Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

M. Danhof · SciRah

Researcher profile · Semantic Scholar

M. Danhof

Share profile

M. Danhof — researcher profile on SciRah

h-index: 68
Works: 586
Citations: 17K

Most-cited papers

Drug disposition in obesity: toward evidence-based dosing.
C. Knibbe, M. J. Brill, A. van Rongen, J. Diepstraten +2 more
2015Annual Review of Pharmacology and Toxicology133 citations
Semantic Scholar
In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant.
W. D. de Witte, M. Danhof, P. H. van der Graaf, E. D. de Lange
2016TIPS - Trends in Pharmacological Sciences121 citations
Semantic Scholar
Systems pharmacology - Towards the modeling of network interactions.
M. Danhof
2016European Journal of Pharmaceutical Sciences117 citations Open access
Semantic Scholar
Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?
E. Calvier, E. Krekels, Pyry A. J. Välitalo, A. Rostami-Hodjegan +3 more
2016Clinical Pharmacokinetics102 citations Open access
Semantic Scholar
Simultaneous Pharmacokinetic Modeling of Gentamicin, Tobramycin and Vancomycin Clearance from Neonates to Adults: Towards a Semi-physiological Function for Maturation in Glomerular Filtration
R. D. Cock, K. Allegaert, J. M. Brussee, Catherine M Sherwin +5 more
2014Pharmaceutical Research94 citations Open access
Semantic Scholar
A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations
Yumi Yamamoto, Pyry A. J. Välitalo, D. van den Berg, Robin Hartman +14 more
2016Pharmaceutical Research77 citations Open access
Semantic Scholar
Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model
Yumi Yamamoto, Pyry A. J. Välitalo, D. Huntjens, J. Proost +9 more
2017CPT: Pharmacometrics & Systems Pharmacology72 citations Open access
Semantic Scholar
Prediction of human CNS pharmacokinetics using a physiologically‐based pharmacokinetic modeling approach
Yumi Yamamoto, Pyry A. J. Välitalo, Y. Wong, D. Huntjens +9 more
2018European Journal of Pharmaceutical Sciences70 citations Open access
Semantic Scholar
The allometric exponent for scaling clearance varies with age: a study on seven propofol datasets ranging from preterm neonates to adults.
Chen-guang Wang, K. Allegaert, M. Peeters, D. Tibboel +2 more
2014British Journal of Clinical Pharmacology57 citations Open access
Semantic Scholar
Challenges in translational drug research in neuropathic and inflammatory pain: the prerequisites for a new paradigm
A. Taneja, O. Della Pasqua, M. Danhof
2017European Journal of Clinical Pharmacology52 citations Open access
Semantic Scholar
Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs
J. Mochel, M. Fink, C. Bon, Mathieu Peyrou +5 more
2014Chronobiology International50 citations
Semantic Scholar
Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations
Yumi Yamamoto, M. Danhof, E. D. de Lange
2017AAPS Journal42 citations Open access
Semantic Scholar
Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1‐OH‐midazolam in morbidly obese and weight loss surgery patients
M. Brill, Paj Välitalo, AS Darwich, B. van Ramshorst +4 more
2015CPT: Pharmacometrics & Systems Pharmacology40 citations Open access
Semantic Scholar
The implications of target saturation for the use of drug–target residence time
W. D. de Witte, M. Danhof, P. H. van der Graaf, E. de Lange
2018Nature reviews. Drug discovery38 citations Open access
Semantic Scholar
Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid.
J. V. van Hasselt, Matthew L. Rizk, Mallika Lala, C. Chavez-Eng +5 more
2016British Journal of Clinical Pharmacology37 citations Open access
Semantic Scholar
Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials
S. V. van Dijkman, N. D. de Jager, Willem M Rauwé, M. Danhof +1 more
2018Clinical Pharmacokinetics36 citations
Semantic Scholar
Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans.
Tarjinder Sahota, M. Danhof, O. Della Pasqua
2016Mutagenesis33 citations Open access
Semantic Scholar
Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children
S. V. van Dijkman, Willem M Rauwé, M. Danhof, O. Della Pasqua
2018British Journal of Clinical Pharmacology32 citations Open access
Semantic Scholar
Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients
W. D. de Witte, Y. Wong, I. Nederpelt, L. Heitman +4 more
2016Expert Opinion on Drug Discovery32 citations Open access
Semantic Scholar
The future of drug development: the paradigm shift towards systems therapeutics.
M. Danhof, Kevin Klein, P. Stolk, Murray L. Aitken +1 more
2018Drug Discovery Today31 citations Open access
Semantic Scholar
Sacubitril/valsartan (LCZ696) Significantly Reduces Aldosterone and Increases cGMP Circulating Levels in a Canine Model of RAAS Activation
J. Mochel, C. Teng, Mathieu Peyrou, J. Giraudel +2 more
2018bioRxiv30 citations Open access
Semantic Scholar
Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants
E. Krekels, Saskia van Ham, K. Allegaert, J. D. de Hoon +3 more
2015European Journal of Clinical Pharmacology30 citations Open access
Semantic Scholar
Individualized Dosing Algorithms and Therapeutic Monitoring for Antiepileptic Drugs
Sven C. Dijkman, S. Wicha, M. Danhof, O. Della Pasqua
2018Clinical pharmacology and therapy26 citations Open access
Semantic Scholar
Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans
Vincent F. S. Dubois, W. D. de Witte, S. Visser, M. Danhof +2 more
2015Pharmaceutical Research26 citations Open access
Semantic Scholar
Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned?
J. Mochel, M. Danhof
2015Reviews of Physiology, Biochemistry and Pharmacology25 citations
Semantic Scholar
Population pharmacokinetics of deferiprone in healthy subjects.
F. Bellanti, M. Danhof, O. Della Pasqua
2014British Journal of Clinical Pharmacology25 citations Open access
Semantic Scholar
Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration
Laura Kervezee, V. Gotta, J. Stevens, W. Birkhoff +4 more
2016CPT: Pharmacometrics & Systems Pharmacology24 citations Open access
Semantic Scholar
Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments
E. Calvier, E. Krekels, Hui-Xin Yu, Pyry A. J. Välitalo +6 more
2018CPT: Pharmacometrics & Systems Pharmacology23 citations Open access
Semantic Scholar
Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models
M. Danhof
2015Journal of Pharmacokinetics and Pharmacodynamics22 citations Open access
Semantic Scholar
Integration of PKPD relationships into benefit–risk analysis
F. Bellanti, R. V. van Wijk, M. Danhof, O. Della Pasqua
2015British Journal of Clinical Pharmacology21 citations Open access
Semantic Scholar
Low but Inducible Contribution of Renal Elimination to Clearance of Propylene Glycol in Preterm and Term Neonates
Roosmarijn F. W. de Cock, K. Allegaert, S. Vanhaesebrouck, J. D. de Hoon +3 more
2014Therapeutic Drug Monitoring20 citations
Semantic Scholar
Translational Modeling in Schizophrenia: Predicting Human Dopamine D2 Receptor Occupancy
Martin Johnson, M. Kozielska, Venkatesh Pilla Reddy, A. Vermeulen +6 more
2015Pharmaceutical Research19 citations Open access
Semantic Scholar
Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop
K. Romero, V. Sinha, S. Allerheiligen, M. Danhof +20 more
2014Journal of Pharmacokinetics and Pharmacodynamics18 citations
Semantic Scholar
Application of a systems pharmacology model for translational prediction of hERG‐mediated QTc prolongation
V. Gotta, Zhiyi Yu, F. Cools, K. van Ammel +6 more
2016Pharmacology Research & Perspectives17 citations Open access
Semantic Scholar
Sensitivity of pharmacokinetic-pharmacodynamic analysis for detecting small magnitudes of QTc prolongation in preclinical safety testing.
V. Gotta, F. Cools, K. van Ammel, D. Gallacher +5 more
2015Journal of pharmacological and toxicological methods17 citations
Semantic Scholar
Pharmacotherapy in pediatric epilepsy: from trial and error to rational drug and dose selection – a long way to go
S. V. van Dijkman, R. Alvarez-Jimenez, M. Danhof, O. Della Pasqua
2016Expert Opinion on Drug Metabolism & Toxicology16 citations Open access
Semantic Scholar
Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid
Pyry A. J. Välitalo, K. Griffioen, Matthew L. Rizk, Sandra A. G. Visser +4 more
2015Pharmaceutical Research15 citations Open access
Semantic Scholar
Translational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated Phosphorylation
N. Snelder, B. Ploeger, O. Luttringer, D. Stanski +1 more
2014Drug Metabolism And Disposition15 citations Open access
Semantic Scholar
Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints
Heleen J. Blussé van Oud-Alblas, M. J. Brill, M. Peeters, D. Tibboel +2 more
2019BMC Anesthesiology14 citations Open access
Semantic Scholar
Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling
A. Vlot, W. D. de Witte, M. Danhof, P. H. van der Graaf +2 more
2017AAPS Journal14 citations Open access
Semantic Scholar
Sampling Optimization in Pharmacokinetic Bridging Studies: Example of the Use of Deferiprone in Children With β‐Thalassemia
F. Bellanti, V. L. Di Iorio, M. Danhof, O. Della Pasqua
2016Journal of clinical pharmacology14 citations
Semantic Scholar
Influence of covariate distribution on the predictive performance of pharmacokinetic models in paediatric research.
C. Piana, M. Danhof, O. Della Pasqua
2014British Journal of Clinical Pharmacology14 citations Open access
Semantic Scholar
A comparison of two semi-mechanistic models for prolactin release and prediction of receptor occupancy following administration of dopamine D2 receptor antagonists in rats.
A. Taneja, A. Vermeulen, D. Huntjens, M. Danhof +2 more
2016European Journal of Pharmacology13 citations
Semantic Scholar
Exploring genetic and non-genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients.
D. Moes, R. R. Press, O. Ackaert, B. Ploeger +9 more
2016British Journal of Clinical Pharmacology13 citations Open access
Semantic Scholar
Extending a Systems Model of the APP Pathway: Separation of β- and γ-Secretase Sequential Cleavage Steps of APP
Eline M. T. van Maanen, T. V. van Steeg, Maurice J. Ahsman, Maria S. Michener +5 more
2018Journal of Pharmacology and Experimental Therapeutics12 citations Open access
Semantic Scholar
In vitro and in silico analysis of the effects of D 2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
W. D. de Witte, Joost W Versfelt, M. Kuzikov, Solene Rolland +9 more
2018British Journal of Pharmacology12 citations Open access
Semantic Scholar
Model-based evaluation of drug-induced QTc prolongation for compounds in early development.
Vincent F. S. Dubois, Hui-Xin Yu, M. Danhof, O. Della Pasqua
2015British Journal of Clinical Pharmacology11 citations Open access
Semantic Scholar
Model-Based Optimisation of Deferoxamine Chelation Therapy
F. Bellanti, G. D. Del Vecchio, M. Putti, C. Cosmi +4 more
2015Pharmaceutical Research11 citations Open access
Semantic Scholar
Translating QT interval prolongation from conscious dogs to humans
Vincent F. S. Dubois, G. Smania, Hui-Xin Yu, R. Graf +3 more
2017British Journal of Clinical Pharmacology10 citations Open access
Semantic Scholar
Systems Pharmacology Analysis of the Amyloid Cascade after β-Secretase Inhibition Enables the Identification of an Aβ42 Oligomer Pool
Eline M. T. van Maanen, T. V. van Steeg, Maria S. Michener, M. Savage +4 more
2016Journal of Pharmacology and Experimental Therapeutics10 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

O. Della Pasqua×13
Invite
O. Della Pasqua — researcher profile on SciRah
P. H. van der Graaf×11
Invite
P. H. van der Graaf — researcher profile on SciRah
W. D. de Witte×6
Invite
W. D. de Witte — researcher profile on SciRah
Pyry A. J. Välitalo×6
Invite
Pyry A. J. Välitalo — researcher profile on SciRah

Invite

E. de Lange — researcher profile on SciRah

Invite

D. Tibboel — researcher profile on SciRah

Invite

C. Knibbe — researcher profile on SciRah

Invite

D. Huntjens — researcher profile on SciRah

Invite

J. Proost — researcher profile on SciRah

A. Vermeulen×5

Invite

A. Vermeulen — researcher profile on SciRah

E. D. de Lange×4

Invite

E. D. de Lange — researcher profile on SciRah

K. Allegaert×4

Invite

K. Allegaert — researcher profile on SciRah