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K. Knobeloch · SciRah

Researcher profile · Semantic Scholar

K. Knobeloch

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K. Knobeloch — researcher profile on SciRah

h-index: 50
Works: 127
Citations: 9,637

Most-cited papers

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, D. Bojkova +18 more
2020Nature1,007 citations Open access
Semantic Scholar
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions
Marius Schwabenland, Henrike Salié, J. Tanevski, Saskia Killmer +22 more
2021Immunity303 citations Open access
Semantic Scholar
Novel Hexb-based tools for studying microglia in the CNS
Takahiro Masuda, Lukas Amann, R. Sankowski, O. Staszewski +13 more
2020Nature Immunology257 citations
Semantic Scholar
Specification of CNS macrophage subsets occurs postnatally in defined niches
Takahiro Masuda, Lukas Amann, G. Monaco, R. Sankowski +26 more
2022Nature247 citations
Semantic Scholar
USP18 lack in microglia causes destructive interferonopathy of the mouse brain
Tobias Goldmann, N. Zeller, Jennifer L. Raasch, Katrin Kierdorf +19 more
2015EMBO Journal209 citations Open access
Semantic Scholar
Control of bone formation by the serpentine receptor Frizzled-9
J. Albers, Jochen Schulze, F. Beil, M. Gebauer +19 more
2011Journal of Cell Biology128 citations Open access
Semantic Scholar
Structural basis for the specificity of USP18 towards ISG15
A. Basters, P. Geurink, Annika Röcker, K. Witting +7 more
2017Nature Structural &Molecular Biology127 citations Open access
Semantic Scholar
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance
L. Ketscher, Ronny Hannß, D. Morales, A. Basters +9 more
2015Proceedings of the National Academy of Sciences of the United States of America122 citations Open access
Semantic Scholar
ISG15 counteracts Listeria monocytogenes infection
L. Radoshevich, F. Impens, D. Ribet, J. Quereda +7 more
2015eLife120 citations Open access
Semantic Scholar
Genetic targeting of microglia
P. Wieghofer, K. Knobeloch, M. Prinz
2015Glia117 citations
Semantic Scholar
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
Fabien Théry, Lia Martina, Caroline Asselman, Yifeng Zhang +22 more
2021Nature Communications114 citations Open access
Semantic Scholar
IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system.
Jennifer L. Raasch, N. Zeller, G. van Loo, D. Merkler +13 more
2011Brain : a journal of neurology107 citations Open access
Semantic Scholar
STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling
Andreas Begitt, Mathias Droescher, T. Meyer, C. Schmid +7 more
2014Nature Immunology103 citations Open access
Semantic Scholar
Ubiquitin-Like Protein ISG15 (Interferon-Stimulated Gene of 15 kDa) in Host Defense Against Heart Failure in a Mouse Model of Virus-Induced Cardiomyopathy
A. Rahnefeld, K. Klingel, Anett Schuermann, N. Diny +13 more
2014Circulation102 citations Open access
Semantic Scholar
The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
Yifeng Zhang, Fabien Théry, Nicholas C. Wu, Emma K. Luhmann +10 more
2019Nature Communications98 citations Open access
Semantic Scholar
USP18 – a multifunctional component in the interferon response
A. Basters, K. Knobeloch, G. Fritz
2018Bioscience Reports91 citations Open access
Semantic Scholar
USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation
S. Torre, Maria J. Polyak, D. Langlais, Nassima Fodil +17 more
2016Nature Immunology89 citations
Semantic Scholar
A comparative analysis of microglial inducible Cre lines
Travis E. Faust, Philip A. Feinberg, Ciara O’Connor, Riki Kawaguchi +10 more
2023bioRxiv80 citations Open access
Semantic Scholar
Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity
Katrin Peschke, M. Achleitner, Kathrin Frenzel, A. Gerbaulet +14 more
2016Journal of Immunology80 citations Open access
Semantic Scholar
SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.
Andreas Begitt, Mathias Droescher, K. Knobeloch, U. Vinkemeier
2011Blood80 citations Open access
Semantic Scholar
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells
Almut Dufner, Agnes Kisser, S. Niendorf, A. Basters +12 more
2015Nature Immunology77 citations Open access
Semantic Scholar
HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia
Albino Troilo, Irina Alexander, Sarah Muehl, Daniela Jaramillo +2 more
2013EMBO Reports77 citations Open access
Semantic Scholar
Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS
A. Dann, H. Poeck, A. Croxford, S. Gaupp +13 more
2011Nature Neuroscience75 citations
Semantic Scholar
Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage
M. C. Raso, Nikola Djoric, Franziska Walser, S. Hess +4 more
2020Journal of Cell Biology68 citations Open access
Semantic Scholar
Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions
Almut Dufner, K. Knobeloch
2019Biochemical Society Transactions62 citations Open access
Semantic Scholar
Molecular characterization of ubiquitin‐specific protease 18 reveals substrate specificity for interferon‐stimulated gene 15
A. Basters, P. Geurink, F. El Oualid, L. Ketscher +5 more
2014The FEBS Journal58 citations
Semantic Scholar
Strategies to Target ISG15 and USP18 Toward Therapeutic Applications
Daniel Jiménez Fernández, S. Hess, K. Knobeloch
2020Frontiers in Chemistry55 citations Open access
Semantic Scholar
Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing
Jun-Bao Fan, S. Miyauchi, Hui Xu, Dan Liu +12 more
2020Cancer Discovery55 citations Open access
Semantic Scholar
mHERC6 is the essential ISG15 E3 ligase in the murine system.
L. Ketscher, A. Basters, M. Prinz, K. Knobeloch
2012Biochemical and Biophysical Research Communications - BBRC53 citations
Semantic Scholar
ISG15 Regulates Peritoneal Macrophages Functionality against Viral Infection
E. Yángüez, A. García-Culebras, A. Frau, C. Llompart +6 more
2013PLoS Pathogens50 citations Open access
Semantic Scholar
Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming
Meike Kespohl, Clara Bredow, K. Klingel, M. Voss +15 more
2020Science Advances47 citations Open access
Semantic Scholar
Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds.
S. Brunner, S. Skosyrski, R. Kirschner-Schwabe, K. Knobeloch +6 more
2010Investigative Ophthalmology and Visual Science46 citations Open access
Semantic Scholar
Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator.
Berati Cerikan, R. Shaheen, G. Coló, C. Gläßer +5 more
2016Developmental Cell44 citations Open access
Semantic Scholar
Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection
Anna Napolitano, A. G. van der Veen, Monique Bunyan, A. Borg +7 more
2018Journal of Immunology41 citations Open access
Semantic Scholar
Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis
Maximilian Frosch, Takashi Shimizu, Emile Wogram, Lukas Amann +18 more
2025Nature39 citations Open access
Semantic Scholar
Type I Interferons as Ambiguous Modulators of Chronic Inflammation in the Central Nervous System
M. Prinz, K. Knobeloch
2012Front. Immun.36 citations Open access
Semantic Scholar
Post-translational control of T cell development by the ESCRT protein CHMP5
S. Adoro, K. H. Park, Sarah Bettigole, R. Lis +6 more
2017Nature Immunology33 citations Open access
Semantic Scholar
ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection
Clara Bredow, Fabien Théry, E. Wirth, Sarah Ochs +19 more
2024Cardiovascular Research31 citations Open access
Semantic Scholar
IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell–Dependent Route
Victoria Iglesias-Guimarais, T. Ahrends, E. de Vries, K. Knobeloch +2 more
2020Journal of Immunology31 citations Open access
Semantic Scholar
A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
S. Klein-Hessling, Ronald Rudolf, K. Muhammad, K. Knobeloch +9 more
2016Nature Communications30 citations Open access
Semantic Scholar
The probacterial effect of type I interferon signaling requires its own negative regulator USP18
N. Shaabani, N. Honke, N. Nguyen, Zhe Huang +8 more
2018Science immunology28 citations Open access
Semantic Scholar
USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism
Jin Gan, Adán Pinto-Fernández, D. Flierman, J. J. Akkermans +12 more
2023Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
Semantic Scholar
How USP18 deals with ISG15‐modified proteins: structural basis for the specificity of the protease
A. Basters, K. Knobeloch, G. Fritz
2018The FEBS Journal25 citations
Semantic Scholar
Evidence for an involvement of the ubiquitin‐like modifier ISG15 in MHC class I antigen presentation
Tobias Held, M. Basler, K. Knobeloch, M. Groettrup
2020European Journal of Immunology21 citations Open access
Semantic Scholar
ISG15 Modulates Development of the Erythroid Lineage
A. Maragno, M. Pironin, Hélène Alcalde, Xiuli Cong +5 more
2011PLoS ONE21 citations Open access
Semantic Scholar
High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system
A. Basters, L. Ketscher, E. Deuerling, C. Arkona +3 more
2012BMC Biotechnology20 citations Open access
Semantic Scholar
Inhibition of papain-like protease PLpro blocks SARS-CoV-2 spread and promotes anti-viral immunity
Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, D. Bojkova +16 more
202019 citations Open access
Semantic Scholar
DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node
C. Curato, B. Bernshtein, E. Zupančič, Almut Dufner +9 more
2019Frontiers in Immunology19 citations Open access
Semantic Scholar
Loss of USP18 in microglia induces white matter pathology
Marius Schwabenland, Omar Mossad, Adam G. Peres, Franziska Kessler +11 more
2019Acta Neuropathologica Communications19 citations Open access
Semantic Scholar
Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling
Sachin Chaugule, Jung-Min Kim, Yeon-Suk Yang, K. Knobeloch +2 more
2021International Journal of Molecular Sciences17 citations Open access
Semantic Scholar

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M. Prinz×13
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M. Prinz — researcher profile on SciRah
A. Basters×9
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A. Basters — researcher profile on SciRah
L. Ketscher×6
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L. Ketscher — researcher profile on SciRah
G. Fritz×6
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H. Ovaa — researcher profile on SciRah

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A. Beling — researcher profile on SciRah

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Lukas Amann — researcher profile on SciRah

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