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F. Machetti · SciRah

Researcher profile · Semantic Scholar

F. Machetti

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F. Machetti — researcher profile on SciRah

h-index: 21
Works: 80
Citations: 1,240

Most-cited papers

1,4-Diazabicyclo[2.2.2]octane (DABCO) as an Efficient Reagent for the Synthesis of Isoxazole Derivatives from Primary Nitro Compounds and Dipolarophiles: The Role of the Base
L. Cecchi, Francesco De Sarlo, F. Machetti
2006130 citations
Semantic Scholar
Synthesis of 4,5-dihydroisoxazoles by condensation of primary nitro compounds with alkenes by using a copper/base catalytic system.
L. Cecchi, Francesco De Sarlo, F. Machetti
2008Chemistry64 citations
Semantic Scholar
Isoxazoles and Isoxazolines by 1,3-Dipolar Cycloaddition: Base-Catalysed Condensation of Primary Nitro Compounds with Dipolarophiles
F. Machetti, L. Cecchi, E. Trogu, Francesco De Sarlo
200764 citations
Semantic Scholar
Interactions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain
M. Frosini, C. Sesti, S. Dragoni, M. Valoti +4 more
2003British Journal of Pharmacology50 citations Open access
Semantic Scholar
Acid-base-catalysed condensation reaction in water: isoxazolines and isoxazoles from nitroacetates and dipolarophiles.
E. Trogu, C. Vinattieri, Francesco De Sarlo, F. Machetti
2012Chemistry49 citations Open access
Semantic Scholar
19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2.
A. Guarna, C. Belle, F. Machetti, Ernesto G. Occhiato +8 more
1997Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation
M. Frosini, C. Sesti, S. Saponara, Lorenzo Ricci +4 more
2003British Journal of Pharmacology44 citations Open access
Semantic Scholar
Synthesis and Reactivity of Bicycles Derived from Tartaric Acid and α-Amino Acids: A Novel Class of Conformationally Constrained Dipeptide Isosteres Based upon Enantiopure 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid
A. Guarna, Antonio Guidi, F. Machetti, G. Menchi +4 more
199942 citations
Semantic Scholar
Michael additions versus cycloaddition condensations with ethyl nitroacetate and electron-deficient olefins.
E. Trogu, Francesco De Sarlo, F. Machetti
2009Chemistry41 citations
Semantic Scholar
Isoxazoline derivatives from activated primary nitrocompounds and tertiary diamines
L. Cecchi, Francesco De Sarlo, F. Machetti
200539 citations
Semantic Scholar
Conjugate addition versus cycloaddition/condensation of nitro compounds in water: selectivity, acid-base catalysis, and induction period.
Luca Guideri, Francesco De Sarlo, F. Machetti
2013Chemistry28 citations
Semantic Scholar
Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds.
A. Trabocchi, C. Mannino, F. Machetti, F. de Bernardis +4 more
2010Journal of Medicinal Chemistry28 citations
Semantic Scholar
A new synthesis of (2S)-4-oxopipecolic acid by thermal rearrangement of enantiopure spirocyclopropaneisoxazolidine
F. Machetti, F. Cordero, Francesco De Sarlo, A. Guarna +1 more
199627 citations
Semantic Scholar
A new bicyclic dipeptide isostere with pyrrolizidinone skeleton.
F. Cordero, Federica Pisaneschi, Karina Meschini Batista, Silvia Valenza +2 more
2005Journal of Organic Chemistry26 citations
Semantic Scholar
1,2,5-Oxadiazole (Furazan) Derivatives from Benzoylnitromethane and Dipolarophiles in the Presence of DABCO: Structure and Intermediates
L. Cecchi, Francesco De Sarlo, C. Faggi, F. Machetti
200625 citations
Semantic Scholar
19-Nor-10-azasteroids. 5.(1) A Synthetic Strategy for the Preparation of (+)-17-(3-Pyridyl)-(5beta)-10-azaestra-1,16- dien-3-one, a Novel Potential Inhibitor for Human Cytochrome P450(17)(alpha) (17alpha-Hydroxylase/C(17,20)-lyase).
A. Guarna, E. Occhiato, F. Machetti, V. Giacomelli
1999Journal of Organic Chemistry25 citations
Semantic Scholar
Five-Membered Heterocycles: 1,3-Azoles
J. Revuelta, F. Machetti, S. Cicchi
201124 citations
Semantic Scholar
The Synthesis of 4-Hydroxypipecolic Acids by Stereoselective Cycloaddition of Configurationally Stable Nitrones
F. Cordero, Simona Bonollo, F. Machetti, A. Brandi
200624 citations
Semantic Scholar
Base- and Copper-Catalysed Condensation of Primary Activated Nitro Compounds with Enolisable Compounds
E. Trogu, L. Cecchi, Francesco De Sarlo, Luca Guideri +2 more
200922 citations Open access
Semantic Scholar
Enantiospecific synthesis of 3-aza-6,8-dioxa-bicyclo[3.2.1]octane carboxylic acids from erythrose
A. Trabocchi, G. Menchi, Massimo Rolla, F. Machetti +2 more
200322 citations
Semantic Scholar
Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors.
C. Mannino, M. Nievo, F. Machetti, A. Papakyriakou +3 more
2006Bioorganic & Medicinal Chemistry21 citations Open access
Semantic Scholar
Synthesis of a new enantiopure bicyclic γ/δ-amino acid (BTKa) derived from tartaric acid and α-amino acetophenone
A. Guarna, Ilaria Bucelli, F. Machetti, G. Menchi +3 more
200221 citations
Semantic Scholar
Novel inhibitors of 5α-reductase
F. Machetti, A. Guarna
200221 citations
Semantic Scholar
Competitive Copper Catalysis in the Condensation of Primary Nitro Compounds with Terminal Alkynes: Synthesis of Isoxazoles
Ausilia Baglieri, Luca Meschisi, Francesco De Sarlo, F. Machetti
201620 citations
Semantic Scholar
A CONCISE ROUTE TO 19-NOR-10-AZASTEROIDS, A NEW CLASS OF STEROID 5ALPHA -REDUCTASE INHIBITORS. 3. SYNTHESIS OF (+)-19-NOR-10-AZATESTOSTERONE AND (+)-1 7BETA -(ACETYLOXY)-(5BETA )-10-AZAESTR-1-EN-3-ONE
A. Guarna, E. Occhiato, F. Machetti, D. Scarpi
199820 citations
Semantic Scholar
19-nor-10-azasteroids, a new class of steroid 5 alpha-reductase inhibitors. 2. X-ray structure, molecular modeling, conformational analysis of 19-nor-10-azasteroids and comparison with 4-azasteroids and 6-azasteroids.
A. Guarna, Ernesto G. Occhiato, F. Machetti, A. Marrucci +3 more
1997Journal of Medicinal Chemistry20 citations
Semantic Scholar
Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study
Giacomo Biagiotti, Federica Pisaneschi, S. Gammon, F. Machetti +9 more
2019Journal of materials chemistry. B19 citations Open access
Semantic Scholar
Practical Synthesis of Both Enantiomers of Protected 4-Oxopipecolic Acid.
F. Machetti, F. Cordero, Francesco De Sarlo, A. Brandi
200119 citations
Semantic Scholar
Parallel synthesis of an amide library based on the 6,8-dioxa-3-azabicyclo[3.2.1]octane scaffold by direct aminolysis of methyl esters.
F. Machetti, Ilaria Bucelli, Giovanni Indiani, C. Kappe +1 more
2007Journal of combinatorial chemistry17 citations
Semantic Scholar
New Synthesis of (Methoxycarbonyl)‐indolizidin‐7‐one and ‐quinolizidin‐ 2‐one: An Access to β‐Amino Acids with Indolizidine and Quinolizidine Backbone.
F. Cordero, F. Machetti, F. De Sarlo, A. Brandi
199717 citations
Semantic Scholar
Amino‐Sulfonation of Alkenes in a Three‐Component Reaction
F. Cordero, M. Cacciarini, F. Machetti, Francesco De Sarlo
200215 citations
Semantic Scholar
Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5 alpha-reductase 1.
A. Guarna, Ernesto G. Occhiato, F. Machetti, A. Trabocchi +5 more
2001Bioorganic & Medicinal Chemistry15 citations
Semantic Scholar
Conversion of a nitrosocarbonyl hetero Diels–Alder cycloadduct to useful isoxazoline-carbocyclic aminols
P. Quadrelli, B. Bovio, A. Piccinini, P. Caramella +2 more
200914 citations
Semantic Scholar
Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis.
Lorenzo Ricci, M. Frosini, N. Gaggelli, G. Valensin +3 more
2006Biochemical Pharmacology14 citations
Semantic Scholar
Modification of the aza-robinson annulation for the synthesis of 4-methyl-benzo[c]quinolizin-3-ones, potent inhibitors of steroid 5alpha-reductase 1.
A. Guarna, E. Lombardi, F. Machetti, E. Occhiato +1 more
2000Journal of Organic Chemistry14 citations
Semantic Scholar
Synthesis of Free and Nα-Fmoc-/Nγ-Boc-Protected (2S,4S)- and (2S,4R)-4-Aminopipecolic Acids
F. Machetti, F. Cordero, Francesco De Sarlo, A. Papini +2 more
200413 citations
Semantic Scholar
Reactivity of [60]Fullerene with Primary Nitro Compounds: Addition or Catalysed Condensation to Isoxazolo[60]fullerenes
Giacomo Biagiotti, S. Cicchi, Francesco De Sarlo, F. Machetti
201411 citations
Semantic Scholar
Oligomers of Enantiopure Bicyclic γ/δ-Amino Acids (BTAa). 1. Synthesis and Conformational Analysis of 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid Oligomers (PolyBTG)
F. Machetti, Alessandro Ferrali, G. Menchi, E. Occhiato +1 more
200011 citations
Semantic Scholar
Synthesis and X‐ray study of hexahydro‐ and tetrahydrophospholo‐[2,3‐d]isoxazoles, a new class of heterocycles of potential fungicidal activity
F. Machetti, B. Anichini, S. Cicchi, A. Brandi +3 more
199610 citations
Semantic Scholar
Repository istituzionale dell'Università degli Studi di Firenze
Antonio Guarna, Ernesto G. Occhiato, F. Machetti, A. Marrucci +3 more
10 citations
Semantic Scholar
Probing the Structure of Toxic Amyloid-β Oligomers with Electron Spin Resonance and Molecular Modeling
M. Banchelli, R. Cascella, C. D'Andrea, G. La Penna +4 more
2021ACS Chemical Neuroscience9 citations Open access
Semantic Scholar
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study.
M. Frosini, Casilde Sesti, S. Saponara, A. Donati +4 more
2000Advances in Experimental Medicine and Biology8 citations
Semantic Scholar
19-Nor-10-azasteroids: A Novel Class of Inhibitors for Human Steroid 5. alpha.-Reductases 1 and 2.
A. Guarna, C. Belle, F. Machetti, E. Occhiato +8 more
19978 citations
Semantic Scholar
Design, Synthesis, and Applications of 3‐Aza‐6,8‐dioxabicyclo[3.2.1]octane‐Based Scaffolds for Peptidomimetic Chemistry
A. Trabocchi, G. Menchi, F. Guarna, F. Machetti +2 more
20067 citations
Semantic Scholar
Design and synthesis of a new bicyclic dipeptide isostere.
F. Cordero, Silvia Valenza, F. Machetti, A. Brandi
2001Chemical Communications7 citations
Semantic Scholar
Stereoselectivity in the TiCl4-catalysed reaction of Danishefsky's diene with a N-(acyloxy)iminium ion: Synthesis of 5α versus 5β Δ1(2)-19-Nor-10-azasteroids. 4
E. Occhiato, D. Scarpi, F. Machetti, A. Guarna
19987 citations
Semantic Scholar
Primary nitro compounds: progress in the synthesis of isoxazoles by condensation with aldehydes or activated ketones.
Francesco De Sarlo, F. Machetti
2023Organic and biomolecular chemistry5 citations Open access
Semantic Scholar
Design, Synthesis, and Applications of 3-Aza-6,8-Dioxabicyclo[3.2.1]Octane-Based Scaffolds for Peptidomimetic Chemistry
A. Trabocchi, G. Menchi, F. Guarna, F. Machetti +2 more
20065 citations
Semantic Scholar
Bicyclic Compounds Derived from Tartaric Acid and α‐Amino Acids (BTAas): Synthesis of New Molecular Scaffolds Derived from the Combination of (R,R)‐Tartaric Acid and L‐Serine
N. Cini, F. Machetti, G. Menchi, E. Occhiato +1 more
20025 citations
Semantic Scholar
Neat reaction of carboxylic acid methyl esters and amines for efficient parallel synthesis of scaffold amide libraries
F. Machetti, Ilaria Bucelli, Giovanni Indiani, A. Guarna
20034 citations Open access
Semantic Scholar

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A. Guarna×21
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A. Guarna — researcher profile on SciRah
Francesco De Sarlo×17
E. Occhiato×9
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E. Occhiato — researcher profile on SciRah
F. Cordero×8
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F. Cordero — researcher profile on SciRah
A. Brandi×8
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A. Brandi — researcher profile on SciRah

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G. Menchi — researcher profile on SciRah

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D. Scarpi — researcher profile on SciRah

A. Trabocchi×7

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A. Trabocchi — researcher profile on SciRah

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L. Cecchi — researcher profile on SciRah

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G. Danza — researcher profile on SciRah

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E. Trogu — researcher profile on SciRah

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M. Frosini — researcher profile on SciRah