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H. Kojima · SciRah

Researcher profile · Semantic Scholar

H. Kojima

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H. Kojima — researcher profile on SciRah

h-index: 47
Works: 155
Citations: 12K

Most-cited papers

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Tetsuya Saito, Y. Ichimura, K. Taguchi, Takafumi Suzuki +34 more
2016Nature Communications322 citations Open access
Semantic Scholar
Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes.
D. Oushiki, H. Kojima, T. Terai, M. Arita +3 more
2010Journal of the American Chemical Society317 citations
Semantic Scholar
Rational design of ratiometric near-infrared fluorescent pH probes with various pKa values, based on aminocyanine.
Takuya Myochin, Kazuki Kiyose, K. Hanaoka, H. Kojima +2 more
2011Journal of the American Chemical Society257 citations
Semantic Scholar
Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity
M. Arita, H. Kojima, T. Nagano, T. Okabe +2 more
2010Journal of Virology168 citations Open access
Semantic Scholar
Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells.
Y. Fujikawa, Y. Urano, Toru Komatsu, K. Hanaoka +4 more
2008Journal of the American Chemical Society134 citations
Semantic Scholar
Molecular design strategies for near-infrared ratiometric fluorescent probes based on the unique spectral properties of aminocyanines.
Kazuki Kiyose, Sakiko Aizawa, E. Sasaki, H. Kojima +4 more
2009Chemistry121 citations
Semantic Scholar
Oxysterol-Binding Protein Family I Is the Target of Minor Enviroxime-Like Compounds
M. Arita, H. Kojima, T. Nagano, T. Okabe +2 more
2013Journal of Virology115 citations Open access
Semantic Scholar
Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
Y. Terashima, E. Toda, M. Itakura, M. Otsuji +23 more
2020Nature Communications99 citations Open access
Semantic Scholar
Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide
K. Hanaoka, Kiyoshi Sasakura, Y. Suwanai, S. Toma-Fukai +17 more
2017Scientific Reports86 citations Open access
Semantic Scholar
Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).
H. Sakamoto, Shin-ichiro Egashira, Nae Saito, T. Kirisako +13 more
2015ACS Chemical Biology79 citations
Semantic Scholar
Development of 2,6-carboxy-substituted boron dipyrromethene (BODIPY) as a novel scaffold of ratiometric fluorescent probes for live cell imaging.
Toru Komatsu, Y. Urano, Y. Fujikawa, Tomonori Kobayashi +4 more
2009Chemical Communications72 citations
Semantic Scholar
Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound.
H. Nakano, Nae Saito, L. Parker, Y. Tada +7 more
2012Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response[S]
Ke-Wei Liu, N. Kunii, Megumi Sakuma, Atsumi Yamaki +10 more
2016Journal of Lipid Research63 citations Open access
Semantic Scholar
Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe.
Mitsuyasu Kawaguchi, T. Okabe, S. Okudaira, H. Nishimasu +5 more
2013ACS Chemical Biology57 citations Open access
Semantic Scholar
Near-infrared fluorescence probes for enzymes based on binding affinity modulation of squarylium dye scaffold.
D. Oushiki, H. Kojima, Yuki Takahashi, Toru Komatsu +5 more
2012Analytical Chemistry54 citations
Semantic Scholar
Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice
Satoshi Morooka, Mitsuteru Hoshina, I. Kii, T. Okabe +16 more
2015Molecular Pharmacology52 citations
Semantic Scholar
Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti
K. Inaba, Kana Ebihara, M. Senda, Ryunosuke Yoshino +21 more
2022BMC Biology43 citations Open access
Semantic Scholar
Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies
Yu Takahashi, Makoto Noguchi, Yuuka Inoue, Shintaro Sato +6 more
2022iScience42 citations Open access
Semantic Scholar
Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.
Daisuke Yasuda, Mao Nakajima, Akihiro Yuasa, R. Obata +10 more
2016Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
A long-lived luminescent probe to sensitively detect arylamine N-acetyltransferase (NAT) activity of cells.
T. Terai, K. Kikuchi, Y. Urano, H. Kojima +1 more
2012Chemical Communications41 citations
Semantic Scholar
Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies
Yu Takahashi, Yuka Inoue, Shintaro Sato, T. Okabe +5 more
2023Scientific Reports37 citations Open access
Semantic Scholar
Development of a highly sensitive, high-throughput assay for glycosyltransferases using enzyme-coupled fluorescence detection.
K. Kumagai, H. Kojima, T. Okabe, T. Nagano
2014Analytical Biochemistry36 citations
Semantic Scholar
High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway
S. Ishii, K. Fukui, S. Yokoshima, K. Kumagai +7 more
2017Scientific Reports35 citations Open access
Semantic Scholar
A dual inhibitor against prolyl isomerase Pin1 and cyclophilin discovered by a novel real-time fluorescence detection method.
Tadashi Mori, Masafumi Hidaka, Yi-Chin Lin, I. Yoshizawa +7 more
2011Biochemical and Biophysical Research Communications - BBRC35 citations
Semantic Scholar
Fluorescence probe for lysophospholipase C/NPP6 activity and a potent NPP6 inhibitor.
Mitsuyasu Kawaguchi, T. Okabe, S. Okudaira, K. Hanaoka +6 more
2011Journal of the American Chemical Society34 citations
Semantic Scholar
A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application in inhibitor screening.
Mitsuyasu Kawaguchi, T. Okabe, T. Terai, K. Hanaoka +3 more
2010Chemistry34 citations
Semantic Scholar
Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2
M. Tarui, H. Shindou, K. Kumagai, R. Morimoto +7 more
2014Journal of Lipid Research33 citations Open access
Semantic Scholar
A practical strategy to create near-infrared luminescent probes: conversion from fluorescein-based sensors.
T. Terai, Y. Urano, Saki Izumi, H. Kojima +1 more
2012Chemical Communications33 citations
Semantic Scholar
Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics
Yutaka Yoshii, Ken-ichi Okuda, Satomi Yamada, Mari Nagakura +7 more
2017npj Biofilms and Microbiomes32 citations Open access
Semantic Scholar
Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line
Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura +7 more
2020Free radical research31 citations
Semantic Scholar
Identification of novel selective P2Y6 receptor antagonists by high‐throughput screening assay
Masa-Aki Ito, Shin-ichiro Egashira, K. Yoshida, T. Mineno +6 more
2017Life Science30 citations
Semantic Scholar
Practical fluorescence detection of acrolein in human plasma via a two-step tethering approach.
M. Togashi, T. Terai, H. Kojima, K. Hanaoka +4 more
2014Chemical Communications30 citations
Semantic Scholar
A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide.
K. Tsuganezawa, Hisami Watanabe, L. Parker, H. Yuki +13 more
2012Journal of Molecular Biology30 citations
Semantic Scholar
Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor.
Daisuke Yasuda, Akihiro Yuasa, R. Obata, Mao Nakajima +10 more
2017Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity
Keisuke Kitakaze, S. Taniuchi, E. Kawano, Y. Hamada +8 more
2019eLife27 citations Open access
Semantic Scholar
Sensitive detection of acrolein in serum using time-resolved luminescence.
M. Togashi, Y. Urano, H. Kojima, T. Terai +4 more
2010Organic Letters27 citations
Semantic Scholar
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
Naomi Tsuburaya, Kengo Homma, T. Higuchi, Andrii G. Balia +18 more
2018Nature Communications26 citations Open access
Semantic Scholar
Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness.
T. Hirano, Reiko Satow, Asami Kato, M. Tamura +6 more
2013Biochemical Pharmacology26 citations
Semantic Scholar
Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket.
H. Nakano, Tsukasa Hasegawa, H. Kojima, T. Okabe +1 more
2017ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Identification of novel ASK1 inhibitors using virtual screening.
M. Okamoto, Nae Saito, H. Kojima, T. Okabe +4 more
2011Bioorganic & Medicinal Chemistry24 citations Open access
Semantic Scholar
A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors.
Y. Fujikawa, Fumika Morisaki, A. Ogura, K. Morohashi +7 more
2015Chemical Communications22 citations
Semantic Scholar
Inexpensive High-Throughput Screening of Kinase Inhibitors Using One-Step Enzyme-Coupled Fluorescence Assay for ADP Detection
Riyo Imamura, K. Kumagai, H. Nakano, T. Okabe +2 more
2018SLAS discovery : advancing life sciences R & D21 citations Open access
Semantic Scholar
Ligand Recognition by the Lipid Transfer Domain of Human OSBP Is Important for Enterovirus Replication.
J. Kobayashi, M. Arita, S. Sakai, H. Kojima +4 more
2022ACS Infectious Diseases20 citations
Semantic Scholar
A Fluorescent-Based High-Throughput Screening Assay for Small Molecules That Inhibit the Interaction of MdmX with p53
K. Tsuganezawa, Yukari Nakagawa, Miki Kato, Shigenao Taruya +15 more
2013Journal of biomolecular screening19 citations Open access
Semantic Scholar
An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo
K. Koiwai, K. Inaba, K. Morohashi, S. Enya +14 more
2020Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Virtual screening and further development of novel ALK inhibitors.
M. Okamoto, H. Kojima, Nae Saito, T. Okabe +3 more
2011Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation
Honami Echizen, K. Hanaoka, K. Shimamoto, R. Hibi +15 more
2023Scientific Reports12 citations Open access
Semantic Scholar
Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells.
Kouichi Yanagi, Toru Komatsu, Shusuke Ogihara, T. Okabe +5 more
2021Cell Reports12 citations Open access
Semantic Scholar
Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl-l-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols.
Shusuke Ogihara, Toru Komatsu, Yukihiro Itoh, Yuka Miyake +9 more
2019Journal of the American Chemical Society12 citations
Semantic Scholar
Development of Chemical Tools to Monitor and Control Isoaspartyl Peptide Methyltransferase Activity.
Y. Kimura, Toru Komatsu, Kouichi Yanagi, K. Hanaoka +6 more
2017Angewandte Chemie12 citations
Semantic Scholar

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