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T. Nakahata · SciRah

Researcher profile · Semantic Scholar

T. Nakahata

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T. Nakahata — researcher profile on SciRah

h-index: 82
Works: 643
Citations: 29K

Most-cited papers

Identification of a High‐Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell–Based Phenotype Dissection
Yuri Kawasaki, H. Oda, Jun Ito, A. Niwa +15 more
2017Arthritis & Rheumatology120 citations
Semantic Scholar
Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells
Emi Shoji, H. Sakurai, Tokiko Nishino, T. Nakahata +6 more
2015Scientific Reports114 citations Open access
Semantic Scholar
iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases.
Chuang-Yu Lin, Michiko Yoshida, Li-Tzu Li, Akihiro Ikenaka +6 more
2019JCI Insight59 citations Open access
Semantic Scholar
MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1
Hong-Tao Wang, Cui-Cui Liu, Xin Liu, Mengge Wang +9 more
2018Stem Cell Reports58 citations Open access
Semantic Scholar
Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition
Kosuke Kirino, T. Nakahata, T. Taguchi, M. Saito
2018Scientific Reports56 citations Open access
Semantic Scholar
Early Development of Definitive Erythroblasts from Human Pluripotent Stem Cells Defined by Expression of Glycophorin A/CD235a, CD34, and CD36
Bin Mao, Shu Huang, Xu-Lin Lu, Wencui Sun +11 more
2016Stem Cell Reports51 citations Open access
Semantic Scholar
Pluripotent stem cell models of Blau syndrome reveal an IFN‐&ggr;–dependent inflammatory response in macrophages
S. Takada, N. Kambe, Yuri Kawasaki, A. Niwa +13 more
2018Journal of Allergy and Clinical Immunology50 citations Open access
Semantic Scholar
Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells
Ryosaku Ohta, A. Niwa, Yukimasa Taniguchi, Naoya M. Suzuki +9 more
2016Scientific Reports48 citations Open access
Semantic Scholar
Mislocalization of syntaxin‐1 and impaired neurite growth observed in a human iPSC model for STXBP1‐related epileptic encephalopathy
S. Yamashita, T. Chiyonobu, Michiko Yoshida, Hiroshi Maeda +10 more
2016Epilepsia46 citations
Semantic Scholar
Preserved High Probability of Overall Survival with Significant Reduction of Chemotherapy for Myeloid Leukemia in Down Syndrome: A Nationwide Prospective Study in Japan
T. Taga, Tomoyuki Watanabe, D. Tomizawa, K. Kudo +17 more
2016Pediatric Blood & Cancer45 citations
Semantic Scholar
RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells
Yoshihide Mitsuda, Ken Morita, Gengo Kashiwazaki, Junichi Taniguchi +11 more
2018Scientific Reports37 citations Open access
Semantic Scholar
Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.
Anfeng Mu, Asuka Hira, A. Niwa, M. Osawa +15 more
2021Blood34 citations Open access
Semantic Scholar
Overexpression of GATA2 Enhances Development and Maintenance of Human Embryonic Stem Cell-Derived Hematopoietic Stem Cell-like Progenitors
Ya Zhou, Yong-Gang Zhang, Bo Chen, Yong Dong +11 more
2019Stem Cell Reports34 citations Open access
Semantic Scholar
Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells
Ken Morita, M. Noura, Chieko Tokushige, Shintaro Maeda +13 more
2017Scientific Reports34 citations Open access
Semantic Scholar
Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.
I. Kato, Y. Nishinaka, Masahiro Nakamura, A. Akarca +23 more
2017Blood34 citations Open access
Semantic Scholar
Risk-adjusted therapy for pediatric non-T cell ALL improves outcomes for standard risk patients: results of JACLS ALL-02
Daiichiro Hasegawa, T. Imamura, K. Yumura-Yagi, Yoshihiro Takahashi +19 more
2020Blood Cancer Journal33 citations Open access
Semantic Scholar
Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress
Fumiko Honda-Ozaki, Madoka Terashima, A. Niwa, Norikazu Saiki +12 more
2018Stem Cell Reports31 citations Open access
Semantic Scholar
Induction of human pluripotent stem cell-derived natural killer cells for immunotherapy under chemically defined conditions.
Hiroyuki Matsubara, A. Niwa, T. Nakahata, M. Saito
2019Biochemical and Biophysical Research Communications - BBRC28 citations
Semantic Scholar
Establishment of isogenic iPSCs from an individual with SCN1A mutation mosaicism as a model for investigating neurocognitive impairment in Dravet syndrome
Hiroshi Maeda, T. Chiyonobu, Michiko Yoshida, S. Yamashita +8 more
2016Journal of Human Genetics26 citations
Semantic Scholar
SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis
Akihiro Ikenaka, Y. Kitagawa, Michiko Yoshida, Chuang-Yu Lin +3 more
2022Life Science Alliance24 citations Open access
Semantic Scholar
Establishment of a Robust Platform for Induced Pluripotent Stem Cell Research Using Maholo LabDroid
M. Sasamata, D. Shimojo, H. Fuse, Yohei Nishi +4 more
2021SLAS technology24 citations Open access
Semantic Scholar
Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate
Kazuki Taoka, S. Arai, K. Kataoka, Masataka Hosoi +12 more
2018Scientific Reports23 citations Open access
Semantic Scholar
Human pluripotent stem cell–derived erythropoietin-producing cells ameliorate renal anemia in mice
H. Hitomi, T. Kasahara, Naoko Katagiri, Azusa Hoshina +10 more
2017Science Translational Medicine21 citations Open access
Semantic Scholar
CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor
Seishiro Nodomi, K. Umeda, S. Saida, T. Kinehara +12 more
2016Oncogene21 citations Open access
Semantic Scholar
CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia
N. Imayoshi, Makoto Yoshioka, Kuniaki Tanaka, Shyh-Ming Yang +10 more
2021Biochemical and Biophysical Research Communications - BBRC18 citations Open access
Semantic Scholar
RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice.
Ken Morita, Chieko Tokushige, Shintaro Maeda, Hiroki Kiyose +12 more
2018Blood Advances17 citations Open access
Semantic Scholar
Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors.
K. Oshima, Norikazu Saiki, Michihiro Tanaka, H. Imamura +23 more
2018Biochemical and Biophysical Research Communications - BBRC17 citations Open access
Semantic Scholar
Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity
Ryosuke Seki, Akira Ohta, A. Niwa, Yoshinori Sugimine +3 more
2020PLoS ONE15 citations Open access
Semantic Scholar
Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia
T. Shigemura, K. Matsuda, T. Kurata, K. Sakashita +9 more
2019British Journal of Haematology15 citations Open access
Semantic Scholar
Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells
Hiroaki Ono, Ryosaku Ohta, Yuri Kawasaki, A. Niwa +4 more
2018Inflammation Research15 citations Open access
Semantic Scholar
Inducible overexpression of RUNX1b/c in human embryonic stem cells blocks early hematopoiesis from mesoderm
Bo Chen, Jiawen Teng, Hong-Wei Liu, Xu Pan +10 more
2017Journal of Molecular Cell Biology15 citations Open access
Semantic Scholar
Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythroblasts
Yi-Jin Chen, Yong Dong, Xu-Lin Lu, Wanjing Li +20 more
2022Journal of Molecular Cell Biology14 citations Open access
Semantic Scholar
Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals
Yong Dong, Ju Bai, Yi-Meng Zhang, Ya Zhou +13 more
2020Journal of Leukocyte Biology14 citations Open access
Semantic Scholar
Direct Delivery of piggyBac CD19 CAR T Cells Has Potent Anti-tumor Activity against ALL Cells in CNS in a Xenograft Mouse Model
Kuniaki Tanaka, I. Kato, Miyuki Tanaka, D. Morita +8 more
2020Molecular Therapy: Oncolytics14 citations Open access
Semantic Scholar
High event‐free survival rate with minimum‐dose‐anthracycline treatment in childhood acute promyelocytic leukaemia: a nationwide prospective study by the Japanese Paediatric Leukaemia/Lymphoma Study Group
Hiroyuki Takahashi, Tomoyuki Watanabe, A. Kinoshita, Yuki Yuza +21 more
2016British Journal of Haematology14 citations Open access
Semantic Scholar
Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification
Shiori Matsuo, Yoko Nishinaka-Arai, Y. Kazuki, M. Oshimura +3 more
2021PLoS ONE13 citations Open access
Semantic Scholar
A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
E. Hattori, Tatsuya Masuda, Y. Mineharu, Masamitsu Mikami +12 more
2022Communications Biology12 citations Open access
Semantic Scholar
Attempts to optimize postinduction treatment in childhood acute myeloid leukemia without core‐binding factors: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)
Daiichiro Hasegawa, A. Tawa, D. Tomizawa, Tomoyuki Watanabe +17 more
2020Pediatric Blood & Cancer11 citations
Semantic Scholar
Dasatinib induces autophagy in mice with Bcr-Abl-positive leukemia
Makiko Morita, Y. Nishinaka, I. Kato, S. Saida +5 more
2017International journal of hematology11 citations
Semantic Scholar
Screening Station, a novel laboratory automation system for physiologically relevant cell-based assays.
I. Namatame, K. Ishii, Takashi Shin, D. Shimojo +8 more
2023SLAS technology10 citations Open access
Semantic Scholar
Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation
Yoko Nishinaka-Arai, A. Niwa, Shiori Matsuo, Y. Kazuki +9 more
2020Haematologica10 citations Open access
Semantic Scholar
Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell‐derived neural crest cells
Kyosuke Mukae, H. Takenobu, Yuki Endo, Masayuki Haruta +9 more
2023Cancer Science8 citations Open access
Semantic Scholar
Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors
T. Hamabata, K. Umeda, Kagehiro Kouzuki, Takayuki Tanaka +20 more
2020Scientific Reports8 citations Open access
Semantic Scholar
Pluripotent stem cell‐based screening identifies CUDC‐907 as an effective compound for restoring the in vitro phenotype of Nakajo‐Nishimura syndrome
Naoya Kase, Madoka Terashima, Akira Ohta, A. Niwa +5 more
2020Stem Cells Translational Medicine8 citations Open access
Semantic Scholar
Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model
Jose Ichisima, Naoya M. Suzuki, Bumpei Samata, Tomonari Awaya +4 more
2019Journal of Human Genetics8 citations Open access
Semantic Scholar
The first Japanese biobank of patient‐derived pediatric acute lymphoblastic leukemia xenograft models
Kuniaki Tanaka, I. Kato, Yuu Dobashi, Jun-ichi Imai +12 more
2022Cancer Science7 citations Open access
Semantic Scholar
Biomimetic aorta-gonad-mesonephros-on-a-chip to study human developmental hematopoiesis
Ryohichi Sugimura, Ryosaku Ohta, Chihiro Mori, A. Li +7 more
2019Biomedical microdevices7 citations Open access
Semantic Scholar
RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
Masamitsu Mikami, Tatsuya Masuda, T. Kanatani, M. Noura +22 more
2022Molecules and Cells6 citations Open access
Semantic Scholar
JACLS ALL-02 SR protocol reduced-intensity chemotherapy produces excellent outcomes in patients with low-risk childhood acute lymphoblastic leukemia
Yoshihiro Takahashi, H. Ishida, T. Imamura, Kosuke Tamefusa +20 more
2022International journal of hematology6 citations
Semantic Scholar
RUNX1 transactivates BCR‐ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia
Tatsuya Masuda, Shintaro Maeda, Sae Shimada, N. Sakuramoto +20 more
2021Cancer Science6 citations Open access
Semantic Scholar

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