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R. Brush · SciRah

Researcher profile · Semantic Scholar

R. Brush

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R. Brush — researcher profile on SciRah

h-index: 26
Works: 93
Citations: 1,989

Most-cited papers

Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids
M. Agbaga, R. Brush, M. A. Mandal, K. Henry +2 more
2008Proceedings of the National Academy of Sciences of the United States of America269 citations Open access
Semantic Scholar
Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice
Manuel Roqueta‐Rivera, Chad K. Stroud, W. M. Haschek, Sandeep Akare +6 more
2010Journal of Lipid Research148 citations Open access
Semantic Scholar
Detailed characterization of the lipid composition of detergent-resistant membranes from photoreceptor rod outer segment membranes.
Rex E. Martin, Michael H. Elliott, R. Brush, R. E. Anderson
2005Investigative Ophthalmology and Visual Science96 citations Open access
Semantic Scholar
Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies
Shun-Yun Cheng, Joris Cipi, Shan Ma, B. Hafler +4 more
2020Proceedings of the National Academy of Sciences of the United States of America80 citations Open access
Semantic Scholar
Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors.
Xiao-Hong Wen, Li-Xin Shen, R. Brush, N. Michaud +7 more
2009Biophysical Journal78 citations Open access
Semantic Scholar
Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors
M. Agbaga, Dana K. Merriman, R. Brush, T. Lydic +7 more
2018Journal of Lipid Research73 citations Open access
Semantic Scholar
Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4
G. K. Yeboah, E. Lobanova, R. Brush, M. Agbaga
2021Journal of Lipid Research63 citations Open access
Semantic Scholar
Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration[S]
Hui Chen, Julie-Thu A. Tran, A. Eckerd, Tuan-Phat Huynh +3 more
2013Journal of Lipid Research58 citations Open access
Semantic Scholar
ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3[S]
Man Yu, Aaron Benham, Sreemathi Logan, R. Brush +3 more
2012Journal of Lipid Research56 citations Open access
Semantic Scholar
Retinal sphingolipids and their very-long-chain fatty acid-containing species.
R. Brush, Julie-Thu A. Tran, K. Henry, Mark E. McClellan +2 more
2010Investigative Ophthalmology and Visual Science56 citations Open access
Semantic Scholar
Pyruvate kinase M2 regulates photoreceptor structure, function, and viability
A. Rajala, Yuhong Wang, R. Brush, Kristine A. Tsantilas +6 more
2018Cell Death and Disease53 citations Open access
Semantic Scholar
Lipidomic analysis of the retina in a rat model of Smith–Lemli–Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species
D. Ford, Julie K. Monda, R. Brush, R. E. Anderson +2 more
2008Journal of Neurochemistry50 citations Open access
Semantic Scholar
Decreased very long chain polyunsaturated fatty acids in sperm correlates with sperm quantity and quality
L. Craig, R. Brush, M. T. Sullivan, M. T. Zavy +2 more
2019Journal of Assisted Reproduction and Genetics49 citations Open access
Semantic Scholar
Deciphering mutant ELOVL4 activity in autosomal-dominant Stargardt macular dystrophy
Sreemathi Logan, M. Agbaga, Michael D. Chan, Nabila Kabir +3 more
2013Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice.
A. Mohammed, N. Janakiram, Misty F. Brewer, Ashley Duff +4 more
2012Neoplasia47 citations Open access
Semantic Scholar
Effect of reduced retinal VLC-PUFA on rod and cone photoreceptors.
Lea D. Bennett, R. Brush, Michael D. Chan, T. Lydic +5 more
2014Investigative Ophthalmology and Visual Science44 citations Open access
Semantic Scholar
Ceramide Signaling in Retinal Degeneration
Hui Chen, Julie-Thu A. Tran, R. Brush, Anisse Saadi +8 more
2012Advances in Experimental Medicine and Biology41 citations Open access
Semantic Scholar
DHA does not protect ELOVL4 transgenic mice from retinal degeneration
Feng Li, L. Marchette, R. Brush, Michael H. Elliott +7 more
2009Molecular Vision40 citations
Semantic Scholar
Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency
B. Hopiavuori, F. Deák, Joseph L. Wilkerson, R. Brush +12 more
2017Molecular Neurobiology39 citations Open access
Semantic Scholar
Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice
Angela Cai, Erin C. D. Hutchison, Joanna Hudson, Yusuke Kawashima +7 more
2014Osteoarthritis and Cartilage37 citations Open access
Semantic Scholar
Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint[S]
B. Hopiavuori, M. Agbaga, R. Brush, M. T. Sullivan +2 more
2017Journal of Lipid Research33 citations Open access
Semantic Scholar
Examination of VLC-PUFA-deficient photoreceptor terminals.
Lea D. Bennett, B. Hopiavuori, R. Brush, Michael D. Chan +3 more
2014Investigative Ophthalmology and Visual Science32 citations Open access
Semantic Scholar
Response of the Glutathione (GSH) Antioxidant Defense System to Oxidative Injury in Necrotizing Enterocolitis
Alena Golubkova, Tyler Leiva, K. Snyder, Camille Schlegel +6 more
2023Antioxidants31 citations Open access
Semantic Scholar
Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina.
K. N. Rao, Linjing Li, Wei Zhang, R. Brush +2 more
2016Human Molecular Genetics31 citations Open access
Semantic Scholar
Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity
Sreemathi Logan, M. Agbaga, Michael D. Chan, R. Brush +1 more
2014Journal of Lipid Research28 citations Open access
Semantic Scholar
Bright cyclic rearing protects albino mouse retina against acute light-induced apoptosis.
I. Káldi, Rex E. Martin, Hu Huang, R. Brush +2 more
2003Molecular Vision27 citations
Semantic Scholar
Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors.
J. Karpac, K. Czyżewska, A. Kern, R. Brush +2 more
2008American Journal of Physiology. Endocrinology and Metabolism24 citations
Semantic Scholar
P23H and S334ter opsin mutations: Increasing photoreceptor outer segment n-3 fatty acid content does not affect the course of retinal degeneration.
Rex E. Martin, I. Ranchon-Cole, R. Brush, C. Williamson +3 more
2004Molecular Vision22 citations
Semantic Scholar
Obesity promotes lipid accumulation in mouse cartilage—a potential role of acetyl-CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis
Huanhuan Liu, Luke Witzigreuter, Roshini Sathiaseelan, M. Agbaga +3 more
2022Journal of Orthopaedic Research21 citations Open access
Semantic Scholar
Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis
Katarzyna Zyla-Jackson, Dorothy A. Walton, Kendra S. Plafker, S. Kovats +5 more
2023bioRxiv18 citations Open access
Semantic Scholar
Role of Elovl4 Protein in the Biosynthesis of Docosahexaenoic Acid
M. Agbaga, R. Brush, M. A. Mandal, Michael H. Elliott +2 more
2010Advances in Experimental Medicine and Biology18 citations Open access
Semantic Scholar
Effects of low AIPL1 expression on phototransduction in rods.
C. Makino, Xiao-Hong Wen, N. Michaud, I. Peshenko +12 more
2006Investigative Ophthalmology and Visual Science18 citations Open access
Semantic Scholar
The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration
M. Agbaga, Megan A. Stiles, R. Brush, M. T. Sullivan +4 more
2020Molecular Neurobiology17 citations Open access
Semantic Scholar
ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis
Y. K. Gyening, Neeraj Chauhan, Madison Tytanic, Vicki Ea +2 more
2022Journal of Lipid Research16 citations Open access
Semantic Scholar
Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver
Kameron Y. Sugino, Ashok Mandala, R. Janssen, Sunam Gurung +10 more
2022bioRxiv16 citations Open access
Semantic Scholar
W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34
R. Nagaraja, D. M. Sherry, Jennifer L. Fessler, Megan A. Stiles +8 more
2021Molecular Neurobiology14 citations Open access
Semantic Scholar
Phosphoinositide Lipids in Ocular Tissues
A. Rajala, Austin McCauley, R. Brush, Khuong T L Nguyen +1 more
2020Biology14 citations Open access
Semantic Scholar
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
Michael Landowski, Vijesh J. Bhute, Samuel Grindel, Zachary Haugstad +10 more
2023Communications Biology13 citations Open access
Semantic Scholar
High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice
Feng Li, L. Marchette, R. Brush, Michael H. Elliott +3 more
2010Molecular Vision12 citations
Semantic Scholar
Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling
Nikhil Y. Patil, I. Rus, Felix Ampadu, Hassan M. Abushukair +7 more
2025American Journal of Physiology - Gastrointestinal and Liver Physiology11 citations Open access
Semantic Scholar
Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration
Alexandra Bernardo-Colón, Li-Jin Dong, M. Abu-Asab, R. Brush +2 more
2023Journal of Lipid Research11 citations Open access
Semantic Scholar
PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage
Megan A. Stiles, G. Moiseyev, Madeline L. Budda, Annette Linens +8 more
2015PLoS ONE11 citations Open access
Semantic Scholar
In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.
Nawajes A. Mandal, Julie-Thu A. Tran, Li-Xin Zheng, Joseph L. Wilkerson +7 more
2014Investigative Ophthalmology and Visual Science11 citations Open access
Semantic Scholar
Lipid differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations.
Rex E. Martin, S. Fliesler, R. Brush, M. J. Richards +2 more
2005Molecular Vision10 citations
Semantic Scholar
Very Long Chain Polyunsaturated Fatty Acids and Rod Cell Structure and Function
L. Marchette, D. M. Sherry, R. Brush, Michael D. Chan +5 more
2014Advances in Experimental Medicine and Biology9 citations Open access
Semantic Scholar
Biosynthesis of very long-chain polyunsaturated fatty acids in hepatocytes expressing ELOVL4.
M. Agbaga, Sreemathi Logan, R. Brush, R. E. Anderson
2014Advances in Experimental Medicine and Biology9 citations
Semantic Scholar
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report
Y. K. Gyening, Keren Boris, M. Cyril, R. Brush +2 more
2023Acta Neuropathologica Communications8 citations Open access
Semantic Scholar
Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse
C. Schori, M. Agbaga, R. Brush, R. Ayyagari +2 more
2018PLoS ONE8 citations Open access
Semantic Scholar
Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina.
S. Azadi, R. Brush, R. E. Anderson, R. Rajala
2016Advances in Experimental Medicine and Biology8 citations
Semantic Scholar
HK2 Mediated Glycolytic Metabolism in Mouse Photoreceptors Is Not Required to Cause Late Stage Age-Related Macular Degeneration-Like Pathologies
Shun-Yun Cheng, Anneliese Malachi, Joris Cipi, Shan Ma +3 more
2021Biomolecules7 citations Open access
Semantic Scholar

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