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M. Stubbs · SciRah

Researcher profile · Semantic Scholar

M. Stubbs

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M. Stubbs — researcher profile on SciRah

h-index: 18
Works: 59
Citations: 1,606

Most-cited papers

Studies on the mechanism of the antifungal action of benzoate.
H. A. Krebs, D. Wiggins, M. Stubbs, A. Sols +1 more
1983Biochemical Journal382 citations Open access
Semantic Scholar
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
T. Dale, P. Clarke, C. Esdar, Dennis C. J. Waalboer +27 more
2015Nature Chemical Biology140 citations Open access
Semantic Scholar
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
A. Acar, D. Nichol, J. Fernández-Mateos, George D. Cresswell +15 more
2020Nature Communications111 citations Open access
Semantic Scholar
MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma
A. Lampis, P. Carotenuto, G. Vlachogiannis, L. Cascione +30 more
2017Gastroenterology110 citations Open access
Semantic Scholar
A Useful Approach To Identify Novel Small Molecule Inhibitors Of Wnt-Dependent Transcription
K. Ewan, B. Pajak, M. Stubbs, H. Todd +16 more
2010Cancer Research104 citations Open access
Semantic Scholar
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
A. Mallinger, K. Schiemann, Christian Rink, F. Stieber +24 more
2016Journal of Medicinal Chemistry103 citations Open access
Semantic Scholar
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)
N. Chessum, S. Sharp, J. Caldwell, A. E. Pasqua +13 more
2017Journal of Medicinal Chemistry80 citations Open access
Semantic Scholar
Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen
A. Mallinger, Simon Crumpler, M. Pichowicz, Dennis C. J. Waalboer +28 more
2015Journal of Medicinal Chemistry76 citations Open access
Semantic Scholar
Molecular mechanisms of human IRE1 activation through dimerization and ligand binding
A. Joshi, Yvette M Newbatt, P. McAndrew, M. Stubbs +7 more
2015OncoTarget59 citations Open access
Semantic Scholar
Evidence for glucose and sorbitol‐induced nuclear export of glucokinase regulatory protein in hepatocytes
Mohammed Mukhtar, M. Stubbs, L. Agius
1999FEBS Letters48 citations Open access
Semantic Scholar
Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: evidence for two glucose binding sites.
Loranne Agius, M. Stubbs
2000Biochemical Journal44 citations Open access
Semantic Scholar
Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.
M. Stubbs, Susan Aiston, Loranne Agius
2000Diabetes44 citations Open access
Semantic Scholar
2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19
A. Mallinger, K. Schiemann, Christian Rink, Jimmy J. P. Sejberg +18 more
2016ACS Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Formation of n.m.r.-invisible ADP during renal ischaemia in rats.
M. Stubbs, D. Freeman, B. Ross
1984Biochemical Journal38 citations Open access
Semantic Scholar
The glucose sensor in HIT cells is the glucose transporter
S. Ashcroft, M. Stubbs
1987FEBS Letters30 citations Open access
Semantic Scholar
Effect of hibernation on liver and kidney metabolism in 13-lined ground squirrels.
Cj Green, J. Brosnan, Bj Fuller, M. Lowry +2 more
1984Comparative biochemistry and physiology. B, Comparative biochemistry26 citations
Semantic Scholar
A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity **
Habib Bouguenina, A. Scarpino, Jack A. O'Hanlon, J. Warne +18 more
2023ChemBioChem24 citations Open access
Semantic Scholar
DIPG harbour alterations targetable by MEK inhibitors, with acquired resistance mechanisms overcome by combinatorial inhibition
E. Izquierdo, Diana M. Carvalho, A. Mackay, Sara Temelso +33 more
2021Cancer Discovery24 citations Open access
Semantic Scholar
Targeting of cholecystokinin B/gastrin receptor in colonic, pancreatic and hepatocellular carcinoma cell lines.
K. Savage, H. Waller, M. Stubbs, K. Khan +6 more
2006International Journal of Oncology18 citations Open access
Semantic Scholar
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery
Man-Juan Liu, Amin Mirza, P. McAndrew, A. Thapaliya +13 more
2023Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Identification of Novel Keratinocyte Differentiation Modulating Compounds by High-Throughput Screening
Masaru Honma, M. Stubbs, I. Collins, P. Workman +2 more
2006Journal of biomolecular screening15 citations Open access
Semantic Scholar
Loss of cell constituents from hepatocytes on centrifugation.
G. Sainsbury, M. Stubbs, R. Hems, H. Krebs
1979Biochemical Journal15 citations Open access
Semantic Scholar
Exploiting evolutionary herding to control drug resistance in cancer
A. Acar, D. Nichol, J. Fernández-Mateos, George D. Cresswell +12 more
2019bioRxiv12 citations Open access
Semantic Scholar
Expression of c-kit (CD117) in neuroendocrine tumours--a target for therapy?
V. Kostoula, K. Khan, K. Savage, M. Stubbs +4 more
2003Oncology Report9 citations
Semantic Scholar
iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells
Habib Bouguenina, S. Nicolaou, Y. Le Bihan, Elizabeth A. Bowling +21 more
2023iScience8 citations Open access
Semantic Scholar
CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines.
M. Stubbs, K. Khan, R. Wickremasinghe, K. Ganeshaguru +1 more
2005Oncology Report7 citations
Semantic Scholar
Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes
K. Davidson, Paul Grevitt, Maria F. Contreras G., Katherine S. Bridge +10 more
2021Cell Death and Disease6 citations Open access
Semantic Scholar
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
O. Pierrat, Man-Juan Liu, G. Collie, Kartika Shetty +30 more
2022Scientific Reports5 citations Open access
Semantic Scholar
Abstract LBA004: Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer
G. Gavory, B. Fasching, D. Bonenfant, Amine Sadok +28 more
2021Poster Presentations - Late-Breaking Proffered Abstracts4 citations
Semantic Scholar
Endocytosis of Anti-CCK-B/Gastrin Receptor Antibody and Effect on Hepatoma Cell Lines
M. Stubbs, K. Khan, S. Watson, K. Savage +2 more
2002Journal of Histochemistry and Cytochemistry4 citations Open access
Semantic Scholar
Abstract 3025: Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential
P. Clarke, C. Esdar, A. Mallinger, K. Schiemann +30 more
20161 citations
Semantic Scholar
Targeting of Cholecystokinin B/gastrin receptor in cancer cell lines
K. Savage, A. Waller, M. Stubbs, K. Khan +6 more
20061 citations
Semantic Scholar
Neuroendocrine-like differentiation in hepatocellular and pancreatic cancers
M. Mcstay, K. Khan, K. Savage, M. Stubbs +2 more
20041 citations
Semantic Scholar
Expression of parathyroid hormone-related peptide and its receptor in neuroendocrine tumours
M. Mcstay, M. Stubbs, K. Savage, K. Khan +1 more
20031 citations
Semantic Scholar
Expression and uptake of parathyroid hormone related peptide in hepatocellular carcinoma
M. Mcstay, K. Savage, M. Stubbs, K. Khan +2 more
20031 citations
Semantic Scholar
MODL-19. DIPG HARBOUR ALTERATIONS TARGETABLE BY MEK INHIBITORS, WITH ACQUIRED RESISTANCE MECHANISMS OVERCOME BY COMBINATORIAL UP- OR DOWN-STREAM INHIBITION
E. Izquierdo, Diana M. Carvalho, A. Mackay, Sara Temelso +9 more
2020Neuro-Oncology0 citations Open access
Semantic Scholar
DIPG-25. GENETIC ALTERATIONS TARGETING THE MAPK PATHWAY CONFERS PRECLINICAL SENSITIVITY TO TRAMETINIB IN A CO-CLINICAL TRIAL IN DIPG
E. Izquierdo, Diana M. Carvalho, J. Boult, A. Mackay +10 more
2019Neuro-Oncology0 citations Open access
Semantic Scholar
Abstract 2976: Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin
S. Sharp, N. Chessum, J. Caldwell, M. Powers +12 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
PO-498 Quantifying the dynamics of acquired treatment resistance and evolutionary herding for the prediction of collateral sensitivity in cancer model systems
A. Acar, D. Nichol, P. Thavasu, I. Sagastume +6 more
2018ESMO Open0 citations Open access
Semantic Scholar
Abstract 3869: Phosphoproteomic-based identification of CDK8/CDK19 substrates in colorectal cancer
Olajumoke Popoola, Rahul S. Samant, M. Ortiz-Ruiz, A. Mallinger +12 more
20160 citations
Semantic Scholar
HSP-90 Inhibition is a Promising Therapeutic Strategy in Cholangiocarcinoma and MIR-21 may Serve as a Biomarker of Sensitivity
A. Lampis, L. Cascione, R. Burke, P. Clarke +13 more
20160 citations
Semantic Scholar
Abstract 1069: MiR-21 may serve as a predictive biomarker of response in the assessment of efficacy of HSP-90 inhibition in gastrointestinal (GI) cancers
A. Lampis, L. Cascione, R. Burke, P. Clarke +13 more
20160 citations
Semantic Scholar
Abstract 1775: Identification of small molecule inhibitors of HSF1 stress pathway activation in cancer cells
E. Billy, N. Chessum, R. T. Poele, Jennifer R. Smith +6 more
20140 citations
Semantic Scholar
Abstract A239: MPS1 (TTK) kinase inhibition selectively kills aneuploid cells
Teeara Rawjee, M. Rowlands, C. McAndrew, M. Stubbs +7 more
20090 citations
Semantic Scholar
Gastrin and CCK2 processing in neuroendocrine tumours and cell lines: Therapeutic targets
K. Khan, M. Stubbs, T. Shah, K. Savage +2 more
20060 citations
Semantic Scholar
CCK2 receptor as a potential target for therapy in leukaemia cell lines
M. Stubbs, K. Khan, G. Gungerang, A. Dhillon +1 more
20050 citations
Semantic Scholar
Expression of parathyroid hormone related protein and the PTH/PTHrP receptor in human pancreatic adenocarcinoma
M. Mcstay, K. Savage, M. Stubbs, K. Khan +2 more
20050 citations
Semantic Scholar
Specific targeting of CCK-2 receptor on gastric cancer cells with pentagastrin analogues
M. Stubbs, K. Khan, S. Watson, S. Grimes +6 more
20040 citations
Semantic Scholar
CCK2 receptor as a therapeutic target for neuroendocrine tumours
M. Stubbs, K. Khan, K. Savage, M. Mcstay +2 more
20030 citations
Semantic Scholar
Peptide targeting of CCK-2 receptor in hepatic and pancreatic tumour cell lines
M. Stubbs, K. Khan, S. Watson, S. Grimes +5 more
20030 citations Open access
Semantic Scholar

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