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M. Schaich · SciRah

Researcher profile · Semantic Scholar

M. Schaich

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M. Schaich — researcher profile on SciRah

h-index: 13
Works: 43
Citations: 631

Most-cited papers

Base excision repair of oxidative DNA damage: from mechanism to disease
A. Whitaker, M. Schaich, Mallory R. Smith, Tony S. Flynn +1 more
2017Frontiers in Bioscience208 citations Open access
Semantic Scholar
Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.
J. Akakpo, A. Ramachandran, Lu-Qi Duan, M. Schaich +5 more
2019Toxicological Sciences87 citations Open access
Semantic Scholar
Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE)
M. Schaich, Brittani L. Schnable, Namrata Kumar, V. Roginskaya +5 more
2022bioRxiv40 citations Open access
Semantic Scholar
Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors
P. Bastola, Feng Wang, M. Schaich, Taiping Gan +3 more
2017Cell Death Discovery35 citations Open access
Semantic Scholar
Structure and function relationships in mammalian DNA polymerases
N. M. Hoitsma, A. Whitaker, M. Schaich, Mallory R. Smith +2 more
2019Cellular and Molecular Life Sciences30 citations Open access
Semantic Scholar
Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover
Sunbok Jang, M. Schaich, Cindy Khuu, Brittani L. Schnable +4 more
2021Nucleic Acids Research28 citations Open access
Semantic Scholar
UV irradiation remodels the specificity landscape of transcription factors
Zachery Mielko, Yu-Ning Zhang, Harshit Sahay, Yiling Liu +9 more
2022bioRxiv24 citations Open access
Semantic Scholar
Capturing a mammalian DNA polymerase extending from an oxidized nucleotide
A. Whitaker, Mallory R. Smith, M. Schaich, B. Freudenthal
2017Nucleic Acids Research23 citations Open access
Semantic Scholar
Cooperative interaction between AAG and UV-DDB in the removal of modified bases
Sunbok Jang, Namrata Kumar, M. Schaich, Zhou Zhong +3 more
2022Nucleic Acids Research20 citations Open access
Semantic Scholar
Mechanisms of nucleotide selection by telomerase
M. Schaich, Samantha L. Sanford, Griffin A. Welfer, Samuel A Johnson +3 more
2020eLife18 citations Open access
Semantic Scholar
Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine
Brittani L. Schnable, M. Schaich, V. Roginskaya, Liam P. Leary +4 more
2023bioRxiv16 citations Open access
Semantic Scholar
Searching for DNA Damage: Insights From Single Molecule Analysis
M. Schaich, B. Van Houten
2021Frontiers in Molecular Biosciences15 citations Open access
Semantic Scholar
UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties
Sunbok Jang, Sripriya J. Raja, V. Roginskaya, M. Schaich +2 more
2023Nucleic Acids Research13 citations Open access
Semantic Scholar
Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues
M. Schaich, Mallory R. Smith, A. Cloud, S. Holloran +1 more
2017Chemical Research in Toxicology12 citations Open access
Semantic Scholar
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA
S. R. Hengel, Katherine G. Oppenheimer, Chelsea M. Smith, M. Schaich +8 more
2024bioRxiv9 citations Open access
Semantic Scholar
Single-molecule analysis of purified proteins and nuclear extracts: insights from 8-oxoguanine glycosylase 1
M. Schaich, Tyler M. Weaver, V. Roginskaya, B. Freudenthal +1 more
2024DNA Repair7 citations Open access
Semantic Scholar
Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex
Samantha L. Sanford, Mareike Badstübner, Michael Gerber, W. Mannherz +10 more
2025Nature Communications6 citations
Semantic Scholar
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA
S. R. Hengel, Katherine G. Oppenheimer, Chelsea M. Smith, M. Schaich +9 more
2024Nature Communications6 citations Open access
Semantic Scholar
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies
William Dion, Yuren Tao, Maci Chambers, Shan-Shan Zhao +20 more
2025Nature Communications5 citations Open access
Semantic Scholar
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies
William Dion, Yuren Tao, Maci Chambers, Shan-Shan Zhao +20 more
2024bioRxiv5 citations Open access
Semantic Scholar
Single-molecule analysis of purified proteins and nuclear extracts: insights from 8-oxoguanine glycosylase 1
M. Schaich, Tyler M. Weaver, V. Roginskaya, B. Freudenthal +1 more
2023bioRxiv5 citations Open access
Semantic Scholar
Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks
M. Schaich, Tyler M. Weaver, Jennifer A Rakowski, V. Roginskaya +5 more
2025Nature Communications3 citations Open access
Semantic Scholar
Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity
Li Wan, Sabrina Toland, Lindsey R. Robinson-McCarthy, Nara Lee +7 more
2023Proceedings of the National Academy of Sciences of the United States of America3 citations Open access
Semantic Scholar
A dynamic search mechanism enables APE1 to identify AP-sites in DNA
Kaitlin M. DeHart, Peyton N. Oden, Tyler M. Weaver, M. Schaich +2 more
2026bioRxiv2 citations Open access
Semantic Scholar
Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks
M. Schaich, Tyler M. Weaver, Jennifer A Rakowski, V. Roginskaya +5 more
2025bioRxiv2 citations
Semantic Scholar
Utilizing nuclear extracts to characterize protein: DNA interactions at the single molecule level
Jennifer A Rakowski, M. Schaich, Brittani L. Schnable, B. Van Houten
2024Methods in Enzymology2 citations
Semantic Scholar
Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease
R. Roddan, M. Schaich, W. Nathan, Iulia Kis +13 more
2024bioRxiv2 citations
Semantic Scholar
PARP1 recruits SPRTN to DNA-protein crosslinks through a conserved poly-ADP-ribose binding domain
K. Hurley, Liam P. Leary, Martin E. Garcia, Ayesha Rahman +13 more
2026bioRxiv1 citations
Semantic Scholar
The zinc finger of DNA Ligase 3α binds to nucleosomes via an arginine anchor
B. Van Houten, Ashna Nagpal, M. Schaich, Tyler Weaver +5 more
2025Research Square1 citations Open access
Semantic Scholar
The zinc finger of DNA ligase 3α binds to nucleosomes via an arginine anchor
Ashna Nagpal, M. Schaich, Tyler M. Weaver, V. Roginskaya +5 more
2025Nature Communications1 citations Open access
Semantic Scholar
Chemotherapeutic 6-thio-2’-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex
Samantha L. Sanford, Mareike Badstübner, Michael Gerber, W. Mannherz +10 more
2025bioRxiv1 citations Open access
Semantic Scholar
Stimulation of TDG by UV-DDB.
Brittani L. Schnable, M. Schaich, A. Drohat, B. Van Houten
2023Biophysical Journal1 citations Open access
Semantic Scholar
Abstract 3117: Defining the role of nucleolar stress in mediating DDB2 induced oxaliplatin resistance in colorectal cancer
Vinod Kumar, D. Hsu, O. Schärer, M. Schaich +3 more
2026Cancer Research0 citations
Semantic Scholar
XRCC1 Enables the Efficient Local Search for DNA Damage by DNA Polymerase Beta
Spencer H. Thompson, Kaitlin M. DeHart, M. Schaich, B. Freudenthal
2026bioRxiv0 citations Open access
Semantic Scholar
Single-molecule analysis reveals TDG exhibits multiple modes of linear diffusion to process 5-formylcytosine.
Brittani L. Schnable, M. Schaich, V. Roginskaya, Liam P. Leary +4 more
20230 citations
Semantic Scholar
Telomerase Reverse Transcriptase ternary complex, TERT:DNA:dGpCpp
M. Schaich, B. Freudenthal
20200 citations
Semantic Scholar
Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA
M. Schaich, B. Freudenthal, Thu H. Khoang
20200 citations
Semantic Scholar
Telomerase Reverse Transcriptase prenucleotide binary complex, TERT:DNA
M. Schaich, B. Freudenthal
20200 citations
Semantic Scholar
Telomerase Reverse Transcriptase product complex, TERT:DNA
M. Schaich, B. Freudenthal
20200 citations
Semantic Scholar
DNA polymerase beta binary complex with 8-oxoG:A at the primer terminus
B. Freudenthal, M. Schaich, A. Whitaker, M. Smith
20170 citations
Semantic Scholar
DNA polymerase beta ternary product complex with 8-oxoG:C and inserted dCTP
B. Freudenthal, M. Smith, A. Whitaker, M. Schaich
20170 citations
Semantic Scholar
DNA polymerase beta substrate complex with 8-oxoG:C at the primer terminus and incoming dCTP analog
B. Freudenthal, M. Schaich, A. Whitaker, M. Smith
20170 citations
Semantic Scholar
DNA polymerase beta substrate complex with incoming 5-FodCTP
M. Schaich, M. Smith, A. Cloud, S. Holloran +1 more
20170 citations
Semantic Scholar

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B. Van Houten×25
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B. Freudenthal×15
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V. Roginskaya×10
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Tyler M. Weaver

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