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N. Bédard · SciRah

Researcher profile · Semantic Scholar

N. Bédard

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N. Bédard — researcher profile on SciRah

h-index: 26
Works: 61
Citations: 1,896

Most-cited papers

Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells
Gamal Badr, N. Bédard, Mohamed S. Abdel-Hakeem, L. Trautmann +6 more
2008Journal of Virology152 citations Open access
Semantic Scholar
Galectin-9 and IL-21 Mediate Cross-regulation between Th17 and Treg Cells during Acute Hepatitis C
H. Kared, T. Fabre, N. Bédard, J. Bruneau +1 more
2013PLoS Pathogens147 citations Open access
Semantic Scholar
Increased Degranulation of Natural Killer Cells during Acute HCV Correlates with the Magnitude of Virus-specific T cell Responses
S. Pelletier, C. Drouin, N. Bédard, S. Khakoo +2 more
2010Journal of Hepatology120 citations Open access
Semantic Scholar
USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states.
L. Combaret, Olasunkanmi A. J. Adegoke, N. Bédard, V. Baracos +2 more
2005American Journal of Physiology. Endocrinology and Metabolism107 citations Open access
Semantic Scholar
USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1
Yu Lu, Olasunkanmi A. J. Adegoke, A. Nepveu, K. Nakayama +4 more
2008Molecular and Cellular Biology93 citations Open access
Semantic Scholar
Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme*
T. Durcan, M. Kontogiannea, N. Bédard, Simon S. Wing +1 more
2011Journal of Biological Chemistry84 citations Open access
Semantic Scholar
The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting
Derek T. Hall, Takla Griss, Jennifer F. Ma, B. J. Sánchez +12 more
2018EMBO Molecular Medicine77 citations Open access
Semantic Scholar
Divergent N-Terminal Sequences Target an Inducible Testis Deubiquitinating Enzyme to Distinct Subcellular Structures
Hai-Jiang Lin, A. Keriel, C. Morales, N. Bédard +5 more
2000Molecular and Cellular Biology77 citations Open access
Semantic Scholar
Mice Lacking the USP2 Deubiquitinating Enzyme Have Severe Male Subfertility Associated with Defects in Fertilization and Sperm Motility1
N. Bédard, Yaoming Yang, M. Gregory, D. Cyr +8 more
2011Biology of Reproduction73 citations Open access
Semantic Scholar
Activation of a UBC4-dependent pathway of ubiquitin conjugation during postnatal development of the rat testis.
Venkatesh Rajapurohitam, Carlos R. Morales, Mohamed el-Alfy, S. Lefrancois +2 more
1999Developmental Biology69 citations Open access
Semantic Scholar
Signatures of Protective Memory Immune Responses During HCV Reinfection
Mohamed S. Abdel-Hakeem, N. Bédard, D. Murphy, J. Bruneau +1 more
2014Gastroenterology67 citations Open access
Semantic Scholar
Comparison of Immune Restoration in Early versus Late Alpha Interferon Therapy against Hepatitis C Virus
Mohamed S. Abdel-Hakeem, N. Bédard, Gamal Badr, M. Ostrowski +5 more
2010Journal of Virology63 citations Open access
Semantic Scholar
Insulin-like growth factor I stimulates degradation of an mRNA transcript encoding the 14 kDa ubiquitin-conjugating enzyme.
Simon S. Wing, N. Bédard
1996Biochemical Journal56 citations Open access
Semantic Scholar
IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection
Jean-Christophe Beltra, Sara Bourbonnais, N. Bédard, T. Charpentier +7 more
2016Proceedings of the National Academy of Sciences of the United States of America52 citations Open access
Semantic Scholar
Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2
Yaoming Yang, D. Duguay, N. Bédard, A. Rachalski +7 more
2012Biology Open48 citations Open access
Semantic Scholar
Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle.
D. Gonçalves, E. Lira, A. M. Baviera, Peirang Cao +8 more
2009Endocrinology48 citations Open access
Semantic Scholar
Control of ubiquitination of proteins in rat tissues by ubiquitin conjugating enzymes and isopeptidases.
V. Rajapurohitam, N. Bédard, Simon S. Wing
2002American Journal of Physiology. Endocrinology and Metabolism48 citations
Semantic Scholar
Inactivation of the ubiquitin‐specific protease 19 deubiquitinating enzyme protects against muscle wasting
N. Bédard, Samer Jammoul, T. Moore, L. Wykes +8 more
2015The FASEB Journal47 citations
Semantic Scholar
Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection in patients with spontaneous viral clearance
Brad R. Rosenberg, M. Depla, C. Freije, D. Gaucher +6 more
2018PLoS Pathogens38 citations Open access
Semantic Scholar
The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice
Erin S Coyne, N. Bédard, Ying-Jia Gong, May Faraj +2 more
2018Diabetologia34 citations Open access
Semantic Scholar
A Novel Rat Homolog of the Saccharomyces cerevisiae Ubiquitin-Conjugating Enzymes UBC4 and UBC5 with Distinct Biochemical Features Is Induced during Spermatogenesis
Simon S. Wing, N. Bédard, C. R. Morales, P. Hingamp +1 more
2005Molecular and Cellular Biology33 citations Open access
Semantic Scholar
Ubiquitin-conjugating enzyme E214k/HR6B is dispensable for increased protein catabolism in muscle of fasted mice.
Olasunkanmi A. J. Adegoke, N. Bédard, H. Roest, Simon S. Wing
2002American Journal of Physiology. Endocrinology and Metabolism33 citations
Semantic Scholar
Identification of Distinctive Patterns of USP19-Mediated Growth Regulation in Normal and Malignant Cells
Yu Lu, N. Bédard, S. Chevalier, Simon S. Wing
2011PLoS ONE31 citations Open access
Semantic Scholar
Role of galK and galM in Galactose Metabolism by Streptococcus thermophilus
Katy Vaillancourt, N. Bédard, Christian Bart, M. Tessier +5 more
2007Applied and Environmental Microbiology31 citations Open access
Semantic Scholar
Mice Lacking the UBC4-testis Gene Have a Delay in Postnatal Testis Development but Normal Spermatogenesis and Fertility
N. Bédard, P. Hingamp, Zhi-Yu Pang, A. Karaplis +5 more
2005Molecular and Cellular Biology28 citations Open access
Semantic Scholar
Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis
Mohamed N. Abdelnabi, M. F. Molina, Geneviève Soucy, Vincent Quoc-Huy Trinh +8 more
2022Cellular and Molecular Gastroenterology and Hepatology26 citations Open access
Semantic Scholar
Distinct spatial distribution and roles of Kupffer cells and monocyte-derived macrophages in mouse acute liver injury
Manuel Flores Molina, Mohamed N. Abdelnabi, Sabrina Mazouz, Deborah Villafranca-Baughman +7 more
2022Frontiers in Immunology25 citations Open access
Semantic Scholar
Early T follicular helper cell activity accelerates hepatitis C virus-specific B cell expansion.
E. Salinas, M. Boisvert, Amit A. Upadhyay, N. Bédard +8 more
2021Journal of Clinical Investigation24 citations Open access
Semantic Scholar
Characterization of rat100, a 300-kilodalton ubiquitin-protein ligase induced in germ cells of the rat testis and similar to the Drosophila hyperplastic discs gene.
R. Oughtred, N. Bédard, Olasunkanmi A. J. Adegoke, C. Morales +3 more
2002Endocrinology23 citations
Semantic Scholar
Transient CD86 expression on HCV specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling
Henry Radziewicz, C. Ibegbu, Huiming Hon, N. Bédard +7 more
2010Journal of Immunology21 citations Open access
Semantic Scholar
Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling
Erin S Coyne, N. Bédard, L. Wykes, Cynthia Stretch +8 more
2018Endocrinology20 citations
Semantic Scholar
Identification of Amino Acid Residues in a Class I Ubiquitin-conjugating Enzyme Involved in Determining Specificity of Conjugation of Ubiquitin to Proteins*
R. Oughtred, N. Bédard, A. Vrielink, Simon S. Wing
1998Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Sustained Hyperresponsiveness of Dendritic Cells Is Associated with Spontaneous Resolution of Acute Hepatitis C
S. Pelletier, N. Bédard, Elias A. Said, P. Ancuța +2 more
2013Journal of Virology17 citations Open access
Semantic Scholar
USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice
L. Schorova, N. Bédard, A. Khayachi, Hung-Hsiang Ho +16 more
2023npj Parkinson's Disease16 citations Open access
Semantic Scholar
Mice Lacking the USP 2 Deubiquitinating Enzyme Have Severe Male Subfertility Associated with Defects in Fertilization and Sperm Motility 1
N. Bédard, Yaoming Yang, M. Gregory, D. Cyr +8 more
20118 citations
Semantic Scholar
A novel rat homolog of the Saccharomyces cerevisiae ubiquitin-conjugating enzymes UBC4 and UBC5 with distinct biochemical features is induced during spermatogenesis
Simon S. Wing, N. Bédard, C. Morales, P. Hingamp +1 more
1996Molecular and Cellular Biology8 citations
Semantic Scholar
Differential immune transcriptomic profiles between vaccinated and resolved HCV reinfected subjects
Sabrina Mazouz, E. Salinas, N. Bédard, Ali El Filali +8 more
2022PLoS Pathogens7 citations Open access
Semantic Scholar
Evidence for a human leucocyte antigen‐DM‐induced structural change in human leucocyte antigen‐DOβ
F. Deshaies, Djibril A. Diallo, Jean-Simon Fortin, Helen M. O'Rourke +7 more
2009Immunology6 citations Open access
Semantic Scholar
A proinflammatory tumor that activates protein degradation sensitizes rats to catabolic effects of endotoxin.
M. Mackenzie, N. Bédard, Simon S. Wing, V. Baracos
2005American Journal of Physiology. Endocrinology and Metabolism6 citations
Semantic Scholar
IFN‐λ3 polymorphism indirectly influences NK cell phenotype and function during acute HCV infection
M. Depla, S. Pelletier, N. Bédard, C. Brunaud +2 more
2016Immunity, Inflammation and Disease5 citations Open access
Semantic Scholar
Signatures of Protective Memory Immune Responses During HCV Reinfection
Mohamed S. Abdel-Hakeem, N. Bédard, Donald Murphy, J. Bruneau +1 more
20143 citations
Semantic Scholar
USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1
Yu Lu, Olasunkanmi A. J. Adegoke, A. Nepveu, K. Nakayama +4 more
2009Molecular and Cellular Biology3 citations Open access
Semantic Scholar
Divergent N-Terminal Sequences Target an Inducible Testis Deubiquitinating Enzyme to Distinct Subcellular Structures
Hai-Jiang Lin, A. Keriel, C. Morales, N. Bédard +5 more
2001Molecular and Cellular Biology3 citations Open access
Semantic Scholar
Abstract LB-087: Discovery and development of first-in-class orally bioavailable USP19 inhibitors
X. Jacq, G. Gavory, C. O'Dowd, A. Cranston +20 more
2019Molecular and Cellular Biology / Genetics2 citations
Semantic Scholar
P1254 : Hepatitis C spontaneous clearance may induce partial protection against reinfection among persons who inject drugs: Results from a cohort study
J. Bruneau, G. Zang, D. Jutras-Aswad, N. Bédard +4 more
20151 citations
Semantic Scholar
Effect of inactivation of the USP19 deubiquitinase gene in mice on important phenotypes of aging
K. Sheng, Erin S Coyne, N. Bédard, Emilie Lu +3 more
2026The journals of gerontology. Series A, Biological sciences and medical sciences0 citations Open access
Semantic Scholar
Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice
L. Schorova, N. Bédard, A. Khayachi, Joao Bolivar-Pedroso +11 more
2022bioRxiv0 citations Open access
Semantic Scholar
Sex-dependent hepatoprotective role of IL-22 in NAFLD-related fibrosis
Mohamed Noureldin Hassan Ali Abdelanbi, M. F. Molina, Geneviève Soucy, Vincent Quoc-Huy Trinh +6 more
2022Journal of Hepatology0 citations
Semantic Scholar
IL-2 and IL-15 on CD8 T cells during chronic viral infection: The exhaustion program awakens
Jean-Christophe Beltra, Sara Bourbonnais, N. Bédard, T. Charpentier +7 more
2016Journal of Immunology0 citations
Semantic Scholar
Spontaneous Resolution of Hepatitis C Virus Reinfection Is Associated With an Increase in the Magnitude and Breadth of the Hepatitis C Virus
Mohamed S. Abdel-Hakeem, N. Bédard, D. Murphy, J. Bruneau +1 more
20140 citations
Semantic Scholar

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