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P. Pathuri · SciRah

Researcher profile · Semantic Scholar

P. Pathuri

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P. Pathuri — researcher profile on SciRah

h-index: 9
Works: 26
Citations: 390

Most-cited papers

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
S. Saalau-Bethell, A. Woodhead, G. Chessari, M. Carr +9 more
2012Nature Chemical Biology108 citations Open access
Semantic Scholar
Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
D. Tisi, E. Chiarparin, E. Tamanini, P. Pathuri +20 more
2016ACS Chemical Biology58 citations
Semantic Scholar
Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
T. Heightman, V. Berdini, Hannah Braithwaite, I. Buck +32 more
2018Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
Crystal structure of metastasis-associated protein S100A4 in the active calcium-bound form.
P. Pathuri, L. Vogeley, H. Luecke
2008Journal of Molecular Biology42 citations Open access
Semantic Scholar
Fragment-to-Lead Medicinal Chemistry Publications in 2022.
A. Woodhead, Daniel A. Erlanson, I. D. de Esch, R. Holvey +2 more
2024Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Fragment-based discovery of 6-azaindazoles as inhibitors of bacterial DNA ligase.
S. Howard, N. Amin, Andrew B. Benowitz, E. Chiarparin +15 more
2014ACS Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Apo and calcium-bound crystal structures of cytoskeletal protein alpha-14 giardin (annexin E1) from the intestinal protozoan parasite Giardia lamblia.
P. Pathuri, E. Nguyen, G. Ozorowski, S. Svärd +1 more
2009Journal of Molecular Biology20 citations
Semantic Scholar
Apo and calcium-bound crystal structures of Alpha-11 giardin, an unusual annexin from Giardia lamblia.
P. Pathuri, E. Nguyen, S. Svärd, H. Luecke
2007Journal of Molecular Biology20 citations Open access
Semantic Scholar
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
T. Heightman, V. Berdini, L. Bevan, I. Buck +31 more
2021Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function
S. Sharp, Marianna Martella, Sabrina D’Agostino, Christopher I. Milton +21 more
2024Nature Communications6 citations Open access
Semantic Scholar
Selecting the Right Targets for Fragment‐Based Drug Discovery
T. G. Davies, H. Jhoti, P. Pathuri, G. Williams
20163 citations
Semantic Scholar
Expression, purification, crystallization and preliminary X-ray diffraction analysis of alpha-11 giardin from Giardia lamblia.
P. Pathuri, E. Nguyen, H. Luecke
2006Acta Crystallographica. Section F : Structural Biology and Crystallization Communications3 citations Open access
Semantic Scholar
Structural Biology and Anticancer Drug Design
P. Pathuri, D. Norton, H. Willems, D. Tisi +1 more
20142 citations
Semantic Scholar
Abstract B161: Fragment-based discovery of a highly potent, orally bioavailable ERK1/2 inhibitor that modulates the phosphorylation and catalytic activity of ERK1/2
T. Heightman, V. Berdini, Hannah Braithwaite, I. Buck +27 more
20181 citations
Semantic Scholar
Fragment-based drug discovery applied to heat shock protein 90 (HSP90)
P. Pathuri, G. Chessari, M. Carr, M. Congreve +13 more
20111 citations Open access
Semantic Scholar
Abstract 5902: Targeting MAPK-driven tumors via inhibition of MAP2K4
Mark Wade, E. Tamanini, Mathieu Unbekandt, Nicola G. Wallis +9 more
2024Cancer Research0 citations
Semantic Scholar
Abstract B154: Characterization of a novel ERK1/2 inhibitor, which modulates the phosphorylation and catalytic activity of ERK1/2
J. Munck, V. Berdini, L. Bevan, Hannah Braithwaite +33 more
20180 citations
Semantic Scholar
Identification of novel allosteric inhibitors through Fragment-Based Drug Discovery and X-ray crystallography
P. Pathuri, Susanne M. Saalau-Bethell, A. Woodhead, V. Berdini +17 more
20150 citations Open access
Semantic Scholar
Structure of Bacterial DNA Ligase with small-molecule ligand pyrimidin-2-amine (AT371) in an alternate binding site.
H. Jhoti, R. F. Ludlow, P. Pathuri, H. Saini +4 more
20150 citations
Semantic Scholar
Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 2-(1-methyl-1H-indol-3-yl)acetic acid (AT3437) in an alternate binding site.
H. Jhoti, R. F. Ludlow, H. Saini, I. Tickle +3 more
20150 citations
Semantic Scholar
Discovery of novel allosteric inhibitors of HCV NS3/4a enzyme via structure-based drug design
P. Pathuri, S. Saalau-Bethell, A. Woodhead, M. Carr +19 more
20120 citations Open access
Semantic Scholar
Crystal Structure of Alpha-14 Giardin
P. Pathuri, H. Luecke
20090 citations
Semantic Scholar
Crystal Structure of Alpha-14 Giardin with magnesium bound
P. Pathuri, H. Luecke
20090 citations
Semantic Scholar
Calcium bound structure of alpha-14 giardin
P. Pathuri, H. Luecke
20090 citations
Semantic Scholar
Crystal Structure of Alpha-11 Giardin
P. Pathuri, E. Nguyen, H. Luecke
20070 citations
Semantic Scholar
Calcium bound structure of alpha-11 giardin
P. Pathuri, E. Nguyen, H. Luecke
20070 citations
Semantic Scholar

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