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P. Ruvolo · SciRah

Researcher profile · Semantic Scholar

P. Ruvolo

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P. Ruvolo — researcher profile on SciRah

h-index: 44
Works: 176
Citations: 9,102

Most-cited papers

Selective BCL-2 Inhibition by ABT-199 Causes On Target Cell Death in Acute Myeloid Leukemia
Rongqing Pan, L. Hogdal, J. Benito, D. Bucci +28 more
2013Cancer Discovery681 citations Open access
Semantic Scholar
Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance.
R. Jacamo, Ye Chen, Zhi-Qiang Wang, Wen-Cai Ma +16 more
2014Blood273 citations Open access
Semantic Scholar
Galectin 3 as a guardian of the tumor microenvironment.
P. Ruvolo
2016Biochimica et Biophysica Acta209 citations Open access
Semantic Scholar
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
J. Ishizawa, Kensuke Kojima, D. Chachad, P. Ruvolo +22 more
2016Science Signaling182 citations Open access
Semantic Scholar
Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.
M. Dany, S. Gencer, Rose Nganga, Raquela J. Thomas +7 more
2016Blood178 citations Open access
Semantic Scholar
The broken “Off” switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance
P. Ruvolo
2016BBA Clinical143 citations Open access
Semantic Scholar
A miR-155/TP53 regulatory feedback loop involved in resistance to therapy in lung cancer and leukemia
K. Van Roosbroeck, F. Fanini, T. Setoyama, C. Ivan +36 more
2016Clinical Cancer Research141 citations Open access
Semantic Scholar
Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.
Rongqing Pan, V. Ruvolo, Jun Wei, M. Konopleva +4 more
2015Blood138 citations Open access
Semantic Scholar
Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia.
S. Piya, S. Kornblau, V. Ruvolo, H. Mu +7 more
2016Blood128 citations Open access
Semantic Scholar
Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization
Zhao-Qi Liu, A. Yoshimi, Ji-Guang Wang, Hana Cho +12 more
2020Cancer Discovery103 citations Open access
Semantic Scholar
Preclinical and Early Clinical Evaluation of the Oral AKT Inhibitor, MK-2206, for the Treatment of Acute Myeloid Leukemia
M. Konopleva, R. Walter, S. Faderl, E. Jabbour +16 more
2014Clinical Cancer Research80 citations Open access
Semantic Scholar
MYC Protein Expression is an Important Prognostic Factor in Acute Myeloid Leukemia
M. Ohanian, U. Rozovski, R. Kanagal-Shamanna, L. Abruzzo +26 more
2018Leukemia and Lymphoma79 citations Open access
Semantic Scholar
Disruption of Wnt/β-catenin exerts anti-leukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia
Xue-Jie Jiang, P. Mak, H. Mu, Wen-Jing Tao +14 more
2018Clinical Cancer Research69 citations Open access
Semantic Scholar
Role of protein phosphatases in the cancer microenvironment.
P. Ruvolo
2019Biochimica et biophysica acta. Molecular cell research55 citations Open access
Semantic Scholar
Galectins as regulators of cell survival in the leukemia niche.
P. Ruvolo
2019Advances in Biological Regulation50 citations
Semantic Scholar
Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival
S. Kornblau, P. Ruvolo, Rui-Yu Y. Wang, V. Battula +13 more
2018Haematologica44 citations Open access
Semantic Scholar
Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells
P. Ruvolo, V. Ruvolo, C. Benton, A. Alrawi +7 more
2015Biochimica et Biophysica Acta44 citations Open access
Semantic Scholar
GSK-3 as a novel prognostic indicator in leukemia.
P. Ruvolo
2017Advances in Biological Regulation38 citations
Semantic Scholar
Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients
P. Ruvolo, Yi-Hua Qiu, K. Coombes, N. Zhang +7 more
2015BBA Clinical38 citations Open access
Semantic Scholar
The CXCR4–STAT3–IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide
Hila Shaim, Z. Estrov, D. Harris, Mayra Hernandez Sanabria +20 more
2018Frontiers in Immunology36 citations Open access
Semantic Scholar
MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation
G. Borthakur, S. Duvvuri, V. Ruvolo, D. Tripathi +8 more
2015PLoS ONE34 citations Open access
Semantic Scholar
Introduction to tumor microenvironment regulation of cancer cell survival, metastasis, inflammation, and immune surveillance.
G. Semenza, P. Ruvolo
2016Biochimica et Biophysica Acta33 citations Open access
Semantic Scholar
The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells
P. Ruvolo, V. Ruvolo, R. Jacamo, Jared K. Burks +13 more
2014Biochimica et Biophysica Acta30 citations Open access
Semantic Scholar
LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML
P. Ruvolo, Chen-Yue W. Hu, Yi-Hua Qiu, V. Ruvolo +6 more
2019EBioMedicine28 citations Open access
Semantic Scholar
AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill F LT 3-ITD acute myeloid leukemia
S. Post, Hua-Xian Ma, P. Malaney, Xiao-Rui Zhang +13 more
2021Haematologica27 citations Open access
Semantic Scholar
TP53/miR-34a-associated signaling targets SERPINE1 expression in human pancreatic cancer
S. Akula, P. Ruvolo, J. McCubrey
2020Aging27 citations Open access
Semantic Scholar
LGALS1 acts as a pro-survival molecule in AML.
P. Ruvolo, Hua-Xian Ma, V. Ruvolo, Xiao-Rui Zhang +2 more
2020Biochimica et biophysica acta. Molecular cell research27 citations Open access
Semantic Scholar
The TGF-β/SMAD Signaling Pathway As a Mediator of NK Cell Dysfunction and Immune Evasion in Myelodysplastic Syndrome
May Daher, R. Başar, Hila Shaim, Elif Gokdemir +16 more
201725 citations
Semantic Scholar
Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms
P. Ruvolo, Hua-Xian Ma, V. Ruvolo, Xiao-Rui Zhang +8 more
2017Haematologica24 citations Open access
Semantic Scholar
Cancer testis antigen Sperm Protein 17 as a new target for triple negative breast cancer immunotherapy
L. Mirandola, E. Pedretti, J. Figueroa, R. Chiaramonte +12 more
2017OncoTarget23 citations Open access
Semantic Scholar
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals
S. Abrams, S. Akula, A. Meher, L. Steelman +13 more
2021Cells22 citations Open access
Semantic Scholar
TAM kinases as regulators of cell death.
S. Post, M. Andreeff, Courtney Dinardo, J. Khoury +1 more
2021Biochimica et biophysica acta. Molecular cell research22 citations Open access
Semantic Scholar
Role of MSC-derived Galectin 3 in the AML Microenvironment
P. Ruvolo, V. Ruvolo, Jared K. Burks, Yi-Hua Qiu +11 more
2018Biochimica et biophysica acta. Molecular cell research22 citations Open access
Semantic Scholar
Apoptosis repressor with caspase recruitment domain is regulated by MAPK/PI3K and confers drug resistance and survival advantage to AML
P. Mak, D. Mak, H. Mu, Yuxie Shi +9 more
2013Apoptosis21 citations Open access
Semantic Scholar
A heavy metal baseline score predicts outcome in AML
M. Ohanian, P. Télouk, S. Kornblau, F. Albarède +8 more
2020American journal of hematology/oncology18 citations Open access
Semantic Scholar
The Interplay between PP2A and microRNAs in Leukemia
P. Ruvolo
2015Frontiers in Oncology17 citations Open access
Semantic Scholar
Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells
S. Abrams, P. Ruvolo, V. Ruvolo, G. Ligresti +8 more
2017OncoTarget16 citations Open access
Semantic Scholar
Pharmacologic Protein Kinase Cα Inhibition Uncouples Human Platelet-Stimulated Angiogenesis from Collagen-Induced Aggregation
Cesar Moncada de la Rosa, A. Radziwon-Balicka, H. El-Sikhry, J. Seubert +3 more
2013Journal of Pharmacology and Experimental Therapeutics15 citations
Semantic Scholar
Effects of CCL2/CCR2 Blockade in Acute Myeloid Leukemia
R. Jacamo, H. Mu, Qi Zhang, D. Chachad +14 more
201513 citations Open access
Semantic Scholar
Heat Shock Factor 1 (HSF1-pSer326) Predicts Response to Bortezomib-Containing Chemotherapy in Pediatric AML: A COG Study.
F. Hoff, Anneke D. van Dijk, Yi-Hua Qiu, P. Ruvolo +12 more
2020Blood10 citations Open access
Semantic Scholar
Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression
L. Steelman, S. Abrams, P. Ruvolo, V. Ruvolo +7 more
2017OncoTarget8 citations Open access
Semantic Scholar
Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia
R. Jacamo, R. Davis, Xiaoyang Ling, S. Sonnylal +12 more
2017OncoTarget8 citations Open access
Semantic Scholar
Abstract 3205: Defining the immune checkpoint landscape of acute myeloid leukemia (AML)
N. Daver, S. Basu, G. Garcia-Manero, J. Cortes +19 more
20168 citations
Semantic Scholar
The potential of enzastaurin to enhance platelet aggregation and growth factor secretion: implications for cancer cell survival
G. Lesyk, T. Fong, P. Ruvolo, P. Jurasz
2015Journal of Thrombosis and Haemostasis8 citations Open access
Semantic Scholar
ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition
J. Ishizawa, K. Kojima, D. Chachad, P. Ruvolo +15 more
20148 citations
Semantic Scholar
Comment on “PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia”
D. Perrotti, A. Agarwal, C. Lucas, G. Narla +4 more
2019Science Translational Medicine6 citations Open access
Semantic Scholar
RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences
Anneke D. van Dijk, Ti’ara L. Griffen, Yi-Hua Qiu, F. Hoff +8 more
2021Leukemia5 citations Open access
Semantic Scholar
SDF-1 Inhibition Using Spiegelmer® Nox-A12 As a Novel Strategy For Targeting AML Cells Within Their BM Microenvironment
Z. Zeng, Ye Chen, Yuexi Shi, T. McQueen +4 more
20135 citations
Semantic Scholar
BCL-2-Selective BH3 Mimetic ABT-199 Is a Potent Agent For Acute Myeloid Leukemia
Rongqing Pan, Lakeisha Debose, J. Benito, L. Golfman +13 more
20135 citations
Semantic Scholar
Proteomic, Gene Expression, and Micro-RNA Analysis Of Bone Marrow Mesenchymal Stromal Cells In Acute Myeloid Leukemia Identifies Pro-Inflammatory, Pro-Survival Signatures In Vitro and In Vivo
M. Andreeff, Rui-Yu Y. Wang, R. Davis, R. Jacamo +27 more
20134 citations
Semantic Scholar

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