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A. Grakoui · SciRah

Researcher profile · Semantic Scholar

A. Grakoui

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A. Grakoui — researcher profile on SciRah

h-index: 47
Works: 131
Citations: 16K

Most-cited papers

Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics
T. Marcello, A. Grakoui, G. Barba-Spaeth, Erica S. Machlin +3 more
2006546 citations Open access
Semantic Scholar
Glucagon-like Peptide-1 Receptor (GLP-1R) is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
Nitika Gupta, Jamie Mells, R. Dunham, A. Grakoui +3 more
2010Hepatology511 citations Open access
Semantic Scholar
Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders
Daniel M. Chopyk, A. Grakoui
2020Gastroenterology457 citations Open access
Semantic Scholar
Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication
K. L. Berger, J. D. Cooper, Nicholas S. Heaton, Rosa Yoon +5 more
2009Proceedings of the National Academy of Sciences of the United States of America371 citations Open access
Semantic Scholar
Structure of the Core Ectodomain of the Hepatitis C Virus Envelope Glycoprotein 2
A. Khan, Jillian Whidby, Matthew T. Miller, Hannah Scarborough +8 more
2014Nature279 citations Open access
Semantic Scholar
Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures
Abigail Vanderheiden, Philipp Ralfs, T. Chirkova, Amit A. Upadhyay +17 more
2020Journal of Virology274 citations Open access
Semantic Scholar
Cas9-mediated targeting of viral RNA in eukaryotic cells
Aryn A. Price, T. Sampson, Hannah K. Ratner, A. Grakoui +1 more
2015Proceedings of the National Academy of Sciences of the United States of America224 citations Open access
Semantic Scholar
mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant
V. Edara, K. Manning, Madison Ellis, Lilin Lai +28 more
2021bioRxiv191 citations Open access
Semantic Scholar
Structural and functional insights into alphavirus polyprotein processing and pathogenesis
G. Shin, S. Yost, Matthew T. Miller, Elizabeth J. Elrod +2 more
2012Proceedings of the National Academy of Sciences of the United States of America179 citations Open access
Semantic Scholar
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)
M. Fuller, Benoît Callendret, Baogong Zhu, G. Freeman +8 more
2013Proceedings of the National Academy of Sciences of the United States of America169 citations Open access
Semantic Scholar
Evidence for a functional RNA element in the hepatitis C virus core gene
L. McMullan, A. Grakoui, M. Evans, K. Mihalik +4 more
2007Proceedings of the National Academy of Sciences of the United States of America154 citations Open access
Semantic Scholar
Hepatic Stellate Cells Preferentially Induce FoxP3+ Regulatory T Cells by Production of Retinoic Acid
R. Dunham, M. Thapa, Victoria M. Velazquez, Elizabeth J. Elrod +3 more
2013Journal of Immunology150 citations Open access
Semantic Scholar
Polyphasic innate immune responses to acute and chronic LCMV infection
B. Norris, Luke S. Uebelhoer, H. Nakaya, Aryn A. Price +2 more
2013Immunity140 citations Open access
Semantic Scholar
Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-cell Receptor-positive Cells and Pathogenesis of Cholestatic Liver Disease
Dana Tedesco, M. Thapa, Chui‐Yoke Chin, Yong Ge +12 more
2018Gastroenterology126 citations Open access
Semantic Scholar
Hepatitis C Virus Is Primed by CD81 Protein for Low pH-dependent Fusion*
N. Sharma, G. Mateu, M. Dreux, A. Grakoui +2 more
2011Journal of Biological Chemistry126 citations Open access
Semantic Scholar
Impaired Hepatitis C Virus (HCV)-Specific Effector CD8+ T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection
Henry Radziewicz, C. Ibegbu, Huiming Hon, M. Osborn +7 more
2008Journal of Virology108 citations Open access
Semantic Scholar
Liver Fibrosis Occurs Through Dysregulation of MyD88-dependent Innate B cell Activity
M. Thapa, Raghavan Chinnadurai, Victoria M. Velazquez, Dana Tedesco +9 more
2015Hepatology100 citations Open access
Semantic Scholar
Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses
J. Honegger, Seungtaek Kim, Aryn A. Price, J. Kohout +5 more
2013Nature Medicine92 citations Open access
Semantic Scholar
Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness
Luke S. Uebelhoer, Jin-Hwan Han, Benoît Callendret, G. Mateu +5 more
2008PLoS Pathogens89 citations Open access
Semantic Scholar
STRUCTURAL INSIGHTS INTO HEPATITIS C VIRUS RECEPTOR BINDING AND ENTRY
Ashish Kumar, R. Hossain, S. Yost, Wei Bu +5 more
2021Nature69 citations Open access
Semantic Scholar
Blocking Hepatitis C Virus Infection with Recombinant Form of Envelope Protein 2 Ectodomain
Jillian Whidby, G. Mateu, Hannah Scarborough, B. Demeler +2 more
2009Journal of Virology66 citations Open access
Semantic Scholar
Hepatitis C virus: why do we need a vaccine to prevent a curable persistent infection?
C. Walker, A. Grakoui
2015Current Opinion in Immunology64 citations Open access
Semantic Scholar
Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death.
G. Mateu, R. Donis, T. Wakita, J. Bukh +1 more
2008Virology60 citations Open access
Semantic Scholar
Rare Birds in North America: Acute Hepatitis C Cohorts
A. Cox, K. Page, J. Bruneau, N. Shoukry +9 more
2008Gastroenterology60 citations Open access
Semantic Scholar
CCR2 Signaling Restricts SARS-CoV-2 Infection
Abigail Vanderheiden, Jeronay Thomas, A. Soung, Meredith E. Davis-Gardner +14 more
2021mBio59 citations Open access
Semantic Scholar
Variable Patterns of Programmed Death-1 Expression on Fully Functional Memory T Cells after Spontaneous Resolution of Hepatitis C Virus Infection
D. Bowen, N. Shoukry, A. Grakoui, M. Fuller +9 more
2008Journal of Virology47 citations Open access
Semantic Scholar
PD-1 tempers Tregs in chronic HCV infection.
Henry Radziewicz, R. Dunham, A. Grakoui
2009Journal of Clinical Investigation46 citations Open access
Semantic Scholar
The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice
Patrice N. Mimche, Lauren M. Brady, Christian Bray, Sylvie M. Mimche +8 more
2015Hepatology45 citations Open access
Semantic Scholar
Immune System Control of Hepatitis C Virus Infection
J. Stuart, E. Salinas, A. Grakoui
2020Current Opinion in Virology44 citations Open access
Semantic Scholar
Presentation of hepatocellular antigens
A. Grakoui, I. Crispe
2016Cellular & Molecular Immunology44 citations Open access
Semantic Scholar
B7-H4 mediates inhibition of T cell responses by activated murine hepatic stellate cells
Raghavan Chinnadurai, A. Grakoui
2010Hepatology44 citations Open access
Semantic Scholar
Differential expression of CD26 on virus‐specific CD8+ T cells during active, latent and resolved infection
Chris C. Ibegbu, Yong-Xian Xu, D. Fillos, Henry Radziewicz +2 more
2009Immunology42 citations Open access
Semantic Scholar
EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells
Patrice N Mimche, Choon‐myung Lee, Sylvie M. Mimche, M. Thapa +3 more
2018Scientific Reports41 citations Open access
Semantic Scholar
Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures
Abigail Vanderheiden, Philipp Ralfs, T. Chirkova, Amit A. Upadhyay +11 more
2020bioRxiv40 citations Open access
Semantic Scholar
Dynamics of Tissue-Specific CD8+ T Cell Responses during West Nile Virus Infection
Renan A Aguilar-valenzuela, Jason Netland, Y. Seo, M. Bevan +2 more
2018Journal of Virology37 citations Open access
Semantic Scholar
Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection
Victoria M. Velazquez, Huiming Hon, C. Ibegbu, S. Knechtle +2 more
2012Hepatology36 citations Open access
Semantic Scholar
Mechanotransduction in T Cell Development, Differentiation and Function
M. Rushdi, Kai-Tao Li, Zhou Yuan, S. Travaglino +2 more
2020Cells35 citations Open access
Semantic Scholar
Acetaminophen Intoxication Rapidly Induces Apoptosis of Intestinal Crypt Stem Cells and Enhances Intestinal Permeability
Daniel M. Chopyk, J. Stuart, Matthew G. Zimmerman, Jing Wen +5 more
2019Hepatology Communications31 citations Open access
Semantic Scholar
Future landscape of hepatitis C research - Basic, translational and clinical perspectives.
D. Moradpour, A. Grakoui, M. Manns
2016Journal of Hepatology27 citations Open access
Semantic Scholar
Local cellular and cytokine cues in the spleen regulate in situ T cell receptor affinity as well as function and fate of CD8+ T cells
Y. Seo, P. Jothikumar, M. Suthar, Cheng Zhu +1 more
2016Immunity27 citations Open access
Semantic Scholar
Translocation of gut commensal bacteria to the brain
M. Thapa, Anuradha Kumari, Chui‐Yoke Chin, Jacob E. Choby +9 more
2023bioRxiv26 citations Open access
Semantic Scholar
Novel E2 glycoprotein tetramer detects HCV-specific memory B cells
M. Boisvert, Wanrui Zhang, Elizabeth J. Elrod, N. Bernard +5 more
2016Journal of Immunology26 citations Open access
Semantic Scholar
Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense
Aryn A. Price, A. Grakoui, D. S. Weiss
2016Trends in Microbiology26 citations Open access
Semantic Scholar
Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype
Aryn A. Price, Dana Tedesco, M. Prasad, K. Workowski +4 more
2016Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
Semantic Scholar
Memory CD8+ T cell differentiation in viral infection: a cell for all seasons.
Henry Radziewicz, Luke S. Uebelhoer, B. Bengsch, A. Grakoui
2007World Journal of Gastroenterology25 citations Open access
Semantic Scholar
Early T follicular helper cell activity accelerates hepatitis C virus-specific B cell expansion.
E. Salinas, M. Boisvert, Amit A. Upadhyay, N. Bédard +8 more
2021Journal of Clinical Investigation24 citations Open access
Semantic Scholar
Acute hepatitis C and HIV coinfection.
J. Dionne-Odom, M. Osborn, Henry Radziewicz, A. Grakoui +1 more
2009Lancet. Infectious Diseases (Print)22 citations
Semantic Scholar
Transient CD86 expression on HCV specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling
Henry Radziewicz, C. Ibegbu, Huiming Hon, N. Bédard +7 more
2010Journal of Immunology21 citations Open access
Semantic Scholar
Unraveling the role of PD-1/PD-L interactions in persistent hepatotropic infections: potential for therapeutic application?
Henry Radziewicz, H. L. Hanson, R. Ahmed, A. Grakoui
2008Gastroenterology21 citations
Semantic Scholar
Blockade of B-cell activating factor (BAFF) reshapes the hepatic B cell receptor repertoire and attenuates autoantibody production in cholestatic liver disease
M. Thapa, Dana Tedesco, S. Gumber, Elizabeth J. Elrod +5 more
2020Journal of Immunology19 citations Open access
Semantic Scholar

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