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Shi-Hua Li · SciRah

Researcher profile · Semantic Scholar

Shi-Hua Li

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Shi-Hua Li — researcher profile on SciRah

h-index: 74
Works: 257
Citations: 20K

Most-cited papers

A huntingtin knock-in pig model recapitulates features of selective neurodegeneration in Huntington’s disease
Sen Yan, Zhu-Chi Tu, Zhao-Ming Liu, Na-Na Fan +17 more
2018Cell286 citations Open access
Semantic Scholar
PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models
Rui Han, Yanting Liu, Shi-Hua Li, Xiao-Jiang Li +1 more
2022Autophagy217 citations Open access
Semantic Scholar
CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys
Wei-Li Yang, Yun-Bo Liu, Zhu-Chi Tu, C. Xiao +11 more
2019Cell Research85 citations Open access
Semantic Scholar
Neuroinflammation in Huntington’s disease: From animal models to clinical therapeutics
Qingqing Jia, Shi-Hua Li, Xiao-Jiang Li, Peng Yin
2022Frontiers in Immunology64 citations Open access
Semantic Scholar
Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
Hui-Ming Yang, Su Yang, Liang Jing, Luo-Xiu Huang +9 more
2020Nature Communications64 citations Open access
Semantic Scholar
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis
Wei-Li Yang, Xiang-Yu Guo, Zhu-Chi Tu, Xiu-Sheng Chen +17 more
2021Protein & Cell60 citations Open access
Semantic Scholar
Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains
Peng Yin, Xiang-Yu Guo, Wei-Li Yang, Sen Yan +6 more
2019Acta Neuropathologica57 citations Open access
Semantic Scholar
Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4
Kai Zhao, Cheng-Yong Shen, Lei Li, Haitao Wu +15 more
2018Journal of Neuroscience56 citations Open access
Semantic Scholar
New pathogenic insights from large animal models of neurodegenerative diseases
Peng Yin, Shi-Hua Li, Xiao-Jiang Li, Wei-Li Yang
2022Protein & Cell55 citations Open access
Semantic Scholar
Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity
Su Yang, Shi-Hua Li, Xiao-Jiang Li
2018Cell Reports53 citations Open access
Semantic Scholar
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease
Sen Yan, Xiao Zheng, Ying-Qi Lin, Cai-Juan Li +14 more
2023Nature Biomedical Engineering48 citations
Semantic Scholar
A CRISPR monkey model unravels a unique function of PINK1 in primate brains
Wei-Li Yang, Shi-Hua Li, Xiao-Jiang Li
2019Molecular Neurodegeneration48 citations Open access
Semantic Scholar
Application of CRISPR/Cas9 System in Establishing Large Animal Models
Ying-Qi Lin, Jun Li, Cai-Juan Li, Zhu-Chi Tu +3 more
2022Frontiers in Cell and Developmental Biology37 citations Open access
Semantic Scholar
Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17
Qiong Liu, Shan-Shan Huang, Peng Yin, Su Yang +7 more
2020Nature Communications37 citations Open access
Semantic Scholar
Piperine ameliorates SCA17 neuropathology by reducing ER stress
Ji-Feng Guo, Yiting Cui, Qiong Liu, Yang Yang +7 more
2018Molecular Neurodegeneration37 citations Open access
Semantic Scholar
Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice
Qiong Liu, Si-Ying Cheng, Hui-Ming Yang, Louyin Zhu +5 more
2020Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice
Su Yang, Hui-Ming Yang, Luo-Xiu Huang, Luxiao Chen +3 more
2020Proceedings of the National Academy of Sciences of the United States of America33 citations Open access
Semantic Scholar
Microglial autophagy in Alzheimer’s disease and Parkinson’s disease
Zhifu F. Wang, Qi Wang, Shi-Hua Li, Xiao-Jiang Li +2 more
2023Frontiers in Aging Neuroscience32 citations Open access
Semantic Scholar
Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges
Longhong Zhu, Shi-Hua Li, Xiao-Jiang Li, Peng Yin
2023Translational Neurodegeneration29 citations Open access
Semantic Scholar
Genetically modified large animal models for investigating neurodegenerative diseases
Wei-Li Yang, Xiu-Sheng Chen, Shi-Hua Li, Xiao-Jiang Li
2021Cell & Bioscience29 citations Open access
Semantic Scholar
Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models
Rui Han, Qi Wang, Xin Xiong, Xiu-Sheng Chen +19 more
2024Journal of Clinical Investigation28 citations Open access
Semantic Scholar
CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate
Bang Li, Hui Zhao, Zhu-Chi Tu, Wei-Li Yang +23 more
2023Cell Discovery26 citations Open access
Semantic Scholar
Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system.
Peng Yin, Dazhang Bai, Longhong Zhu, Fuyu Deng +5 more
2021Experimental Neurology26 citations
Semantic Scholar
Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease
Peng Yin, Qiong Liu, Yong-Cheng Pan, Wei-Li Yang +7 more
2020EMBO Reports26 citations Open access
Semantic Scholar
Neuroinflammatory Proteins in Huntington’s Disease: Insights into Mechanisms, Diagnosis, and Therapeutic Implications
Xin-Hui Li, Hui-Chun Tong, Shuying Xu, Gong-Ke Zhou +5 more
2024International Journal of Molecular Sciences24 citations
Semantic Scholar
Mitochondrial-Dependent and Independent Functions of PINK1
Xiu-Sheng Chen, Qi Wang, Shi-Hua Li, Xiao-Jiang Li +1 more
2022Frontiers in Cell and Developmental Biology24 citations Open access
Semantic Scholar
Molecular Mechanisms and Therapeutics for SCA17
Qiong Liu, Yong-Cheng Pan, Xiao-Jiang Li, Shi-Hua Li
2019Neurotherapeutics24 citations Open access
Semantic Scholar
Insights into White Matter Defect in Huntington’s Disease
Yize Sun, Huichun Tong, Tianqi Yang, Li Liu +2 more
2022Cells22 citations Open access
Semantic Scholar
Ahi1 regulates the nuclear translocation of glucocorticoid receptor to modulate stress response
Bin Wang, N. Xin, Xuan-Chen Qian, Lijing Zhai +6 more
2021Translational Psychiatry21 citations Open access
Semantic Scholar
Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response
Xing-Xing Chen, N. Xin, Yong-Cheng Pan, Louyin Zhu +6 more
2020Frontiers in Cellular Neuroscience20 citations Open access
Semantic Scholar
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
Ying-Qi Lin, Cai-Juan Li, Yi-Zhi Chen, Jia-Le Gao +14 more
2025Molecular Neurodegeneration19 citations Open access
Semantic Scholar
CRISPR-Based Genome-Editing Tools for Huntington’s Disease Research and Therapy
Yiyang Qin, Shi-Hua Li, Xiao-Jiang Li, Su Yang
2022Neuroscience Bulletin18 citations Open access
Semantic Scholar
Accumulation of Endogenous Mutant Huntingtin in Astrocytes Exacerbates Neuropathology of Huntington Disease in Mice
Liang Jing, Si-Ying Cheng, Yong-Cheng Pan, Qiong Liu +3 more
2021Molecular Neurobiology18 citations
Semantic Scholar
Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease
Kaili Ou, Qingqing Jia, Dandan Li, Shi-Hua Li +2 more
2025Translational Neurodegeneration17 citations
Semantic Scholar
The Expanding Clinical Universe of Polyglutamine Disease
Shan-Shan Huang, Sui-Qiang Zhu, Xiao-Jiang Li, Shi-Hua Li
2019The Neuroscientist17 citations Open access
Semantic Scholar
Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta
Chen Zhang, Qingqing Jia, Longhong Zhu, Junqi Hou +11 more
2024Alzheimer's & Dementia16 citations Open access
Semantic Scholar
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Zhu-Chi Tu, Sen Yan, Bo-Feng Han, Cai-Juan Li +10 more
2023Signal Transduction and Targeted Therapy16 citations Open access
Semantic Scholar
Physical exercise modulates the microglial complement pathway in mice to relieve cortical circuitry deficits induced by mutant human TDP-43.
Ji-An Wei, Linglin Liu, Xichen Song, Bi-Lian Lin +8 more
2023Cell Reports15 citations Open access
Semantic Scholar
SQSTM1-mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain
Peng Yin, Dazhang Bai, Fuyu Deng, Chen Zhang +10 more
2021Autophagy15 citations Open access
Semantic Scholar
Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer’s Disease Model Cells
Lai-Lei Ting, Hsien-Tsung Lu, Shu-Fen Yen, T. Ngo +10 more
2019Molecular Neurobiology15 citations
Semantic Scholar
TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease
Yiyang Qin, Lai-Qiang Chen, Wenzhen Zhu, Jiahong Song +17 more
2024Science Advances14 citations Open access
Semantic Scholar
Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease
Yiran Zhang, Xiu-Sheng Chen, Lai-Qiang Chen, Mingting Shao +11 more
2024Molecular Neurodegeneration13 citations Open access
Semantic Scholar
Huntingtin Interacting Proteins and Pathological Implications
Li Liu, Huichun Tong, Yize Sun, Xing-Xing Chen +4 more
2023International Journal of Molecular Sciences13 citations Open access
Semantic Scholar
Expression and Localization of Huntingtin‑Associated Protein 1 (HAP1) in the Human Digestive System
Tian Li, Shi-Hua Li, Xiao-Zhong Gao, Q. Cai +1 more
2018Digestive Diseases and Sciences13 citations Open access
Semantic Scholar
Use of large animal models to investigate Huntington's diseases
Sen Yan, Shi-Hua Li, Xiao-Jiang Li
2019Cell Regeneration12 citations Open access
Semantic Scholar
PRRT2 frameshift mutation reduces its mRNA stability resulting loss of function in Paroxysmal Kinesigenic Dyskinesia
Yong-Cheng Pan, Qiong Liu, Jennifer Zhang, Yang Yang +8 more
2019Biochemical and Biophysical Research Communications - BBRC11 citations Open access
Semantic Scholar
Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.
Dazhang Bai, Longhong Zhu, Qingqing Jia, Xue-Zhi Duan +8 more
2023Progress in neurobiology10 citations Open access
Semantic Scholar
Large animal models for Huntington’s disease research
Bo-Feng Han, Wei-En Liang, Xiao-Jiang Li, Shi-Hua Li +2 more
2024Zoological Research9 citations Open access
Semantic Scholar
Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish via Toxic Gain of Function
Louyin Zhu, Lai-Qiang Chen, Lingya Yan, B. Perkins +4 more
2019Frontiers in Cellular Neuroscience9 citations Open access
Semantic Scholar
Pathologic TDP‐43 downregulates myelin gene expression in the monkey brain
Longhong Zhu, Dazhang Bai, Xiang Wang, Kaili Ou +10 more
2024Brain Pathology8 citations Open access
Semantic Scholar

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Xiao-Jiang Li×33
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Xiao-Jiang Li — researcher profile on SciRah
Peng Yin×21
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Wei-Li Yang×18
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Su Yang×14
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Sen Yan — researcher profile on SciRah

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Xiao-Jiang Li×10

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Yong-Cheng Pan×8

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Qiong Liu — researcher profile on SciRah

Xiang-Yu Guo×7

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Xiu-Sheng Chen×7

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Bang Li — researcher profile on SciRah