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K. Flannigan · SciRah

Researcher profile · Semantic Scholar

K. Flannigan

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K. Flannigan — researcher profile on SciRah

h-index: 26
Works: 61
Citations: 2,078

Most-cited papers

Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production
Jean-Paul Motta, K. Flannigan, T. Agbor, Jennifer K. Beatty +6 more
2015Inflammatory Bowel Diseases181 citations
Semantic Scholar
Anti-Inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics
J. Wallace, Rory W. Blackler, M. Chan, G. D. da Silva +7 more
2015Antioxidants and Redox Signaling151 citations
Semantic Scholar
IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria
K. Flannigan, Vu L. Ngo, Duke Geem, Akihito Harusato +8 more
2016Mucosal Immunology134 citations Open access
Semantic Scholar
Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage
Óscar Medina-Contreras, Akihito Harusato, H. Nishio, K. Flannigan +13 more
2016Journal of Immunology124 citations Open access
Semantic Scholar
Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity
Michael R. Taylor, K. Flannigan, Hannah Rahim, Amina Mohamud +3 more
2019Science Advances122 citations Open access
Semantic Scholar
Segmented filamentous bacteria‐induced immune responses: a balancing act between host protection and autoimmunity
K. Flannigan, T. Denning
2018Immunology105 citations Open access
Semantic Scholar
Gaseous mediators in resolution of inflammation.
J. Wallace, A. Ianaro, K. Flannigan, G. Cirino
2015Seminars in Immunology105 citations
Semantic Scholar
Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis
K. Flannigan, T. Agbor, Rory W. Blackler, Janice J. Kim +4 more
2014Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
Semantic Scholar
The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis
K. Flannigan, K. Nieves, H. Szczepanski, A. Serra +5 more
2022Cellular and Molecular Gastroenterology and Hepatology87 citations Open access
Semantic Scholar
An intact microbiota is required for the gastrointestinal toxicity of the immunosuppressant mycophenolate mofetil.
K. Flannigan, Michael R. Taylor, Sheldon K. Pereira, J. Rodriguez-Arguello +13 more
2018The Journal of Heart and Lung Transplantation85 citations Open access
Semantic Scholar
Enhanced Synthesis and Diminished Degradation of Hydrogen Sulfide in Experimental Colitis: A Site-Specific, Pro-Resolution Mechanism
K. Flannigan, J. Ferraz, Rui Wang, J. Wallace
2013PLoS ONE75 citations Open access
Semantic Scholar
Targeting the pregnane X receptor using microbial metabolite mimicry
Z. Dvořák, F. Kopp, Cait M. Costello, Jazmin S. Kemp +38 more
2019bioRxiv74 citations Open access
Semantic Scholar
Eukaryotic and prokaryotic contributions to colonic hydrogen sulfide synthesis.
K. Flannigan, K. McCoy, J. Wallace
2011American Journal of Physiology - Gastrointestinal and Liver Physiology68 citations Open access
Semantic Scholar
Hydrogen Sulfide: Its Production, Release and Functions
K. Flannigan, J. Wallace
201363 citations
Semantic Scholar
Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia‐inducible factor‐1α
K. Flannigan, T. Agbor, Jean-Paul Motta, J. Ferraz +3 more
2015The FASEB Journal57 citations Open access
Semantic Scholar
Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer.
Wagdi Elsheikh, Rory W. Blackler, K. Flannigan, J. Wallace
2014Nitric oxide55 citations
Semantic Scholar
Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation.
K. Flannigan, Duke Geem, Akihito Harusato, T. Denning
2015American Journal of Pathology52 citations Open access
Semantic Scholar
Deciphering the pathogenesis of NSAID enteropathy using proton pump inhibitors and a hydrogen sulfide-releasing NSAID.
Rory W. Blackler, G. De Palma, A. Manko, G. D. da Silva +5 more
2015American Journal of Physiology - Gastrointestinal and Liver Physiology51 citations
Semantic Scholar
Harnessing Regulatory T Cells for the Treatment of Inflammatory Bowel Disease
Duke Geem, Akihito Harusato, K. Flannigan, T. Denning
2015Inflammatory Bowel Diseases46 citations Open access
Semantic Scholar
Constitutive androstane receptor regulates the intestinal mucosal response to injury
G. Hudson, K. Flannigan, Sarah L. Erickson, F. Vicentini +9 more
2017British Journal of Pharmacology38 citations Open access
Semantic Scholar
Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity
H. S. Ranhotra, K. Flannigan, Martina Brave, Subhajit Mukherjee +3 more
2016Nuclear Receptor Research35 citations Open access
Semantic Scholar
Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation
G. Hudson, K. Flannigan, V. P. Venu, L. Alston +6 more
2019Journal of Pharmacology and Experimental Therapeutics33 citations Open access
Semantic Scholar
Changes in Composition of the Gut Bacterial Microbiome after Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in a Pediatric Heart Transplant Patient
K. Flannigan, Taylor Rajbar, Andrew Moffat, L. S. McKenzie +6 more
2017Frontiers in Cardiovascular Medicine32 citations Open access
Semantic Scholar
Xenobiotic receptors and the regulation of intestinal homeostasis - harnessing the chemical output of the intestinal microbiota.
K. Nieves, S. Hirota, K. Flannigan
2021American Journal of Physiology - Gastrointestinal and Liver Physiology29 citations
Semantic Scholar
Regulation of cholecystokinin-mediated amylase secretion by leptin in rat pancreatic acinar tumor cell line AR42J.
D. M. Harris, K. Flannigan, V. Go, S.Vincent Wu
1999Pancreas29 citations
Semantic Scholar
Dextran sulfate sodium induces pan-gastroenteritis in rodents: implications for studies of colitis.
Wagdi Elsheikh, K. Flannigan, W. Mcknight, JoséGeraldo P. Ferraz +1 more
2012Journal of Physiology and Pharmacology26 citations
Semantic Scholar
Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract.
J. Wallace, K. Flannigan, W. Mcknight, Lei Wang +2 more
2013Journal of Physiology and Pharmacology22 citations
Semantic Scholar
Hydrogen sulfide-based anti-inflammatory and chemopreventive therapies: an experimental approach.
K. Flannigan, J. Wallace
2015Current pharmaceutical design21 citations
Semantic Scholar
Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis
M. Paul-Clark, Wagdi Elsheikh, Nicholas S. Kirkby, M. Chan +8 more
2016PLoS ONE19 citations Open access
Semantic Scholar
Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3+ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis
Hirohito Abo, K. Flannigan, Duke Geem, Vu L. Ngo +2 more
2019Frontiers in Immunology18 citations Open access
Semantic Scholar
The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins
Sarah L. Erickson, L. Alston, K. Nieves, T. Chang +3 more
2019The FASEB Journal17 citations Open access
Semantic Scholar
NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation‐associated intestinal remodeling
H. Szczepanski, K. Flannigan, B. Mainoli, L. Alston +6 more
2022The FASEB Journal11 citations
Semantic Scholar
Phenotypic and functional profiling of mouse intestinal antigen presenting cells
Akihito Harusato, K. Flannigan, Duke Geem, T. Denning
2015JIM - Journal of Immunological Methods10 citations Open access
Semantic Scholar
A16 SENSING OF A MICROBIAL METABOLITE BY FIBROBLASTS THROUGH THE PREGNANE X RECEPTOR RESTRAINS INFLAMMATION AND FIBROSIS IN MICE
K. Flannigan, K. Nieves, L. Alston, S. Mani +1 more
2019Journal of the Canadian Association of Gastroenterology3 citations Open access
Semantic Scholar
Mycobacterium avium subspecies paratuberculosis targets M cells in enteroid-derived monolayers through interactions with β1 integrins
G. Baruta, K. Flannigan, L. Alston, Hong Zhang +3 more
2024bioRxiv2 citations Open access
Semantic Scholar
Resident bacteria in the small intestine can shape host drug metabolism through innate lymphoid cell‐derived IL‐22
K. Flannigan, Sarah L. Erickson, Michael Johnston, H. Jijon +2 more
2020The FASEB Journal1 citations Open access
Semantic Scholar
P101 Comparative study with hydrogen sulfide (H2S)-releasing derivative of naproxen ATB-346, naproxen and cyclooxygenase (COX)-2 inhibitor in the mechanisms of gastric mucosa injury induced by stress
M. Magierowski, K. Jasnos, D. Drozdowicz, M. Strzałka +4 more
20141 citations
Semantic Scholar
Disrupting the CTGF–MMP7 Axis in Pulmonary Fibrosis: A Novel High-Affinity Antibody Outperforms Pamrevlumab in Patient-Derived Models
M. Myzithras, F. Ramírez, R. Sheehan, Priyanka Gupta +29 more
2026Airway pharmacology and treatment0 citations
Semantic Scholar
A58 ENTERIC TUFT CELLS MODULATE LOCAL BUT NOT SYSTEMIC HOST IMMUNE RESPONSES TO CO-ORDINATE TIMELY EXPULSION OF HYMENOLEPIS DIMINUTA
S. Rajeev, S. Li, K. Flannigan, A. Wang +1 more
2023Journal of the Canadian Association of Gastroenterology0 citations Open access
Semantic Scholar
A12 STEPWISE COORDINATION OF COLONIC NEUTROPHILS AND INNATE LYMPHOID CELLS IN THE ONSET AND RESOLUTION OF CLOSTRIDIOIDES DIFFICILE TOXIN-INDUCED INJURY
K. Flannigan, A. Serra, S. Hirota
2022Journal of the Canadian Association of Gastroenterology0 citations Open access
Semantic Scholar
A20 INTESTINAL SMOOTH MUSCLE AND FIBROSTENOSIS: TARGETING NR4A1 TO MODULATE PROLIFERATIVE SIGNALLING
J. Lee, H. Szczepanski, K. Flannigan, S. Hirota
2022Journal of the Canadian Association of Gastroenterology0 citations Open access
Semantic Scholar
A28 CHARACTERIZING THE ROLE OF NR4A1 IN THE REGULATION OF INTESTINAL SMOOTH MUSCLE CELL PHENOTYPE AND FUNCTION
H. Szczepanski, K. Flannigan, B. Mainoli, L. Alston +6 more
20210 citations Open access
Semantic Scholar
A36 THE ROLE OF MICROBIAL INDOLE METABOLITES IN CONTROLLING INFLAMMATORY RESPONSES AND HEALING IN RESPONSE TO DSS-INDUCED COLITIS
K. Nieves, K. Flannigan, L. Alston, C. Thomson +3 more
20200 citations Open access
Semantic Scholar
A14 GUT-RESIDING BACTERIA CAN SHAPE HOST DRUG METABOLISM IN THE SMALL INTESTINE THROUGH AN INNATE LYMPHOID CELL-IL-22 DRIVEN AXIS
K. Flannigan, Michael J. Johnston, Sarah L. Erickson, K. Nieves +4 more
2020Journal of the Canadian Association of Gastroenterology0 citations Open access
Semantic Scholar
A275 COMMENSAL BACTERIA IN THE SMALL INTESTINE INFLUENCE IMMUNE CELLS TO DICTATE HOST DRUG METABOLISM
K. Flannigan, K. Nieves, Sarah L. Erickson, L. Alston +1 more
20180 citations Open access
Semantic Scholar
Alberta Transplant Institute Research Day 2018
Andrew Rasmussen, Ronald B. Moore, Trevor D. Schuler, G. Todd +8 more
20180 citations
Semantic Scholar
Alterations in the intestinal microbiota contribute to the gastrointestinal toxicity of the anti‐rejection drug mycophenolate mofetil
K. Flannigan, Sheldon K. Pereira, Michael R. Taylor, L. Alston +6 more
20180 citations
Semantic Scholar
A119 THE MICROBIAL METABOLITE SENSOR PREGNANE X RECEPTOR (PXR) RESTRAINS FIBROBLASTS FROM PROMOTING INTESTINAL INFLAMMATION AND FIBROSIS IN MICE
K. Flannigan, L. Alston, S. Mani, S. Hirota
20180 citations Open access
Semantic Scholar
The Microbial Metabolite Sensor Pregnane X Receptor (PXR) Restrains Fibroblasts from Promoting Gastrointestinal Inflammation and Fibrosis in Mice
K. Flannigan, L. Alston, S. Mani, T. Chang +1 more
20170 citations
Semantic Scholar
Xenobiotic Receptor Regulation of Clostridium difficile‐Associated Tissue Damage and Inflammation
Sarah L. Erickson, K. Flannigan, L. Alston, S. Hirota
2017The FASEB Journal0 citations
Semantic Scholar

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