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C. Simard · SciRah

Researcher profile · Semantic Scholar

C. Simard

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C. Simard — researcher profile on SciRah

h-index: 18
Works: 39
Citations: 5,941

Most-cited papers

Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele
P. Middleton, M. Mall, P. Dřevínek, L. Lands +17 more
2019New England Journal of Medicine1,720 citations Open access
Semantic Scholar
Efficacy and safety of the elexacaftor/tezacaftor/ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial
H. Heijerman, E. McKone, D. Downey, E. Van Braeckel +16 more
2019The Lancet970 citations Open access
Semantic Scholar
Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del
J. Taylor-Cousar, A. Munck, E. McKone, C. K. van der Ent +8 more
2017New England Journal of Medicine672 citations Open access
Semantic Scholar
VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
D. Keating, Gautham Marigowda, L. Burr, C. Daines +16 more
2018New England Journal of Medicine636 citations Open access
Semantic Scholar
Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and Phe508del and a Residual Function Mutation
S. Rowe, C. Daines, F. Ringshausen, E. Kerem +9 more
2017New England Journal of Medicine431 citations Open access
Semantic Scholar
Disease progression in patients with cystic fibrosis treated with ivacaftor: Data from national US and UK registries.
N. Volkova, Kristin Moy, Jennifer Evans, D. Campbell +9 more
2020Journal of Cystic Fibrosis236 citations Open access
Semantic Scholar
VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
J. Davies, S. Moskowitz, C. Brown, A. Horsley +17 more
2018New England Journal of Medicine204 citations Open access
Semantic Scholar
Data from the US and UK cystic fibrosis registries support disease modification by CFTR modulation with ivacaftor
L. Bessonova, N. Volkova, M. Higgins, L. Bengtsson +9 more
2018Thorax194 citations Open access
Semantic Scholar
Flufenamic acid as an ion channel modulator
R. Guinamard, C. Simard, C. Del Negro
2013Pharmacology and Therapeutics153 citations Open access
Semantic Scholar
Molecular Genetics and Functional Anomalies in a Series of 248 Brugada Cases with 11 Mutations in the TRPM4 Channel
Hui Liu, S. Chatel, C. Simard, N. Syam +9 more
2013PLoS ONE150 citations Open access
Semantic Scholar
The non-selective monovalent cationic channels TRPM4 and TRPM5.
R. Guinamard, L. Sallé, C. Simard
2011Advances in Experimental Medicine and Biology93 citations
Semantic Scholar
Transient receptor potential melastatin 4 inhibitor 9‐phenanthrol abolishes arrhythmias induced by hypoxia and re‐oxygenation in mouse ventricle
C. Simard, L. Sallé, R. Rouet, R. Guinamard
2012British Journal of Pharmacology87 citations Open access
Semantic Scholar
The TRPM4 non-selective cation channel contributes to the mammalian atrial action potential.
C. Simard, T. Hof, Zakia Keddache, P. Launay +1 more
2013Journal of Molecular and Cellular Cardiology82 citations
Semantic Scholar
Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm.
T. Hof, C. Simard, R. Rouet, L. Sallé +1 more
2013Heart Rhythm77 citations
Semantic Scholar
TRPM4 in cardiac electrical activity.
R. Guinamard, P. Bouvagnet, T. Hof, Hui Liu +2 more
2015Cardiovascular Research74 citations
Semantic Scholar
Argon Exposure Induces Postconditioning in Myocardial Ischemia–Reperfusion
S. Lemoine, K. Blanchart, Mathieu Souplis, A. Lemaître +10 more
2017Journal of Cardiovascular Pharmacology and Therapeutics31 citations
Semantic Scholar
Molecular Genetics and Functional Anomalies in a Series of 248 Brugada Cases with 11 Mutations in the TRPM 4 Channel
Hui Liu, S. Chatel, C. Simard, N. Syam +9 more
201326 citations
Semantic Scholar
Epac activator critically regulates action potential duration by decreasing potassium current in rat adult ventricle.
F. Brette, Erick Blandin, C. Simard, R. Guinamard +1 more
2013Journal of Molecular and Cellular Cardiology25 citations
Semantic Scholar
TRPM4 non-selective cation channel in human atrial fibroblast growth
C. Simard, C. Magaud, Racim Adjlane, Quentin Dupas +5 more
2020Pflügers Archiv: European Journal of Physiology18 citations
Semantic Scholar
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Lionel Froux, A. Elbahnsi, Benjamin Boucherle, A. Billet +16 more
2020European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Proarrhythmic Effects of Aldosterone During Myocardial Ischemia–Reperfusion: Implication of the Sarcolemmal-KATP Channels
J. Alexandre, P. Puddu, C. Simard, T. Hof +6 more
2014Journal of Cardiovascular Pharmacology13 citations
Semantic Scholar
TRPM4 Participates in Aldosterone-Salt-Induced Electrical Atrial Remodeling in Mice
C. Simard, V. Ferchaud, L. Sallé, P. Milliez +3 more
2021Cells10 citations Open access
Semantic Scholar
Ion Channels in the Development and Remodeling of the Aortic Valve
C. Simard, Margaux Aize, S. Chaigne, Harlyne Mpweme Bangando +1 more
2023International Journal of Molecular Sciences5 citations Open access
Semantic Scholar
TRPM4 Participates in Irradiation-Induced Aortic Valve Remodeling in Mice
Harlyne Mpweme Bangando, C. Simard, Margaux Aize, Alexandre Lebrun +2 more
2022Cancers5 citations Open access
Semantic Scholar
PAR1 contribution in acute electrophysiological properties of oral anticoagulants in rabbit pulmonary vein sleeve preparations
J. Font, M. Simeon, C. Simard, S. Allouche +9 more
2018Fundamental & Clinical Pharmacology5 citations
Semantic Scholar
False-positive cannabinoid screens in adult cystic fibrosis patients treated with lumacaftor/ivacaftor.
D. Kissner, Yvette LeFlore, Srinivas B. Narayan, Gautham Marigowda +2 more
2018Journal of Cystic Fibrosis4 citations Open access
Semantic Scholar
IPD2.01 Disease progression in patients with CF treated with ivacaftor: analyses of real-world data from the US and UK CF Registries
N. Volkova, J. Evans, M. Higgins, D. Campbell +7 more
2018Journal of Cystic Fibrosis4 citations Open access
Semantic Scholar
EPAC1 and 2 inhibit K+ currents via PLC/PKC and NOS/PKG pathways in rat ventricular cardiomyocytes.
Arthur Boilève, Olivier Romito, T. Hof, Aurélia Levallois +7 more
2024American Journal of Physiology - Cell Physiology3 citations Open access
Semantic Scholar
P021 A phase 3, open-label study of tezacaftor/ivacaftor (TEZ/IVA) therapy: interim analysis of pooled safety, and efficacy in patients homozygous for F508del-CFTR
P. Flume, J. Lekstrom-Himes, R. Biner, C. Simard +4 more
2018Journal of Cystic Fibrosis3 citations Open access
Semantic Scholar
TRPM4 contribution in mouse uterine contractions.
Alexandre Fouchet, Harlyne Mpweme Bangando, Margaux Aize, C. Simard +1 more
2023Reproduction2 citations Open access
Semantic Scholar
WS15.6 A phase 3, open-label study of tezacaftor/ivacaftor (TEZ/IVA) therapy: interim analysis of pooled safety, and efficacy in patients heterozygous for F508del-CFTR and a residual function mutation
P. Flume, C. Owen, R. Biner, C. Simard +4 more
2018Journal of Cystic Fibrosis2 citations Open access
Semantic Scholar
IPD2.02 Real-world outcomes in patients with CF treated with ivacaftor: 2016 US and UK CF Registry analyses
N. Volkova, J. Evans, M. Higgins, D. Campbell +7 more
2018Journal of Cystic Fibrosis1 citations Open access
Semantic Scholar
EPS5.10 Real-world outcomes in patients (pts) with cystic fibrosis (CF) treated with ivacaftor (IVA): analysis of 2015 US and UK CF registry data
L. Bessonova, N. Volkova, M. Higgins, L. Bengtsson +6 more
20161 citations Open access
Semantic Scholar
TRPM4: New actor in osteogenic differentiation of human valvular interstitial cells
Margaux Aize, Harlyne Mpweme Bangando, Laura Brard, Arthur Boilève +6 more
2023Archives of Cardiovascular Diseases Supplements0 citations Open access
Semantic Scholar
Implication of TRPM4 ionic channel in osteogenic differentiation of human valvular interstitial cells
Margaux Aize, Harlyne Mpweme Bangando, Laura Brard, N. Perzo +2 more
2022Archives of Cardiovascular Diseases Supplements0 citations Open access
Semantic Scholar
TRPM4 in radiation-induced aortic valve remodeling
Harlyne Mpweme Bangando, C. Simard, Margaux Aize, Alexandre Lebrun +2 more
2022Archives of Cardiovascular Diseases Supplements0 citations Open access
Semantic Scholar
158 Background incidence of liver function test (LFT) abnormalities in patients (pts) with cystic fibrosis (CF)
V. Seliger, L. Bessonova, N. Volkova, C. Simard +1 more
20160 citations Open access
Semantic Scholar
Implication du canal cationique non-sélectif TRPM4 dans l'activité électrique cardiaque
C. Simard
20120 citations
Semantic Scholar
No apparent effect of Epac activation on Ca2+ dependent properties of L type Ca2+ current in rat ventricular myocytes.
L. Sall, C. Simard, R. Rouet, R. Guinamard +2 more
20100 citations
Semantic Scholar

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