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Xiang-Yu Guo · SciRah

Researcher profile · Semantic Scholar

Xiang-Yu Guo

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Xiang-Yu Guo — researcher profile on SciRah

h-index: 18
Works: 31
Citations: 1,504

Most-cited papers

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9.
Yongchang Chen, Yinghui Zheng, Yu Kang, Wei-Li Yang +11 more
2015Human Molecular Genetics243 citations Open access
Semantic Scholar
Cell transcriptomic atlas of the non-human primate Macaca fascicularis
Lei Han, Xiaoyu Wei, Chuan-Yu Liu, G. Volpe +73 more
2021Nature201 citations Open access
Semantic Scholar
Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos
Zhu-Chi Tu, Wei-Li Yang, Sen Yan, An Yin +9 more
2017Scientific Reports123 citations Open access
Semantic Scholar
CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases
Zhu-Chi Tu, Wei-Li Yang, Sen Yan, Xiang-Yu Guo +1 more
2015Molecular Neurodegeneration122 citations Open access
Semantic Scholar
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates
Hui Zhao, Qi-Qi Wang, Ting Yan, Yu Zhang +8 more
2019Translational Psychiatry96 citations Open access
Semantic Scholar
Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate
Hui Zhao, Zhu-Chi Tu, Huijuan Xu, Sen Yan +11 more
2017Cell Research87 citations Open access
Semantic Scholar
CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys
Wei-Li Yang, Yun-Bo Liu, Zhu-Chi Tu, C. Xiao +11 more
2019Cell Research85 citations Open access
Semantic Scholar
Early Parkinson's disease symptoms in α-synuclein transgenic monkeys.
Yu-Yu Niu, Xiang-Yu Guo, Yongchang Chen, Chuan-En Wang +9 more
2014Human Molecular Genetics82 citations Open access
Semantic Scholar
Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain
Wei-Li Yang, Guohao Wang, Chuan-En Wang, Xiang-Yu Guo +8 more
2015Journal of Neuroscience61 citations Open access
Semantic Scholar
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis
Wei-Li Yang, Xiang-Yu Guo, Zhu-Chi Tu, Xiu-Sheng Chen +17 more
2021Protein & Cell60 citations Open access
Semantic Scholar
CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms
Zhu-Chi Tu, Hui Zhao, Bang Li, Sen Yan +13 more
2018Human Molecular Genetics60 citations Open access
Semantic Scholar
Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains
Peng Yin, Xiang-Yu Guo, Wei-Li Yang, Sen Yan +6 more
2019Acta Neuropathologica57 citations Open access
Semantic Scholar
Targeted genome editing in primate embryos
Xiang-Yu Guo, Xiao-Jiang Li
2015Cell Research43 citations Open access
Semantic Scholar
Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin.
Peng Yin, Zhu-Chi Tu, An Yin, Ting Zhao +10 more
2015Human Molecular Genetics31 citations Open access
Semantic Scholar
Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models
Rui Han, Qi Wang, Xin Xiong, Xiu-Sheng Chen +19 more
2024Journal of Clinical Investigation28 citations Open access
Semantic Scholar
CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate
Bang Li, Hui Zhao, Zhu-Chi Tu, Wei-Li Yang +23 more
2023Cell Discovery26 citations Open access
Semantic Scholar
Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system.
Peng Yin, Dazhang Bai, Longhong Zhu, Fuyu Deng +5 more
2021Experimental Neurology26 citations
Semantic Scholar
Genetically modified non-human primate models for research on neurodegenerative diseases
Ming-Tian Pan, Han Zhang, Xiao-Jiang Li, Xiang-Yu Guo
2024Zoological Research25 citations Open access
Semantic Scholar
SQSTM1-mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain
Peng Yin, Dazhang Bai, Fuyu Deng, Chen Zhang +10 more
2021Autophagy15 citations Open access
Semantic Scholar
Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang +10 more
2025Advancement of science9 citations Open access
Semantic Scholar
Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains
Xing-Xing Chen, Yize Sun, Lai-Qiang Chen, Xiu-Sheng Chen +12 more
2022Cellular and Molecular Life Sciences8 citations
Semantic Scholar
Brain Region- and Age-Dependent 5-Hydroxymethylcytosine Activity in the Non-Human Primate
Yanru Xu, Liying Zhong, Huixian Wei, Yuwei Li +9 more
2022Frontiers in Aging Neuroscience8 citations Open access
Semantic Scholar
Mutant THAP11 causes cerebellar neurodegeneration and triggers TREM2-mediated microglial activation in mice
Eshu Ruan, Jing-Pan Lin, Zhao Chen, Qianai Sheng +13 more
2025Journal of Clinical Investigation5 citations Open access
Semantic Scholar
Mutant HTT does not affect glial development but impairs myelination in the early disease stage
Sitong Yang, Jingjing Ma, Han Zhang, Lai-Qiang Chen +8 more
2023Frontiers in Neuroscience5 citations Open access
Semantic Scholar
Understanding Tau pathology: Insights from animal models
Han Zhang, Ming-Tian Pan, Yuxuan Li, Xiaojiang Li +2 more
2025Zoological Research2 citations Open access
Semantic Scholar
Regulation of UBC12 expression and protein neddylation by PINK1 suggests a primate-specific function
Wei Huang, Ting Xu, Gong-Ke Zhou, Yuxuan Li +11 more
2025Zoological Research1 citations Open access
Semantic Scholar
Modeling Tau-Mediated Pathology in Monkey Brain Slices
Ming-Tian Pan, Qintian Guo, Pei-Si Huang, Xiang Han +9 more
2026Biology0 citations Open access
Semantic Scholar
Multimodal brain cell atlas across the adult macaque lifespan.
Xiao Zhang, Guang-Shun Lai, Xiang-Yu Guo, Wen Ma +75 more
2026Cell0 citations
Semantic Scholar
Primate abnormal spindle-like microcephaly-associated knockout causes severe microcephaly and oligodendrocyte loss in the brain
Dajian He, Mingtian Pan, Feng-Wei Sun, Liang Jiang +7 more
2025Protein & Cell0 citations Open access
Semantic Scholar
Multimodal brain cell atlas across the adult macaque lifespan
Xiao Zhang, Guang-Shun Lai, Xiang-Yu Guo, Wen Ma +64 more
2025bioRxiv0 citations Open access
Semantic Scholar
Cas9 fusion proteins and its coded sequence
Xiao-Jiang Li, Zhu-Chi Tu, Wei-Li Yang, Xiang-Yu Guo +1 more
20160 citations
Semantic Scholar

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