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T. Gioannini · SciRah

Researcher profile · Semantic Scholar

T. Gioannini

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T. Gioannini — researcher profile on SciRah

h-index: 32
Works: 73
Citations: 4,213

Most-cited papers

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
A. Trompette, Senad Divanovic, A. Visintin, C. Blanchard +7 more
2008Nature793 citations Open access
Semantic Scholar
The TLR4 Antagonist, Eritoran, Protects Mice from Lethal Influenza Infection
K. Shirey, Wendy Lai, Alison J. Scott, M. Lipsky +12 more
2013Nature430 citations Open access
Semantic Scholar
Isolation of an endotoxin–MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations
T. Gioannini, Athmane Teghanemt, De-Sheng Zhang, N. Coussens +3 more
2004Proceedings of the National Academy of Sciences of the United States of America393 citations Open access
Semantic Scholar
Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells
T. Gioannini, J. Weiss
2007Immunologic research204 citations
Semantic Scholar
Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2.
Hong-Peng Jia, J. Kline, Andrea K Penisten, M. Apicella +3 more
2004American Journal of Physiology - Lung cellular and Molecular Physiology175 citations
Semantic Scholar
Molecular Basis of Reduced Potency of Underacylated Endotoxins1
Athmane Teghanemt, De-Sheng Zhang, E. N. Levis, J. Weiss +1 more
2005Journal of Immunology164 citations Open access
Semantic Scholar
The role of MicroRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation
Erik B. Wendlandt, Joel W. Graff, T. Gioannini, A. McCaffrey +1 more
2012Innate Immunity155 citations Open access
Semantic Scholar
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses
De Yang, Y. Postnikov, Yana Li, Poonam Tewary +8 more
2012Journal of Experimental Medicine146 citations Open access
Semantic Scholar
Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin*
Nuša Resman, Jožica Vašl, A. Oblak, P. Pristovsek +3 more
2009Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2
Prasad Rallabhandi, Rachel L. Phillips, M. Boukhvalova, Lioubov M. Pletneva +7 more
2012mBio112 citations Open access
Semantic Scholar
Monomeric endotoxin:protein complexes are essential for TLR4-dependent cell activation
T. Gioannini, Athmane Teghanemt, De-Sheng Zhang, E. N. Levis +1 more
2005Journal of Endotoxin Research105 citations Open access
Semantic Scholar
An Essential Role for Albumin in the Interaction of Endotoxin with Lipopolysaccharide-binding Protein and sCD14 and Resultant Cell Activation*
T. Gioannini, De-Sheng Zhang, Athmane Teghanemt, J. Weiss
2002Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Specific High Affinity Interactions of Monomeric Endotoxin·Protein Complexes with Toll-like Receptor 4 Ectodomain*
Polonca Prohinar, Fabio Re, R. Widstrom, De-Sheng Zhang +3 more
2007Journal of Biological Chemistry98 citations Open access
Semantic Scholar
The Carboxyl-terminal Domain of Closely Related Endotoxin-binding Proteins Determines the Target of Protein-Lipopolysaccharide Complexes*
Nicole M. Iovine, Joshua S. Eastvold, P. Elsbach, J. Weiss +1 more
2002Journal of Biological Chemistry91 citations Open access
Semantic Scholar
Covalent labeling of opioid receptors with radioiodinated human beta-endorphin. Identification of binding site subunit.
Andrew D. Howard, S. de La Baume, T. Gioannini, J. M. Hiller +1 more
1985Journal of Biological Chemistry84 citations
Semantic Scholar
A Novel Role for the Bactericidal/Permeability Increasing Protein in Interactions of Gram-Negative Bacterial Outer Membrane Blebs with Dendritic Cells1
H. Schultz, J. Hume, De-Sheng Zhang, T. Gioannini +1 more
2007Journal of Immunology67 citations Open access
Semantic Scholar
Lectin binding of solubilized opiate receptors: evidence for their glycoprotein nature.
T. Gioannini, Bernard Foucaud, J. M. Hiller, M. Hatten +1 more
1982Biochemical and Biophysical Research Communications - BBRC65 citations
Semantic Scholar
Construction of Acetate Auxotrophs of Neisseria meningitidis to Study Host-Meningococcal Endotoxin Interactions*
P. Giardina, T. Gioannini, Ben Buscher, A. Zaleski +5 more
2001Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Novel Roles in Human MD-2 of Phenylalanines 121 and 126 and Tyrosine 131 in Activation of Toll-like Receptor 4 by Endotoxin*
Athmane Teghanemt, Fabio Re, Polonca Prohinar, R. Widstrom +2 more
2008Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Evidence of a specific interaction between new synthetic antisepsis agents and CD14
M. Piazza, Li-Ping Yu, Athmane Teghanemt, T. Gioannini +2 more
2009Biochemistry53 citations Open access
Semantic Scholar
Regulation of interactions of endotoxin with host cells
T. Gioannini, Athmane Teghanemt, Kol A. Zarember, J. Weiss
2003Journal of Endotoxin Research53 citations
Semantic Scholar
Isolation of Monomeric and Dimeric Secreted MD-2
Athmane Teghanemt, R. Widstrom, T. Gioannini, J. Weiss
2008Journal of Biological Chemistry48 citations Open access
Semantic Scholar
NMR Studies of Hexaacylated Endotoxin Bound to Wild-type and F126A Mutant MD-2 and MD-2·TLR4 Ectodomain Complexes*
Li-Ping Yu, Rachel L. Phillips, De-Sheng Zhang, Athmane Teghanemt +2 more
2012Journal of Biological Chemistry44 citations Open access
Semantic Scholar
Endotoxin-binding Proteins Modulate the Susceptibility of Bacterial Endotoxin to Deacylation by Acyloxyacyl Hydrolase*
T. Gioannini, Athmane Teghanemt, De-Sheng Zhang, Polonca Prohinar +3 more
2007Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Endotoxin·albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of Toll-Like Receptor-4
G. Esparza, Athmane Teghanemt, De-Sheng Zhang, T. Gioannini +1 more
2011Innate Immunity42 citations Open access
Semantic Scholar
Expression of Functional D299G.T399I Polymorphic Variant of TLR4 Depends More on Coexpression of MD-2 Than Does Wild-Type TLR4
Polonca Prohinar, Prasad Rallabhandi, J. Weiss, T. Gioannini
2010Journal of Immunology42 citations Open access
Semantic Scholar
Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets
M. Piazza, G. Damore, B. Costa, T. Gioannini +2 more
2010Innate Immunity40 citations Open access
Semantic Scholar
Uniform LPS-Loaded Magnetic Nanoparticles for the Investigation of LPS/TLR4 Signaling
M. Piazza, M. Colombo, I. Zanoni, F. Granucci +5 more
2010Angewandte Chemie40 citations Open access
Semantic Scholar
Immunohistochemical localization of mu-opioid receptors in rat brain using antibodies generated against a peptide sequence present in a purified mu-opioid binding protein.
J. Hiller, Yi Zhang, G. Bing, T. Gioannini +2 more
1994Neuroscience37 citations Open access
Semantic Scholar
The cationic amphiphile 3,4-bis(tetradecyloxy)benzylamine inhibits LPS signaling by competing with endotoxin for CD14 binding
M. Piazza, V. Calabrese, C. Baruffa, T. Gioannini +2 more
2010Biochemical Pharmacology32 citations Open access
Semantic Scholar
Antibodies to dynorphin A(1–13) but not β-endorphin inhibit electrically elicited feeding in the rat
K. Carr, T. H. Bak, T. Gioannini, E. J. Simon
198732 citations Open access
Semantic Scholar
Opiate receptor heterogeneity in human brain regions.
K. Bonnet, J. Groth, T. Gioannini, Martha V. Cortes +1 more
1981Brain Research32 citations
Semantic Scholar
Transfer of Monomeric Endotoxin from MD-2 to CD14
Athmane Teghanemt, Polonca Prohinar, T. Gioannini, J. Weiss
2007Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Functional Activity of MD-2 Polymorphic Variant Is Significantly Different in Soluble and TLR4-Bound Forms: Decreased Endotoxin Binding by G56R MD-2 and Its Rescue by TLR4 Ectodomain1
Jožica Vašl, Polonca Prohinar, T. Gioannini, J. Weiss +1 more
2008Journal of Immunology28 citations Open access
Semantic Scholar
Novel Roles of Lysines 122, 125, and 58 in Functional Differences between Human and Murine MD-2
Jožica Vašl, A. Oblak, T. Gioannini, J. Weiss +1 more
2009Journal of Immunology27 citations Open access
Semantic Scholar
Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins
T. Gioannini, Athmane Teghanemt, De-Sheng Zhang, G. Esparza +2 more
2014Immunologic research26 citations Open access
Semantic Scholar
Opioid Receptor Multiplicity: Isolation, Purification, and Chemical Characterization of Binding Sites
E. J. Simon, T. Gioannini
199325 citations
Semantic Scholar
Tetraacylated Lipid A and Paclitaxel-Selective Activation of TLR4/MD-2 Conferred through Hydrophobic Interactions
Nuša Resman, A. Oblak, T. Gioannini, J. Weiss +1 more
2014Journal of Immunology21 citations Open access
Semantic Scholar
A synthetic lipid A mimetic modulates human TLR4 activity
M. Piazza, V. Calabrese, G. Damore, R. Cighetti +3 more
2011ChemMedChem20 citations Open access
Semantic Scholar
Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high affinity ligand for TLR4
Athmane Teghanemt, J. Weiss, T. Gioannini
2013Innate Immunity12 citations Open access
Semantic Scholar
Molecular Basis of the Functional differences between soluble human vs. murine MD-2: Role of Val-135 in transfer of LPS from CD14 to MD-2
Jožica Vašl, A. Oblak, T. Peternelj, J. Klett +4 more
2016Journal of Immunology10 citations Open access
Semantic Scholar
Reconstitution of a purified μ-opioid binding protein in liposomes : selective, high affinity, GTPγS-sensitive μ-opioid agonist binding is restored
T. Gioannini, Li-Qun Fan, L. Hyde, D. Ofri +3 more
199310 citations Open access
Semantic Scholar
Affinity crosslinking of 125I-labeled human ß-endorphin to cell lines possessing either μ- or δ-type opioid binding sites
O. Keren, T. Gioannini, J. M. Hiller, Eric J. Simon
19888 citations Open access
Semantic Scholar
Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone.
Gary A. Koolpe, Wendel L. Nelson, T. Gioannini, L. Angel +2 more
1985Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
An opiate receptor-associated aminopeptidase that degrades enkephalins
K. Hui, T. Gioannini, M. Hui, E. J. Simon +1 more
1985Neurochemical Research4 citations
Semantic Scholar
Evidence for the solubilization of multiple opioid binding sites from mammalian brain.
Y. Itzhak, J. Hiller, T. Gioannini, E. J. Simon
1983Life Science4 citations
Semantic Scholar
Inactivation of the Purified Bovine μ Opioid Receptor by Sulfhydryl Reagents
T. Gioannini, I. Onoprishvili, J. Hiller, E. J. Simon
2004Neurochemical Research3 citations
Semantic Scholar
Reconstitution of a purified mu-opioid binding protein in liposomes: selective, high affinity, GTP gamma S-sensitive mu-opioid agonist binding is restored.
T. Gioannini, L.-Q. Fan, L. Hyde, D. Ofri +3 more
1993Biochemical and Biophysical Research Communications - BBRC3 citations
Semantic Scholar
Opioid ligands related to tifluadom
S. Archer, A. Seyed-Mozaffari, E. J. Simon, T. Gioannini
19893 citations
Semantic Scholar
Immunoblots with rhodopsin antisera suggest that a purified ji opioid binding protein has structural characteristics of a G-protein-coupled receptor
T. Gioannini, R. E, WEISSf, G. Johnson +2 more
20042 citations
Semantic Scholar

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