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I. Samudio · SciRah

Researcher profile · Semantic Scholar

I. Samudio

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I. Samudio — researcher profile on SciRah

h-index: 48
Works: 132
Citations: 9,506

Most-cited papers

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.
M. Konopleva, R. Contractor, T. Tsao, I. Samudio +22 more
2006Cancer Cell1,024 citations Open access
Semantic Scholar
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction.
I. Samudio, R. Harmancey, M. Fiegl, H. Kantarjian +7 more
2010Journal of Clinical Investigation689 citations Open access
Semantic Scholar
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.
Z. Zeng, Yuexi Shi, I. Samudio, Rui-Yu Y. Wang +9 more
2009Blood548 citations Open access
Semantic Scholar
MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.
K. Kojima, M. Konopleva, I. Samudio, M. Shikami +7 more
2005Blood417 citations Open access
Semantic Scholar
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.
Z. Zeng, D. Sarbassov, I. Samudio, K. Yee +6 more
2007Blood367 citations Open access
Semantic Scholar
Mitochondrial uncoupling and the Warburg effect: Molecular basis for the reprogramming of cancer cell metabolism
I. Samudio, M. Fiegl, M. Andreeff
2009Cancer Research309 citations Open access
Semantic Scholar
Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).
M. Konopleva, J. Watt, R. Contractor, T. Tsao +7 more
2008Cancer Research269 citations Open access
Semantic Scholar
Effects of natural antioxidants in neurodegenerative disease
S. Albarracin, Ben Stab, Zulma Casas, J. Sutachan +6 more
2012Nutritional neuroscience261 citations Open access
Semantic Scholar
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.
M. Abdelrahim, K. Newman, Kathy Vanderlaag, I. Samudio +1 more
2006Carcinogenesis211 citations Open access
Semantic Scholar
Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment.
Shannon M. Kidd, L. Caldwell, M. Dietrich, I. Samudio +7 more
2010Cytotherapy196 citations
Semantic Scholar
Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
Z. Zeng, I. Samudio, M. Munsell, J. An +4 more
2006Molecular Cancer Therapeutics194 citations Open access
Semantic Scholar
The Warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation
I. Samudio, M. Fiegl, T. McQueen, K. Clise-Dwyer +1 more
2008Cancer Research174 citations Open access
Semantic Scholar
Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes
Polina R Matre, Juliana Vélez, R. Jacamo, Yuan Qi +21 more
2016OncoTarget161 citations Open access
Semantic Scholar
CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure.
M. Fiegl, I. Samudio, K. Clise-Dwyer, Jared K. Burks +2 more
2009Blood135 citations Open access
Semantic Scholar
The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML
K. Kojima, Masaya Shimanuki, M. Shikami, I. Samudio +6 more
2008Leukemia120 citations Open access
Semantic Scholar
Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment
O. Frolova, I. Samudio, J. Benito, R. Jacamo +15 more
2012Cancer Biology & Therapy118 citations Open access
Semantic Scholar
Cellular and molecular mechanisms of antioxidants in Parkinson's disease
J. Sutachan, Zulma Casas, S. Albarracin, B. R. Stab +4 more
2012Nutritional neuroscience118 citations
Semantic Scholar
A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia.
R. Contractor, I. Samudio, Z. Estrov, D. Harris +4 more
2005Cancer Research112 citations
Semantic Scholar
2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) Directly Targets Mitochondrial Glutathione to Induce Apoptosis in Pancreatic Cancer*
I. Samudio, M. Konopleva, N. Hail, Yuexi Shi +9 more
2005Journal of Biological Chemistry111 citations Open access
Semantic Scholar
DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis
I. Elisia, Hisae Nakamura, V. Lam, Elyse Hofs +10 more
2016PLoS ONE110 citations Open access
Semantic Scholar
Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Z. Zeng, I. Samudio, Weiguo Zhang, Z. Estrov +11 more
2006Cancer Research106 citations Open access
Semantic Scholar
Concomitant Inhibition of MDM2 and Bcl-2 Protein Function Synergistically Induce Mitochondrial Apoptosis in AML
K. Kojima, M. Konopleva, I. Samudio, W. Schober +2 more
2006Cell Cycle106 citations Open access
Semantic Scholar
Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel
C. Giraldo, C. López, M. Álvarez, I. Samudio +2 more
2013BMC Veterinary Research105 citations Open access
Semantic Scholar
Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a
Indira Jutooru, G. Chadalapaka, M. Abdelrahim, M. Basha +4 more
2010Molecular Pharmacology103 citations Open access
Semantic Scholar
Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.
V. Nair, Satya S. Pathi, Indira Jutooru, Sandeep Sreevalsan +4 more
2013Carcinogenesis93 citations Open access
Semantic Scholar
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid and Related Compounds Inhibit Growth of Colon Cancer Cells through Peroxisome Proliferator-Activated Receptor γ-Dependent and -Independent Pathways
Sudhakar Chintharlapalli, Sabitha Papineni, M. Konopleva, M. Andreef +2 more
2005Molecular Pharmacology93 citations
Semantic Scholar
The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming
L. Phan, Ping-Chieh Chou, Guermarie Velázquez-Torres, I. Samudio +44 more
2015Nature Communications79 citations Open access
Semantic Scholar
Cell-surface proteomics for the identification of novel therapeutic targets in cancer
L. Kuhlmann, E. Cummins, I. Samudio, T. Kislinger
2018Espert Review of Proteomics70 citations
Semantic Scholar
Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure
I. Samudio, M. Konopleva, S. Safe, T. McQueen +1 more
2005Molecular Cancer Therapeutics69 citations Open access
Semantic Scholar
Tumor Stroma Engraftment of Gene-Modified Mesenchymal Stem Cells as Anti-Tumor Therapy against Ovarian Cancer
J. Dembinski, S. Wilson, Erika L. Spaeth, M. Studeny +5 more
2013Cytotherapy67 citations Open access
Semantic Scholar
A Novel Mechanism of Action of Methyl-2-cyano-3,12 Dioxoolean-1,9 Diene-28-oate: Direct Permeabilization of the Inner Mitochondrial Membrane to Inhibit Electron Transport and Induce Apoptosis
I. Samudio, M. Konopleva, H. Pelicano, Peng Huang +6 more
2005Molecular Pharmacology62 citations
Semantic Scholar
HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML
Li-Ran Zhou, V. Ruvolo, T. McQueen, Wenjing Chen +4 more
2012Leukemia57 citations Open access
Semantic Scholar
Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.
K. Kojima, M. Konopleva, I. Samudio, V. Ruvolo +1 more
2007Cancer Research55 citations Open access
Semantic Scholar
Paracrine factors of human mesenchymal stem cells increase wound closure and reduce reactive oxygen species production in a traumatic brain injury in vitro model
D. Torrente, M. Avila, R. Cabezas, Ludis Morales +3 more
2014Human and Experimental Toxicology54 citations
Semantic Scholar
Induction of Durable Antitumor Response by a Novel Oncolytic Herpesvirus Expressing Multiple Immunomodulatory Transgenes
Dmitry V. Chouljenko, Jun Ding, I-Fang Lee, Y. Murad +8 more
2020Biomedicines53 citations Open access
Semantic Scholar
Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells
I. Samudio, S. Kurinna, P. Ruvolo, B. Korchin +6 more
2008Molecular Cancer Therapeutics53 citations Open access
Semantic Scholar
Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport
Juliana Vélez, Rongqing Pan, Jason T. C. Lee, L. Enciso +10 more
2016OncoTarget41 citations Open access
Semantic Scholar
Mitochondrial Uncoupling and the Reprograming of Intermediary Metabolism in Leukemia Cells
Juliana Vélez, Numsen Hail, M. Konopleva, Z. Zeng +3 more
2013Frontiers in Oncology41 citations Open access
Semantic Scholar
In vitro bactericidal activity of equine platelet concentrates, platelet poor plasma, and plasma against methicillin-resistant Staphylococcus aureus
M. Álvarez, C. López, CE Giraldo, I. Samudio +1 more
201137 citations Open access
Semantic Scholar
UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.
I. Samudio, K. Rezvani, Hila Shaim, Elyse Hofs +12 more
2016Blood36 citations Open access
Semantic Scholar
Platelets Promote Mitochondrial Uncoupling and Resistance to Apoptosis in Leukemia Cells: A Novel Paradigm for the Bone Marrow Microenvironment
Juliana Vélez, L. Enciso, Marta Suarez, M. Fiegl +11 more
2014Cancer Microenvironment34 citations Open access
Semantic Scholar
Effects over time of two platelet gel supernatants on growth factor, cytokine and hyaluronan concentrations in normal synovial membrane explants challenged with lipopolysaccharide
Diana L. Ríos, C. López, M. Álvarez, I. Samudio +1 more
2015BMC Musculoskeletal Disorders32 citations Open access
Semantic Scholar
Pre-Existing HSV-1 Immunity Enhances Anticancer Efficacy of a Novel Immune-Stimulating Oncolytic Virus
Jun Ding, Y. Murad, Yi Sun, I-Fang Lee +4 more
2022Viruses30 citations Open access
Semantic Scholar
3 , 3 0-Diindolylmethane ( DIM ) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR 5
M. Abdelrahim, K. Newman, Kathy Vanderlaag, I. Samudio +1 more
200630 citations
Semantic Scholar
Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.
Kathy Vanderlaag, I. Samudio, R. Burghardt, R. Barhoumi +1 more
2006Cancer Letters26 citations
Semantic Scholar
The mitochondria target drug avocatin B synergizes with induction chemotherapeutics to induce leukemia cell death
Matthew Tcheng, I. Samudio, Eric A. Lee, M. Minden +1 more
2017Leukemia and Lymphoma25 citations
Semantic Scholar
Apoptosis in Leukemias: Regulation and Therapeutic Targeting
I. Samudio, M. Konopleva, B. Carter, M. Andreeff
2010Cancer treatment and research24 citations Open access
Semantic Scholar
1,1-Bis(3′-Indolyl)-1-(p-Substituted Phenyl)Methanes Decrease Mitochondrial Membrane Potential and Induce Apoptosis in Endometrial and Other Cancer Cell Lines
J. Hong, I. Samudio, Sudhakar Chintharlapalli, S. Safe
2008Molecular Carcinogenesis24 citations Open access
Semantic Scholar
Targeting leukemia's "fatty tooth".
I. Samudio, M. Konopleva
2015Blood22 citations Open access
Semantic Scholar
Oncolytic virotherapy in hepato‐bilio‐pancreatic cancer: The key to breaking the log jam?
Yu-Wei Li, Yi-Nan Shen, Ronghua Zhao, I. Samudio +3 more
2020Cancer Medicine21 citations Open access
Semantic Scholar

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M. Konopleva×27
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M. Konopleva — researcher profile on SciRah
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S. Safe — researcher profile on SciRah

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V. Ruvolo — researcher profile on SciRah

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M. Fiegl — researcher profile on SciRah

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W. Bornmann — researcher profile on SciRah

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K. Kojima — researcher profile on SciRah

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