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K. Talbot · SciRah

Researcher profile · Semantic Scholar

K. Talbot

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K. Talbot — researcher profile on SciRah

h-index: 81
Works: 352
Citations: 20K

Most-cited papers

A proposal for new diagnostic criteria for ALS.
J. Shefner, A. Al-Chalabi, M. Baker, L. Cui +19 more
2020Clinical Neurophysiology560 citations Open access
Semantic Scholar
Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model.
H. Westeneng, Thomas P. A. Debray, A. Visser, R. V. van Eijk +43 more
2018Lancet Neurology473 citations Open access
Semantic Scholar
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
A. Nicolas, K. Kenna, A. Renton, N. Ticozzi +200 more
2018Neuron409 citations Open access
Semantic Scholar
Improving clinical trial outcomes in amyotrophic lateral sclerosis
M. Kiernan, S. Vucic, K. Talbot, C. Mcdermott +11 more
2020Nature Reviews Neurology259 citations Open access
Semantic Scholar
Advances in therapy for spinal muscular atrophy: promises and challenges
E. Groen, K. Talbot, T. Gillingwater
2018Nature Reviews Neurology223 citations Open access
Semantic Scholar
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.
M. Prudencio, J. Humphrey, Sarah R Pickles, Anna L. Brown +48 more
2020Journal of Clinical Investigation191 citations Open access
Semantic Scholar
Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers
B. F. Vahsen, Elizabeth Gray, A. Thompson, O. Ansorge +4 more
2021Nature Reviews Neurology134 citations
Semantic Scholar
Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins
Topaz Altman, A. Ionescu, Amjad Ibraheem, Dominik Priesmann +12 more
2021Nature Communications131 citations Open access
Semantic Scholar
Towards a TDP-43-Based Biomarker for ALS and FTLD
E. Feneberg, Elizabeth Gray, O. Ansorge, K. Talbot +1 more
2018Molecular Neurobiology129 citations Open access
Semantic Scholar
Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis
A. Thompson, Elizabeth Gray, M. Thézénas, P. Charles +6 more
2018Annals of Neurology126 citations
Semantic Scholar
Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD
R. Dafinca, P. Barbagallo, Lucy Farrimond, A. Candalija +6 more
2020Stem Cell Reports122 citations Open access
Semantic Scholar
HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease
V. Benoy, Lawrence Van Helleputte, Robert Prior, C. d’Ydewalle +11 more
2018Brain : a journal of neurology114 citations Open access
Semantic Scholar
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
Scott P. Allen, Benjamin J. Hall, L. Castelli, Laura Francis +19 more
2019Brain : a journal of neurology98 citations Open access
Semantic Scholar
CSF chitinase proteins in amyotrophic lateral sclerosis
A. Thompson, Elizabeth Gray, A. Bampton, D. Raciborska +2 more
2019Journal of Neurology Neurosurgery & Psychiatry93 citations Open access
Semantic Scholar
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
D. Gordon, R. Dafinca, Jakub Scaber, J. Alegre-Abarrategui +9 more
2019Neurobiology of Disease84 citations Open access
Semantic Scholar
Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes
J. N. Sleigh, Andrew P. Tosolini, D. Gordon, A. Devoy +4 more
2020Cell Reports80 citations Open access
Semantic Scholar
ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function
M. de Majo, S. Topp, Bradley Smith, A. Nishimura +29 more
2018Neurobiology of Aging80 citations Open access
Semantic Scholar
The Role of Mitochondrial Dysfunction and ER Stress in TDP-43 and C9ORF72 ALS
R. Dafinca, P. Barbagallo, K. Talbot
2021Frontiers in Cellular Neuroscience67 citations Open access
Semantic Scholar
Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair
Nidaa A. Ababneh, Jakub Scaber, R. Flynn, A. Douglas +7 more
2019bioRxiv63 citations Open access
Semantic Scholar
Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis
Helena Chaytow, Emily Carroll, D. Gordon, Yu-Ting Huang +7 more
2022EBioMedicine54 citations Open access
Semantic Scholar
CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis
A. Thompson, Elizabeth Gray, I. Mäger, M. Thézénas +6 more
2020Clinical Proteomics54 citations Open access
Semantic Scholar
Objectively Monitoring Amyotrophic Lateral Sclerosis Patient Symptoms During Clinical Trials With Sensors: Observational Study
Luis Garcia-Gancedo, M. Kelly, A. Lavrov, Jim Parr +7 more
2019JMIR mHealth and uHealth54 citations Open access
Semantic Scholar
Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis
A. Thompson, K. Talbot, M. Turner
2021Journal of Neurology Neurosurgery & Psychiatry53 citations Open access
Semantic Scholar
Regional thalamic MRI as a marker of widespread cortical pathology and progressive frontotemporal involvement in amyotrophic lateral sclerosis
Si-Cong Tu, R. Menke, K. Talbot, M. Kiernan +1 more
2018Journal of Neurology Neurosurgery & Psychiatry53 citations Open access
Semantic Scholar
Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource
M. Keogh, Wei Wei, I. Wilson, J. Coxhead +17 more
2017Genome Research53 citations Open access
Semantic Scholar
Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.
Phillippa J. Carling, H. Mortiboys, Claire Green, Simeon R. Mihaylov +20 more
2020Progress in neurobiology52 citations Open access
Semantic Scholar
Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis
Greig Joilin, Elizabeth Gray, A. Thompson, Y. Bobeva +8 more
2020Brain Communications52 citations Open access
Semantic Scholar
Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation
M. M. Wong, S. Hoekstra, J. Vowles, L. Watson +6 more
2018Acta Neuropathologica Communications50 citations Open access
Semantic Scholar
Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis.
M. Proudfoot, F. van Ede, A. Quinn, G. Colclough +6 more
2018Clinical Neurophysiology49 citations
Semantic Scholar
Quantitative patterns of motor cortex proteinopathy across ALS genotypes
M. Nolan, Connor Scott, M. P. Gamarallage, D. Lunn +8 more
2020Acta Neuropathologica Communications45 citations Open access
Semantic Scholar
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
B. F. Vahsen, Elizabeth Gray, A. Candalija, Kaitlyn M. L. Cramb +10 more
2022Scientific Reports44 citations Open access
Semantic Scholar
The impact of age on genetic testing decisions in amyotrophic lateral sclerosis
P. Mehta, A. Iacoangeli, S. Opie-Martin, J. V. van Vugt +9 more
2022Brain : a journal of neurology43 citations Open access
Semantic Scholar
An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.
E. Feneberg, D. Gordon, A. Thompson, M. Finelli +10 more
2020Neurobiology of Disease43 citations Open access
Semantic Scholar
Amyotrophic lateral sclerosis: the complex path to precision medicine
K. Talbot, E. Feneberg, Jakub Scaber, A. Thompson +1 more
2018Journal of Neurology43 citations Open access
Semantic Scholar
Genetic testing in motor neurone disease
T. Dharmadasa, Jakub Scaber, E. Edmond, R. Marsden +3 more
2022Practical Neurology41 citations Open access
Semantic Scholar
Quantitative FLAIR MRI in Amyotrophic Lateral Sclerosis
J. Fabes, Lucy Matthews, N. Filippini, K. Talbot +2 more
2017Academic Radiology41 citations Open access
Semantic Scholar
CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis
Elizabeth Gray, A. Thompson, J. Wuu, J. van Pelt +3 more
2020Annals of Clinical and Translational Neurology40 citations Open access
Semantic Scholar
Detection and quantification of novel C‐terminal TDP‐43 fragments in ALS‐TDP
E. Feneberg, P. Charles, M. Finelli, Connor Scott +6 more
2020Brain Pathology37 citations Open access
Semantic Scholar
The relationships between symptoms, disability, perceived health and quality of life in amyotrophic lateral sclerosis/motor neuron disease
Carolyn A. Young, J. Ealing, C. Mcdermott, Tim L. Williams +12 more
2019Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration35 citations Open access
Semantic Scholar
Increased cerebral functional connectivity in ALS
M. Proudfoot, G. Colclough, A. Quinn, J. Wuu +5 more
2018Neurology35 citations Open access
Semantic Scholar
UFLC‐Derived CSF Extracellular Vesicle Origin and Proteome
A. Thompson, Elizabeth Gray, I. Mäger, R. Fischer +7 more
2018Proteomics34 citations
Semantic Scholar
Primary lateral sclerosis: diagnosis and management
M. Turner, K. Talbot
2020Practical Neurology33 citations Open access
Semantic Scholar
Multicentre appraisal of amyotrophic lateral sclerosis biofluid biomarkers shows primacy of blood neurofilament light chain
A. Thompson, Elizabeth Gray, Nick Verber, Y. Bobeva +19 more
2022Brain Communications32 citations Open access
Semantic Scholar
Cerebellar tract alterations in PLS and ALS
Si-Cong Tu, R. Menke, K. Talbot, M. Kiernan +1 more
2019Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration30 citations Open access
Semantic Scholar
Limited value of serum neurofilament light chain in diagnosing amyotrophic lateral sclerosis
J. C. Davies, T. Dharmadasa, A. Thompson, E. Edmond +4 more
2023Brain Communications29 citations Open access
Semantic Scholar
Leukoencephalopathy with calcifications and cysts: Genetic and phenotypic spectrum
Y. Crow, Heather Marshall, G. Rice, L. Seabra +64 more
2020American Journal of Medical Genetics. Part A28 citations Open access
Semantic Scholar
Tracheostomy in motor neurone disease
M. Turner, C. Faull, C. Mcdermott, A. Nickol +2 more
2019Practical Neurology27 citations
Semantic Scholar
Initial Identification of a Blood-Based Chromosome Conformation Signature for Aiding in the Diagnosis of Amyotrophic Lateral Sclerosis
M. Salter, E. Corfield, A. Ramadass, F. Grand +14 more
2018EBioMedicine27 citations Open access
Semantic Scholar
Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice.
Alicia Dubinski, Myriam Gagné, Sarah Peyrard, D. Gordon +2 more
2022Human Molecular Genetics26 citations Open access
Semantic Scholar
Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo
M. Williamson, M. Finelli, J. N. Sleigh, A. Reddington +4 more
2019Human Molecular Genetics26 citations Open access
Semantic Scholar

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