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L. Madge · SciRah

Researcher profile · Semantic Scholar

L. Madge

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L. Madge — researcher profile on SciRah

h-index: 25
Works: 39
Citations: 4,515

Most-cited papers

Biological action of leptin as an angiogenic factor.
M. R. Sierra-Honigmann, A. Nath, C. Murakami, G. García-Cardeña +7 more
1998Science1,486 citations
Semantic Scholar
Selective inhibition of NF-κB activation by a peptide that blocks the interaction of NEMO with the IκB kinase complex
M. May, F. D'Acquisto, L. Madge, J. Glöckner +2 more
2000699 citations
Semantic Scholar
TNF signaling in vascular endothelial cells.
L. Madge, J. Pober
2001Experimental and molecular pathology (Print)324 citations
Semantic Scholar
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.
M. May, F. D'Acquisto, L. Madge, J. Glöckner +2 more
2000Science298 citations
Semantic Scholar
Hypomorphic NEMO mutation database and reconstitution system identifies phenotypic and immunologic diversity
E. Hanson, Linda Monaco-Shawver, Laura A. Solt, L. Madge +3 more
2008Journal of Allergy and Clinical Immunology244 citations Open access
Semantic Scholar
A Phosphatidylinositol 3-Kinase/Akt Pathway, Activated by Tumor Necrosis Factor or Interleukin-1, Inhibits Apoptosis but Does Not Activate NFκB in Human Endothelial Cells*
L. Madge, J. Pober
2000Journal of Biological Chemistry212 citations Open access
Semantic Scholar
Caveolin-1 Associates with TRAF2 to Form a Complex That Is Recruited to Tumor Necrosis Factor Receptors*
Xiao Feng, M. Gaeta, L. Madge, Jeong-Hee Yang +2 more
2001Journal of Biological Chemistry99 citations Open access
Semantic Scholar
Cytoprotection of Human Umbilical Vein Endothelial Cells Against Apoptosis and CTL-Mediated Lysis Provided by Caspase-Resistant Bcl-2 Without Alterations in Growth or Activation Responses1
Lian Zheng, T. Dengler, Martin S. Kluger, L. Madge +4 more
2000Journal of Immunology84 citations Open access
Semantic Scholar
Interferon-(cid:2) Augments CD95(APO-1/Fas) and Pro-Caspase-8 Expression and Sensitizes Human Vascular Endothelial Cells to CD95-Mediated Apoptosis
Jie-Hui Li, Martin S. Kluger, L. Madge, Zheng Lian +2 more
83 citations
Semantic Scholar
Interleukin-1-induced NF-κB Activation Is NEMO-dependent but Does Not Require IKKβ*
Laura A. Solt, L. Madge, J. Orange, M. May
2007Journal of Biological Chemistry78 citations Open access
Semantic Scholar
Lymphotoxin-α1β2 and LIGHT Induce Classical and Noncanonical NF-κB-Dependent Proinflammatory Gene Expression in Vascular Endothelial Cells1
L. Madge, Martin S. Kluger, J. Orange, M. May
2008Journal of Immunology77 citations Open access
Semantic Scholar
Apoptosis-inducing Agents Cause Rapid Shedding of Tumor Necrosis Factor Receptor 1 (TNFR1)
L. Madge, M. R. Sierra-Honigmann, J. Pober
1999Journal of Biological Chemistry69 citations Open access
Semantic Scholar
T Cell Receptor-induced Nuclear Factor κB (NF-κB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry*
Xiao-Hong Liu, C. Berry, G. Ruthel, Jonathan J. Madara +8 more
2016Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Inhibition of Phosphatidylinositol 3-Kinase Sensitizes Vascular Endothelial Cells to Cytokine-initiated Cathepsin-dependent Apoptosis*
L. Madge, Jie-Hui Li, Jaehyuk Choi, J. Pober
2003Journal of Biological Chemistry64 citations Open access
Semantic Scholar
A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells.
L. Madge, J. Pober
2000Journal of Biological Chemistry61 citations
Semantic Scholar
TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β
R. da Silva Antunes, A. Mehta, L. Madge, J. Tocker +1 more
2018Frontiers in Immunology56 citations Open access
Semantic Scholar
A Novel Ubiquitin-like Domain in IκB Kinase β Is Required for Functional Activity of the Kinase*
M. May, S. E. Larsen, Jae-hyuck Shim, L. Madge +1 more
2004Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells.
L. Madge, Martin S. Kluger, J. Orange, M. May
2008Journal of Immunology46 citations
Semantic Scholar
Classical NF-κB Activation Negatively Regulates Noncanonical NF-κB-dependent CXCL12 Expression*
L. Madge, M. May
2010Journal of Biological Chemistry45 citations Open access
Semantic Scholar
NEMO-binding Domains of Both IKKα and IKKβ Regulate IκB Kinase Complex Assembly and Classical NF-κB Activation*
Laura A. Solt, L. Madge, M. May
2009Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.
Laura A. Solt, L. Madge, J. Orange, M. May
2007Journal of Biological Chemistry43 citations
Semantic Scholar
Caspase Inhibition Sensitizes Inhibitor of NF-κB Kinase β-deficient Fibroblasts to Caspase-independent Cell Death via the Generation of Reactive Oxygen Species*
M. May, L. Madge
2007Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Delayed autoregulation of the Ca2+ signals resulting from capacitative Ca2+ entry in bovine pulmonary artery endothelial cells.
L. Madge, Ian C. B. Marshall, C. W. Taylor
1997Journal of Physiology37 citations Open access
Semantic Scholar
A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase.
M. May, S. E. Larsen, Jae-hyuck Shim, L. Madge +1 more
2004Journal of Biological Chemistry33 citations
Semantic Scholar
NKp30 Ligation Induces Rapid Activation of the Canonical NF-κB Pathway in NK Cells1
R. Pandey, C. DeStephan, L. Madge, M. May +1 more
2007Journal of Immunology32 citations Open access
Semantic Scholar
Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species.
M. May, L. Madge
2007Journal of Biological Chemistry23 citations
Semantic Scholar
The TNF Family Molecules LIGHT and Lymphotoxin αβ Induce a Distinct Steroid-Resistant Inflammatory Phenotype in Human Lung Epithelial Cells
R. da Silva Antunes, L. Madge, P. Soroosh, J. Tocker +1 more
2015Journal of Immunology21 citations Open access
Semantic Scholar
Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease.
K. Leonard, L. Madge, Paul J. Krawczuk, Ai-Hua Wang +17 more
2020Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
The NFκB paradox: RelB induces and inhibits gene expression
L. Madge, M. May
2011Cell Cycle19 citations Open access
Semantic Scholar
NKp30 ligation induces rapid activation of the canonical NF-kappaB pathway in NK cells.
R. Pandey, C. DeStephan, L. Madge, M. May +1 more
2008Journal of Immunology18 citations
Semantic Scholar
Inhibiting proinflammatory NF-kappaB signaling using cell-penetrating NEMO binding domain peptides.
L. Madge, M. May
2009Methods in molecular biology17 citations
Semantic Scholar
Effects of antisense oligonucleotide-mediated depletion of tumor necrosis factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression.
A. Siwkowski, L. Madge, S. Koo, Erin L. McMillan +3 more
2004Molecular Pharmacology15 citations
Semantic Scholar
Cutting Edge: Association with IκB Kinase β Regulates the Subcellular Localization of Homer3
Gayatri Yatherajam, P. Banerjee, K. A. McCorkell, Laura A. Solt +6 more
2010Journal of Immunology6 citations Open access
Semantic Scholar
A Phosphatidylinositol 3-Kinase/Akt Pathway, Activated by Tumor Necrosis Factor or Interleukin-1, Inhibits Apoptosis but Does Not Activate NF k B in Human Endothelial Cells*
L. Madge, J. Pober
20003 citations
Semantic Scholar
Novel calcium-dependent mechanisms of NF-B activation 1 T Cell Receptor-Induced NF-B Signaling and Transcriptional Activation Are Regulated by STIM 1-and Orai 1-Mediated Calcium Entry *
Xiao-Hong Liu, C. Berry, G. Ruthel, Jonathan J. Madara +8 more
20151 citations
Semantic Scholar
IL-1-INDUCED NF- κ B 1 ACTIVATION IS NEMO-DEPENDENT BUT DOES NOT REQUIRE IKK β *.
Laura A. Solt, L. Madge, J. Orange, M. May
20071 citations
Semantic Scholar
THE NEMO BINDING DOMAINS OF BOTH IKK α AND IKK β REGULATE IKK COMPLEX ASSEMBLY AND CLASSICAL NF- κ B ACTIVATION *
Laura A. Solt, L. Madge, M. May
20090 citations
Semantic Scholar
Expression in Vascular Endothelial Cells B-Dependent Proinflammatory Gene κ Classical and Noncanonical NF2 and LIGHT Induce β 1 α
L. Madge, Martin S. Kluger, J. Orange, M. May
20080 citations
Semantic Scholar
L-Glutamine Transporter in Cultured Human Umbilical Vein Endothelial Cells: Characteristics and Role in Oxidant Stress
L. Madge, A. Baydoun, J. Pearson, G. Mann
19930 citations
Semantic Scholar

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M. May×23
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J. Pober×12
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J. Orange×10
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Laura A. Solt×7
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Martin S. Kluger

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