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F. Markwardt · SciRah

Researcher profile · Semantic Scholar

F. Markwardt

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F. Markwardt — researcher profile on SciRah

h-index: 39
Works: 381
Citations: 5,878

Most-cited papers

The development of hirudin as an antithrombotic drug.
F. Markwardt
1994Thrombosis Research256 citations
Semantic Scholar
The Elusive P2X7 Macropore.
F. Di Virgilio, G. Schmalzing, F. Markwardt
2018Trends in Cell Biology255 citations Open access
Semantic Scholar
Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor
E. Adinolfi, M. Cirillo, Ronja Woltersdorf, S. Falzoni +7 more
2010The FASEB Journal253 citations
Semantic Scholar
Hirudin As Alternative Anticoagulant- A Historical Review
F. Markwardt
2002Seminars in Thrombosis and Hemostasis135 citations
Semantic Scholar
TMEM16A(a)/anoctamin-1 Shares a Homodimeric Architecture with CLC Chloride Channels
Ghada Fallah, T. Römer, Silvia Detro-dassen, U. Braam +2 more
2010Molecular & Cellular Proteomics112 citations Open access
Semantic Scholar
Pharmacology of r-hirudin in renal impairment.
G. Nowak, E. Bucha, Th. Gööck, H. Thieler +1 more
1992Thrombosis Research89 citations
Semantic Scholar
Functional evidence of distinct ATP activation sites at the human P2X7 receptor
M. Klapperstück, Cora Büttner, G. Schmalzing, F. Markwardt
2001Journal of Physiology83 citations Open access
Semantic Scholar
Interaction of Purinergic P2X4 and P2X7 Receptor Subunits
F. Markwardt, M. Schneider, Kirsten Prudic, Anja Pippel +5 more
2017Frontiers in Pharmacology80 citations Open access
Semantic Scholar
NF449, a novel picomolar potency antagonist at human P2X1 receptors.
M. Hülsmann, P. Nickel, M. Kassack, G. Schmalzing +2 more
2003European Journal of Pharmacology73 citations
Semantic Scholar
Localization of the gate and selectivity filter of the full-length P2X7 receptor
Anja Pippel, M. Stolz, Ronja Woltersdorf, A. Kless +2 more
2017Proceedings of the National Academy of Sciences of the United States of America70 citations Open access
Semantic Scholar
Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages
P. Burow, M. Klapperstück, F. Markwardt
2014Pflügers Archiv: European Journal of Physiology69 citations Open access
Semantic Scholar
Glu496Ala polymorphism of human P2X7 receptor does not affect its electrophysiological phenotype.
W. Boldt, M. Klapperstück, Cora Büttner, S. Sadtler +2 more
2003American Journal of Physiology - Cell Physiology69 citations
Semantic Scholar
The P2X7 Carboxyl Tail Is a Regulatory Module of P2X7 Receptor Channel Activity*
D. Becker, Ronja Woltersdorf, W. Boldt, Stephan Schmitz +3 more
2008Journal of Biological Chemistry67 citations Open access
Semantic Scholar
Gating of maxi K+ channels studied by Ca2+ concentration jumps in excised inside-out multi-channel patches (myocytes from guinea pig urinary bladder)
F. Markwardt, G. Isenberg
1992The Journal of General Physiology63 citations Open access
Semantic Scholar
Transport of the advanced glycation end products alanylpyrraline and pyrralylalanine by the human proton-coupled peptide transporter hPEPT1.
Stefanie Geissler, M. Hellwig, Madlen Zwarg, F. Markwardt +2 more
2010Journal of Agricultural and Food Chemistry56 citations
Semantic Scholar
Hirudin: The Promising Antithrombotic
F. Markwardt
199250 citations Open access
Semantic Scholar
Pharmacologic Aspects of the Development of Selective Synthetic Thrombin Inhibitors as Anticoagulants
J. Hauptmann, F. Markwardt
1992Seminars in Thrombosis and Hemostasis40 citations
Semantic Scholar
The bioactive dipeptide anserine is transported by human proton‐coupled peptide transporters
Stefanie Geissler, Madlen Zwarg, Ilka Knütter, F. Markwardt +1 more
2010The FEBS Journal39 citations Open access
Semantic Scholar
Nonselective cationic currents elicited by extracellular ATP in human B-lymphocytes
F. Bretschneider, M. Klapperstück, M. Löhn, F. Markwardt
1995Pflügers Archiv38 citations
Semantic Scholar
Homodimeric anoctamin-1, but not homodimeric anoctamin-6, is activated by calcium increases mediated by the P2Y1 and P2X7 receptors
M. Stolz, M. Klapperstück, Thomas Kendzierski, Silvia Detro-dassen +3 more
2015Pflügers Archiv: European Journal of Physiology34 citations
Semantic Scholar
Salt Bridge Switching from Arg290/Glu167 to Arg290/ATP Promotes the Closed-to-Open Transition of the P2X2 Receptor
R. Hausmann, Janka Günther, A. Kless, D. Kuhlmann +4 more
2013Molecular Pharmacology31 citations
Semantic Scholar
Block by extracellular Mg2+ of single human purinergic P2X4 receptor channels expressed in human embryonic kidney cells.
Y. Negulyaev, F. Markwardt
2000Neuroscience Letters31 citations
Semantic Scholar
Hirudin in disseminated intravascular coagulation.
G. Nowak, F. Markwardt
1991Haemostasis31 citations
Semantic Scholar
Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation
M. Kuehnel, Miriam Reiss, P. Anand, Irina Treede +6 more
2009Journal of Cell Science30 citations
Semantic Scholar
Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia
M. Trang, G. Schmalzing, Christa E. Müller, F. Markwardt
2020International Journal of Molecular Sciences29 citations Open access
Semantic Scholar
Electrophysiological characterization of human keratinocytes using the patch‐clamp technique
D. Wohlrab, Johannes Wohlrab, F. Markwardt
2000Experimental Dermatology29 citations
Semantic Scholar
Sphingosine-1-phosphate induces migration of microglial cells via activation of volume-sensitive anion channels, ATP secretion and activation of purinergic receptors.
Danyal Zahiri, P. Burow, C. Grossmann, Christa E. Müller +2 more
2020Biochimica et biophysica acta. Molecular cell research28 citations Open access
Semantic Scholar
The orally active antihyperglycemic drug beta-guanidinopropionic acid is transported by the human proton-coupled amino acid transporter hPAT1.
Linda Metzner, Madlen Dorn, F. Markwardt, M. Brandsch
2009Molecular Pharmaceutics28 citations
Semantic Scholar
Coagulation inhibitors from blood-sucking animals. A new line of developing antithrombotic drugs.
F. Markwardt
1994Pharmazie28 citations
Semantic Scholar
The effect of anions on the human P2X7 receptor.
C. Kubick, G. Schmalzing, F. Markwardt
2011Biochimica et Biophysica Acta25 citations Open access
Semantic Scholar
Dissecting individual current components of co-expressed human P2X1 and P2X7 receptors.
Christian Seyffert, G. Schmalzing, F. Markwardt
2004Current Topics in Medicinal Chemistry24 citations
Semantic Scholar
Historical Perspective of the Development of Thrombin Inhibitors
F. Markwardt
2003Pathophysiology of Haemostasis and Thrombosis24 citations
Semantic Scholar
Drug-dependent ion channel gating by application of concentration jumps using U-tube technique.
F. Bretschneider, F. Markwardt
1999Methods in Enzymology24 citations
Semantic Scholar
Inventory of Coagulation Inhibitors from Animals Feeding on Blood
F. Markwardt
1994Thrombosis and Haemostasis23 citations
Semantic Scholar
Identification of a Disulfide Bridge Essential for Transport Function of the Human Proton-coupled Amino Acid Transporter hPAT1*
Madlen Dorn, M. Weiwad, F. Markwardt, Linda Laug +3 more
2009Journal of Biological Chemistry22 citations Open access
Semantic Scholar
The Comeback of Hirudin as an Antithrombotic Agent
F. Markwardt
1991Seminars in Thrombosis and Hemostasis22 citations
Semantic Scholar
Influence of recombinant hirudin and unfractionated heparin on thrombin and factor Xa generation in extrinsic and intrinsic activated systems.
B. Kaiser, J. Fareed, D. Hoppensteadt, B. Birdsong +2 more
1992Thrombosis Research21 citations
Semantic Scholar
Inhibition of antigen receptor-dependent Ca(2+) signals and NF-AT activation by P2X7 receptors in human B lymphocytes.
Anja Pippel, B. Beßler, M. Klapperstück, F. Markwardt
2015Cell Calcium20 citations
Semantic Scholar
Synthesis and intestinal transport of the iron chelator maltosine in free and dipeptide form.
Stefanie Geissler, M. Hellwig, F. Markwardt, T. Henle +1 more
2011European journal of pharmaceutics and biopharmaceutics20 citations
Semantic Scholar
The role of N‐glycosylation in transport function and surface targeting of the human solute carrier PAT1
Madlen Dorn, Michael Jaehme, M. Weiwad, F. Markwardt +3 more
2009FEBS Letters20 citations
Semantic Scholar
Biochemical Characterization of a Thrombin Inhibitor from the Bloodsucking Bug Dipetalogaster maximus
U. Lange, W. Keilholz, G. A. Schaub, H. Landmann +2 more
1999Pathophysiology of Haemostasis and Thrombosis20 citations
Semantic Scholar
Influence of Ion Channel Blockers on Proliferation and Free Intracellular Ca2+ Concentration of Human Keratinocytes
D. Wohlrab, F. Markwardt
1999Skin Pharmacology and Physiology19 citations
Semantic Scholar
Pharmacological stimulation of t-PA release.
H. Kloecking, F. Markwardt
1994Pharmazie18 citations
Semantic Scholar
Human P2X7 receptors - properties of single ATP-gated ion channels.
F. Markwardt
2020Biochemical Pharmacology17 citations
Semantic Scholar
Calibration procedures for the quantitative determination of membrane potential in human cells using anionic dyes
T. Klapperstück, D. Glanz, S. Hanitsch, M. Klapperstück +2 more
2013Cytometry Part A14 citations Open access
Semantic Scholar
A recombinant hirudin (IK-HIR02) in healthy volunteers. I. Effects on coagulation parameters and bleeding time.
J. Schenk, E. Glusa, P. Radziwon, A. Butti +2 more
1996Haemostasis13 citations
Semantic Scholar
The mineralocorticoid receptor leads to increased expression of EGFR and T-type calcium channels that support HL-1 cell hypertrophy
Katharina Stroedecke, S. Meinel, F. Markwardt, U. Kloeckner +6 more
2021Scientific Reports12 citations Open access
Semantic Scholar
Transport of the areca nut alkaloid arecaidine by the human proton‐coupled amino acid transporter 1 (hPAT1)
Valerie Voigt, Linda Laug, Katja Zebisch, I. Thondorf +2 more
2013The Journal of pharmacy and pharmacology12 citations
Semantic Scholar
Nomenclature of Exogenous Hemostatic Factors
D. Aronson, K. Brinkhous, A. Henschen, S. Iwanaga +6 more
1991Thrombosis and Haemostasis11 citations
Semantic Scholar
Activation kinetics of single P2X receptors
F. Markwardt
2007Purinergic Signalling Purinergic Signalling10 citations Open access
Semantic Scholar

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G. Schmalzing×14
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G. Schmalzing — researcher profile on SciRah
M. Klapperstück×9
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M. Brandsch×7
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Ronja Woltersdorf×3
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Anja Pippel — researcher profile on SciRah

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Stefanie Geissler×3

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F. Di Virgilio×2

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