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C. Fearns · SciRah

Researcher profile · Semantic Scholar

C. Fearns

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C. Fearns — researcher profile on SciRah

h-index: 29
Works: 44
Citations: 3,789

Most-cited papers

Targeting Protein Aggregation for the Treatment of Degenerative Diseases
Yvonne S. Eisele, Cecília Monteiro, C. Fearns, S. Encalada +3 more
2015Nature reviews. Drug discovery377 citations Open access
Semantic Scholar
The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory Agency Approved Drug
Steven M. Johnson, S. Connelly, C. Fearns, E. Powers +1 more
2012Journal of Molecular Biology324 citations Open access
Semantic Scholar
Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4 Published, JLR Papers in Press, February 14, 2006.
C. R. Raetz, Teresa A. Garrett, C. M. Reynolds, W. Shaw +16 more
2006Journal of Lipid Research224 citations Open access
Semantic Scholar
Inhibition of the tissue factor-thrombin pathway limits infarct size after myocardial ischemia-reperfusion injury by reducing inflammation.
J. Erlich, Edward M. Boyle, J. Labriola, J. Kovacich +10 more
2000American Journal of Pathology223 citations Open access
Semantic Scholar
Pharmacological Inhibition of BMK1 Suppresses Tumor Growth Through PML
Qingkai Yang, Xianming Deng, B. Lu, Michael Cameron +5 more
2010Cancer Cell199 citations Open access
Semantic Scholar
MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury.
L. Otterbein, Sherrie L. Otterbein, E. Ifedigbo, Fang Liu +6 more
2003American Journal of Pathology189 citations Open access
Semantic Scholar
Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest
Xiao-Fei Wang, C. McGowan, Ming-zhe Zhao, Liu-Sheng He +5 more
2000Molecular and Cellular Biology186 citations Open access
Semantic Scholar
Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide
C. Fearns, V. Kravchenko, R. Ulevitch, D. Loskutoff
1995Journal of Experimental Medicine175 citations Open access
Semantic Scholar
MDP‐induced interleukin‐1β processing requires Nod2 and CIAS1/NALP3
Qilin Pan, J. Mathison, C. Fearns, V. Kravchenko +10 more
2007Journal of Leukocyte Biology163 citations
Semantic Scholar
N-(3-Oxo-acyl)homoserine Lactones Signal Cell Activation through a Mechanism distinct from the Canonical Pathogen-associated Molecular Pattern Recognition Receptor Pathways*
V. Kravchenko, G. Kaufmann, J. Mathison, D. Scott +12 more
2006Journal of Biological Chemistry130 citations Open access
Semantic Scholar
Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation.
J. Erlich, G. Parry, C. Fearns, M. Müller +3 more
1999Proceedings of the National Academy of Sciences of the United States of America121 citations Open access
Semantic Scholar
CDC25B mediates rapamycin-induced oncogenic responses in cancer cells
Run-Qiang Chen, Qingkai Yang, B. Lu, Wei Yi +5 more
2009Cancer Research119 citations Open access
Semantic Scholar
Lipopolysaccharide Induction of Tissue Factor Expression in Rabbits
J. Erlich, C. Fearns, J. Mathison, R. Ulevitch +1 more
1999Infection and Immunity111 citations Open access
Semantic Scholar
Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment.
Jin-Yun Yuan, Jianbin Wang, K. Crain, C. Fearns +5 more
2012Molecular Therapy106 citations Open access
Semantic Scholar
Triad3A Regulates Ubiquitination and Proteasomal Degradation of RIP1 following Disruption of Hsp90 Binding*
C. Fearns, Qilin Pan, J. Mathison, Tsung-Hsien Chuang
2006Journal of Biological Chemistry104 citations Open access
Semantic Scholar
Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis.
M. Hayashi, C. Fearns, B. Eliceiri, Young Yang +1 more
2005Cancer Research103 citations Open access
Semantic Scholar
Combined Integrin Phosphoproteomic Analyses and siRNA-based Functional Screening Identified Key Regulators for Cancer Cell Adhesion and Migration
Yan-ling Chen, B. Lu, Qingkai Yang, C. Fearns +2 more
2009Cancer Research95 citations Open access
Semantic Scholar
A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy
M. Hayashi, K. Imanaka-Yoshida, Toshimichi Yoshida, M. Wood +3 more
2006Nature Medicine94 citations
Semantic Scholar
The origin and function of soluble CD14 in experimental bacterial meningitis.
A. Cauwels, K. Frei, S. Sansano, C. Fearns +3 more
1999Journal of Immunology93 citations
Semantic Scholar
Current and future treatment of amyloid diseases
M. Ankarcrona, B. Winblad, Cecília Monteiro, C. Fearns +6 more
2016Journal of Internal Medicine84 citations Open access
Semantic Scholar
Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling
J-H Zhu, Run-qiang Chen, W. Yi, Greg T. Cantin +4 more
2008Oncogene78 citations Open access
Semantic Scholar
Tid1, the Human Homologue of a Drosophila Tumor Suppressor, Reduces the Malignant Activity of ErbB-2 in Carcinoma Cells
Sung-Woo Kim, T. Chao, R. Xiang, Jeng-Fan Lo +3 more
2004Cancer Research58 citations Open access
Semantic Scholar
Tid1, a Cochaperone of the Heat Shock 70 Protein and the Mammalian Counterpart of the Drosophila Tumor Suppressor l(2)tid, Is Critical for Early Embryonic Development and Cell Survival
Jeng-Fan Lo, M. Hayashi, Sung Woo Kim, Bin Tian +6 more
2004Molecular and Cellular Biology57 citations Open access
Semantic Scholar
Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interleukin-8.
Sung-Woo Kim, M. Hayashi, Jeng-Fan Lo, C. Fearns +4 more
2005Cancer Research50 citations
Semantic Scholar
The desmoplastic response: Induction of collagen synthesis by melanoma cells in vitro
C. Fearns, E. Dowdle
1992International Journal of Cancer50 citations
Semantic Scholar
Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide
C. Fearns, D. Loskutoff
1997Infection and Immunity38 citations Open access
Semantic Scholar
Kinome Sirna Screen Identifies SMG-1 as a Negative Regulator of Hypoxia-inducible Factor-1α in Hypoxia
Run-Qiang Chen, Qingkai Yang, Yan-ling Chen, Vasco Oliveira +3 more
2009Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Kdo 2-Lipid A of Escherichia coli , a defined endotoxin that activates macrophages via TLR4
C. R. Raetz, Teresa A. Garrett, C. M. Reynolds, W. Shaw +16 more
200633 citations
Semantic Scholar
Unusual growth characteristics of human melanoma xenografts in the nude mouse: a model for desmoplasia, dormancy and progression.
M. Gartner, C. Fearns, EL Wilson, James S. Campbell +1 more
1992British Journal of Cancer29 citations Open access
Semantic Scholar
EFFECT OF RECOMBINANT INTERLEUKIN‐1β ON MURINE CD14 GENE EXPRESSION IN VIVO
C. Fearns, R. Ulevitch
1998Shock27 citations Open access
Semantic Scholar
Expression and role of CD14 in mice sensitized to lipopolysaccharide by Propionibacterium acnes
T. Merlin, Regina Woelky-Bruggmann, C. Fearns, M. Freudenberg +1 more
2002European Journal of Immunology23 citations Open access
Semantic Scholar
NF-κB activation primes cells to a pro-inflammatory polarized response to a TLR7 agonist
Jongdae Lee, M. Hayashi, Jeng-Fan Lo, C. Fearns +4 more
2009Biochemical Journal22 citations Open access
Semantic Scholar
Zinc-finger Nuclease Editing of Human cxcr4 Promotes HIV-1 CD4+ T Cell Resistance and Enrichment.
Jin-Yun Yuan, Jianbin Wang, K. Crain, C. Fearns +5 more
2012Molecular Therapy21 citations Open access
Semantic Scholar
Involvement of the MKK6-p38g Cascade in g-Radiation-Induced Cell Cycle Arrest†
Xiao-Fei Wang, C. McGowan, Ming-zhe Zhao, Liu-Sheng He +5 more
200016 citations
Semantic Scholar
Tid1 Is Required for T Cell Transition from Double-Negative 3 to Double-Positive Stages 1
Jeng-Fan Lo, He Zhou, C. Fearns, R. Reisfeld +2 more
2005Journal of Immunology15 citations Open access
Semantic Scholar
A REGULATES UBIQUITINATION AND PROTEASOMAL DEGRADATION OF RIP 1 FOLLOWING DISRUPTION OF HSP 90 BINDING
C. Fearns, Qilin Pan, J. Mathison, Tsung-Hsien Chuang
20069 citations
Semantic Scholar
Tid 1 , a Cochaperone of the Heat Shock 70 Protein and the Mammalian Counterpart of the Drosophila Tumor Suppressor l ( 2 ) tid , Is Critical for Early Embryonic Development and Cell Survival
Jeng-Fan Lo, M. Hayashi, Sung Woo Kim, Bin Tian +6 more
20047 citations
Semantic Scholar
INHIBITION OF TISSUE FACTOR EXPRESSED BY ISCHAEMIC CARDIOMYOCYTES REDUCES INFARCT SIZE AFTER MYOCARDIAL ISCHEMIA/REPERFUSION INJURY
Erlich Jh, Boyle Em, Santucci Ra, Kovacic Jc +8 more
20002 citations
Semantic Scholar
Development of Therapeutic Strategies for the Transthyretin Amyloidoses
C. Fearns, S. Connelly, E. Powers, J. Kelly
20131 citations
Semantic Scholar
NF- κ B activation primes cells to a pro-inflammatory polarized response to a TLR7 agonist
Jongdae Lee, M. Hayashi, Jeng-Fan Lo, C. Fearns +4 more
20090 citations
Semantic Scholar
Purification and Properties of Escherichia coli Kdo 2-Lipid A , a Defined Endotoxin that Activates Macrophages via TLR4
C. R. Raetz, Teresa A. Garrett, C. M. Reynolds, W. Shaw +19 more
20060 citations
Semantic Scholar
Double-Negative 3 to Double-Positive Stages Tid 1 Is Required for T Cell Transition from
Jeng-Fan Lo, He Zhou, C. Fearns, R. Reisfeld +2 more
20050 citations
Semantic Scholar
Influence of menstrual cycle , parity and oral contraceptive use on steroid hormone receptors in normal breast
M. Gartner, C. Fearns, E. L. Wilson, J. Campbell +54 more
19920 citations
Semantic Scholar
The desmoplastic response : mechanisms of tumour-induced fibrogenesis
C. Fearns
19890 citations
Semantic Scholar

Frequent co-authors

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Jiing-Dwan Lee×13
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R. Ulevitch×9
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Jeng-Fan Lo×8
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M. Hayashi×7
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Young Yang — researcher profile on SciRah

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J. Mathison — researcher profile on SciRah

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N. Mackman — researcher profile on SciRah

Qingkai Yang×4

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Qingkai Yang — researcher profile on SciRah

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J. Yates — researcher profile on SciRah

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Qilin Pan — researcher profile on SciRah

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E. Powers — researcher profile on SciRah

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J. Kelly — researcher profile on SciRah