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Y. Ichimura · SciRah

Researcher profile · Semantic Scholar

Y. Ichimura

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Y. Ichimura — researcher profile on SciRah

h-index: 34
Works: 62
Citations: 15K

Most-cited papers

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
M. Komatsu, H. Kurokawa, S. Waguri, K. Taguchi +15 more
2010Nature Cell Biology2,396 citations
Semantic Scholar
A ubiquitin-like system mediates protein lipidation
Y. Ichimura, T. Kirisako, T. Takao, Y. Satomi +8 more
2000Nature2,085 citations
Semantic Scholar
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.
Hitoshi Nakatogawa, Y. Ichimura, Y. Ohsumi
2007Cell1,239 citations
Semantic Scholar
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Y. Ichimura, S. Waguri, Y. Sou, S. Kageyama +16 more
2013Molecules and Cells1,145 citations Open access
Semantic Scholar
The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy*
Takao Hanada, N. Noda, Y. Satomi, Y. Ichimura +4 more
2007Journal of Biological Chemistry1,130 citations Open access
Semantic Scholar
The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway
T. Kirisako, Y. Ichimura, H. Okada, Y. Kabeya +6 more
2000Journal of Cell Biology1,015 citations Open access
Semantic Scholar
Structural Basis for Sorting Mechanism of p62 in Selective Autophagy*
Y. Ichimura, Taichi Kumanomidou, Y. Sou, T. Mizushima +6 more
2008Journal of Biological Chemistry797 citations Open access
Semantic Scholar
p62/SQSTM1 functions as a signaling hub and an autophagy adaptor
Y. Katsuragi, Y. Ichimura, M. Komatsu
2015The FEBS Journal776 citations
Semantic Scholar
Physiological significance of selective degradation of p62 by autophagy
M. Komatsu, Y. Ichimura
2010FEBS Letters528 citations
Semantic Scholar
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Tetsuya Saito, Y. Ichimura, K. Taguchi, Takafumi Suzuki +34 more
2016Nature Communications322 citations Open access
Semantic Scholar
p62/SQSTM1/A170: physiology and pathology.
M. Komatsu, S. Kageyama, Y. Ichimura
2012Pharmacological Research301 citations
Semantic Scholar
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response
S. Kageyama, S. Gudmundsson, Y. Sou, Y. Ichimura +17 more
2021Nature Communications270 citations Open access
Semantic Scholar
Selective degradation of p62 by autophagy
Y. Ichimura, M. Komatsu
2010Seminars in Immunopathology256 citations
Semantic Scholar
Selective turnover of p62/A170/SQSTM1 by autophagy
Y. Ichimura, E. Kominami, Keiji Tanaka, M. Komatsu
2008Autophagy238 citations Open access
Semantic Scholar
In Vivo and in Vitro Reconstitution of Atg8 Conjugation Essential for Autophagy*
Y. Ichimura, Yuko Imamura, K. Emoto, M. Umeda +2 more
2004Journal of Biological Chemistry221 citations Open access
Semantic Scholar
Autophagy regulates lipid metabolism through selective turnover of NCoR1
Tetsuya Saito, Akiko Kuma, Y. Sugiura, Y. Ichimura +15 more
2019Nature Communications174 citations Open access
Semantic Scholar
Regulation of the Keap1–Nrf2 pathway by p62/SQSTM1
Y. Katsuragi, Y. Ichimura, M. Komatsu
2016165 citations Open access
Semantic Scholar
MBSJ MCC Young Scientist Award 2009 REVIEW: Selective autophagy regulates various cellular functions
M. Komatsu, Y. Ichimura
2010Genes to Cells163 citations
Semantic Scholar
The Crystal Structure of Atg3, an Autophagy-related Ubiquitin Carrier Protein (E2) Enzyme that Mediates Atg8 Lipidation*
Yuya Yamada, N. Suzuki, Takao Hanada, Y. Ichimura +4 more
2007Journal of Biological Chemistry149 citations Open access
Semantic Scholar
Crucial role for autophagy in degranulation of mast cells.
H. Ushio, T. Ueno, Y. Kojima, M. Komatsu +13 more
2011Journal of Allergy and Clinical Immunology142 citations
Semantic Scholar
Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer
Y. Ichimura, M. Komatsu
2018Frontiers in Oncology116 citations Open access
Semantic Scholar
Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development
M. Nahorski, S. Maddirevula, Ryosuke Ishimura, S. Alsahli +23 more
2018Brain : a journal of neurology113 citations Open access
Semantic Scholar
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
M. Muona, Ryosuke Ishimura, Anni Laari, Y. Ichimura +24 more
2016American Journal of Human Genetics110 citations Open access
Semantic Scholar
Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B‐positive structures
Alf Håkon Lystad, Y. Ichimura, K. Takagi, Yinjie Yang +8 more
2014EMBO Reports104 citations Open access
Semantic Scholar
Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain
J. Dragich, Takaaki Kuwajima, Megumi Hirose-Ikeda, M. Yoon +14 more
2016eLife93 citations Open access
Semantic Scholar
Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant
S. Kageyama, Tetsuya Saito, Miki Obata, Ryo-hei Koide +2 more
2018Molecular and Cellular Biology87 citations Open access
Semantic Scholar
Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation*
Sabrina Habisov, J. Huber, Y. Ichimura, M. Akutsu +9 more
2016Journal of Biological Chemistry74 citations Open access
Semantic Scholar
Two newly identified sites in the ubiquitin‐like protein Atg8 are essential for autophagy
Nira Amar, G. Lustig, Y. Ichimura, Y. Ohsumi +1 more
2006EMBO Reports60 citations Open access
Semantic Scholar
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response
Ryo Ikeda, D. Noshiro, H. Morishita, Shuhei Takada +16 more
2022bioRxiv54 citations Open access
Semantic Scholar
LC3B is indispensable for selective autophagy of p62 but not basal autophagy.
Yoko Maruyama, Y. Sou, S. Kageyama, Takao Takahashi +4 more
2014Biochemical and Biophysical Research Communications - BBRC53 citations
Semantic Scholar
Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models.
Y. Ichimura, M. Komatsu
2011Experimental animals51 citations Open access
Semantic Scholar
Selective autophagy
M. Faruk, Y. Ichimura, Masaaki Komatsu
2021Cancer Science47 citations Open access
Semantic Scholar
Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.
Daisuke Yasuda, Mao Nakajima, Akihiro Yuasa, R. Obata +10 more
2016Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
A description of novel variants and review of phenotypic spectrum in UBA5-related early epileptic encephalopathy
L. Briere, M. Walker, F. High, Cynthia M. Cooper +14 more
2021Cold Spring Harbor molecular case studies34 citations Open access
Semantic Scholar
Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line
Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura +7 more
2020Free radical research31 citations
Semantic Scholar
Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor.
Daisuke Yasuda, Akihiro Yuasa, R. Obata, Mao Nakajima +10 more
2017Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Anti-proliferative and apoptosis-inducible activity of Sarcodonin G from Sarcodon scabrosus in HeLa cells.
Mei Dong, Shi-Ping Chen, K. Kita, Y. Ichimura +10 more
2009International Journal of Oncology25 citations Open access
Semantic Scholar
Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity
M. Faruk, Y. Ichimura, S. Kageyama, Satoko Komatsu-Hirota +5 more
2021Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Annexin II, a Novel HSP27‐interacted Protein, is Involved in Resistance to UVC‐induced Cell Death in Human APr‐1 Cells
Xiao-Bo Tong, K. Kita, K. Karata, Chang-Lin Zhu +7 more
2008Photochemistry and Photobiology13 citations
Semantic Scholar
Down-Regulation of Molecular Chaperone 78-kd Glucose-Regulated Protein/Immunoglobulin-Binding Protein Expression Involved in Enhancement of Human RS Cell Mutability
J. Hirano, K. Kita, S. Sugaya, Y. Ichimura +3 more
2008Pancreas9 citations
Semantic Scholar
Crystallization and preliminary X-ray analysis of Atg3.
Yuya Yamada, N. Suzuki, Y. Fujioka, Y. Ichimura +2 more
2006Acta Crystallographica. Section F : Structural Biology and Crystallization Communications7 citations Open access
Semantic Scholar
Regulation of the Keap 1 – Nrf 2 pathway by p 62 / SQSTM 1
Y. Katsuragi, Y. Ichimura, M. Komatsu
20164 citations
Semantic Scholar
Development of P62-Keap1 Protein-Protein Interaction Inhibitors as Doxorubicin-Sensitizers Against Non-Small Cell Lung Cancer
Daisuke Yasuda, Ippei Yoshida, Riyo Imamura, Daiki Katagishi +7 more
2022Social Science Research Network3 citations Open access
Semantic Scholar
GENETIC MOUSE MODELS FOR ELUCIDATION OF AUTOPHAGY-LYSOSOMAL SYSTEMS IN NEURONS UNDER PHYSIOLOGIC AND PATHOLOGIC CONDITIONS
M. Komatsu, M. Koike, Y. Ichimura, Y. Uchiyama
20123 citations
Semantic Scholar
Author response: Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain
J. Dragich, Takaaki Kuwajima, Megumi Hirose-Ikeda, M. Yoon +14 more
20162 citations Open access
Semantic Scholar
Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia
Y. Ichimura, Yuki Sugiura, Yoshinori Katsuragi, Y. Sou +7 more
2024bioRxiv1 citations Open access
Semantic Scholar
A redox-independent stress response mediated by phase-separated SQSTM1/p62
Y. Ichimura, Masaaki Komatsu
2024Autophagy Reports1 citations Open access
Semantic Scholar
Considering the mechanism by which droplets of ALS-FTD-associated SQSTM1/p62 mutants cause pathology
Y. Ichimura, M. Komatsu
2022Autophagy Reports1 citations Open access
Semantic Scholar
Autophagy Protects Integrity of Tumor Suppressors From Replication Stress
Tsuyoshi Kawabata, R. Unno, Tadashi Yamamuro, S. Kageyama +15 more
2021Social Science Research Network1 citations
Semantic Scholar
[Involvement of ubiquitin system in mammalian autophagy].
M. Komatsu, Y. Ichimura
2012Seikagaku. The Journal of Japanese Biochemical Society1 citations
Semantic Scholar

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