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Hedwich F. Kuipers · SciRah

Researcher profile · Semantic Scholar

Hedwich F. Kuipers

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Hedwich F. Kuipers — researcher profile on SciRah

h-index: 19
Works: 50
Citations: 1,756

Most-cited papers

4-Methylumbelliferone Treatment and Hyaluronan Inhibition as a Therapeutic Strategy in Inflammation, Autoimmunity, and Cancer
N. Nagy, Hedwich F. Kuipers, Adam R. Frymoyer, Heather D. Ishak +3 more
2015Frontiers in Immunology263 citations Open access
Semantic Scholar
Common variants in P2RY11 are associated with narcolepsy
B. Kornum, Minae Kawashima, J. Faraco, Ling Lin +56 more
2010Nature Genetics229 citations Open access
Semantic Scholar
Transcriptional regulation of antigen presentation.
P. J. van den Elsen, T. Holling, Hedwich F. Kuipers, N. van der Stoep
2004Current Opinion in Immunology200 citations
Semantic Scholar
CX3CL1 and CX3CR1 Expression in Human Brain Tissue: Noninflammatory Control versus Multiple Sclerosis
S. Hulshof, E. V. van Haastert, Hedwich F. Kuipers, P. J. van den Elsen +4 more
2003Journal of Neuropathology and Experimental Neurology97 citations
Semantic Scholar
Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of Amyloid-β in Th1- and Th17-Versions of Experimental Autoimmune Encephalomyelitis
Jacqueline L. Grant, E. Ghosn, R. Axtell, Katja Herges +6 more
2012Science Translational Medicine95 citations Open access
Semantic Scholar
Statins affect cell-surface expression of major histocompatibility complex class II molecules by disrupting cholesterol-containing microdomains.
Hedwich F. Kuipers, P. Biesta, T. Groothuis, J. Neefjes +2 more
2005Human Immunology93 citations Open access
Semantic Scholar
Hyaluronan in Autoimmunity and Immune Dysregulation
N. Nagy, Hedwich F. Kuipers, Payton L. Marshall, E-erdun Wang +2 more
2018Matrix Biology86 citations Open access
Semantic Scholar
Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis.
N. Nagy, G. Kaber, Pamela Y. Johnson, J. Gebe +11 more
2015Journal of Clinical Investigation81 citations Open access
Semantic Scholar
Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization
Hedwich F. Kuipers, M. Rieck, Irina Gurevich, N. Nagy +5 more
2016Proceedings of the National Academy of Sciences of the United States of America70 citations Open access
Semantic Scholar
She Doesn’t Even Go Here: The Role of Inflammatory Astrocytes in CNS Disorders
J. K. Reid, Hedwich F. Kuipers
2021Frontiers in Cellular Neuroscience55 citations Open access
Semantic Scholar
Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination
Hedwich F. Kuipers, Jane Yoon, J. van Horssen, May H. Han +3 more
2017Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
The pharmacokinetics and dosing of oral 4‐methylumbelliferone for inhibition of hyaluronan synthesis in mice
Hedwich F. Kuipers, N. Nagy, S. Ruppert, V. Sunkari +9 more
2016Clinical and Experimental Immunology46 citations Open access
Semantic Scholar
Immunomodulation by statins: inhibition of cholesterol vs. isoprenoid biosynthesis.
Hedwich F. Kuipers, P. J. van den Elsen
2007Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie46 citations
Semantic Scholar
4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition
N. Nagy, Irina Gurevich, Hedwich F. Kuipers, S. Ruppert +10 more
2019Journal of Biological Chemistry45 citations Open access
Semantic Scholar
CC chemokine receptor 5 gene promoter activation by the cyclic AMP response element binding transcription factor.
Hedwich F. Kuipers, P. Biesta, L. Montagne, E. V. van Haastert +2 more
2008Blood38 citations
Semantic Scholar
Simvastatin affects cell motility and actin cytoskeleton distribution of microglia
Hedwich F. Kuipers, Angelika Rappert, A. Mommaas, E. V. van Haastert +4 more
2006Glia38 citations
Semantic Scholar
Cuprizone-induced Demyelination in Mouse Brain is not due to Depletion of Copper
M. Morgan, W. Teo, Yda Hernandez, C. Brideau +3 more
2022ASN Neuro31 citations Open access
Semantic Scholar
Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors
R. J. Wierda, Hedwich F. Kuipers, M. van Eggermond, A. Bénard +7 more
2012Journal of Cellular and Molecular Medicine30 citations Open access
Semantic Scholar
Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection
Payton L. Marshall, N. Nagy, G. Kaber, G. Barlow +24 more
2020bioRxiv19 citations Open access
Semantic Scholar
The Heparan Sulfate Mimetic PG545 Modulates T Cell Responses and Prevents Delayed-Type Hypersensitivity
I. Koliesnik, Hedwich F. Kuipers, C. Medina, Svenja Zihsler +3 more
2020Frontiers in Immunology19 citations Open access
Semantic Scholar
Statins and control of MHC2TA gene transcription
Hedwich F. Kuipers, P. J. van den Elsen
2005Nature Medicine19 citations
Semantic Scholar
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue
Hunter A. Martinez, I. Koliesnik, G. Kaber, J. K. Reid +20 more
2024Nature Communications16 citations Open access
Semantic Scholar
Ultrasound and neuroinflammation: immune modulation via the heat shock response
Graham M. Seasons, C. Pellow, Hedwich F. Kuipers, G. Pike
2024Theranostics16 citations Open access
Semantic Scholar
Statins amplify TLR‐induced responses in microglia via inhibition of cholesterol biosynthesis
C. van der Putten, Hedwich F. Kuipers, E. Zuiderwijk-Sick, L. van Straalen +3 more
2012Glia14 citations
Semantic Scholar
Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice
N. Nagy, G. Kaber, M. Kratochvil, Hedwich F. Kuipers +7 more
2020Diabetologia10 citations Open access
Semantic Scholar
Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes
N. Nagy, G. Kaber, V. Sunkari, Payton L. Marshall +10 more
2023Matrix Biology8 citations Open access
Semantic Scholar
Piet Mondrian’s trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011
L. Steinman, R. Axtell, Donald Barbieri, R. Bhat +10 more
2013Multiple Sclerosis8 citations
Semantic Scholar
Natural Tr1-like cells do not confer long-term tolerogenic memory
K. Yadava, C. Medina, Heather D. Ishak, Irina Gurevich +7 more
2019eLife7 citations Open access
Semantic Scholar
Blockade of Proteinase-Activated Receptor 2 (PAR2) Attenuates Neuroinflammation in Experimental Autoimmune Encephalomyelitis
Rahil Eftekhari, B. Ewanchuk, Khalil S. Rawji, Robin M. Yates +3 more
2023Journal of Pharmacology and Experimental Therapeutics6 citations
Semantic Scholar
Hematopoietic stem cell requirement for macrophage regeneration is tissue-specific
Devon J. Eddins, A. Kosters, J. Waters, Jasmine Sosa +5 more
2021Journal of Immunology5 citations Open access
Semantic Scholar
Sustained Release of IL-2 Using an Injectable Hydrogel Prevents Autoimmune Diabetes
N. Nagy, G. Kaber, M. Kratochvil, Hedwich F. Kuipers +7 more
2020bioRxiv3 citations Open access
Semantic Scholar
CCR5 in Multiple Sclerosis : expression, regulation, and modulation by statins
Hedwich F. Kuipers
20073 citations
Semantic Scholar
FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues
Hunter A. Martinez, I. Koliesnik, G. Kaber, J. K. Reid +19 more
2023bioRxiv2 citations Open access
Semantic Scholar
Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes
N. Nagy, G. Kaber, V. Sunkari, Payton L. Marshall +10 more
2023bioRxiv2 citations Open access
Semantic Scholar
Genome-wide RNA expression profiling in human grey and white matter tissue reveals a role for PSA-NCAM dysregulation in MS pathogenesis
Ilona B. Bruinsma, V. Eijsink, E. Kooi, S. Baranzini +11 more
20141 citations
Semantic Scholar
Common variants in P2RY11 are associated with narcolepsy (vol 43, pg 66, 2011)
B. Kornum, Minae Kawashima, J. Faraco, Ling Lin +56 more
20111 citations
Semantic Scholar
Cytokine and chemokine production by astrocytes is influenced by Cystatin C.
Alexandra L. Palmer, Ruiqing Wang, Y. R. Zonta, Zachary Bailey +2 more
2025Journal of Neuroimmunology0 citations Open access
Semantic Scholar
HSC-requirement for macrophage regeneration is tissue-specific
E. Ghosn, Hedwich F. Kuipers, J. Waters, Jasmine Sosa +2 more
2018Journal of Immunology0 citations
Semantic Scholar
Traitement par 4-méthylumbelliférone pour l'immunomodulation
P. Bollyky, Nadine Nagy, Thomas N. Wight, Hedwich F. Kuipers
20140 citations
Semantic Scholar
Differential phosphorylation of alpha B-crystallin in astrocytes and oligodendrocytes suggests a diversity in its biological function
Hedwich F. Kuipers, Jane Yoon, Johann Winderl, J. van Horssen +3 more
20140 citations
Semantic Scholar
The role of hyaluronan and 4-methylumbelliferone treatment in multiple sclerosis
Hedwich F. Kuipers, M. Rieck, L. Steinman, P. Bollyky
20140 citations
Semantic Scholar
Rna profiling in grey and white matter tissue yields clues towards multiple sclerosis etiology
Ilona B. Bruinsma, V. Eijsink, E. Kooi, S. Baranzini +11 more
20130 citations
Semantic Scholar
Autoimmune Encephalomyelitis 17 Versions of ExperimentalH 1 and TH-Amyloid in T β Administration of Reversal of Paralysis and Reduced Inflammation from Peripheral
Jacqueline L. Grant, E. Ghosn, R. Axtell, Katja Herges +5 more
20120 citations
Semantic Scholar
The P2Y11 receptor is associated with narcolepsy and with higher susceptibility to ATP induced cell death in T lymphocytes and NK cells. (47.5)
B. Kornum, Ling Lin, M. Kassack, Hedwich F. Kuipers +4 more
2011Journal of Immunology0 citations
Semantic Scholar
CC chemokine receptor 5 ( CCR 5 ) gene promoter activation by the cyclic AMP response element binding ( CREB ) transcription factor
Hedwich F. Kuipers, P. Biesta, L. Montagne, Elise +2 more
20070 citations
Semantic Scholar
Statins: impact on expression and function of microglia and astrocyte expressed immune regulatory molecules
R. Feenstra, Hedwich F. Kuipers, P. J. van den Elsen, P. van der Valk
20060 citations
Semantic Scholar
Simvastatin affects microglia cell motility
Hedwich F. Kuipers, Angelika Rappert, A. Mommaas, E. V. van Haastert +4 more
20060 citations
Semantic Scholar
Statins affect microglia function by reducing membrane expression of critical immune regulatory molecules
Hedwich F. Kuipers, Angelika Rappert, E. V. van Haastert, P. van der Valk +3 more
20040 citations
Semantic Scholar
The regulation of the production of the MHC class I and II proteins involved in the immune system, chemokines and chemokine receptors in multiple sclerosis
P. Biesta, Hedwich F. Kuipers, P. J. van den Elsen, S. Gobin
20010 citations
Semantic Scholar
1 Blockade of proteinase-activated receptor 2 (PAR 2) attenuates neuroinflammation in experimental autoimmune encephalomyelitis
Rahil Eftekhari, B. Ewanchuk, Khalil S. Rawji, Robin M. Yates +3 more
0 citations
Semantic Scholar

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