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J. Orange · SciRah

Researcher profile · Semantic Scholar

J. Orange

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J. Orange — researcher profile on SciRah

h-index: 95
Works: 515
Citations: 36K

Most-cited papers

Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City.
E. Cheung, P. Zachariah, M. Gorelik, A. Boneparth +3 more
2020Journal of the American Medical Association (JAMA)491 citations Open access
Semantic Scholar
Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children's Hospital in New York City, New York.
P. Zachariah, Candace L. Johnson, Katia C. Halabi, D. Ahn +15 more
2020JAMA pediatrics450 citations Open access
Semantic Scholar
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.
M. Hegde, M. Mukherjee, Z. Grada, A. Pignata +17 more
2019Journal of Clinical Investigation367 citations Open access
Semantic Scholar
Amendment history : Expression of Concern ( July 2019 ) Tandem CAR T cells targeting HER 2 and IL 13 R a 2 mitigate tumor antigen escape
M. Hegde, M. Mukherjee, Z. Grada, A. Pignata +17 more
2019315 citations
Semantic Scholar
Outcomes of Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection at a Large Medical Center in New York City.
D. Dumitriu, U. Emeruwa, E. Hanft, Grace Liao +33 more
2020JAMA pediatrics213 citations Open access
Semantic Scholar
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function
Michael T. Lam, Simona Coppola, Oliver H. F. Krumbach, G. Prencipe +56 more
2019Journal of Experimental Medicine176 citations Open access
Semantic Scholar
Global systematic review of primary immunodeficiency registries
Hassan Abolhassani, G. Azizi, L. Sharifi, R. Yazdani +26 more
2020Expert Review of Clinical Immunology119 citations Open access
Semantic Scholar
Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function
C. Gruber, J. Calis, S. Buta, Gilad D. Evrony +14 more
2020Immunity97 citations Open access
Semantic Scholar
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency
Stefano Volpi, M. Cicalese, P. Tuijnenburg, A. Tool +48 more
2019Journal of Allergy and Clinical Immunology93 citations Open access
Semantic Scholar
Diagnostic Interpretation of Genetic Studies in Patients with Primary Immunodeficiency Diseases: A Working Group Report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma, and Immunology.
I. Chinn, Alice Y. Chan, Karin Chen, J. Chou +20 more
2019Journal of Allergy and Clinical Immunology86 citations
Semantic Scholar
Expanding the Spectrum of BAF-Related Disorders: De Novo Variants in SMARCC2 Cause a Syndrome with Intellectual Disability and Developmental Delay.
K. Machol, J. Rousseau, Sophie Ehresmann, T. Garcia +201 more
2019American Journal of Human Genetics86 citations Open access
Semantic Scholar
Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease.
J. Ravell, Mami Matsuda-Lennikov, Samuel D. Chauvin, J. Zou +50 more
2019Journal of Clinical Investigation77 citations Open access
Semantic Scholar
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis
N. Serwas, B. Hoeger, R. Ardy, Sigrun V Stulz +38 more
2019Nature Communications66 citations Open access
Semantic Scholar
Centers for Mendelian Genomics: A decade of facilitating gene discovery
Samantha M. Baxter, J. Posey, N. Lake, N. Sobreira +238 more
2021medRxiv65 citations Open access
Semantic Scholar
CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis.
I. Somekh, M. Thian, David Medgyesi, N. Gulez +32 more
2019Blood62 citations Open access
Semantic Scholar
Growth in diagnosis and treatment of primary immunodeficiency within the global Jeffrey Modell Centers Network
J. Quinn, V. Modell, J. Orange, F. Modell
2022Allergy, Asthma & Clinical Immunology60 citations Open access
Semantic Scholar
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.
M. Hegde, M. Mukherjee, Z. Grada, A. Pignata +17 more
2021Journal of Clinical Investigation60 citations Open access
Semantic Scholar
A review of newborn outcomes during the COVID-19 pandemic
M. Kyle, M. Glassman, Adrita Khan, C. Fernández +25 more
2020Seminars in Perinatology59 citations Open access
Semantic Scholar
Human NK cell deficiency as a result of biallelic mutations in MCM10
E. Mace, S. Paust, M. Conte, Ryan M. Baxley +24 more
2019bioRxiv56 citations Open access
Semantic Scholar
Interaction between nectin-1 and the human natural killer cell receptor CD96
Veronica M. Holmes, Carlos Maluquer de Motes, P. T. Richards, Jessenia Roldan +3 more
2019PLoS ONE38 citations Open access
Semantic Scholar
Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.
Lindsay C. Burrage, J. Reynolds, N. Baratang, J. Phillips +54 more
2019American Journal of Human Genetics35 citations Open access
Semantic Scholar
Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis
Yu Li, J. Orange
2021PLoS Biology34 citations Open access
Semantic Scholar
A Validated Artificial Intelligence-based Pipeline for Population-Wide Primary Immunodeficiency Screening.
N. Rider, M. Coffey, A. Kurian, J. Quinn +3 more
2022Journal of Allergy and Clinical Immunology33 citations Open access
Semantic Scholar
The case for severe combined immunodeficiency (SCID) and T cell lymphopenia newborn screening: saving lives…one at a time
J. Quinn, J. Orange, V. Modell, F. Modell
2020Immunologic research31 citations
Semantic Scholar
Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening
Ryan M. Baxley, Wendy Leung, Megan M. Schmit, J. Matson +22 more
2021Nature Communications30 citations Open access
Semantic Scholar
Antibody Deficiency Testing for Primary Immune Deficiency - A Practical Review for the Clinician.
R. Marsh, J. Orange
2019Annals of Allergy, Asthma & Immunology30 citations
Semantic Scholar
Treatment of Relapsing HPV Diseases by Restored Function of Natural Killer Cells
A. Lisco, Amy P. Hsu, D. Dimitrova, Diana M Proctor +21 more
2021New England Journal of Medicine28 citations Open access
Semantic Scholar
Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function.
A. Vargas-Hernández, A. Witalisz-Siepracka, M. Prchal-Murphy, Klara R. Klein +7 more
2019Journal of Allergy and Clinical Immunology26 citations Open access
Semantic Scholar
Calculation of a Primary Immunodeficiency “Risk Vital Sign” via Population-Wide Analysis of Claims Data to Aid in Clinical Decision Support
N. Rider, Di Miao, M. Dodds, V. Modell +4 more
2019Frontiers in Pediatrics26 citations Open access
Semantic Scholar
HSCT corrects primary immunodeficiency and immune dysregulation in patients with POMP-related auto-inflammatory disease.
C. Martinez, F. Ebstein, S. Nicholas, M. De Guzman +9 more
2021Blood25 citations Open access
Semantic Scholar
Relationship Between Severity of T Cell Lymphopenia and Immune Dysregulation in Patients with DiGeorge Syndrome (22q11.2 Deletions and/or Related TBX1 Mutations): a USIDNET Study
D. Deshpande, Y. Demirdag, R. Marsh, K. Sullivan +2 more
2020Journal of Clinical Immunology24 citations
Semantic Scholar
Reprogramming Human T Cell Function and Specificity With Non–Viral Genome Targeting
D. Deshpande, J. Orange
2019Pediatrics24 citations
Semantic Scholar
A 2020 update on the use of genetic testing for patients with primary immunodeficiency
I. Chinn, J. Orange
2020Expert Review of Clinical Immunology23 citations
Semantic Scholar
Novel Heterozygous Mutation in NFKB2 Is Associated With Early Onset CVID and a Functional Defect in NK Cells Complicated by Disseminated CMV Infection and Severe Nephrotic Syndrome
Alejandra Aird, M. Lagos, A. Vargas-Hernández, J. Posey +11 more
2019Frontiers in Pediatrics23 citations Open access
Semantic Scholar
Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex.
Wayne Bainter, Craig D. Platt, Seung-Yeol Park, Kelsey Stafstrom +19 more
2021Journal of Clinical Investigation21 citations Open access
Semantic Scholar
Immune Dysregulation Mimicking Systemic Lupus Erythematosus in a Patient With Lysinuric Protein Intolerance: Case Report and Review of the Literature
Josefina Contreras, Mabel Ladino, K. Aranguiz, G. Mendez +9 more
2021Frontiers in Pediatrics21 citations Open access
Semantic Scholar
New primary immunodeficiencies 2021 context and future
Y. Demirdag, R. Fuleihan, J. Orange, Joyce E. Yu
2021Current opinion in pediatrics20 citations
Semantic Scholar
Jeffrey’s insights: Jeffrey Modell Foundation’s global genetic sequencing pilot program to identify specific primary immunodeficiency defects to optimize disease management and treatment
J. Quinn, V. Modell, J. Holle, R. Truty +4 more
2020Immunologic research20 citations Open access
Semantic Scholar
Global Expansion of Jeffrey’s Insights: Jeffrey Modell Foundation’s Genetic Sequencing Program for Primary Immunodeficiency
J. Quinn, V. Modell, Britt A. Johnson, S. Poll +3 more
2022Frontiers in Immunology18 citations Open access
Semantic Scholar
Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID.
Marcel Kuhny, L. Forbes, Elif Çakan, Andrea Vega-Loza +17 more
2020Journal of Clinical Investigation18 citations Open access
Semantic Scholar
Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia
M. Conte, M. Poli, A. Taglialatela, G. Leuzzi +10 more
2022JCI Insight17 citations Open access
Semantic Scholar
Myeloid malignancies with somatic GATA2 mutations can be associated with an immunodeficiency phenotype
M. Alfayez, Sa A. Wang, Sarah A. Bannon, D. Kontoyiannis +4 more
2019Leukemia and Lymphoma17 citations
Semantic Scholar
The role of breast-feeding in cytomegalovirus transmission and hematopoietic stem cell transplant outcomes in infants with severe combined immunodeficiency.
William J Kelty, S. A. Beatty, Shuya Wu, I. Hanson +4 more
2019Journal of Allergy and Clinical Immunology: In Practice17 citations Open access
Semantic Scholar
Human NK cells prime inflammatory DC precursors to induce Tc17 differentiation.
M. A. Clavijo-Salomon, R. Salcedo, S. Roy, R. D. das Neves +8 more
2020Blood Advances16 citations Open access
Semantic Scholar
Immunodeficiency Disorders
I. Chinn, J. Orange
2019Pediatrics in review16 citations
Semantic Scholar
The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice
R. Pandey, M. Bakay, Heather S. Hain, Bryan P. Strenkowski +4 more
2019Frontiers in Immunology16 citations Open access
Semantic Scholar
Prophylactic Antibiotics Versus Immunoglobulin Replacement in Specific Antibody Deficiency
J. Hajjar, An L. Nguyen, G. Constantine, Carleigh Kutac +3 more
2019Journal of Clinical Immunology15 citations
Semantic Scholar
Fixing the leaky pipeline: identifying solutions for improving pediatrician-scientist training during pediatric residency
Audrea M Burns, K. Ackerman, S. Thammasitboon, Caroline E. Rassbach +17 more
2020Pediatric Research14 citations
Semantic Scholar
NK cells in treated HIV-infected children display altered phenotype and function
Sanjana Mahapatra, W. Shearer, C. Minard, E. Mace +2 more
2019Journal of Allergy and Clinical Immunology13 citations Open access
Semantic Scholar
An ELF4 hypomorphic variant results in NK cell deficiency
S. Salinas, E. Mace, M. Conte, C. Park +18 more
2022JCI Insight12 citations Open access
Semantic Scholar

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