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G. Dietsch · SciRah

Researcher profile · Semantic Scholar

G. Dietsch

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G. Dietsch — researcher profile on SciRah

h-index: 22
Works: 61
Citations: 2,542

Most-cited papers

Anti-inflammatory properties of a platelet-activating factor acetylhydrolase
L. Tjoelker, Cheryl L. Wilder, C. Eberhardt, Diana M. Stafforinit +10 more
1995Nature526 citations
Semantic Scholar
Chemokine expression in murine experimental allergic encephalomyelitis.
R. Godiska, D. Chantry, G. Dietsch, P. Gray
1995Journal of Neuroimmunology380 citations
Semantic Scholar
VTX-2337 Is a Novel TLR8 Agonist That Activates NK Cells and Augments ADCC
Hai-Ling Lu, G. Dietsch, Maura-Ann H. Matthews, Yi Yang +8 more
2011Clinical Cancer Research166 citations Open access
Semantic Scholar
Inhibition of experimental vasospasm with anti-intercellular adhesion molecule-1 monoclonal antibody in rats.
E. Oshiro, P. Hoffman, G. Dietsch, M. Watts +2 more
1997Stroke121 citations
Semantic Scholar
The Role of Recombinant Platelet-Activating Factor Acetylhydrolase in a Neonatal Rat Model of Necrotizing Enterocolitis
M. Caplan, Matthew J Lickerman, L. Adler, G. Dietsch +1 more
1997Pediatric Research120 citations
Semantic Scholar
Effect of Adding Motolimod to Standard Combination Chemotherapy and Cetuximab Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck: The Active8 Randomized Clinical Trial
R. Ferris, N. Saba, B. Gitlitz, R. Haddad +20 more
2018JAMA Oncology112 citations Open access
Semantic Scholar
Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN
L. Chow, C. Morishima, K. Eaton, C. Baik +8 more
2016Clinical Cancer Research109 citations
Semantic Scholar
The role of mast cells in the elicitation of experimental allergic encephalomyelitis.
G. Dietsch, D. Hinrichs
1989Journal of Immunology94 citations Open access
Semantic Scholar
Deficiency of CD11b or CD11d Results in Reduced Staphylococcal Enterotoxin-Induced T Cell Response and T Cell Phenotypic Changes1
Huai-Zhu Wu, J. Rodgers, X. Perrard, J. Perrard +6 more
2004Journal of Immunology87 citations
Semantic Scholar
Recombinant Human Platelet-Activating Factor- Acetylhydrolase Inhibits Airway Inflammation and Hyperreactivity in Mouse Asthma Model1
W. Henderson, Jiang-Yang Lu, Karen M. Poole, G. Dietsch +1 more
2000Journal of Immunology84 citations Open access
Semantic Scholar
Prevention of cerebral vasospasm by a humanized anti-CD11/CD18 monoclonal antibody administered after experimental subarachnoid hemorrhage in nonhuman primates.
R. Clatterbuck, P. Gailloud, L. Ogata, Abeyu Gebremariam +3 more
2003Journal of Neurosurgery81 citations
Semantic Scholar
The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes
David J. Dowling, Zhen Tan, Z. Prokopowicz, C. Palmer +4 more
2013PLoS ONE72 citations Open access
Semantic Scholar
TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross priming of EGFR-specific CD8+ T cells
R. Stephenson, C. Lim, Maura-Ann H. Matthews, G. Dietsch +2 more
2013Cancer Immunology and Immunotherapy72 citations Open access
Semantic Scholar
Prevention of vasospasm by anti-CD11/CD18 monoclonal antibody therapy following subarachnoid hemorrhage in rabbits.
G. Pradilla, Paul P. Wang, F. Legnani, L. Ogata +2 more
2004Journal of Neurosurgery62 citations
Semantic Scholar
Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity
G. Dietsch, Hai-Ling Lu, Yi Yang, C. Morishima +3 more
2016PLoS ONE61 citations Open access
Semantic Scholar
A Phase I Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX-2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma
D. Northfelt, R. Ramanathan, P. Cohen, D. V. Von Hoff +5 more
2014Clinical Cancer Research57 citations Open access
Semantic Scholar
Characterization of the Inflammatory Response to a Highly Selective PDE4 Inhibitor in the Rat and the Identification of Biomarkers that Correlate with Toxicity
G. Dietsch, C. Dipalma, R. Eyre, T. Pham +6 more
2006Toxicologic pathology (Print)57 citations Open access
Semantic Scholar
Inhibition of vasospasm with lymphocyte function-associated antigen-1 monoclonal antibody in a femoral artery model in rats.
R. Clatterbuck, E. Oshiro, P. Hoffman, G. Dietsch +2 more
2002Journal of Neurosurgery55 citations
Semantic Scholar
Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337)
G. Dietsch, T. D. Randall, R. Gottardo, D. Northfelt +6 more
2015Clinical Cancer Research36 citations Open access
Semantic Scholar
Granzyme B Expression is Enhanced in Human Monocytes by TLR8 Agonists and Contributes to ADCC
Saranya Elavazhagan, Kavin Fatehchand, V. Santhanam, Huiqing Fang +13 more
2015Journal of Immunology36 citations Open access
Semantic Scholar
Requirements for αd in IgG Immune Complex-Induced Rat Lung Injury
T. Shanley, R. Warner, L. Crouch, G. Dietsch +4 more
1998Journal of Immunology29 citations Open access
Semantic Scholar
MV-626, a potent and selective inhibitor of ENPP1 enhances STING activation and augments T-cell mediated anti-tumor activity in vivo
J. Baird, G. Dietsch, V. Florio, M. Gallatin +4 more
201823 citations
Semantic Scholar
TLR8 Ligation Induces Apoptosis of Monocytic Myeloid-Derived Suppressor Cells
Y. Dang, Z. J. Rutnam, G. Dietsch, Hai-Ling Lu +3 more
2017Journal of Leukocyte Biology21 citations Open access
Semantic Scholar
Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination*
Kavin Fatehchand, L. Ren, Saranya Elavazhagan, Huiqing Fang +6 more
2015Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Motolimod effectively drives immune activation in advanced cancer patients
G. Dietsch
2016Oncoimmunology10 citations Open access
Semantic Scholar
Requirements for alpha d in IgG immune complex-induced rat lung injury.
T. Shanley, R. Warner, L. Crouch, G. Dietsch +4 more
1998Journal of Immunology9 citations
Semantic Scholar
Phase 1b Trial of TLR8 Agonist VTX-2337 in Combination With Cetuximab in Patients With Recurrent or Metastatic Squamous Cell Carcinomas of the Head and Neck (SCCHN)
L. Chow, K. Eaton, C. Baik, Bernardo H. L. Goulart +6 more
20148 citations
Semantic Scholar
Phase I clinical trial of VTX-2337, a selective toll-like receptor 8 (TLR8) agonist, in patients with advanced solid tumors.
P. Cohen, D. Northfelt, G. Weiss, D. V. Von Hoff +4 more
2011Journal of Clinical Oncology8 citations
Semantic Scholar
VTX‐1463, a novel TLR‐8 agonist, attenuates nasal congestion after ragweed challenge in sensitized beagle dogs
C. Royer, K. Rudolph, G. Dietsch, R. Hershberg +1 more
2015Immunity, Inflammation and Disease7 citations Open access
Semantic Scholar
immunotherapy of cancerActive8: A randomized, double-blind, placebo-controlled study of chemotherapy plus cetuximab in combination with motolimod immunotherapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
E. Cohen, N. Saba, B. Gitlitz, R. Haddad +9 more
20165 citations Open access
Semantic Scholar
Active8: a randomized, double-blind, placebo-controlled study of chemotherapy plus cetuximab in combination with TLR8 agonist VTX-2337 in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN)
R. Ferris, Ezra E. W. Cohen, K. Gash, S. Whiting +4 more
2014Journal of Immunotherapy for Cancer3 citations Open access
Semantic Scholar
Abstract 4745: TLR8 agonist and Doxil chemotherapy potently activate human antitumor immune response in a human immune system mouse model
A. Facciabene, A. Malykhin, M. Mathews, Chung-An Fang +3 more
20113 citations
Semantic Scholar
The Prevention of Necrotizing Enterocolitis
K. Muguruma, M. Furukawa, L. Tjoelker, G. Dietsch +3 more
19963 citations
Semantic Scholar
A novel TLR-8 agonist attenuates nasal symptoms/congestion in both dog and human allergen challenge studies
E. Barrett, K. Rudolph, Maura-Ann H. Matthews, G. Dietsch +1 more
2013Journal of Inflammation2 citations Open access
Semantic Scholar
Cancer Therapy : Preclinical VTX-2337 Is a Novel TLR 8 Agonist That Activates NK Cells and Augments ADCC
Hai-Ling Lu, G. Dietsch, Maura-Ann H. Matthews, Yi Yang +8 more
20122 citations
Semantic Scholar
Prevention of vasospasm following subarachnoid hemorrhage in rabbits by anti-CD11/CD18 monoclonal antibody therapy
G. Pradilla, Paul P. Wang, F. Legnani, L. Ogata +2 more
20042 citations
Semantic Scholar
Active8: A randomized, double-blind, placebo-controlled study of chemotherapy plus cetuximab in combination with VTX-2337 in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN).
E. Cohen, R. Ferris, K. Gash, K. Manjarrez +3 more
20141 citations
Semantic Scholar
Cancer Therapy : Clinical APhase IDose-FindingStudyof theNovel Toll-likeReceptor 8 Agonist VTX-2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma
D. Northfelt, R. Ramanathan, P. Cohen, D. V. Von Hoff +5 more
20141 citations
Semantic Scholar
VTX-378, A Novel TLR-8 Agonist, Attenuates Nasal Congestion after Ragweed Challenge in Sensitized Beagle Dogs
E. Barrett, K. Rudolph, G. Dietsch, R. Hershberg
20111 citations Open access
Semantic Scholar
Changes T Cell Response and T Cell Phenotypic Enterotoxin-InducedReduced Staphylococcal Deficiency of CD 11 b or CD 11 d Results in
Huai-Zhu Wu, J. Rodgers, X. Perrard, J. Perrard +6 more
20041 citations
Semantic Scholar
Lipopolysaccharide downregulates Fc gamma RIIb via MARCH3-mediated ubiquitination
Jonathan P. Butchar, Kavin Fatehchand, L. Ren, Saranya Elavazhagan +6 more
20160 citations
Semantic Scholar
Lipopolysaccharide downregulates FcγRIIb via MARCH3-mediated ubiquitination
Jonathan P. Butchar, Kavin Fatehchand, L. Ren, Saranya Elavazhagan +6 more
2016Journal of Immunology0 citations
Semantic Scholar
Motolimod, a selective TLR8 agonist induces apoptosis in monocytic myeloid-derived suppressor cells (M-MDSC)
Z. J. Rutnam, Y. Dang, G. Dietsch, Hai-Ling Lu +3 more
2015Journal of Immunotherapy for Cancer0 citations Open access
Semantic Scholar
This information is current as Cytotoxicity Contributes to Antibody-Dependent Cellular Human Monocytes by TLR 8 Agonists and Granzyme B Expression Is Enhanced in Butchar and Susheela
Saranya Elavazhagan, Kavin Fatehchand, V. Santhanam, Huiqing Fang +13 more
20150 citations
Semantic Scholar
Abstract 286: Coordinated activation of TLR8 and NLRP3 by VTX-2337 (motolimod) ignites tumoricidal NK cell activity
G. Dietsch, Haling Lu, Yi Yang, C. Morishima +3 more
20150 citations
Semantic Scholar
TLR7/8 agonists enhance FcγR in CLL patient monocytes (TUM7P.958)
Saranya Elavazhagan, Prexy A. Shah, Kavin Fatehchand, Hemal H. Patel +9 more
2014Journal of Immunology0 citations
Semantic Scholar
Abstract 2540: Immune modulation by the TLR8 agonist VTX-2337; a comparison of the pharmacodynamic response in cancer patients and healthy volunteers
G. Dietsch, D. Northfelt, R. Ramanathan, P. Cohen +4 more
20140 citations
Semantic Scholar
Comparison of immune modulation by TLR8 agonist vtx-2337 (motolimod) in cancer patients and healthy volunteers
G. Dietsch, S. Whiting, D. Northfelt, R. Ramanathan +5 more
2014Journal of Immunotherapy for Cancer0 citations Open access
Semantic Scholar
Abstract 4738: TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross priming of EGFR-specific CD8+ T cells.
R. Stephenson, C. Lim, Maura-Ann H. Matthews, G. Dietsch +2 more
20130 citations
Semantic Scholar
A novel TLR-8 agonist attenuates nasal symptoms/congestion in both dog and human allergen challenge studies
E. Barrett, K. Rudolph, Maura-Ann H. Matthews, G. Dietsch +1 more
2013Journal of Inflammation0 citations Open access
Semantic Scholar

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