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M. Brattain · SciRah

Researcher profile · Semantic Scholar

M. Brattain

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M. Brattain — researcher profile on SciRah

h-index: 65
Works: 319
Citations: 13K

Most-cited papers

The maximal size of protein to diffuse through the nuclear pore is larger than 60 kDa
Ruiwen Wang, M. Brattain
2007FEBS Letters258 citations Open access
Semantic Scholar
Characterization of HCT116 human colon cancer cells in an orthotopic model.
A. Rajput, Ivan Dominguez San Martin, R. Rose, A. Beko +6 more
2008Journal of Surgical Research181 citations
Semantic Scholar
Cell Survival and Metastasis Regulation by Akt Signalling in Colorectal Cancer
E. Agarwal, M. Brattain, S. Chowdhury
2013Cellular Signalling167 citations Open access
Semantic Scholar
MicroRNA-192 Suppresses Liver Metastasis of Colon Cancer
Li-Ying Geng, A. Chaudhuri, G. Talmon, J. Wisecarver +3 more
2013Oncogene135 citations Open access
Semantic Scholar
Trichostatin A Induces Transforming Growth Factor β Type II Receptor Promoter Activity and Acetylation of Sp1 by Recruitment of PCAF/p300 to a Sp1·NF-Y Complex*
Weiqi Huang, Shu-Jie Zhao, S. Ammanamanchi, M. Brattain +2 more
2005Journal of Biological Chemistry133 citations Open access
Semantic Scholar
Activated Akt and Erk Expression and Survival After Surgery in Pancreatic Carcinoma
K. Chadha, T. Khoury, Jihnhee Yu, J. Black +5 more
2006Annals of Surgical Oncology125 citations
Semantic Scholar
Role of the Survivin gene in pathophysiology.
Feng-Zhi Li, M. Brattain
2006American Journal of Pathology117 citations Open access
Semantic Scholar
Suppression of survivin promoter activity by YM155 involves disruption of Sp1-DNA interaction in the survivin core promoter.
Q. Cheng, X. Ling, A. Haller, Takahito Nakahara +6 more
2012International Journal of Biochemistry and Molecular Biology103 citations
Semantic Scholar
Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis.
Yun-Fei Zhou, Song Li, Y. Hu, Jing Wang +7 more
2006Cancer Research99 citations Open access
Semantic Scholar
Sumoylation Inhibits Cleavage of Sp1 N-terminal Negative Regulatory Domain and Inhibits Sp1-dependent Transcription*
M. Spengler, M. Brattain
2006Journal of Biological Chemistry97 citations Open access
Semantic Scholar
A Phase I Pharmacokinetic and Pharmacodynamic Study of Intravenous Calcitriol in Combination with Oral Gefitinib in Patients with Advanced Solid Tumors
M. Fakih, D. Trump, J. Muindi, J. Black +7 more
2007Clinical Cancer Research96 citations Open access
Semantic Scholar
Integrin α2-mediated ERK and Calpain Activation Play a Critical Role in Cell Adhesion and Motility via Focal Adhesion Kinase Signaling
R. S. Sawhney, M. Cookson, Yasin Omar, J. Hauser +1 more
2006Journal of Biological Chemistry96 citations Open access
Semantic Scholar
Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells.
Jing Wang, Li-Min Yang, Jun-Hua Yang, Karen K. Kuropatwinski +4 more
2008Cancer Research88 citations Open access
Semantic Scholar
Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer
E. Agarwal, A. Chaudhuri, Premila D Leiphrakpam, Katie L Haferbier +2 more
2014BMC Cancer87 citations Open access
Semantic Scholar
Heterogeneity of Receptor Function in Colon Carcinoma Cells Determined by Crosstalk between IGF1R and EGFR
Y. Hu, S. Patil, Michelle Panasiewicz, Wen-hui Li +3 more
2008Cancer Research78 citations Open access
Semantic Scholar
Knockdown of Ron Kinase Inhibits Mutant Phosphatidylinositol 3-Kinase and Reduces Metastasis in Human Colon Carcinoma*
Jing Wang, A. Rajput, Julie L. C. Kan, R. Rose +12 more
2009Journal of Biological Chemistry77 citations Open access
Semantic Scholar
AKT can be activated in the nucleus.
Ruiwen Wang, M. Brattain
2006Cellular Signalling75 citations
Semantic Scholar
A NOVEL ROLE OF ERK5 IN INTEGRIN-MEDIATED CELL ADHESION AND MOTILITY IN CANCER CELLS VIA FAK SIGNALING
R. S. Sawhney, Wensheng Liu, M. Brattain
2009Journal of Cellular Physiology71 citations Open access
Semantic Scholar
Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model.
Xiao-Ning Guo, A. Rajput, R. Rose, J. Hauser +6 more
2007Cancer Research67 citations Open access
Semantic Scholar
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis
Jing Wang, Karen K. Kuropatwinski, J. Hauser, M. Rossi +7 more
2007Molecular Cancer Therapeutics65 citations Open access
Semantic Scholar
Differential regulation of survivin expression and apoptosis by vitamin D3 compounds in two isogenic MCF-7 breast cancer cell sublines
Feng-Zhi Li, X. Ling, Huayi Huang, L. Brattain +4 more
2005Oncogene60 citations Open access
Semantic Scholar
Smad4-dependent TGF-β Signaling Suppresses RON Receptor Tyrosine Kinase-dependent Motility and Invasion of Pancreatic Cancer Cells*
Shu-Jie Zhao, S. Ammanamanchi, M. Brattain, Lin Cao +3 more
2008Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Dual inhibitors of PI3K/mTOR or mTOR-selective inhibitors: which way shall we go?
D. Sabbah, M. Brattain, Hai-Zhen A. Zhong
2011Current Medicinal Chemistry54 citations
Semantic Scholar
A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo.
A. Rajput, A. Koterba, J. Kreisberg, J. Foster +2 more
2007Cancer Research53 citations
Semantic Scholar
Akt expression may predict favorable prognosis in cholangiocarcinoma
M. Javle, Jihnhee Yu, T. Khoury, K. Chadha +7 more
2006Journal of Gastroenterology and Hepatology51 citations
Semantic Scholar
Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation
M. Spengler, Li-Wu Guo, M. Brattain
2008Cell Cycle47 citations Open access
Semantic Scholar
Synergy of epidermal growth factor receptor kinase inhibitor AG1478 and ErbB2 kinase inhibitor AG879 in human colon carcinoma cells is associated with induction of apoptosis.
Yun-Fei Zhou, M. Brattain
2005Cancer Research47 citations Open access
Semantic Scholar
Ezrin expression and cell survival regulation in colorectal cancer
Premila D Leiphrakpam, A. Rajput, M. Mathiesen, E. Agarwal +4 more
2014Cellular Signalling44 citations Open access
Semantic Scholar
Identification of a Novel TGFβ/PKA Signaling Transduceome in Mediating Control of Cell Survival and Metastasis in Colon Cancer
S. Chowdhury, G. Howell, A. Rajput, Carol A. Teggart +4 more
2011PLoS ONE44 citations Open access
Semantic Scholar
Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis
E. Agarwal, Caroline M. Robb, L. Smith, M. Brattain +3 more
2017Oncogene40 citations Open access
Semantic Scholar
In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer
Premila D Leiphrakpam, E. Agarwal, M. Mathiesen, Katie L Haferbier +2 more
2013Oncology Report37 citations Open access
Semantic Scholar
Histone Deacetylase Inhibitor Belinostat Represses Survivin Expression through Reactivation of Transforming Growth Factor β (TGFβ) Receptor II Leading to Cancer Cell Death*
S. Chowdhury, G. Howell, Carol A. Teggart, Aparajita Chowdhury +3 more
2011Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism.
M. Spengler, Sarah B. Kennett, K. Scott Moorefield, Steven O. Simmons +2 more
2005Cellular Signalling36 citations
Semantic Scholar
TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells
Katie L. Bailey, E. Agarwal, S. Chowdhury, Jiang-Tao Luo +3 more
2017PLoS ONE35 citations Open access
Semantic Scholar
AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival
K. Fisher, Binita Das, Hyun Seok Kim, B. Clymer +9 more
2015Molecular and Cellular Biology35 citations Open access
Semantic Scholar
Selective Inhibition of Histone Deacetylases 1/2/6 in Combination with Gemcitabine: A Promising Combination for Pancreatic Cancer Therapy
Richard S Laschanzky, L. Humphrey, Jih-Yun Ma, L. Smith +9 more
2019Cancers34 citations Open access
Semantic Scholar
Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases
D. Sabbah, Neka A. Simms, M. Brattain, J. Vennerstrom +1 more
2011Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα).
D. Sabbah, Neka A. Simms, Wang Wang, Yuxiang Dong +4 more
2012Bioorganic & Medicinal Chemistry30 citations
Semantic Scholar
Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy
Caroline M. Robb, Smit Kour, Jacob I. Contreras, E. Agarwal +13 more
2017OncoTarget29 citations Open access
Semantic Scholar
Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines
S. Chowdhury, Melanie Ongchin, Elizabeth A Sharratt, I. Dominguez +3 more
2013PLoS ONE29 citations Open access
Semantic Scholar
Reorganization of ErbB Family and Cell Survival Signaling after Knock-down of ErbB2 in Colon Cancer Cells*
Y. Hu, S. Venkateswarlu, N. Sergina, G. Howell +7 more
2005Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Restoration of PTEN Activity Decreases Metastases in an Orthotopic Model of Colon Cancer
S. Chowdhury, Melanie Ongchin, G. Wan, Elizabeth A Sharratt +2 more
2010Journal of Surgical Research26 citations Open access
Semantic Scholar
Ron Knockdown and Ron Monoclonal Antibody IMC-RON8 Sensitize Pancreatic Cancer to Histone Deacetylase Inhibitors (HDACi)
Y. Zou, G. Howell, L. Humphrey, Jing Wang +1 more
2013PLoS ONE25 citations Open access
Semantic Scholar
Differential PKA activation and AKAP association determines cell fate in cancer cells
E. Hedrick, E. Agarwal, Premila D Leiphrakpam, Katie L Haferbier +2 more
2013Journal of Molecular Signaling22 citations Open access
Semantic Scholar
TGFβ and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells
Premila D Leiphrakpam, M. Brattain, J. Black, Jing Wang
2018Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Establishment and Validation of an Orthotopic Metastatic Mouse Model of Colorectal Cancer
A. Rajput, E. Agarwal, Premila D Leiphrakpam, M. Brattain +1 more
2013ISRN Hepatology17 citations Open access
Semantic Scholar
Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells
Neka A. Simms, A. Rajput, Elizabeth A Sharratt, Melanie Ongchin +3 more
2012BMC Cancer16 citations Open access
Semantic Scholar
Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer
Premila D Leiphrakpam, A. Lazenby, S. Chowdhury, L. Smith +5 more
2019Journal of Surgical Oncology15 citations Open access
Semantic Scholar
The effects of epidermal growth factor receptor activation and attenuation of the TGFbeta pathway in an orthotopic model of colon cancer.
Melanie Ongchin, Elizabeth A Sharratt, I. Dominguez, Neka A. Simms +5 more
2009Journal of Surgical Research15 citations
Semantic Scholar
Stathmin expression in metastatic colorectal cancer
Premila D Leiphrakpam, A. Lazenby, L. Smith, M. Brattain +1 more
2021Journal of Surgical Oncology14 citations
Semantic Scholar

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A. Rajput×11
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E. Agarwal×9
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Premila D Leiphrakpam×8

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Elizabeth A Sharratt×6

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