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C. Doty · SciRah

Researcher profile · Semantic Scholar

C. Doty

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C. Doty — researcher profile on SciRah

h-index: 20
Works: 25
Citations: 2,847

Most-cited papers

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
R. Graham, Yu Deng, E. Slow, Brendan Haigh +14 more
2006Cell720 citations Open access
Semantic Scholar
Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.
J. Carroll, S. Warby, Amber L. Southwell, C. Doty +6 more
2011Molecular Therapy290 citations Open access
Semantic Scholar
HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia
S. Warby, H. Visscher, J. Collins, C. Doty +6 more
2011European Journal of Human Genetics166 citations Open access
Semantic Scholar
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Michael E. Østergaard, Amber L. Southwell, Holly B. Kordasiewicz, A. Watt +8 more
2013Nucleic Acids Research155 citations Open access
Semantic Scholar
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
S. Warby, C. Doty, R. Graham, J. Carroll +4 more
2008Human Molecular Genetics148 citations
Semantic Scholar
In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.
Amber L. Southwell, N. Skotte, Holly B. Kordasiewicz, Michael E. Østergaard +12 more
2014Molecular Therapy137 citations Open access
Semantic Scholar
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
R. Singaraja, Kun Huang, S. Sanders, A. Milnerwood +14 more
2011Human Molecular Genetics122 citations Open access
Semantic Scholar
A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease
K. Bečanović, A. Nørremølle, S. J. Neal, C. Kay +18 more
2015Nature Neuroscience116 citations
Semantic Scholar
HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
Virginia B. Mattis, Colton M. Tom, S. Akimov, Jasmine Saeedian +12 more
2015Human Molecular Genetics113 citations Open access
Semantic Scholar
Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients
N. Skotte, Amber L. Southwell, Michael E. Østergaard, J. Carroll +12 more
2014PLoS ONE113 citations Open access
Semantic Scholar
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
Amber L. Southwell, Holly B. Kordasiewicz, D. Langbehn, N. H. Skotte +15 more
2018Science Translational Medicine112 citations Open access
Semantic Scholar
A fully humanized transgenic mouse model of Huntington disease.
Amber L. Southwell, S. Warby, Jeffrey B. Carroll, C. Doty +10 more
2013Human Molecular Genetics109 citations Open access
Semantic Scholar
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.
S. Warby, C. Doty, R. Graham, Jonathan D. Shively +2 more
2009Molecular and cellular neurosciences109 citations
Semantic Scholar
CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease
A. Semaka, C. Kay, C. Doty, J. Collins +4 more
2013Journal of Medical Genetics81 citations
Semantic Scholar
Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry.
C. Kay, J. Collins, N. Skotte, Amber L. Southwell +8 more
2015Molecular Therapy76 citations Open access
Semantic Scholar
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
L. Sutton, S. Sanders, S. Butland, R. Singaraja +9 more
2013Human Molecular Genetics73 citations Open access
Semantic Scholar
Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes
F. Baine, C. Kay, M. Ketelaar, J. Collins +5 more
2013European Journal of Human Genetics59 citations Open access
Semantic Scholar
High frequency of intermediate alleles on huntington disease‐associated haplotypes in British Columbia's general population
A. Semaka, C. Kay, C. Doty, J. Collins +2 more
2013American Journal of Medical Genetics Part B: Neuropsychiatric Genetics46 citations
Semantic Scholar
Bidirectional Control of Postsynaptic Density-95 (PSD-95) Clustering by Huntingtin*
Matthew P. Parsons, Rujun Kang, Caodu Buren, A. Dau +5 more
2013Journal of Biological Chemistry43 citations Open access
Semantic Scholar
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Amber L. Southwell, N. Skotte, Erika B. Villanueva, Michael E. Østergaard +18 more
2017Human Molecular Genetics37 citations Open access
Semantic Scholar
SCN9A: another sodium channel excited to play a role in human epilepsies
C. Doty
2010Clinical Genetics13 citations
Semantic Scholar
Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting
N. Caron, Christine Anderson, Hailey Findlay Black, S. Sanders +3 more
2021Journal of Huntington's Disease9 citations
Semantic Scholar
Finding bald spots on chromosome 20p11
C. Doty
2009Clinical Genetics1 citations
Semantic Scholar
Three‐allele risk haplotype of ENPP1 links obesity to type 2 diabetes risk
C. Doty
20051 citations
Semantic Scholar
696. Pre-Clinical Evaluation of Allele-Specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides
Amber L. Southwell, N. Skotte, N. Caron, Holly B. Kordasiewicz +10 more
20150 citations Open access
Semantic Scholar

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