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A. Drohat · SciRah

Researcher profile · Semantic Scholar

A. Drohat

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A. Drohat — researcher profile on SciRah

h-index: 34
Works: 94
Citations: 3,862

Most-cited papers

Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine
A. Maiti, A. Drohat
2011Journal of Biological Chemistry778 citations Open access
Semantic Scholar
Replication-dependent unhooking of DNA interstrand cross-links by the NEIL3 glycosylase
Daniel R. Semlow, Jie-Qiong Zhang, Magda Budzowska, A. Drohat +1 more
2016Cell196 citations Open access
Semantic Scholar
Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability.
Matthew T. Bennett, M. Rodgers, Alexander S. Hebert, Lindsay E. Ruslander +2 more
2006Journal of the American Chemical Society171 citations Open access
Semantic Scholar
Solution structure of calcium-bound rat S100B(betabeta) as determined by nuclear magnetic resonance spectroscopy,.
A. Drohat, D. Baldisseri, R. R. Rustandi, David J Weber
1998Biochemistry151 citations
Semantic Scholar
Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition
A. Maiti, M. Morgan, E. Pozharski, A. Drohat
2008Proceedings of the National Academy of Sciences of the United States of America123 citations Open access
Semantic Scholar
The Ca2+-Dependent Interaction of S100B(ββ) with a Peptide Derived from p53†
R. R. Rustandi, A. Drohat, D. Baldisseri, P. Wilder +1 more
1998123 citations
Semantic Scholar
Solution structure of rat apo-S100B(beta beta) as determined by NMR spectroscopy.
A. Drohat, J. C. Amburgey, F. Abildgaard, M. Starich +2 more
1996Biochemistry117 citations
Semantic Scholar
Coordinating the Initial Steps of Base Excision Repair
Megan E. Fitzgerald, A. Drohat
2008Journal of Biological Chemistry112 citations Open access
Semantic Scholar
Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites
A. Bellacosa, A. Drohat
2015DNA Repair102 citations Open access
Semantic Scholar
Excision of 5-Halogenated Uracils by Human Thymine DNA Glycosylase
M. Morgan, Matthew T. Bennett, A. Drohat
2007Journal of Biological Chemistry100 citations Open access
Semantic Scholar
Role of Base Excision “Repair” Enzymes in Erasing Epigenetic Marks from DNA
A. Drohat, Christopher T. Coey
2016Chemical Reviews97 citations Open access
Semantic Scholar
Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase.
A. Drohat, J. Jagadeesh, Eric Ferguson, J. Stivers
1999Biochemistry94 citations
Semantic Scholar
The use of dipolar couplings for determining the solution structure of rat apo‐S100B(ββ)
A. Drohat, N. Tjandra, D. Baldisseri, David J Weber
2008Protein Science83 citations Open access
Semantic Scholar
Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA
A. Maiti, Anna Michelson, Cherece J. Armwood, Jeehiun K. Lee +1 more
2013Journal of the American Chemical Society80 citations Open access
Semantic Scholar
The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase
Xin-min Guan, A. Madabushi, D. Chang, Megan E. Fitzgerald +3 more
2007Nucleic Acids Research74 citations Open access
Semantic Scholar
S100B(ββ) inhibits the protein kinase C‐dependent phosphorylation of a peptide derived from p53 in a Ca2+‐dependent manner
P. Wilder, R. R. Rustandi, A. Drohat, David J Weber
199870 citations Open access
Semantic Scholar
Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA
A. Drohat, A. Maiti
2014Organic and biomolecular chemistry64 citations Open access
Semantic Scholar
Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues
Christopher T. Coey, S. Malik, L. Pidugu, Kristen M. Varney +2 more
2016Nucleic Acids Research63 citations Open access
Semantic Scholar
Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187.
A. Drohat, G. Xiao, M. Tordova, J. Jagadeesh +4 more
1999Biochemistry61 citations
Semantic Scholar
NMR Evidence for an Unusually Low N1 pKa for Uracil Bound to Uracil DNA Glycosylase: Implications for Catalysis
A. Drohat, J. Stivers
200059 citations
Semantic Scholar
Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA
A. Maiti, M. Noon, Alexander D. MacKerell, E. Pozharski +1 more
2012Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
Role of Two Strictly Conserved Residues in Nucleotide Flipping and N-Glycosylic Bond Cleavage by Human Thymine DNA Glycosylase*
A. Maiti, M. Morgan, A. Drohat
2009Journal of Biological Chemistry56 citations Open access
Semantic Scholar
3-methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member
A. Drohat, K. Kwon, D. Krosky, J. Stivers
2002Nature Structural Biology56 citations
Semantic Scholar
Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNA
M. Morgan, A. Maiti, Megan E. Fitzgerald, A. Drohat
2010Nucleic Acids Research55 citations Open access
Semantic Scholar
Escherichia coli uracil DNA glycosylase: NMR characterization of the short hydrogen bond from His187 to uracil O2.
A. Drohat, J. Stivers
2000Biochemistry49 citations
Semantic Scholar
Structural basis for excision of 5-formylcytosine by thymine DNA glycosylase
L. Pidugu, Joshua W. Flowers, Christopher T. Coey, E. Pozharski +2 more
2016Biochemistry48 citations Open access
Semantic Scholar
Dependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairs
A. Maiti, A. Drohat
2011DNA Repair45 citations Open access
Semantic Scholar
Raman spectroscopy of uracil DNA glycosylase-DNA complexes: insights into DNA damage recognition and catalysis.
Jian Dong, A. Drohat, J. Stivers, K. Pankiewicz +1 more
2000Biochemistry45 citations
Semantic Scholar
Crystal Structure of Human Methyl Binding Domain IV Glycosylase Bound to Abasic DNA
Brittney A. Manvilla, A. Maiti, Matthew C. Begley, E. Toth +1 more
2012Journal of Molecular Biology40 citations Open access
Semantic Scholar
Structural changes in the C‐terminus of Ca2+‐bound rat S100B(ββ) upon binding to a peptide derived from the C‐terminal regulatory domain of p53
R. R. Rustandi, D. Baldisseri, A. Drohat, David J Weber
1999Protein Science40 citations Open access
Semantic Scholar
Biological Crystallography Structure of Human Apurinic/apyrimidinic Endonuclease 1 with the Essential Mg 2+ Cofactor
Brittney A. Manvilla, E. Pozharski, E. Toth, A. Drohat
38 citations
Semantic Scholar
Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA
S. Malik, Christopher T. Coey, Kristen M. Varney, E. Pozharski +1 more
2015Nucleic Acids Research37 citations Open access
Semantic Scholar
Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions
P. Luncsford, Brittney A. Manvilla, Dimeka N. Patterson, S. Malik +10 more
2013DNA Repair36 citations Open access
Semantic Scholar
Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging
Claudia N. Buechner, A. Maiti, A. Drohat, I. Tessmer
2015Nucleic Acids Research35 citations Open access
Semantic Scholar
Probing the Limits of Electrostatic Catalysis by Uracil DNA Glycosylase Using Transition State Mimicry and Mutagenesis* 210
Yu-Lin Jiang, A. Drohat, Y. Ichikawa, J. Stivers
2002Journal of Biological Chemistry34 citations Open access
Semantic Scholar
TET-TDG active DNA demethylation at CpG and non-CpG sites
J. Denizio, Blaine J Dow, J. C. Serrano, Uday Ghanty +2 more
2021Journal of Molecular Biology33 citations Open access
Semantic Scholar
Solution Structure and Base Perturbation Studies Reveal a Novel Mode of Alkylated Base Recognition by 3-Methyladenine DNA Glycosylase I*
C. Cao, K. Kwon, Yu-Ling Jiang, A. Drohat +1 more
2003Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Nucleosomes and the Three Glycosylases: High, Medium, and Low Levels of Excision by the Uracil DNA Glycosylase Superfamily
Mary E. Tarantino, Blaine J Dow, A. Drohat, S. Delaney
2018DNA Repair32 citations Open access
Semantic Scholar
The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53.
R. R. Rustandi, A. Drohat, D. Baldisseri, P. Wilder +1 more
1998Biochemistry32 citations
Semantic Scholar
Functional Assessment of Population and Tumor-Associated APE1 Protein Variants
Jennifer L. Illuzzi, Nicole Harris, Brittney A. Manvilla, Daemyung Kim +3 more
2013PLoS ONE31 citations Open access
Semantic Scholar
Defining the Role of Nucleotide Flipping in Enzyme Specificity using 19F NMR
Blaine J Dow, S. Malik, A. Drohat
2019Journal of the American Chemical Society30 citations Open access
Semantic Scholar
Excision of 5-carboxylcytosine by Thymine DNA Glycosylase
L. Pidugu, Qing Dai, S. Malik, E. Pozharski +1 more
2019Journal of the American Chemical Society29 citations Open access
Semantic Scholar
The role of cysteine residues in S100B dimerization and regulation of target protein activity.
A. Landar, T. L. Hall, E. H. Cornwall, J. Correia +3 more
1997Biochimica et Biophysica Acta27 citations
Semantic Scholar
NMR Studies Reveal an Unexpected Binding Site for a Redox Inhibitor of AP Endonuclease 1
Brittney A. Manvilla, Orrette R Wauchope, K. Seley-Radtke, A. Drohat
2011Biochemistry26 citations Open access
Semantic Scholar
E2-mediated Small Ubiquitin-like Modifier (SUMO) Modification of Thymine DNA Glycosylase Is Efficient but Not Selective for the Enzyme-Product Complex*
Christopher T. Coey, Megan E. Fitzgerald, A. Maiti, K. Reiter +3 more
2014Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Structural Insights into the Mechanism of Base Excision by MBD4
L. Pidugu, H. Bright, Wen Lin, C. Majumdar +4 more
2021Journal of Molecular Biology20 citations Open access
Semantic Scholar
S100B(betabeta) inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner.
P. Wilder, R. R. Rustandi, A. Drohat, David J Weber
1998Protein Science20 citations
Semantic Scholar
Kinetic Methods for Studying DNA Glycosylases Functioning in Base Excision Repair
Christopher T. Coey, A. Drohat
2017Methods in Enzymology19 citations Open access
Semantic Scholar
Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase
Christopher T. Coey, A. Drohat
2018Nucleic Acids Research17 citations Open access
Semantic Scholar
Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine
Brittani L. Schnable, M. Schaich, V. Roginskaya, Liam P. Leary +4 more
2023bioRxiv16 citations Open access
Semantic Scholar

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E. Pozharski×8
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Christopher T. Coey

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