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S. Geschwindner · SciRah

Researcher profile · Semantic Scholar

S. Geschwindner

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S. Geschwindner — researcher profile on SciRah

h-index: 27
Works: 67
Citations: 2,274

Most-cited papers

Structural insight into allosteric modulation of protease-activated receptor 2
R. Cheng, C. Fiez-Vandal, O. Schlenker, K. Edman +24 more
2017Nature216 citations
Semantic Scholar
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
P. D. Edwards, J. Albert, M. Sylvester, D. Aharony +18 more
2007Journal of Medicinal Chemistry208 citations Open access
Semantic Scholar
Single-molecule biosensors: Recent advances and applications.
N. Akkilic, S. Geschwindner, F. Höök
2020Biosensors & bioelectronics141 citations
Semantic Scholar
Discovery of a novel warhead against beta-secretase through fragment-based lead generation.
S. Geschwindner, L. Olsson, J. Albert, J. Deinum +3 more
2007Journal of Medicinal Chemistry139 citations Open access
Semantic Scholar
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.
J. Albert, N. Blomberg, A. Breeze, Alastair J. H. Brown +10 more
2007Current Topics in Medicinal Chemistry119 citations
Semantic Scholar
Ligand Binding Thermodynamics in Drug Discovery: Still a Hot Tip?
S. Geschwindner, J. Ulander, P. Johansson
2015Journal of Medicinal Chemistry110 citations
Semantic Scholar
Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily
T. Sjögren, J. Nord, M. Ek, P. Johansson +2 more
2013Proceedings of the National Academy of Sciences of the United States of America100 citations Open access
Semantic Scholar
Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
K. Edman, A. Hosseini, Magnus K. Bjursell, A. Aagaard +16 more
2015Structure93 citations Open access
Semantic Scholar
Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.
Rachel H. Church, Arjun Krishnakumar, Annika Urbanek, S. Geschwindner +9 more
2015Biochemical Journal90 citations Open access
Semantic Scholar
Preserved transmembrane protein mobility in polymer-supported lipid bilayers derived from cell membranes.
Hudson P. Pace, Lisa Simonsson Nyström, A. Gunnarsson, E. Eck +4 more
2015Analytical Chemistry86 citations
Semantic Scholar
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion
K. Bamberg, U. Johansson, K. Edman, L. William-Olsson +10 more
2018PLoS ONE72 citations Open access
Semantic Scholar
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
L. Ripa, K. Edman, M. Dearman, G. Edenro +20 more
2018Journal of Medicinal Chemistry72 citations Open access
Semantic Scholar
Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: matching high information content with high throughput.
G. Holdgate, M. Anderson, F. Edfeldt, S. Geschwindner
2010Journal of Structural Biology61 citations
Semantic Scholar
Molecular architecture of potassium chloride co-transporter KCC2
Morgane Agez, P. Schultz, I. Medina, D. J. Baker +15 more
2017Scientific Reports58 citations Open access
Semantic Scholar
Application of Optical Biosensors in Small-Molecule Screening Activities
S. Geschwindner, Johan F. Carlsson, W. Knecht
2012Italian National Conference on Sensors54 citations Open access
Semantic Scholar
Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem.
R. Folmer, S. Geschwindner, Ya-Feng Xue
2002Biochemistry42 citations
Semantic Scholar
A protein tertiary structure mimetic modulator of the Hippo signalling pathway
H. Adihou, R. Gopalakrishnan, Tim Förster, Stéphanie M. Guéret +18 more
2020Nature Communications41 citations Open access
Semantic Scholar
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors.
J. Malmström, J. Viklund, Can Slivo, Ana R. Costa +8 more
2012Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
Biophysical methods in drug discovery from small molecule to pharmaceutical.
G. Holdgate, S. Geschwindner, A. Breeze, Gareth Davies +3 more
2013Methods in molecular biology40 citations
Semantic Scholar
Mining Natural Products for Macrocycles to Drug Difficult Targets
F. Begnini, Vasanthanathan Poongavanam, Björn Over, Marie Castaldo +8 more
2020Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition
Amanda J. Kennedy, L. Sundström, S. Geschwindner, Eunice K. Poon +14 more
2020Communications Biology37 citations Open access
Semantic Scholar
Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target
Dean G. Brown, Giles A. Brown, Paolo A. Centrella, Kaan Certel +20 more
2018SLAS discovery : advancing life sciences R & D37 citations Open access
Semantic Scholar
Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors.
J. Winquist, S. Geschwindner, Ya-Feng Xue, Lars Gustavsson +3 more
2013Biochemistry34 citations
Semantic Scholar
Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 That Accelerates the Transition into the Latent Conformation*
O. Fjellström, J. Deinum, T. Sjögren, C. Johansson +8 more
2012Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Harnessing the Versatility of Optical Biosensors for Target-Based Small-Molecule Drug Discovery.
Tim Kaminski, A. Gunnarsson, S. Geschwindner
2017ACS Sensors29 citations
Semantic Scholar
X-Ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors
Michael R. Witten, L. Wissler, M. Snow, S. Geschwindner +6 more
2017Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Role of calcium ions in the structure and function of the di-isopropylfluorophosphatase from Loligo vulgaris.
J. Hartleib, S. Geschwindner, E. I. Scharff, H. Rüterjans
2001Biochemical Journal27 citations Open access
Semantic Scholar
Drug discovery at the single molecule level: inhibition-in-solution assay of membrane-reconstituted β-secretase using single-molecule imaging.
A. Gunnarsson, A. Snijder, Jennifer Hicks, J. Gunnarsson +2 more
2015Analytical Chemistry23 citations
Semantic Scholar
Direct cell extraction of membrane proteins for structure–function analysis
I. Drulyte, A. R. Gutgsell, Pilar Lloris-Garcerá, M. Liss +4 more
2022bioRxiv22 citations Open access
Semantic Scholar
The current impact of water thermodynamics for small-molecule drug discovery
S. Geschwindner, J. Ulander
2019Expert Opinion on Drug Discovery21 citations Open access
Semantic Scholar
Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents
O. Fjellström, Niklas Larsson, Shin-ichiro Yasuda, Takuma Tsuchida +16 more
2015PLoS ONE21 citations Open access
Semantic Scholar
Development of a plate-based optical biosensor fragment screening methodology to identify phosphodiesterase 10A inhibitors.
S. Geschwindner, N. Dekker, R. Horsefield, Anna Tigerström +3 more
2013Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR
A. Gunnarsson, C. Stubbs, P. Rawlins, Eleanor Taylor-Newman +6 more
2020SLAS discovery : advancing life sciences R & D18 citations Open access
Semantic Scholar
Hot-Spotting with Thermal Scanning: A Ligand- and Structure-Independent Assessment of Target Ligandability.
M. Chilton, B. Clennell, F. Edfeldt, S. Geschwindner
2017Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Biosensor-Enabled Deconvolution of the Avidity-Induced Affinity Enhancement for the SARS-CoV-2 Spike Protein and ACE2 Interaction
A. R. Gutgsell, A. Gunnarsson, P. Forssén, E. Gordon +2 more
2021Analytical Chemistry12 citations
Semantic Scholar
Avidity-based affinity enhancement using nanoliposome-amplified SPR sensing enables low picomolar detection of biologically active Neuregulin 1.
N. Akkilic, M. Liljeblad, S. Blaho, Mikko Hölttä +2 more
2019ACS Sensors11 citations Open access
Semantic Scholar
Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations
Jared M. Sampson, Daniel A. Cannon, Jianxin Duan, Jordan Epstein +19 more
2024bioRxiv9 citations Open access
Semantic Scholar
Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9.
S. Geschwindner, Gunilla M K Andersson, H. Beisel, S. Breuer +7 more
2015Protein engineering, design & selection : PEDS9 citations
Semantic Scholar
Equilibrium-fluctuation analysis for interaction studies between natural ligands and single G protein-coupled receptors in native lipid vesicles.
Olov Wahlsten, A. Gunnarsson, Lisa Simonsson Nyström, Hudson P. Pace +2 more
2015Langmuir9 citations
Semantic Scholar
Fragments as Novel Starting Points for tRNA‐Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies
E. Hassaan, P. Eriksson, S. Geschwindner, A. Heine +1 more
2019ChemMedChem8 citations Open access
Semantic Scholar
Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors.
Jeffrey Varnes, S. Geschwindner, C. Holmquist, J. Forst +6 more
2016Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
An enhanced biophysical screening strategy to investigate the affinity of ASOs for their target RNA
Rouven Stulz, Michael Lerche, Olivia Luige, Agnes R. Taylor +2 more
2023RSC Chemical Biology5 citations Open access
Semantic Scholar
Solution structure of the recombinant oxidized rabbit uteroglobin using homonuclear and heteronuclear multidimensional NMR.
Rolf Winkelmann, S. Geschwindner, Matthias F. Haun, H. Rüterjans
1998European Journal of Biochemistry5 citations Open access
Semantic Scholar
Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction
F. Begnini, S. Geschwindner, P. Johansson, Lisa Wissler +11 more
2022Journal of Medicinal Chemistry4 citations Open access
Semantic Scholar
Perspectives on optical biosensor utility in small-molecule screening
Tim Kaminski, S. Geschwindner
2017Expert Opinion on Drug Discovery4 citations Open access
Semantic Scholar
Affinity Capturing and Surface Enrichment of a Membrane Protein Embedded in a Continuous Supported Lipid Bilayer
A. Gunnarsson, Lisa Simonsson Nyström, Sabina Burazerovic, J. Gunnarsson +3 more
2016ChemistryOpen4 citations Open access
Semantic Scholar
Label-Free Inhibition in Solution Assays for Fragment Screening
S. Geschwindner
20151 citations
Semantic Scholar
Thermodynamics and Kinetics of Drug Binding. Edited by György M. Keseru and David C. Swinney
S. Geschwindner
20151 citations
Semantic Scholar
Correction to “Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction”
F. Begnini, S. Geschwindner, Patrik G. Johansson, L. Wissler +11 more
2023Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar
Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition
Amanda J. Kennedy, L. Sundström, S. Geschwindner, Eunice K. Poon +14 more
2020Communications Biology0 citations Open access
Semantic Scholar

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