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Kyohei Higashi · SciRah

Researcher profile · Semantic Scholar

Kyohei Higashi

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Kyohei Higashi — researcher profile on SciRah

h-index: 26
Works: 95
Citations: 2,143

Most-cited papers

Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.
F. Hamdan, J. Gauthier, Yoichi Araki, Daoyong Lin +29 more
2011American Journal of Human Genetics359 citations Open access
Semantic Scholar
Acrolein toxicity: Comparison with reactive oxygen species.
Madoka Yoshida, H. Tomitori, Yoshiki Machi, M. Hagihara +6 more
2009Biochemical and Biophysical Research Communications - BBRC115 citations
Semantic Scholar
Identification of a Spermidine Excretion Protein Complex (MdtJI) in Escherichia coli
Kyohei Higashi, Hiroyuki Ishigure, Risa Demizu, Takeshi Uemura +4 more
2007Journal of Bacteriology107 citations Open access
Semantic Scholar
Characterization of a Tobacco TPK-type K+ Channel as a Novel Tonoplast K+ Channel Using Yeast Tonoplasts*
S. Hamamoto, J. Marui, K. Matsuoka, Kyohei Higashi +9 more
2008Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Correlation between images of silent brain infarction, carotid atherosclerosis and white matter hyperintensity, and plasma levels of acrolein, IL-6 and CRP.
Madoka Yoshida, Kyohei Higashi, E. Kobayashi, N. Saeki +16 more
2010Atherosclerosis61 citations
Semantic Scholar
Enhancement of +1 Frameshift by Polyamines during Translation of Polypeptide Release Factor 2 in Escherichia coli*
Kyohei Higashi, K. Kashiwagi, S. Taniguchi, Yusuke Terui +3 more
2006Journal of Biological Chemistry54 citations Open access
Semantic Scholar
A Novel Putrescine Exporter SapBCDF of Escherichia coli.
Yuta Sugiyama, A. Nakamura, M. Matsumoto, A. Kanbe +6 more
2016Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-d-aspartate receptor
Xia Han, H. Tomitori, Satomi Mizuno, Kyohei Higashi +9 more
2008Journal of Neurochemistry49 citations Open access
Semantic Scholar
Composition of Glycosaminoglycans in Elasmobranchs including Several Deep-Sea Sharks: Identification of Chondroitin/Dermatan Sulfate from the Dried Fins of Isurus oxyrinchus and Prionace glauca
Kyohei Higashi, Yoshiki Takeuchi, Ann Mukuno, H. Tomitori +3 more
2015PLoS ONE48 citations Open access
Semantic Scholar
Enhancement of the Synthesis of RpoN, Cra, and H-NS by Polyamines at the Level of Translation in Escherichia coli Cultured with Glucose and Glutamate
Yusuke Terui, Kyohei Higashi, S. Taniguchi, Ai Shigemasa +5 more
2007Journal of Bacteriology45 citations Open access
Semantic Scholar
Selective Structural Change by Spermidine in the Bulged-out Region of Double-stranded RNA and Its Effect on RNA Function*
Kyohei Higashi, Yusuke Terui, Akiko Suganami, Yutaka Tamura +3 more
2008Journal of Biological Chemistry44 citations Open access
Semantic Scholar
Sequencing the Dermatan Sulfate Chain of Decorin
Yan-Lei Yu, Jiana Duan, Franklin E. Leach, T. Toida +5 more
2017Journal of the American Chemical Society43 citations Open access
Semantic Scholar
Role of polyamines at the G1/S boundary and G2/M phase of the cell cycle.
Tomoko Yamashita, K. Nishimura, Ryotaro Saiki, H. Okudaira +7 more
2013International Journal of Biochemistry and Cell Biology42 citations
Semantic Scholar
Polyphenol Extract from Phellinus igniarius Protects against Acrolein Toxicity In Vitro and Provides Protection in a Mouse Stroke Model
Papawee Suabjakyong, Ryotaro Saiki, L. V. van Griensven, Kyohei Higashi +3 more
2015PLoS ONE41 citations Open access
Semantic Scholar
Functional chondroitin sulfate from Enteroctopus dofleini containing a 3-O-sulfo glucuronic acid residue.
Kyohei Higashi, Y. Okamoto, Ann Mukuno, J. Wakai +3 more
2015Carbohydrate Polymers40 citations
Semantic Scholar
Photochemical Preparation of a Novel Low Molecular Weight Heparin
Kyohei Higashi, S. Hosoyama, Asami Ohno, Sayaka Masuko +5 more
2012Carbohydrate Polymers40 citations Open access
Semantic Scholar
Identification of acrolein-conjugated protein in plasma of patients with brain infarction.
Madoka Yoshida, Kyohei Higashi, Li-Hua Jin, Yoshiki Machi +10 more
2010Biochemical and Biophysical Research Communications - BBRC39 citations
Semantic Scholar
Identification of proteins whose synthesis is preferentially enhanced by polyamines at the level of translation in mammalian cells.
K. Nishimura, H. Okudaira, E. Ochiai, Kyohei Higashi +6 more
2009International Journal of Biochemistry and Cell Biology38 citations
Semantic Scholar
Polyamine modulon in yeast-Stimulation of COX4 synthesis by spermidine at the level of translation.
Takeshi Uemura, Kyohei Higashi, Miki Takigawa, T. Toida +2 more
2009International Journal of Biochemistry and Cell Biology33 citations
Semantic Scholar
Inverse correlation between stroke and urinary 3-hydroxypropyl mercapturic acid, an acrolein-glutathione metabolite.
Madoka Yoshida, T. Mikami, Kyohei Higashi, Ryotaro Saiki +9 more
2012Clinica chimica acta; international journal of clinical chemistry32 citations
Semantic Scholar
Intense correlation between protein-conjugated acrolein and primary Sjögren's syndrome.
Kyohei Higashi, Madoka Yoshida, Atsuko Igarashi, Kayoko Ito +10 more
2010Clinica chimica acta; international journal of clinical chemistry31 citations
Semantic Scholar
Controlled Photochemical Depolymerization of K5 Heparosan, a Bioengineered Heparin Precursor
Kyohei Higashi, Mellisa Ly, Zhenyu Wang, Sayaka Masuko +6 more
2011Carbohydrate Polymers30 citations Open access
Semantic Scholar
Ribosome Modulation Factor, an Important Protein for Cell Viability Encoded by the Polyamine Modulon*
Yusuke Terui, Yuzuru Tabei, M. Akiyama, Kyohei Higashi +5 more
2010Journal of Biological Chemistry30 citations Open access
Semantic Scholar
Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor‐2 signaling impairment in the aged neurogenic niche
Taihei Yamada, Aurelien Kerever, Yusuke Yoshimura, Yuji Suzuki +5 more
2017Journal of Neurochemistry29 citations
Semantic Scholar
Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance in Escherichia coli
Yusuke Terui, S. Saroj, A. Sakamoto, Taketo Yoshida +6 more
2013Amino Acids29 citations
Semantic Scholar
Singular value decomposition analysis of the secondary structure features contributing to the circular dichroism spectra of model proteins
Tomoki Shiratori, S. Goto, Tomoyo Sakaguchi, Takahiro Kasai +5 more
2021Biochemistry and Biophysics Reports28 citations Open access
Semantic Scholar
Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2
Masataka Imamura, Kyohei Higashi, K. Yamaguchi, Kiryu Asakura +12 more
2016Scientific Reports25 citations Open access
Semantic Scholar
Distinguishing mild cognitive impairment from Alzheimer's disease with acrolein metabolites and creatinine in urine.
Madoka Yoshida, Kyohei Higashi, Kyoshiro Kuni, Mutsumi Mizoi +7 more
2015Clinica chimica acta; international journal of clinical chemistry25 citations
Semantic Scholar
Structural and functional relationship among diamines in terms of inhibition of cell growth.
Kyohei Higashi, K. Yoshida, K. Nishimura, Emi Momiyama +4 more
2004Journal of Biochemistry (Tokyo)25 citations
Semantic Scholar
Sequence Analysis and Domain Motifs in the Porcine Skin Decorin Glycosaminoglycan Chain*
Xue Zhao, Bo Yang, Kemal Solakylidirim, E. Joo +4 more
2013Journal of Biological Chemistry24 citations Open access
Semantic Scholar
Reduction of Spermidine Content Resulting from Inactivation of Two Arginine Decarboxylases Increases Biofilm Formation in Synechocystis sp. Strain PCC 6803
Kota Kera, Tatsuya Nagayama, Kei Nanatani, Chika Saeki-Yamoto +9 more
2018Journal of Bacteriology23 citations Open access
Semantic Scholar
Identification of Functional Amino Acid Residues Involved in Polyamine and Agmatine Transport by Human Organic Cation Transporter 2
Kyohei Higashi, Masataka Imamura, S. Fudo, Takeshi Uemura +5 more
2014PLoS ONE23 citations Open access
Semantic Scholar
Enhancement of the Synthesis of RpoE and StpA by Polyamines at the Level of Translation in Escherichia coli under Heat Shock Conditions
Yusuke Terui, Kyohei Higashi, Yuzuru Tabei, H. Tomitori +4 more
2009Journal of Bacteriology22 citations Open access
Semantic Scholar
Ischemic stroke disrupts the endothelial glycocalyx through activation of proHPSE via acrolein exposure
Kenta Ko, Takehiro Suzuki, R. Ishikawa, N. Hattori +8 more
2020Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Protective Effects of Brain Infarction by N-Acetylcysteine Derivatives
Takeshi Uemura, Kenta Watanabe, Kenta Ko, Kyohei Higashi +10 more
2018Stroke21 citations Open access
Semantic Scholar
Association Between Components of Exudates and Periwound Moisture-Associated Dermatitis in Breast Cancer Patients With Malignant Fungating Wounds
Nao Tamai, Tomoko Akase, T. Minematsu, Kyohei Higashi +3 more
2016Biological Research for Nursing20 citations
Semantic Scholar
Comprehensive analysis of chondroitin sulfate and aggrecan in the head cartilage of bony fishes: Identification of proteoglycans in the head cartilage of sturgeon.
Kento Shionoya, Takehiro Suzuki, Mako Takada, Kazuki Sato +7 more
2022International Journal of Biological Macromolecules19 citations
Semantic Scholar
Effect of Molecular Sizes of Chondroitin Sulfate on Interaction with L-Selectin
N. Igarashi, Atsuko Takeguchi, Shinobu Sakai, H. Akiyama +2 more
201319 citations Open access
Semantic Scholar
Catalytic digestion of human tumor necrosis factor‐α by antibody heavy chain
E. Hifumi, Kyohei Higashi, T. Uda
2010The FEBS Journal19 citations
Semantic Scholar
Comprehensive analysis of glycosaminoglycans from the edible shellfish.
Y. Okamoto, Kyohei Higashi, R. Linhardt, T. Toida
2018Carbohydrate Polymers18 citations
Semantic Scholar
Selective structural change of bulged-out region of double-stranded RNA containing bulged nucleotides by spermidine.
Kyohei Higashi, Yusuke Terui, E. Inomata, D. Katagiri +6 more
2008Biochemical and Biophysical Research Communications - BBRC18 citations
Semantic Scholar
Spermidine and Ca(2+), but not Na(+), can permeate NMDA receptors consisting of GluN1 and GluN2A or GluN2B in the presence of Mg(2+).
Tadao Hirose, Ryotaro Saiki, Y. Yoshizawa, Masataka Imamura +6 more
2015Biochemical and Biophysical Research Communications - BBRC16 citations
Semantic Scholar
GLI1 Inhibitors Identified by Target Protein Oriented Natural Products Isolation (TPO-NAPI) with Hedgehog Inhibition.
M. Arai, Fumie Ochi, Yoshinori Makita, T. Chiba +8 more
2018ACS Chemical Biology15 citations Open access
Semantic Scholar
Identification of keratan sulfate disaccharide at C-3 position of glucuronate of chondroitin sulfate from Mactra chinensis
Kyohei Higashi, K. Takeda, Ann Mukuno, Y. Okamoto +3 more
2016Biochemical Journal15 citations Open access
Semantic Scholar
Polyamine stimulation of eEF1A synthesis based on the unusual position of a complementary sequence to 18S rRNA in eEF1A mRNA
Yusuke Terui, A. Sakamoto, Taketo Yoshida, Takuma Kasahara +4 more
2014Amino Acids15 citations
Semantic Scholar
Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein.
Kyohei Higashi, K. Igarashi, T. Toida
2016Biological and Pharmaceutical Bulletin14 citations Open access
Semantic Scholar
Acetaldehyde-induced cytotoxicity involves induction of spermine oxidase at the transcriptional level.
Takeshi Uemura, Yuka Tanaka, Kyohei Higashi, Daisuke Miyamori +6 more
2013Toxicology14 citations
Semantic Scholar
Ozonolysis of the double bond of the unsaturated uronate residue in low-molecular-weight heparin and K5 heparosan
Sayaka Masuko, Kyohei Higashi, Zhenyu Wang, U. Bhaskar +5 more
2011Carbohydrate Research14 citations Open access
Semantic Scholar
Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes
Masaki Kobayashi, H. Yasukawa, Tomoya Arikawa, Yusuke Deguchi +8 more
2020FEBS Open Bio13 citations Open access
Semantic Scholar
Poly-ion Complex of Chondroitin Sulfate and Spermine and Its Effect on Oral Chondroitin Sulfate Bioavailability.
Dan Ge, Kyohei Higashi, D. Ito, K. Nagano +6 more
2016Chemical and pharmaceutical bulletin12 citations Open access
Semantic Scholar

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K. Igarashi×33
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K. Igarashi — researcher profile on SciRah
T. Toida×31
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T. Toida — researcher profile on SciRah
K. Kashiwagi×24
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K. Kashiwagi — researcher profile on SciRah
Yusuke Terui×13
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Yusuke Terui — researcher profile on SciRah

×12

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R. Linhardt — researcher profile on SciRah

K. Nishimura×11

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K. Nishimura — researcher profile on SciRah

H. Tomitori×10

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H. Tomitori — researcher profile on SciRah

Madoka Yoshida×6

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Madoka Yoshida — researcher profile on SciRah

Ryotaro Saiki×6

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Ryotaro Saiki — researcher profile on SciRah

Takeshi Uemura×5

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Takeshi Uemura — researcher profile on SciRah

Kaneyoshi Yamamoto×4

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Kaneyoshi Yamamoto — researcher profile on SciRah

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A. Ishihama — researcher profile on SciRah