Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

J. Lategahn · SciRah

Researcher profile · Semantic Scholar

J. Lategahn

Share profile

J. Lategahn — researcher profile on SciRah

h-index: 18
Works: 31
Citations: 1,412

Most-cited papers

Organocatalytic, oxidative, intramolecular C-H bond amination and metal-free cross-amination of unactivated arenes at ambient temperature.
A. Antonchick, R. Samanta, K. Kulikov, J. Lategahn
2011Angewandte Chemie329 citations
Semantic Scholar
Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors
J. Fassunke, Fabienne Müller, M. Keul, S. Michels +35 more
2018Nature Communications133 citations Open access
Semantic Scholar
Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
J. Engel, A. Richters, M. Getlik, Stefano Tomassi +23 more
2015Journal of Medicinal Chemistry104 citations Open access
Semantic Scholar
Metal-free direct oxidative intermolecular diarylation of anilides at ambient temperature assisted by cascade selective formation of C-C and C-N bonds.
R. Samanta, J. Lategahn, A. Antonchick
2012Chemical Communications95 citations
Semantic Scholar
Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
Marcel Günther, J. Lategahn, M. Juchum, Eva Döring +5 more
2017Journal of Medicinal Chemistry90 citations Open access
Semantic Scholar
Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer.
J. Engel, J. Lategahn, D. Rauh
2016ACS Medicinal Chemistry Letters79 citations Open access
Semantic Scholar
Resistance to avapritinib in PDGFRA-driven GIST is caused by secondary mutations in the PDGFRA kinase domain.
S. Grunewald, Lillian R. Klug, Thomas Muhlenberg, J. Lategahn +15 more
2020Cancer Discovery75 citations
Semantic Scholar
C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?
Tobias Grabe, J. Lategahn, D. Rauh
2018ACS Medicinal Chemistry Letters66 citations Open access
Semantic Scholar
Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.
J. Engel, C. Becker, J. Lategahn, M. Keul +7 more
2016Angewandte Chemie53 citations
Semantic Scholar
Lessons To Be Learned: The Molecular Basis of Kinase-Targeted Therapies and Drug Resistance in Non-Small Cell Lung Cancer.
J. Lategahn, M. Keul, D. Rauh
2018Angewandte Chemie46 citations
Semantic Scholar
Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
Stefano Tomassi, J. Lategahn, J. Engel, M. Keul +7 more
2017Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands.
J. Niggenaber, Leonie Heyden, Tobias Grabe, M. Müller +2 more
2020ACS Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
A novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives
D. N. Do Amaral, J. Lategahn, H. H. Fokoue, Eduardo Miguez Bastos da Silva +5 more
2019Scientific Reports39 citations Open access
Semantic Scholar
Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA
A. Teuber, T. Schulz, B. Fletcher, R. Gontla +10 more
2024Nature Communications36 citations Open access
Semantic Scholar
Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S
J. Lategahn, M. Keul, Philip Klövekorn, H. Tumbrink +25 more
2019Chemical Science30 citations Open access
Semantic Scholar
Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
J. Engel, Steven Smith, J. Lategahn, H. Tumbrink +11 more
2017Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape
T. Mühlenberg, J. Falkenhorst, T. Schulz, B. Fletcher +24 more
2024Journal of Clinical Oncology21 citations
Semantic Scholar
Structure Defines Function - Clinically Relevant Mutations in ErbB Kinases.
J. Niggenaber, Julia Hardick, J. Lategahn, D. Rauh
2019Journal of Medicinal Chemistry19 citations
Semantic Scholar
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
J. Lategahn, H. Tumbrink, Carsten Schultz-Fademrecht, Alena Heimsoeth +23 more
2022Journal of Medicinal Chemistry17 citations
Semantic Scholar
An Unusual Intramolecular Halogen Bond Guides Conformational Selection.
R. Tesch, C. Becker, M. Müller, M. E. Beck +13 more
2018Angewandte Chemie15 citations
Semantic Scholar
Targeting Her2-insYVMA with Covalent Inhibitors - A Focused Compound Screening and Structure-Based Design Approach.
J. Lategahn, Julia Hardick, Tobias Grabe, J. Niggenaber +16 more
2020Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.
P. Wolle, Julia Hardick, Shane J.F. Cronin, J. Engel +4 more
2019Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).
P. Wolle, J. Engel, Steven Smith, Lisa Goebel +3 more
2019Journal of Medicinal Chemistry10 citations
Semantic Scholar
Insights into the Kinetics of the Resistance Formation of Bacteria against Ciprofloxacin Poly(2-methyl-2-oxazoline) Conjugates.
Martin Schmidt, A. Romanovska, Youssef Wolf, Thanh-Duong Nguyen +8 more
2018Bioconjugate chemistry9 citations Open access
Semantic Scholar
RASPELD to Perform High‐End Screening in an Academic Environment toward the Development of Cancer Therapeutics
P. Wolle, J. Weisner, M. Keul, I. Landel +2 more
2018ChemMedChem5 citations
Semantic Scholar
Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors
J. Fassunke, Fabienne Müller, M. Keul, S. Michels +35 more
2018Nature Communications2 citations Open access
Semantic Scholar
Abstract 3887: ATP-binding pocket substitutions as secondary or tertiary in-cis mutations are major on-target ripretinib resistance mechanisms in gastrointestinal stromal tumor
T. Mühlenberg, J. Falkenhorst, T. Schulz, B. Fletcher +22 more
2023Cancer Research0 citations
Semantic Scholar
Abstract 3005: Comprehensive profile of platelet derived growth factor receptor alpha (PDGFRA) mutations in gastrointestinal stromal tumors
Homma M. Khosroyani, Lillian R. Klug, Ajia Town, J. Lategahn +14 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Targeting EGFR Ex20 mutant lung cancer with the wild type sparing kinase inhibitor PRB001.
M. Sos, H. Tumbrink, Carsten Schultz-Fademrecht, J. Lategahn +11 more
2019Journal of Clinical Oncology0 citations
Semantic Scholar
CCDC 1848022: Experimental Crystal Structure Determination
R. Tesch, C. Becker, M. Müller, M. E. Beck +13 more
20180 citations
Semantic Scholar
Metal-Free Direct Oxidative Intermolecular Diarylation of Anilides at Ambient Temperature Assisted by Cascade Selective Formation of C—C and C—N Bonds.
R. Samanta, J. Lategahn, A. Antonchick
20120 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

D. Rauh×25
Invite
D. Rauh — researcher profile on SciRah
M. Keul×13
Invite
M. Keul — researcher profile on SciRah
H. Tumbrink×10
Invite
H. Tumbrink — researcher profile on SciRah
J. Engel×9
Invite
J. Engel — researcher profile on SciRah

Carsten Schultz-Fademrecht

×7

Invite

Carsten Schultz-Fademrecht — researcher profile on SciRah

Invite

S. Bauer — researcher profile on SciRah

T. Mühlenberg×7

Invite

T. Mühlenberg — researcher profile on SciRah

Matthias Baumann×7

Invite

Matthias Baumann — researcher profile on SciRah

J. Niggenaber×7

Invite

J. Niggenaber — researcher profile on SciRah

Invite

M. Müller — researcher profile on SciRah

Invite

C. Becker — researcher profile on SciRah

Alena Heimsoeth×5

Invite

Alena Heimsoeth — researcher profile on SciRah