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C. Heyworth · SciRah

Researcher profile · Semantic Scholar

C. Heyworth

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C. Heyworth — researcher profile on SciRah

h-index: 29
Works: 86
Citations: 3,427

Most-cited papers

Multilineage gene expression precedes commitment in the hemopoietic system.
Ming Hu, D. Krause, M. Greaves, S. Sharkis +3 more
1997Genes & Development817 citations Open access
Semantic Scholar
Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA‐1 and GATA‐2
E. Anguita, J. Hughes, C. Heyworth, G. Blobel +2 more
2004EMBO Journal245 citations Open access
Semantic Scholar
Transcription factor‐mediated lineage switching reveals plasticity in primary committed progenitor cells
C. Heyworth, S. Pearson, G. May, T. Enver
2002EMBO Journal142 citations Open access
Semantic Scholar
The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells.
C. Heyworth, T. Dexter, O. Kan, A. Whetton
1990Growth Factors120 citations
Semantic Scholar
Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes.
C. Heyworth, A. Wallace, M. Houslay
1983Biochemical Journal118 citations Open access
Semantic Scholar
Molecular Signatures of Self-Renewal, Differentiation, and Lineage Choice in Multipotential Hemopoietic Progenitor Cells In Vitro
L. Bruno, R. Hoffmann, F. McBlane, John Brown +6 more
2004Molecular and Cellular Biology110 citations Open access
Semantic Scholar
A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal.
C. Heyworth, K. Gale, M. Dexter, G. May +1 more
1999Genes & Development102 citations Open access
Semantic Scholar
The phorbol ester, TPA inhibits glucagon‐stimulated adenylate cyclase activity
C. Heyworth, A. Whetton, A. Kinsella, M. Houslay
1984FEBS Letters98 citations Open access
Semantic Scholar
Stromal cells in haemopoiesis.
T. Dexter, L. Coutinho, E. Spooncer, C. Heyworth +4 more
1990Ciba Foundation symposium81 citations
Semantic Scholar
BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties.
M. Hunter, L. Bawden, D. Brotherton, S. Craig +12 more
1995Blood71 citations
Semantic Scholar
Insulin exerts actions through a distinct species of guanine nucleotide regulatory protein: inhibition of adenylate cyclase.
C. Heyworth, M. Houslay
1983Biochemical Journal71 citations Open access
Semantic Scholar
Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line.
Michael A. Cross, C. Heyworth, Amanda Murrell, Ernesto Bockamp +2 more
1994Oncogene67 citations
Semantic Scholar
The role of growth factors in self-renewal and differentiation of haemopoietic stem cells.
T. Dexter, C. Heyworth, E. Spooncer, Ian L. O. Ponting
1990Philosophical transactions of the Royal Society of London. Series B, Biological sciences67 citations
Semantic Scholar
Transforming Growth Factor-β1 Induces Apoptosis Independently of p53 and Selectively Reduces Expression of Bcl-2 in Multipotent Hematopoietic Cells*
Julia M. Francis, C. Heyworth, E. Spooncer, A. Pierce +2 more
2000Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections--a phase I dose toxicity trial.
M. Gilleece, J. H. Scarffe, Anna K. Ghosh, C. Heyworth +4 more
1992British Journal of Cancer64 citations Open access
Semantic Scholar
The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes.
C. Heyworth, A. Grey, S. R. Wilson, E. Hanski +1 more
1986Biochemical Journal59 citations Open access
Semantic Scholar
Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes.
C. Heyworth, A. Whetton, S. Wong, B. Martin +1 more
1985Biochemical Journal58 citations Open access
Semantic Scholar
An Activated Protein Kinase C α Gives a Differentiation Signal for Hematopoietic Progenitor Cells and Mimicks Macrophage Colony-stimulating Factor–stimulated Signaling Events
A. Pierce, C. Heyworth, S. Nicholls, E. Spooncer +5 more
1998Journal of Cell Biology57 citations Open access
Semantic Scholar
AC133+ G0 Cells from Cord Blood Show a High Incidence of Long‐Term Culture–Initiating Cells and a Capacity for More Than 100 Million‐Fold Amplification of Colony‐Forming Cells In Vitro
Y. Summers, C. Heyworth, E. D. de Wynter, C. Hart +2 more
2004Stem Cells56 citations
Semantic Scholar
Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes.
C. Heyworth, M. Houslay
1983Biochemical Journal52 citations Open access
Semantic Scholar
Lineage restriction of the RARα gene expression in myeloid differentiation
Jun Zhu, C. Heyworth, A. Glasow, Qiu-Hua Huang +7 more
200151 citations
Semantic Scholar
Biological and structural properties of MIP-1 alpha expressed in yeast.
J. Clements, S. Craig, A. Gearing, M. Hunter +3 more
1992Cytokine50 citations
Semantic Scholar
The response of haemopoietic cells to growth factors: developmental implications of synergistic interactions.
C. Heyworth, I. Ponting, T. Dexter
1988Journal of Cell Science50 citations
Semantic Scholar
Forskolin and ethanol both perturb the structure of liver plasma membranes and activate adenylate cyclase activity.
A. Whetton, Lindsey Needham, Nicholas J. F. Dodd, C. Heyworth +1 more
1983Biochemical Pharmacology50 citations
Semantic Scholar
Insulin: in search of a mechanism
M. Houslay, C. Heyworth
198343 citations
Semantic Scholar
Biological effects of stroma-derived factor-1α on normal and CML CD34+ haemopoietic cells
J. Durig, C. Rosenthal, Ahmet H. Elmaagacli, C. Heyworth +4 more
2000Leukemia41 citations Open access
Semantic Scholar
Islet-activating protein blocks glucagon desensitization in intact hepatocytes.
C. Heyworth, E. Hanski, M. Houslay
1984Biochemical Journal38 citations Open access
Semantic Scholar
Interleukin-3-stimulated haemopoietic stem cell proliferation. Evidence for activation of protein kinase C and Na+/H+ exchange without inositol lipid hydrolysis.
A. Whetton, S. Vallance, P. N. Monk, E. Cragoe +2 more
1988Biochemical Journal31 citations Open access
Semantic Scholar
Discordant regulation of SCL/TAL-1 mRNA and protein during erythroid differentiation.
Amanda Murrell, Ernesto Bockamp, B. Göttgens, Y. Chan +3 more
1995Oncogene29 citations
Semantic Scholar
Lineage restriction of the RARalpha gene expression in myeloid differentiation.
Jun Zhu, C. Heyworth, A. Glasow, Qiu-Hua Huang +7 more
2001Blood28 citations
Semantic Scholar
Activation of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development.
C. Evans, A. Pierce, S. Winter, E. Spooncer +2 more
1999Blood26 citations
Semantic Scholar
Guanine nucleotides can activate the insulin‐stimulated phosphodiesterase in liver plasma membranes
C. Heyworth, Sushil Rawal, M. Houslay
1983FEBS Letters26 citations Open access
Semantic Scholar
The stability and aggregation properties of human liver acid beta-D-galactosidase.
C. Heyworth, E. Neumann, C. Wynn
1981Biochemical Journal25 citations Open access
Semantic Scholar
Investigation of the molecular mechanisms underlying growth factor synergy: the role of ERK 2 activation in synergy.
M. Pearson, Anne-Marie O'Farrell, T. Dexter, A. Whetton +2 more
1998Growth Factors23 citations
Semantic Scholar
Expression of Macrophage Inflammatory Protein-1 Receptors in Human CD34 + Hematopoietic Cells and Their Modulation by Tumor Necrosis Factor- and Interferon-γ
J. Durig, E. D. de Wynter, C. Kasper, M. Cross +3 more
199823 citations
Semantic Scholar
An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations.
C. Heyworth, A. Wallace, S. R. Wilson, M. Houslay
1984Biochemical Journal23 citations Open access
Semantic Scholar
Differentiating Embryonal Stem Cells Are a Rich Source of Haemopoietic Gene Products and Suggest Erythroid Preconditioning of Primitive Haemopoietic Stem Cells*
J. W. Baird, K. Ryan, I. Hayes, L. Hampson +7 more
2001Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Insulin affects the ability of Gi to be ADP-ribosylated but does not elicit its phosphorylation in intact hepatocytes.
N. J. Pyne, C. Heyworth, Niall W. Balfour, M. Houslay
1989Biochemical and Biophysical Research Communications - BBRC20 citations
Semantic Scholar
The phorbol ester TPA prevents the expression of both glucagon desensitisation and the glucagon‐mediated block of insulin stimulation of the peripheral plasma membrane cyclic AMP phosphodiesterase in rat hepatocytes
C. Heyworth, Sally P. Wilson, Debra J. Gawler, M. Houslay
1985FEBS Letters20 citations
Semantic Scholar
Cord blood G(0) CD34+ cells have a thousand-fold higher capacity for generating progenitors in vitro than G(1) CD34+ cells.
Y. J. Summers, C. Heyworth, E. D. de Wynter, J. Chang +1 more
2001Stem Cells19 citations
Semantic Scholar
Expression and downregulation of cytotoxic cell protease 1 or Granzyme 'B' transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines
I. Hampson, M. Cross, C. Heyworth, L. Fairbairn +3 more
199219 citations
Semantic Scholar
Activation of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Receptor Subunits in a Multipotential Hematopoietic Progenitor Cell Line Leads to Differential Effects on Development
C. Evans, A. Pierce, S. Winter, E. Spooncer +2 more
199917 citations
Semantic Scholar
Haemopoietic stem cell development to neutrophils is associated with subcellular redistribution and differential expression of protein kinase C subspecies.
M. Shearman, C. Heyworth, T. Dexter, B. Haefner +2 more
1993Journal of Cell Science17 citations
Semantic Scholar
Identification of a Serpin Specifically Expressed in Multipotent and Bipotent Hematopoietic Progenitor Cells and in Activated T Cells
I. Hampson, L. Hampson, M. Pinkoski, M. Cross +4 more
199715 citations
Semantic Scholar
Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells.
I. Hampson, L. Hampson, M. Pinkoski, M. Cross +4 more
1997Blood15 citations
Semantic Scholar
NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34+ cells expressing the CCR1 chemokine receptor
E. D. de Wynter, C. Heyworth, N. Mukaida, Koji Matsushima +1 more
2001Leukemia14 citations
Semantic Scholar
Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells
C. Heyworth, T. Dexter, S. Nicholls, A. Whetton
199314 citations Open access
Semantic Scholar
Insulin controls intracellular cyclic AMP concentrations in hepatocytes by activating specific cyclic AMP phosphodiesterases: phosphorylation of the peripheral plasma membrane enzyme.
M. Houslay, A. Wallace, R. J. Marchmont, B. Martin +1 more
1984Advances in cyclic nucleotide and protein phosphorylation research13 citations
Semantic Scholar
N6-(Phenylisopropyl)adenosine prevents glucagon both blocking insulin's activation of the plasma-membrane cyclic AMP phosphodiesterase and uncoupling hormonal stimulation of adenylate cyclase activity in hepatocytes.
A. Wallace, C. Heyworth, M. Houslay
1984Biochemical Journal13 citations Open access
Semantic Scholar
How do stem cells decide what to do
Cross Ma, C. Heyworth, Dexter Tm
199711 citations
Semantic Scholar

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M. Houslay×15
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M. Houslay — researcher profile on SciRah
T. Dexter×13
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T. Dexter — researcher profile on SciRah
A. Whetton×12
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A. Whetton — researcher profile on SciRah
E. Spooncer×7
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T. Enver — researcher profile on SciRah

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A. Wallace — researcher profile on SciRah

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E. D. de Wynter×4

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E. D. de Wynter — researcher profile on SciRah

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M. Cross — researcher profile on SciRah

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James Chang — researcher profile on SciRah

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T. Dexter — researcher profile on SciRah

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L. Hampson — researcher profile on SciRah