D. Zaiss, J. van Loosdregt, A. Gorlani, C. Bekker +6 more
2013Immunity416 citations Open access
Semantic Scholar
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.
J. van Loosdregt, Y. Vercoulen, T. Guichelaar, Y. Gent +8 more
2010Blood400 citations
Semantic Scholar
Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity
J. van Loosdregt, V. Fleskens, Juan Fu, A. Brenkman +14 more
2013Immunity325 citations Open access
Semantic Scholar
Canonical Wnt signaling negatively modulates regulatory T cell function.
J. van Loosdregt, V. Fleskens, M. Tiemessen, M. Mokry +18 more
2013Immunity225 citations Open access
Semantic Scholar
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells
E. Wehrens, G. Mijnheer, Chantal L. Duurland, M. Klein +8 more
2011Blood173 citations Open access
Semantic Scholar
Treatment to Target Using Recombinant Interleukin‐1 Receptor Antagonist as First‐Line Monotherapy in New‐Onset Systemic Juvenile Idiopathic Arthritis: Results From a Five‐Year Follow‐Up Study
N. T. ter Haar, E. V. van Dijkhuizen, Joost F. Swart, A. van Royen-Kerkhof +11 more
2019Arthritis & Rheumatology169 citations Open access
Semantic Scholar
Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1
J. van Loosdregt, D. Brunen, V. Fleskens, Cornelieke Pals +2 more
2011PLoS ONE125 citations Open access
Semantic Scholar
The Chemokine and Chemokine Receptor Profile of Infiltrating Cells in the Wall of Arteries With Cardiac Allograft Vasculopathy Is Indicative of a Memory T–Helper 1 Response
J. van Loosdregt, M. V. van Oosterhout, A. Bruggink, D. V. van Wichen +6 more
2006Circulation122 citations
Semantic Scholar
Ex vivo-expanded, but not in vitro-induced, human regulatory T cells are candidates for cell therapy in autoimmune diseases due to stable demethylation of the FOXP3 TSDRa
M. Rossetti, R. Spreafico, S. Saidin, C. Chua +6 more
2014Journal of Immunology99 citations Open access
Semantic Scholar
Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.
J. Peeters, S. Vervoort, Sander Tan, G. Mijnheer +9 more
2015Cell Reports96 citations Open access
Semantic Scholar
Post-translational modification networks regulating FOXP3 function.
J. van Loosdregt, P. Coffer
2014Trends in immunology94 citations
Semantic Scholar
Increased autophagy in CD4+ T cells of rheumatoid arthritis patients results in T cell hyperactivation and apoptosis resistance
J. van Loosdregt, M. Rossetti, R. Spreafico, M. Moshref +8 more
2016European Journal of Immunology85 citations Open access
Semantic Scholar
A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment
R. Spreafico, M. Rossetti, J. van Loosdregt, C. Wallace +6 more
2014Annals of the Rheumatic Diseases78 citations Open access
Semantic Scholar
Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
G. Mijnheer, L. Lutter, M. Mokry, Marlot van der Wal +15 more
2021Nature Communications75 citations Open access
Semantic Scholar
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60
Yuan Gao, A. Koppen, M. Rakhshandehroo, I. Taşdelen +12 more
2013Nature Communications62 citations Open access
Semantic Scholar
Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy
J. Peeters, L. Picavet, S. Coenen, Mario Mauthe +9 more
2018Autophagy51 citations Open access
Semantic Scholar
The Role of WNT Signaling in Mature T Cells: T Cell Factor Is Coming Home
J. van Loosdregt, P. Coffer
2018Journal of Immunology49 citations Open access
Semantic Scholar
ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts.
C. Angiolilli, E. Leijten, C. Bekker, E. Eeftink +8 more
2021Journal of Investigative Dermatology48 citations Open access
Semantic Scholar
Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: A possible mechanism for therapeutic modulation of T cells
J. van Loosdregt, R. Spreafico, M. Rossetti, B. Prakken +2 more
2013Journal of Allergy and Clinical Immunology48 citations Open access
Semantic Scholar
Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional output
J. Beekman, S. Vervoort, F. Dekkers, M. van Vessem +5 more
2012Oncogene48 citations
Semantic Scholar
Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation.
Enric Mocholi, Laura Russo, K. Gopal, Andrew G. Ramstead +19 more
2023Cell Reports43 citations Open access
Semantic Scholar
Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells
Peter Jan Hooikaas, Hugo G. J. Damstra, Oane Gros, W. V. van Riel +6 more
2020bioRxiv41 citations Open access
Semantic Scholar
Reversal of Sepsis‐Like Features of Neutrophils by Interleukin‐1 Blockade in Patients With Systemic‐Onset Juvenile Idiopathic Arthritis
N. T. ter Haar, T. Tak, M. Mokry, R. Scholman +11 more
2018Arthritis & Rheumatology38 citations Open access
Semantic Scholar
Tissue–Resident Memory T Cells in Chronic Inflammation—Local Cells with Systemic Effects?
A. A. K. Samat, Jolijn van der Geest, S. Vastert, J. van Loosdregt +1 more
2021Cells37 citations Open access
Semantic Scholar
Restoring T Cell Tolerance, Exploring the Potential of Histone Deacetylase Inhibitors for the Treatment of Juvenile Idiopathic Arthritis
L. Nijhuis, J. Peeters, S. Vastert, J. van Loosdregt
2019Frontiers in Immunology28 citations Open access
Semantic Scholar
Dutch juvenile idiopathic arthritis patients, carers and clinicians create a research agenda together following the James Lind Alliance method: a study protocol
C. Schoemaker, W. Armbrust, J. Swart, S. Vastert +21 more
2018Pediatric Rheumatology Online Journal26 citations Open access
Semantic Scholar
Human regulatory T cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint
L. Lutter, M. Marlot van der Wal, E. Brand, P. Maschmeyer +4 more
2022bioRxiv24 citations Open access
Semantic Scholar
Recombinant Interleukin‐1 Receptor Antagonist Is an Effective First‐Line Treatment Strategy in New‐Onset Systemic Juvenile Idiopathic Arthritis, Irrespective of HLA‐DRB1 Background and IL1RN Variants
R. Erkens, J. Calis, A. Verwoerd, S. de Roock +15 more
2023Arthritis & Rheumatology23 citations Open access
Semantic Scholar
NRF2/Itaconate Axis Regulates Metabolism and Inflammatory Properties of T Cells in Children with JIA
Anandhi Rajendiran, Sudheendra Hebbar Subramanyam, Patricia Klemm, V. Jankowski +6 more
2022Antioxidants18 citations Open access
Semantic Scholar
A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs
W. Venema, S. Hiddingh, J. van Loosdregt, J. Bowes +10 more
2023bioRxiv15 citations Open access
Semantic Scholar
Dutch patients, caregivers and healthcare professionals generate first nationwide research agenda for juvenile idiopathic arthritis
A. Verwoerd, W. Armbrust, K. Cowan, L. van den Berg +19 more
2020Pediatric Rheumatology Online Journal15 citations Open access
Semantic Scholar
Increased autophagy contributes to the inflammatory phenotype of juvenile idiopathic arthritis synovial fluid T cells
J. Peeters, N. de Graeff, M. Lotz, S. Albani +2 more
2017Rheumatology15 citations Open access
Semantic Scholar
Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis
Arjan Boltjes, A. A. K. Samat, M. Plantinga, M. Mokry +7 more
2023Frontiers in Immunology14 citations Open access
Semantic Scholar
A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples
R. Spreafico, M. Rossetti, T. van den Broek, N. Jansen +6 more
2014European Journal of Immunology14 citations Open access
Semantic Scholar
Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis.
Pavanish Kumar, L. Yao, S. Saidin, B. Paleja +10 more
2018Journal of Autoimmunity12 citations Open access
Semantic Scholar
Update on research and clinical translation on specific clinical areas from biology to bedside: Unpacking the mysteries of juvenile idiopathic arthritis pathogenesis.
J. van Loosdregt, F. van Wijk, B. Prakken, B. Vastert
2017Baillière's Best Practice & Research : Clinical Rheumatology12 citations
Semantic Scholar
Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition
J. Peeters, Arjan Boltjes, R. Scholman, S. Vervoort +5 more
2023Rheumatology11 citations Open access
Semantic Scholar
CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders
L. Picavet, A. A. K. Samat, J. Calis, L. Nijhuis +6 more
2024Biomedicines10 citations Open access
Semantic Scholar
N6-Methyladenosine Directly Regulates CD40L Expression in CD4+ T Lymphocytes
E. V. van Vroonhoven, L. Picavet, R. Scholman, N. V. D. van den Dungen +6 more
2023Biology10 citations Open access
Semantic Scholar
FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2
V. Fleskens, M. Mokry, A. M. van der Leun, S. Huppelschoten +7 more
2016Oncogene10 citations Open access
Semantic Scholar
m6A Reader YTHDC1 Impairs Respiratory Syncytial Virus Infection by Downregulating Membrane CX3CR1 Expression
L. Picavet, E. V. van Vroonhoven, R. Scholman, Y. Smits +8 more
2024Viruses8 citations Open access
Semantic Scholar
Glycolytic reprogramming shapes the histone acetylation profile of activated CD4+ T cells in juvenile idiopathic arthritis.
Enric Mocholi, E. Corrigan, Theo Chalkiadakis, C. Gulersonmez +5 more
2025Cell Reports7 citations Open access
Semantic Scholar
N6-adenosine methylation (m6A) is involved in the life and death decisions of T cells
J. J. Calis, J. van Loosdregt
2022Cellular & Molecular Immunology7 citations Open access
Semantic Scholar
Review: Enhancers in Autoimmune Arthritis: Implications and Therapeutic Potential
J. Peeters, S. Vastert, F. van Wijk, J. van Loosdregt
2017Arthritis & Rheumatology7 citations Open access
Semantic Scholar
Autoimmune disease-associated gene expression is reduced by BET-inhibition
J. Peeters, S. Vervoort, G. Mijnheer, S. de Roock +6 more
2015Genomics Data7 citations Open access
Semantic Scholar
N6-Methyladenosine Promotes TNF mRNA Degradation In CD4+ T Lymphocytes.
E. V. van Vroonhoven, L. Picavet, R. Scholman, Lyanne J. P. M. Sijbers +10 more
2024Journal of Leukocyte Biology6 citations Open access
Semantic Scholar
Nicotinamide Inhibits CD4+ T-Cell Activation and Function
L. Nijhuis, Alejandra Bodelόn, R. Scholman, Isabelle Houtzager +7 more
2025Cells5 citations Open access
Semantic Scholar
Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscape
G. Mijnheer, L. Lutter, M. Mokry, Marlot M. van der Wal +15 more
2020bioRxiv4 citations Open access
Semantic Scholar
Reduced Expression of m6A Demethylases FTO and ALKBH5 in Monocytes from the Site of Inflammation in Patients with Juvenile Idiopathic Arthritis
Hisham I. Abu-Tawil, L. Picavet, E. V. van Vroonhoven, A. Bodelón +5 more
2025International Journal of Molecular Sciences3 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

S. Vastert×16
Invite
S. Vastert — researcher profile on SciRah
P. Coffer×13
Invite
P. Coffer — researcher profile on SciRah
F. van Wijk×13
Invite
F. van Wijk — researcher profile on SciRah
M. Mokry×11
Invite
M. Mokry — researcher profile on SciRah

×11

Invite

R. Scholman — researcher profile on SciRah

Invite

J. Peeters — researcher profile on SciRah

Invite

B. Prakken — researcher profile on SciRah

Invite

S. de Roock — researcher profile on SciRah

Invite

S. Albani — researcher profile on SciRah

Invite

S. Vervoort — researcher profile on SciRah

Invite

L. Picavet — researcher profile on SciRah

Invite

V. Fleskens — researcher profile on SciRah