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R. Funk · SciRah

Researcher profile · Semantic Scholar

R. Funk

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R. Funk — researcher profile on SciRah

h-index: 14
Works: 46
Citations: 940

Most-cited papers

Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells)
Faraz Kazmi, Tiffini Hensley, Chad Pope, R. Funk +2 more
2013178 citations
Semantic Scholar
Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: Implications for an intracellular distribution-based drug interaction
R. Funk, J. Krise
2012Molecular Pharmaceutics128 citations Open access
Semantic Scholar
Mechanisms of amine accumulation in, and egress from, lysosomes
S. D. B. Goldman, R. Funk, R. Rajewski, J. Krise
2009Bioanalysis115 citations Open access
Semantic Scholar
Precision Pharmacotherapy: Integrating Pharmacogenomics into Clinical Pharmacy Practice
J. K. Hicks, C. Aquilante, H. M. Dunnenberger, Roseann S. Gammal +8 more
2019Journal of the American College of Clinical Pharmacy69 citations Open access
Semantic Scholar
Pediatric pharmacokinetics: human development and drug disposition.
R. Funk, Jacob T. Brown, S. Abdel-Rahman
2012The Pediatric clinics of North America55 citations
Semantic Scholar
A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells.
M. Duvvuri, S. Konkar, R. Funk, Joanna M. Krise +1 more
2005Biochemistry44 citations
Semantic Scholar
Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications
Randall Logan, R. Funk, Eric Axcell, J. Krise
2012Expert Opinion on Drug Metabolism & Toxicology38 citations
Semantic Scholar
Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model
R. Singh, L. van Haandel, Paul K Kiptoo, M. Becker +2 more
2019European Journal of Pharmacology30 citations Open access
Semantic Scholar
Plasma Metabolome Normalization in Rheumatoid Arthritis Following Initiation of Methotrexate and the Identification of Metabolic Biomarkers of Efficacy
Matthew R. Medcalf, P. Bhadbhade, T. Mikuls, J. O'Dell +2 more
2021Metabolites24 citations Open access
Semantic Scholar
Immunogenicity in Clinical Practice and Drug Development: When is it Significant?
V. Shakhnovich, B. Meibohm, A. Rosenberg, A. Kierzek +6 more
2019Clinical and Translational Science24 citations Open access
Semantic Scholar
Low-Dose Methotrexate Results in the Selective Accumulation of Aminoimidazole Carboxamide Ribotide in an Erythroblastoid Cell Line
R. Funk, L. van Haandel, Mara L. Becker, J. Leeder
2013Journal of Pharmacology and Experimental Therapeutics21 citations Open access
Semantic Scholar
Exposure of cells to hydrogen peroxide can increase the intracellular accumulation of drugs.
R. Funk, J. Krise
2007Molecular Pharmaceutics18 citations Open access
Semantic Scholar
Folate Depletion and Increased Glutamation in Juvenile Idiopathic Arthritis Patients Treated with Methotrexate
R. Funk, L. van Haandel, J. Leeder, Mara L. Becker
2014Arthritis & Rheumatology17 citations Open access
Semantic Scholar
Variability in Potency Among Commercial Preparations of Berberine
R. Funk, R. Singh, Robert D. Winefield, Sylvie E. Kandel +3 more
2017Journal of Dietary Supplements16 citations Open access
Semantic Scholar
Factors associated with reduced infliximab exposure in the treatment of pediatric autoimmune disorders: a cross-sectional prospective convenience sampling study
R. Funk, V. Shakhnovich, Yu Kyoung Cho, Kishore Polireddy +3 more
2021Pediatric Rheumatology Online Journal14 citations Open access
Semantic Scholar
Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro
R. Funk, R. Singh, M. Becker
2019Clinical and Translational Science14 citations Open access
Semantic Scholar
Disease modifying anti-rheumatic drugs in juvenile idiopathic arthritis: striving for individualized therapy
R. Funk, M. Becker
201613 citations Open access
Semantic Scholar
Plasma Metabolomic Profiling as a Tool to Identify Predictive Biomarkers of Methotrexate Efficacy in Rheumatoid Arthritis
Matthew R. Medcalf, Leonidas E. Bantis, Peng Shi, P. Bhadbhade +5 more
2022Seminars in Arthritis & Rheumatism12 citations Open access
Semantic Scholar
A population physiologically-based pharmacokinetic model to characterize antibody disposition in pediatrics and evaluation of the model using infliximab
Hsuan-Ping Chang, V. Shakhnovich, Adam R. Frymoyer, R. Funk +3 more
2021British Journal of Clinical Pharmacology12 citations Open access
Semantic Scholar
Altered Folate Homeostasis in Children with Down syndrome: A Potential Basis for Enhanced Methotrexate Toxicity
R. Funk, Nasreen J Talib, K. Zimmerman, L. van Haandel +1 more
2020Jornal de Pediatria12 citations Open access
Semantic Scholar
Cytokine Biomarkers of Disease Activity and Therapeutic Response after Initiating Methotrexate Therapy in Patients with Juvenile Idiopathic Arthritis
R. Funk, M. Chan, M. Becker
2017Pharmacotherapy12 citations
Semantic Scholar
Re-Engineering Clinical Trials: Best Practices for Streamlining the Development Process
R. Funk
201511 citations
Semantic Scholar
Methotrexate Disposition, Anti-Folate Activity, and Metabolomic Profiling to Identify Molecular Markers of Disease Activity and Drug Response in the Collagen-Induced Arthritis Mouse Model
Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho, Matthew R. Medcalf +1 more
2021Metabolites8 citations Open access
Semantic Scholar
Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP
Rakesh Singh, L. van Haandel, D. Heruth, Shui Q. Ye +3 more
2018Journal of Pharmacology and Experimental Therapeutics8 citations Open access
Semantic Scholar
Low Etanercept Concentrations in Children With Obesity and Juvenile Idiopathic Arthritis.
Stephen J. Balevic, M. Becker, Daniel Gonzalez, R. Funk
2021The Journal of Pediatric Pharmacology and Therapeutics6 citations Open access
Semantic Scholar
Metabolomic Profiling Identifies Exogenous and Microbiota-Derived Metabolites as Markers of Methotrexate Efficacy in Juvenile Idiopathic Arthritis
R. Funk, M. Becker
2021Frontiers in Pharmacology6 citations Open access
Semantic Scholar
Leveraging innovative technology to generate drug response phenotypes for the advancement of biomarker‐driven precision dosing
A. Oni-Orisan, N. Srinivas, Krina Mehta, J. Das +6 more
2021Clinical and Translational Science5 citations Open access
Semantic Scholar
Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease
R. Morrow, R. Funk, M. Becker, A. Sherman +4 more
2021Pharmaceuticals5 citations Open access
Semantic Scholar
Facing Real-World Challenges of Immunogenicity in Pediatric Inflammatory Bowel Disease
Kyle L. Gress, J. Bass, R. Funk, R. Morrow +2 more
2020Frontiers in Immunology5 citations Open access
Semantic Scholar
Defining a therapeutic window for rituximab maintenance therapy in ANCA-associated vasculitis
J. Springer, R. Funk
2020Journal of clinical rheumatology5 citations Open access
Semantic Scholar
Reverse Translation in Advancing Pharmacotherapy in Pediatric Rheumatology: A Logical Approach in Rare Diseases with Limited Resources
M. Becker, R. Funk
2017Clinical and Translational Science4 citations Open access
Semantic Scholar
Mast Cell Degranulation Decreases Lipopolysaccharide-Induced Aortic Gene Expression and Systemic Levels of Interleukin-6 In Vivo
J. Springer, V. Raveendran, Ming-Cai Zhang, R. Funk +3 more
2019Mediators of Inflammation3 citations Open access
Semantic Scholar
Association of Pharmacologic Markers of Anti‐Tumor Necrosis Factor‐α Activity and Etanercept Effectiveness in Juvenile Idiopathic Arthritis
M. Arain, Kishore Polireddy, E. Fricovsky, Mara L. Becker +2 more
2025Pharmacology Research & Perspectives2 citations Open access
Semantic Scholar
Dose-dependent Pharmacological Response to Rituximab in the Treatment of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
J. Springer, R. Funk
2021Journal of Rheumatology2 citations Open access
Semantic Scholar
Folates in Children with Down Syndrome and the Impact of Dietary Supplementation
R. Funk, Jordan T. Jones, Kishore Polireddy, K. Zimmerman +3 more
20202 citations Open access
Semantic Scholar
P050 METHOTREXATE POLYGLUTAMATES AS BIOMARKERS OF TREATMENT RESPONSE IN PEDIATRIC INFLAMMATORY BOWEL DISEASE
V. Shakhnovich, Taina Jausurawong, R. Morrow, M. Becker +1 more
2019Gastroenterology2 citations
Semantic Scholar
Development of Extemporaneously Compounded Aripiprazole Oral Suspensions for Use in Children.
L. Pramann, L. W. Davidow, L. van Haandel, R. Funk
2016International journal of pharmaceutical compounding2 citations
Semantic Scholar
Evaluating the impact of a flipped classroom model based on cognitive science of learning strategies in a pharmacotherapy course.
Tiffany R. Shin, Crystal Burkhardt, Robyn E. Kelton, Ashley N. Crowl +2 more
2022Currents in Pharmacy Teaching and Learning1 citations Open access
Semantic Scholar
Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells)
Faraz Kazmi, Tiffini Hensley, Chad Pope, R. Funk +2 more
20131 citations
Semantic Scholar
Metabolomic Profiling of Red Blood Cells to Identify Molecular Markers of Methotrexate Response in the Collagen Induced Arthritis Mouse Model
Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho, R. Funk
2022Future Pharmacology0 citations Open access
Semantic Scholar
221. MAST CELL DEFICIENCY LEADS TO DYSREGULATION OF IL-6 AND INF-Γ HOMOEOSTASIS IN CAWS-INDUCED SYSTEMIC VASCULITIS MOUSE MODEL
J. Springer, Ming-Cai Zhang, R. Funk, O. Tawfik +4 more
2019Rheumatology0 citations Open access
Semantic Scholar
THU0506 MAST CELL DEFICIENCY AMPLIFIES INFLAMMATORY RESPONSE IN A MOUSE MODEL OF KAWASAKI’S DISEASE
J. Springer, Ming-Cai Zhang, R. Funk, O. Tawfik +4 more
2019Poster Presentations0 citations Open access
Semantic Scholar
Evidence of circulating trimethoprim protein adducts in human plasma
L. van Haandel, R. Funk, J. Leeder, J. Goldman
20180 citations
Semantic Scholar
Constitutive Activation of Stat Signaling in Fibroblast‐like Synoviocytes Derived from Patients with Juvenile Idiopathic Arthritis Is Inhibited by Methotrexate
Rakesh Singh, L. Haandel, J. Leeder, M. Becker +1 more
20180 citations
Semantic Scholar
Low-Dose Methotrexate Results in the Selective Accumulation of Aminoimidazole Carboxamide Ribotide in an Erythroblastoid Cell Line s
R. Funk, L. van Haandel, M. Becker, J. Leeder
20130 citations
Semantic Scholar
Studies on the impact of amine-containing compounds on lysosomes
R. Funk
20110 citations
Semantic Scholar

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M. Becker×15
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L. van Haandel×9
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V. Shakhnovich×6
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Kishore Polireddy

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