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Nicholas S. Kirkby · SciRah

Researcher profile · Semantic Scholar

Nicholas S. Kirkby

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Nicholas S. Kirkby — researcher profile on SciRah

h-index: 28
Works: 116
Citations: 3,073

Most-cited papers

Circulating MicroRNAs as Novel Biomarkers for Platelet Activation
P. Willeit, A. Zampetaki, K. Dudek, D. Kaudewitz +12 more
2013Circulation Research398 citations
Semantic Scholar
Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system
J. Mitchell, Nicholas S. Kirkby
2018British Journal of Pharmacology185 citations Open access
Semantic Scholar
Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways
Nicholas S. Kirkby, M. Chan, A. K. Zaiss, E. Garcia-Vaz +8 more
2015Proceedings of the National Academy of Sciences of the United States of America174 citations Open access
Semantic Scholar
Evidence for the Involvement of Type I Interferon in Pulmonary Arterial Hypertension
P. George, Eduardo Oliver, P. Dorfmuller, O. Dubois +17 more
2013Circulation Research149 citations Open access
Semantic Scholar
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
Nicholas S. Kirkby, Martina H. Lundberg, L. Harrington, P. Leadbeater +6 more
2012Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
Role of prostacyclin in pulmonary hypertension
J. Mitchell, B. Ahmetaj-Shala, Nicholas S. Kirkby, William R. Wright +3 more
2014Global Cardiology Science & Practice81 citations Open access
Semantic Scholar
Cyclooxygenases and the cardiovascular system.
J. Mitchell, Nicholas S. Kirkby, B. Ahmetaj-Shala, P. Armstrong +5 more
2020Pharmacology and Therapeutics76 citations Open access
Semantic Scholar
Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine
B. Ahmetaj-Shala, Nicholas S. Kirkby, Rebecca B. M. Knowles, M. Al’Yamani +10 more
2015Circulation71 citations Open access
Semantic Scholar
Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia
Roberta d'Emmanuele di Villa Bianca, E. Mitidieri, M. D. Di Minno, Nicholas S. Kirkby +4 more
2013Proceedings of the National Academy of Sciences of the United States of America65 citations Open access
Semantic Scholar
Differential role of pannexin-1/ATP/P2X7 axis in IL-1β release by human monocytes
K. Parzych, A. Zetterqvist, William R. Wright, Nicholas S. Kirkby +2 more
2017The FASEB Journal60 citations Open access
Semantic Scholar
COX-2 Protects against Atherosclerosis Independently of Local Vascular Prostacyclin: Identification of COX-2 Associated Pathways Implicate Rgl1 and Lymphocyte Networks
Nicholas S. Kirkby, Martina H. Lundberg, William R. Wright, T. Warner +2 more
2014PLoS ONE60 citations Open access
Semantic Scholar
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
Nicholas S. Kirkby, A. K. Zaiss, Paula Urquhart, Jing Jiao +8 more
2013PLoS ONE59 citations Open access
Semantic Scholar
Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide
Nicholas S. Kirkby, Martina H. Lundberg, M. Chan, I. Vojnović +4 more
2013Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1
F. Rauzi, Nicholas S. Kirkby, M. Edin, J. Whiteford +3 more
2016The FASEB Journal52 citations Open access
Semantic Scholar
Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies
Nicholas S. Kirkby, A. K. Zaiss, William R. Wright, Jing Jiao +4 more
2013Biochemical and Biophysical Research Communications - BBRC49 citations Open access
Semantic Scholar
Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells
B. Ahmetaj-Shala, R. Vaja, S. Atanur, P. George +2 more
2020JACC: Basic to Translational Science46 citations Open access
Semantic Scholar
Cyclooxygenase-2 selectively controls renal blood flow through a novel PPARβ/δ-dependent renal vasodilator pathway
Nicholas S. Kirkby, W. O. Sampaio, G. Etelvino, Daniele T. Alves +11 more
2018HYPERTENSION42 citations Open access
Semantic Scholar
Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy
N. Mohamed, Robert P. Davies, P. Lickiss, B. Ahmetaj-Shala +14 more
2017Pulmonary Circulation41 citations Open access
Semantic Scholar
University of Birmingham Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option : use of 96-well Optimul assay
M. Lordkipanidzé, Gillian Lowe, Nicholas S. Kirkby, M. Chan +11 more
201439 citations
Semantic Scholar
Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction.
P. Armstrong, Nicholas S. Kirkby, M. Chan, M. Finsterbusch +3 more
2015Blood35 citations Open access
Semantic Scholar
Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay.
Marie Lordkipanidzé, Gillian C. Lowe, Nicholas S. Kirkby, M. Chan +11 more
2014Blood35 citations Open access
Semantic Scholar
P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation
M. Chan, Rebecca B. M. Knowles, Martina H. Lundberg, A. Tucker +5 more
2016British Journal of Clinical Pharmacology34 citations Open access
Semantic Scholar
Melaleuca alternifolia Induces Heme Oxygenase-1 Expression in Murine RAW264.7 Cells through Activation of the Nrf2-ARE Pathway.
Shih-Yu Lee, Po-Yu Chen, Jung-Chun Lin, Nicholas S. Kirkby +2 more
2017The American Journal of Chinese Medicine29 citations
Semantic Scholar
Studies on metal–organic framework (MOF) nanomedicine preparations of sildenafil for the future treatment of pulmonary arterial hypertension
N. Mohamed, H. Abou-Saleh, Y. Kameno, I. Marei +9 more
2021Scientific Reports28 citations Open access
Semantic Scholar
Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox
J. Mitchell, Fisnik Shala, Youssef Elghazouli, T. Warner +5 more
2019Circulation Research28 citations Open access
Semantic Scholar
Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M
J. Mitchell, Rebecca B. M. Knowles, Nicholas S. Kirkby, D. M. Reed +8 more
2018Circulation Research28 citations Open access
Semantic Scholar
Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation
Nicholas S. Kirkby, D. M. Reed, M. Edin, F. Rauzi +8 more
2015The FASEB Journal28 citations Open access
Semantic Scholar
The COVID‐19 ibuprofen controversy: A systematic review of NSAIDs in adult acute lower respiratory tract infections
R. Vaja, Jeffrey Shi Kai Chan, P. Ferreira, A. Harky +4 more
2020British Journal of Clinical Pharmacology26 citations Open access
Semantic Scholar
Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis
Nicholas S. Kirkby, J. Raouf, B. Ahmetaj-Shala, Bin Liu +11 more
2019Cardiovascular Research26 citations Open access
Semantic Scholar
Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo.
Shih-Yu Lee, Wen-Liang Chang, Zhi-Xiang Li, Nicholas S. Kirkby +4 more
2018Phytomedicine25 citations Open access
Semantic Scholar
A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension
N. Mohamed, B. Ahmetaj-Shala, L. Duluc, L. Mackenzie +10 more
2016Journal of Cardiovascular Translational Research23 citations Open access
Semantic Scholar
Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test
Nicholas S. Kirkby, M. Chan, Martina H. Lundberg, K. Massey +6 more
2013The FASEB Journal21 citations Open access
Semantic Scholar
Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis
M. Paul-Clark, Wagdi Elsheikh, Nicholas S. Kirkby, M. Chan +8 more
2016PLoS ONE19 citations Open access
Semantic Scholar
Drug-free platelets can act as seeds for aggregate formation during antiplatelet therapy
T. Hoefer, P. Armstrong, M. Finsterbusch, M. Chan +2 more
2015Arteriosclerosis, Thrombosis and Vascular Biology19 citations Open access
Semantic Scholar
Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation
J. Mitchell, Fisnik Shala, Maria Elisa Lopes Pires, Rachel Y. Loy +6 more
2021Science Advances18 citations Open access
Semantic Scholar
Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin
M. Crescente, P. Armstrong, Nicholas S. Kirkby, M. Edin +12 more
2020The FASEB Journal14 citations Open access
Semantic Scholar
Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways
Abel Tesfai, N. MacCallum, Nicholas S. Kirkby, H. Gashaw +8 more
2017PLoS ONE14 citations Open access
Semantic Scholar
Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing.
B. Ahmetaj-Shala, Abel Tesfai, C. Constantinou, R. Leszczyński +7 more
2017Biochemical and Biophysical Research Communications - BBRC14 citations Open access
Semantic Scholar
Smooth Muscle Endothelin B Receptors Regulate Blood Pressure But not Vascular Function or Neointimal Remodelling
E. Miller, A. Czopek, Karolina M. Duthie, Nicholas S. Kirkby +11 more
2016HYPERTENSION13 citations Open access
Semantic Scholar
Non-endothelial cell endothelin-B receptors limit neointima formation following vascular injury.
Nicholas S. Kirkby, Karolina M. Duthie, E. Miller, Y. Kotelevtsev +3 more
2012Cardiovascular Research13 citations Open access
Semantic Scholar
Temporal in vivo platelet labeling in mice reveals age-dependent receptor expression and conservation of specific mRNAs
P. Armstrong, Harriet E. Allan, Nicholas S. Kirkby, A. Joshi +5 more
2021bioRxiv12 citations Open access
Semantic Scholar
Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping
B. Ahmetaj-Shala, M. Olanipekun, Abel Tesfai, N. MacCallum +8 more
2018Scientific Reports12 citations Open access
Semantic Scholar
Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis
Nicholas S. Kirkby, Abel Tesfai, B. Ahmetaj-Shala, H. Gashaw +5 more
2016The FASEB Journal12 citations Open access
Semantic Scholar
Morphology and vasoactive hormone profiles from endothelial cells derived from stem cells of different sources.
D. M. Reed, G. Foldes, Nicholas S. Kirkby, B. Ahmetaj-Shala +6 more
2014Biochemical and Biophysical Research Communications - BBRC11 citations Open access
Semantic Scholar
Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns.
William R. Wright, Nicholas S. Kirkby, Neil A. Galloway-Phillipps, D. M. Reed +2 more
2013Prostaglandins & other lipid mediators11 citations
Semantic Scholar
Platelet inhibition by P2Y12 antagonists is potentiated by adenosine signalling activators
C. Shih, M. Chan, Nicholas S. Kirkby, I. Vojnović +3 more
2021British Journal of Pharmacology10 citations Open access
Semantic Scholar
Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs".
B. Ahmetaj-Shala, Nicholas S. Kirkby, Rebecca B. M. Knowles, M. Al’Yamani +10 more
2015Circulation9 citations Open access
Semantic Scholar
A bioassay system of autologous human endothelial, smooth muscle cells, and leukocytes for use in drug discovery, phenotyping, and tissue engineering
B. Ahmetaj-Shala, Ryota Kawai, I. Marei, Z. Nikolakopoulou +6 more
2019The FASEB Journal8 citations Open access
Semantic Scholar
Development and characterization of glutamyl-protected N-hydroxyguanidines as reno-active nitric oxide donor drugs with therapeutic potential in acute renal failure.
Qing-zhi Zhang, P. Milliken, A. Kulczyńska, A. Slawin +5 more
2013Journal of Medicinal Chemistry8 citations
Semantic Scholar
Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti‐platelet therapy
P. Armstrong, P. Ferreira, M. Chan, Martina H. Lundberg Slingsby +5 more
2020Journal of Thrombosis and Haemostasis7 citations Open access
Semantic Scholar

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J. Mitchell×38
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J. Mitchell — researcher profile on SciRah
T. Warner×23
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T. Warner — researcher profile on SciRah
B. Ahmetaj-Shala×17
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B. Ahmetaj-Shala — researcher profile on SciRah
M. Chan×15
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M. Chan — researcher profile on SciRah

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P. Armstrong — researcher profile on SciRah

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D. M. Reed — researcher profile on SciRah

Martina H. Lundberg×8

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Martina H. Lundberg — researcher profile on SciRah

H. Herschman×7

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H. Herschman — researcher profile on SciRah

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N. Mohamed — researcher profile on SciRah

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L. Mackenzie — researcher profile on SciRah

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M. Paul-Clark — researcher profile on SciRah

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Jing Jiao — researcher profile on SciRah