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J. Coyle · SciRah

Researcher profile · Semantic Scholar

J. Coyle

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J. Coyle — researcher profile on SciRah

h-index: 21
Works: 50
Citations: 2,633

Most-cited papers

Serine is a natural ligand and allosteric activator of pyruvate kinase M2
B. Chaneton, Petra Hillmann, Liang Zheng, Agnés C. L. Martin +9 more
2012Nature651 citations Open access
Semantic Scholar
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
T. G. Davies, W. Wixted, J. Coyle, C. Griffiths-Jones +21 more
2016Journal of Medicinal Chemistry272 citations Open access
Semantic Scholar
Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
A. Woodhead, H. Angove, M. Carr, G. Chessari +24 more
2010Journal of Medicinal Chemistry251 citations
Semantic Scholar
Crystal structure of human CDK4 in complex with a D-type cyclin
P. Day, A. Cleasby, I. Tickle, M. O'Reilly +7 more
2009Proceedings of the National Academy of Sciences of the United States of America232 citations Open access
Semantic Scholar
Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.
C. Murray, M. Carr, O. Callaghan, G. Chessari +14 more
2010Journal of Medicinal Chemistry179 citations Open access
Semantic Scholar
Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding.
J. Coyle, S. Qamar, K. Rajashankar, D. Nikolov
2002Neuron153 citations Open access
Semantic Scholar
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
S. Saalau-Bethell, A. Woodhead, G. Chessari, M. Carr +9 more
2012Nature Chemical Biology108 citations Open access
Semantic Scholar
Higher Throughput Calorimetry: Opportunities, Approaches and Challenges
F. Torres, M. Recht, J. Coyle, R. Bruce +1 more
2010Current Opinion in Structural Biology99 citations Open access
Semantic Scholar
The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non‐small cell lung cancer
B. Graham, J. Curry, T. Smyth, L. Fazal +10 more
2012Cancer Science82 citations Open access
Semantic Scholar
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
T. Heightman, J. Callahan, E. Chiarparin, J. Coyle +18 more
2019Journal of Medicinal Chemistry78 citations Open access
Semantic Scholar
GroEL accelerates the refolding of hen lysozyme without changing its folding mechanism
J. Coyle, F. Texter, A. Ashcroft, Dimitris Masselos +2 more
1999Nature Structural Biology69 citations
Semantic Scholar
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.
C. Murray, V. Berdini, I. Buck, M. E. Carr +17 more
2015ACS Medicinal Chemistry Letters61 citations Open access
Semantic Scholar
Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
D. Tisi, E. Chiarparin, E. Tamanini, P. Pathuri +20 more
2016ACS Chemical Biology58 citations
Semantic Scholar
Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket
Susanne M. Saalau-Bethell, V. Berdini, A. Cleasby, M. Congreve +9 more
2014ChemMedChem38 citations Open access
Semantic Scholar
GABARAP: Lessons for Synaptogenesis
J. Coyle, D. Nikolov
2003The Neuroscientist37 citations
Semantic Scholar
Applied Biophysical Methods in Fragment-Based Drug Discovery
J. Coyle, R. Walser
2020SLAS discovery : advancing life sciences R & D35 citations Open access
Semantic Scholar
Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain
A. Ashcroft, A. Brinker, J. Coyle, F. Weber +7 more
2002Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.
Christopher N. Johnson, V. Berdini, Lijs Beke, P. Bonnet +16 more
2015ACS Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.
Christopher N. Johnson, C. Adelinet, V. Berdini, Lijs Beke +17 more
2015ACS Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
A. Woolford, P. Day, Véronique Bénéton, V. Berdini +17 more
2016Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate.
Agni F. M. Gavriilidou, F. Holding, Daniel C. Mayer, J. Coyle +2 more
2018Biochemistry24 citations Open access
Semantic Scholar
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
A. Woolford, Joseph E. Pero, Sridhar Aravapalli, V. Berdini +25 more
2016Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
T. Heightman, V. Berdini, L. Bevan, I. Buck +31 more
2021Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins
Agni F. M. Gavriilidou, F. Holding, J. Coyle, R. Zenobi
2018SLAS discovery : advancing life sciences R & D15 citations Open access
Semantic Scholar
Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase from Erwinia chrysanthemi.
T. Krell, J. Coyle, M. Horsburgh, J. R. Coggins +1 more
1997Acta Crystallographica Section D: Biological Crystallography12 citations
Semantic Scholar
Identification of orally bioavailable small-molecule inhibitors of hematopoietic prostaglandin D2 synthase using X-ray fragment based drug discovery
G. Saxty, D. Norton, K. Affleck, D. Clapham +18 more
20147 citations
Semantic Scholar
Structural Plasticity and Non-Covalent Substrate Binding in the GroEL Apical Domain: A Study using Electrospray Ionisation Mass Spectrometry and Fluorescence Binding Studies
A. Ashcroft, A. Brinker, J. Coyle, F. Weber +9 more
20027 citations
Semantic Scholar
NMR backbone resonance assignment and solution secondary structure determination of human NSD1 and NSD2
N. Amin, D. Nietlispach, S. Qamar, J. Coyle +2 more
2016Biomolecular NMR Assignments6 citations Open access
Semantic Scholar
1H, 15N and 13C backbone assignments of GDP-bound human H-Ras mutant G12V
N. Amin, E. Chiarparin, J. Coyle, D. Nietlispach +1 more
2015Biomolecular NMR Assignments4 citations
Semantic Scholar
Abstract 2944: AT-IAP, a dual cIAP1 and XIAP antagonist with oral antitumor activity in melanoma models.
G. Chessari, A. María, I. Buck, E. Chiarparin +27 more
20133 citations
Semantic Scholar
Fragment-based drug discovery applied to heat shock protein 90 (HSP90)
P. Pathuri, G. Chessari, M. Carr, M. Congreve +13 more
20111 citations Open access
Semantic Scholar
Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.
T. G. Davies, W. Wixted, J. Coyle, C. Griffiths-Jones +21 more
20160 citations
Semantic Scholar
Identification of novel allosteric inhibitors through Fragment-Based Drug Discovery and X-ray crystallography
P. Pathuri, Susanne M. Saalau-Bethell, A. Woodhead, V. Berdini +17 more
20150 citations Open access
Semantic Scholar
Structure of MELK in complex with inhibitors
Christopher N. Johnson, V. Berdini, Lijs Beke, P. Bonnet +16 more
20140 citations
Semantic Scholar
Corrigendum: Serine is a natural ligand and allosteric activator of pyruvate kinase M2
B. Chaneton, Petra Hillmann, Liang Zheng, Agnés C. L. Martin +9 more
2013Nature0 citations Open access
Semantic Scholar
Discovery of novel allosteric inhibitors of HCV NS3/4a enzyme via structure-based drug design
P. Pathuri, S. Saalau-Bethell, A. Woodhead, M. Carr +19 more
20120 citations Open access
Semantic Scholar
human PKM2 with L-serine and FBP bound.
B. Chaneton, P. Hillmann, Liang Zheng, A. C. Martin +9 more
20120 citations
Semantic Scholar
871 FRAGMENT BASED DISCOVERY AND GENOTYPIC PROFILING OF A SERIES OF DIRECT ACTING ANTIVIRAL AGENTS WITH A NOVEL MODE OF ACTION
S. Saalau-Bethell, A. Woodhead, B. Graham, C. Richardson +12 more
20120 citations
Semantic Scholar
Discovery of AT26893, a novel allosteric inhibitor of the regulation of HCV NS3/4a protein function
N. Wilsher, M. Carr, J. Coyle, L. Fazal +15 more
20120 citations
Semantic Scholar
Structure of HSP90 with an inhibitor bound
C. Murray, M. Carr, O. Callaghan, G. Chessari +14 more
20100 citations
Semantic Scholar
592 Characterisation of novel, small molecule antagonists of XIAP, cIAP1 and cIAP2 generated by fragment based drug discovery (FBDD)
G. Ward, G. Chessari, A. Woolford, P. Williams +6 more
20100 citations
Semantic Scholar
Abstract 5778: Fragment-based drug discovery of selective inhibitors of fibroblast growth factor receptor (FGFr)
G. Saxty, M. Squires, C. Murray, V. Berdini +18 more
20100 citations
Semantic Scholar
Structure of HSP90 with small molecule inhibitor bound
C. Murray, M. Carr, O. Callaghan, G. Chessari +14 more
20100 citations
Semantic Scholar
Abstract A211: Fragment‐based drug discovery of the synthetic small molecule HSP90 inhibitor AT13387
C. Murray, M. Carr, G. Chessari, M. Congreve +12 more
20090 citations
Semantic Scholar
Abstract A1: The physiological form of MetAP2 can be inhibited through binding to either of the two active‐site metals
N. Wallis, V. Berdini, G. Besong, G. Chessari +9 more
20090 citations
Semantic Scholar
Structure cristalline d'adenylate cyclase humaine soluble
S. Saalau-Bethell, A. Cleasby, T. Sambrook, J. Coyle +1 more
20060 citations
Semantic Scholar
Gro-EL Fragment (Apical Domain) Comprising Residues 188-379
A. Ashcroft, A. Brinker, J. Coyle, F. Weber +7 more
20020 citations
Semantic Scholar
An Investigation into the Properties of a Chaperone Domain and Analysis of the Non-covalently Bound Complexes with Peptide Substrates using Mass Spectrometry
A. Ashcroft, S. Radford, J. Coyle, M. Pitkeathly +1 more
20000 citations
Semantic Scholar
Abolition of the fast track of lysozyme folding at neutral pH.
F. Texter, J. Coyle, S. K. Kulkarni, C. Robinson +1 more
19970 citations
Semantic Scholar
Crystallographic studies on shikimate kinase from Erwinia chrysanthemi
A. Lapthorn, T. Krell, J. Coyle, J. Coggins
19960 citations Open access
Semantic Scholar

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