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R. Boon · SciRah

Researcher profile · Semantic Scholar

R. Boon

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R. Boon — researcher profile on SciRah

h-index: 20
Works: 42
Citations: 2,927

Most-cited papers

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
K. Vriens, Stefan Christe, S. Parik, D. Broekaert +42 more
2019Nature449 citations Open access
Semantic Scholar
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
Ilaria Elia, D. Broekaert, S. Christen, R. Boon +5 more
2017Nature Communications366 citations Open access
Semantic Scholar
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
Wen-Ting Guo, M. Naujock, L. Fumagalli, T. Vandoorne +22 more
2017Nature Communications342 citations Open access
Semantic Scholar
Breast cancer cells rely on environmental pyruvate to shape the metastatic niche
Ilaria Elia, Matteo Rossi, Steve Stegen, D. Broekaert +9 more
2019Nature279 citations Open access
Semantic Scholar
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.
M. Coll, L. Perea, R. Boon, S. Leite +15 more
2018Cell Stem Cell216 citations Open access
Semantic Scholar
Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis
Christian Lange, Miguel Turrero García, I. Decimo, F. Bifari +13 more
2016EMBO Journal199 citations Open access
Semantic Scholar
Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition
Laura Ordovás, R. Boon, M. Pistoni, Yemiao Chen +18 more
2015Stem Cell Reports131 citations Open access
Semantic Scholar
Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
R. Boon, Manoj Kumar, Tine Tricot, Ilaria Elia +24 more
2020Nature Communications115 citations Open access
Semantic Scholar
Nuclear metabolism and the regulation of the epigenome
R. Boon, Giorgia G. Silveira, R. Mostoslavsky
2020Nature Metabolism113 citations
Semantic Scholar
SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells
J. García-León, Manoj Kumar, R. Boon, D. Chau +14 more
2018Stem Cell Reports109 citations Open access
Semantic Scholar
HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
Raheem Fazal, S. Boeynaems, A. Swijsen, Mathias De Decker +15 more
2021EMBO Journal95 citations Open access
Semantic Scholar
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.
Doriane Lorendeau, Gianmarco Rinaldi, R. Boon, Pieter Spincemaille +12 more
2017Metabolic Engineering85 citations Open access
Semantic Scholar
Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.
J. Manesia, Zhuo-Fei Xu, D. Broekaert, R. Boon +11 more
2015Stem Cell Research80 citations Open access
Semantic Scholar
Human stem cell–derived monocytes and microglia‐like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2
C. Claes, Johanna Van Den Daele, R. Boon, Sarah Schouteden +9 more
2018Alzheimer's & Dementia79 citations Open access
Semantic Scholar
Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication.
Nicky Helsen, Y. Debing, J. Paeshuyse, K. Dallmeier +6 more
2016Journal of Hepatology60 citations Open access
Semantic Scholar
A unique subset of glycolytic tumor propagating cells drives squamous cell carcinoma
Jee-Eun Choi, Carlos Sebastián, C. Ferrer, Caroline A. Lewis +20 more
2021Nature Metabolism47 citations Open access
Semantic Scholar
PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells
J. De Smedt, E. A. van Os, Irene Talon, Sreya Ghosh +10 more
2020Cell Death and Disease35 citations Open access
Semantic Scholar
A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model.
M. Kumar, B. Toprakhisar, M. Van Haele, A. Antoranz +14 more
2021Biomaterials33 citations Open access
Semantic Scholar
Metabolic Fuel for Epigenetic: Nuclear Production Meets Local Consumption
R. Boon
2021Frontiers in Genetics31 citations Open access
Semantic Scholar
H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro
J. Vanhove, M. Pistoni, M. Welters, K. Eggermont +8 more
2016Stem Cell Reports21 citations Open access
Semantic Scholar
Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes.
B. ter Braak, M. Niemeijer, R. Boon, C. Parmentier +6 more
2021Toxicology in Vitro13 citations Open access
Semantic Scholar
Automated generation of hiPSC-derived hepatic progeny by cost-efficient compounds.
Gert Vanmarcke, Jonathan Sai-Hong Chui, A. Cooreman, K. De Vos +10 more
2023Stem Cells8 citations Open access
Semantic Scholar
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
M. Moreno-Torres, Manoj Kumar, Guillem García-Llorens, G. Quintás +7 more
2022Journal of Proteome Research8 citations Open access
Semantic Scholar
Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings
Tine Tricot, H. Thibaut, Kayvan Abbasi, R. Boon +4 more
2022Biomedicines3 citations Open access
Semantic Scholar
A fully defined pluripotent stem cell derived multi-liver-cell model for steatohepatitis and fibrosis
Manoj Kumar, B. Toprakhisar, M. Van Haele, A. Antoranz +14 more
2020bioRxiv3 citations Open access
Semantic Scholar
Abstract 4578: Discovery of a Best-in-Class small molecule p53 Y220C reactivator: Breaking through the potency ceiling
R. Boon, Jo Alen, N. Draoui, Koen Vandyck +10 more
2026Cancer Research2 citations
Semantic Scholar
Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF‐κВ and WNT Signaling
Jonathan Sai-Hong Chui, Teresa Izuel-Idoype, Alessandra Qualizza, Rita Pires de Almeida +11 more
2023bioRxiv2 citations Open access
Semantic Scholar
Dynamic regulation of EZH2 from HPSc to hepatocyte-like cell fate
M. Pistoni, Nicky Helsen, J. Vanhove, R. Boon +3 more
2017PLoS ONE2 citations Open access
Semantic Scholar
Rapid and Efficient Generation of Recombinant Human Pluripotent Stem Cells by Recombinase-mediated Cassette Exchange in the AAVS1 Locus
Laura Ordovás, R. Boon, M. Pistoni, Yemiao Chen +8 more
2016Journal of Visualized Experiments2 citations Open access
Semantic Scholar
Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition
Laura Ordovás, R. Boon, M. Pistoni, Yemiao Chen +18 more
2018Stem Cell Reports1 citations Open access
Semantic Scholar
Directed Differentiation of IPS Cells to Hepatic Stellate Cells
M. Coll, L. Perea, R. Boon, Julia Vallverdú +8 more
20161 citations
Semantic Scholar
Abstract C012: Discovery of a Best-in-Class small molecule p53 Y220C reactivator: Breaking through the potency ceiling
R. Boon, Jo Alen, N. Draoui, Koen Vandyck +9 more
2025Molecular Cancer Therapeutics0 citations
Semantic Scholar
Evidence for an alternative fatty acid desaturation pathway that increases 1 metabolic plasticity in cancer cells 2
K. Vriens, S. Christen, S. Parik, D. Broekaert +45 more
20190 citations
Semantic Scholar
Stem Cell Repor ts Efﬁcient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition
Laura Ordovás, R. Boon, M. Pistoni, Yemiao Chen +18 more
20180 citations
Semantic Scholar
Creation of a stable and highly functional pluripotent stem cell derived hepatocyte model for drug metabolisation and toxicity screening
M. Kumar, F. Chesnais, R. Boon, Alice Krebs +6 more
2018Toxicology Letters0 citations
Semantic Scholar
Multifactorial 3D Niche To Study Cell-matrix Interactions To Improve Maturation Of Pluripotent Derived Hepatocytes
M. Kumar, Gregorius Rustandi, R. Boon, R. Patil +2 more
20160 citations
Semantic Scholar
Identification of Transcription Factors that Regulate Liver Sinusoidal Endothelial Cell Specialization and Liver Regeneration
W. de Haan, Wouter Dheedene, R. Boon, S. Craps +5 more
20150 citations
Semantic Scholar
Generation of functional liver cells from pluripotent stem cells by manipulating transcriptional networks
Marta Aguirre Vazquez, R. Boon, W. de Haan, L. Vidal +3 more
20150 citations
Semantic Scholar
Expression of Liver Sinusoidal Endothelial Cell Markers can be induced in Endothelial Stem Cells by Overexpression of C-MAF, GATA4 and MEIS2
W. de Haan, Wouter Dheedene, R. Boon, Boukje Hoekman +3 more
20150 citations
Semantic Scholar
miRNAs and epigenetic regulation of vascular phenotype
R. Boon
20140 citations
Semantic Scholar
Stem cell engineering for generating an in vitro liver model
L. Vidal, Elena Pistoni, R. Boon, Yemiao Chen +11 more
20140 citations
Semantic Scholar
Biodegradable poly(polyol sebacate)/PLLA core/shell fiber scaffolds for liver tissue growth
D. Mogosanu, R. Boon, C. Verfaillie, J. Vanfleteren +1 more
20140 citations
Semantic Scholar

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