Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

G. Melillo · SciRah

Researcher profile · Semantic Scholar

G. Melillo

Share profile

G. Melillo — researcher profile on SciRah

h-index: 50
Works: 147
Citations: 16K

Most-cited papers

Durvalumab after Chemoradiotherapy in Stage III Non–Small‐Cell Lung Cancer
S. Antonia, A. Villegas, D. Daniel, D. Vicente +26 more
2017New England Journal of Medicine2,703 citations Open access
Semantic Scholar
Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
S. Antonia, A. Villegas, D. Daniel, D. Vicente +29 more
2018New England Journal of Medicine2,405 citations Open access
Semantic Scholar
Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
J. Tatum, G. Kelloff, Robert J. Gillies, J. Arbeit +27 more
2006International Journal of Radiation Biology626 citations
Semantic Scholar
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.
D. Kong, E. Park, A. Stephen, Maura Calvani +5 more
2005Cancer Research495 citations Open access
Semantic Scholar
Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma.
Qin C. Ryan, D. Headlee, M. Acharya, A. Sparreboom +12 more
2005Journal of Clinical Oncology395 citations
Semantic Scholar
Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α.
I. Shalova, J. Lim, Manesh Chittezhath, A. Zinkernagel +14 more
2015Immunity391 citations Open access
Semantic Scholar
Safety and Efficacy of Durvalumab With or Without Tremelimumab in Patients With PD-L1–Low/Negative Recurrent or Metastatic HNSCC: The Phase 2 CONDOR Randomized Clinical Trial
L. Siu, C. Even, R. Mesía, É. Remenár +17 more
2019JAMA Oncology279 citations Open access
Semantic Scholar
Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas
S. Kummar, Alice P. Chen, J. Ji, Yi-Ping Zhang +18 more
2011Cancer Research260 citations Open access
Semantic Scholar
Development of HIF-1 Inhibitors for Cancer Therapy
B. Onnis, A. Rapisarda, G. Melillo
2009Journal of Cellular and Molecular Medicine254 citations Open access
Semantic Scholar
HIF-1: A Target For Cancer, Ischemia and Inflammation—Too Good to be True?
G. Melillo
2004Cell Cycle253 citations Open access
Semantic Scholar
Durvalumab for recurrent or metastatic head and neck squamous cell carcinoma: Results from a single-arm, phase II study in patients with ≥25% tumour cell PD-L1 expression who have progressed on platinum-based chemotherapy.
D. Zandberg, A. Algazi, A. Jimeno, J. Good +21 more
2019European Journal of Cancer242 citations Open access
Semantic Scholar
Targeting hypoxia cell signaling for cancer therapy
G. Melillo
2007Cancer Metastasis Review240 citations
Semantic Scholar
Hypoxia Potentiates Glioma-Mediated Immunosuppression
Jun Wei, Adam Wu, Ling-Yuan Kong, Yong-Tao Wang +5 more
2011PLoS ONE218 citations Open access
Semantic Scholar
Schedule-dependent Inhibition of Hypoxia-inducible Factor-1α Protein Accumulation, Angiogenesis, and Tumor Growth by Topotecan in U251-HRE Glioblastoma Xenografts
A. Rapisarda, J. Zalek, M. Hollingshead, T. Braunschweig +7 more
2004Cancer Research191 citations Open access
Semantic Scholar
Inhibiting Hypoxia-Inducible Factor 1 for Cancer Therapy
G. Melillo
2006Molecular Cancer Research179 citations Open access
Semantic Scholar
Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia
A. Rapisarda, G. Melillo
2012Nature Reviews Clinical Oncology177 citations
Semantic Scholar
Role of the VEGF/VEGFR axis in cancer biology and therapy.
A. Rapisarda, G. Melillo
2012Advances in Cancer Research172 citations
Semantic Scholar
Increased anti-tumor activity of bevacizumab in combination with HIF-1 inhibition
A. Rapisarda, M. Hollingshead, B. Uranchimeg, Carrie A. Bonomi +9 more
2009Molecular Cancer Therapeutics161 citations Open access
Semantic Scholar
Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors
W. Jeong, A. Rapisarda, S. Park, R. Kinders +7 more
2013Cancer Chemotherapy and Pharmacology157 citations Open access
Semantic Scholar
Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies
A. Rapisarda, G. Melillo
2009Drug resistance updates139 citations Open access
Semantic Scholar
Phase I Trial of MS-275, a Histone Deacetylase Inhibitor, Administered Weekly in Refractory Solid Tumors and Lymphoid Malignancies
S. Kummar, M. Gutierrez, E. Gardner, E. A. Donovan +14 more
2007Clinical Cancer Research134 citations Open access
Semantic Scholar
Phase I Trial of 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin (17-DMAG), a Heat Shock Protein Inhibitor, Administered Twice Weekly in Patients with Advanced Malignancies
S. Kummar, M. Gutierrez, E. Gardner, Xiaohong Chen +17 more
2009European Journal of Cancer123 citations Open access
Semantic Scholar
Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1α (HIF-1α) in Advanced Solid Tumors
S. Kummar, M. Raffeld, L. Juwara, Yvonne Horneffer +12 more
2011Clinical Cancer Research117 citations Open access
Semantic Scholar
Aminoflavone, a ligand of the Aryl Hydrocarbon Receptor (AhR), inhibits HIF-1α expression in an AhR-independent fashion
E. Terzuoli, M. Puppo, A. Rapisarda, B. Uranchimeg +4 more
2010Cancer Research101 citations Open access
Semantic Scholar
Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells.
Maura Calvani, D. Trisciuoglio, C. Bergamaschi, R. Shoemaker +1 more
2008Cancer Research82 citations Open access
Semantic Scholar
Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells.
B. Onnis, Nicole Fer, A. Rapisarda, Víctor Pérez +1 more
2013Journal of Clinical Investigation79 citations Open access
Semantic Scholar
NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction
A. Juhász, S. Markel, Shikha Gaur, Han Liu +11 more
2017Journal of Biological Chemistry78 citations Open access
Semantic Scholar
Inhibition of Hypoxia Inducible Factor-1α by Dihydroxyphenylethanol, a Product from Olive Oil, Blocks Microsomal Prostaglandin-E Synthase-1/Vascular Endothelial Growth Factor Expression and Reduces Tumor Angiogenesis
E. Terzuoli, S. Donnini, A. Giachetti, Miguel A. Íñiguez +3 more
2010Clinical Cancer Research71 citations Open access
Semantic Scholar
Synergystic induction of HIF-1α transcriptional activity by hypoxia and lipopolysaccharide in macrophages
Z. Mi, A. Rapisarda, L. Taylor, A. Brooks +3 more
2008Cell Cycle69 citations Open access
Semantic Scholar
Hypoxia: a double-edged sword of immunity
A. Sica, G. Melillo, L. Varesio
2011Journal of molecular medicine64 citations
Semantic Scholar
Accumulation of hypoxia-inducible factor-1α is limited by transcription-dependent depletion
Z. Demidenko, A. Rapisarda, M. Garayoa, P. Giannakakou +2 more
2005Oncogene57 citations Open access
Semantic Scholar
Cell Type–Specific, Topoisomerase II–Dependent Inhibition of Hypoxia-Inducible Factor-1α Protein Accumulation by NSC 644221
M. Creighton-Gutteridge, J. Cardellina, A. Stephen, A. Rapisarda +5 more
2007Clinical Cancer Research49 citations Open access
Semantic Scholar
HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse
N. Coltella, Stefano Percio, Roberta Valsecchi, Roberto Cuttano +6 more
2014EMBO Molecular Medicine45 citations Open access
Semantic Scholar
Targeting the PAS-A Domain of HIF-1α for Development of Small Molecule Inhibitors of HIF-1
Jung-Eun Park, D. Kong, R. Fisher, J. Cardellina +2 more
2006Cell Cycle45 citations Open access
Semantic Scholar
Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide.
D. Trisciuoglio, B. Uranchimeg, J. Cardellina, T. Meragelman +5 more
2008Journal of the National Cancer Institute44 citations Open access
Semantic Scholar
Hypoxia-inducible factor 1 inhibitors.
G. Melillo
2007Methods in Enzymology38 citations
Semantic Scholar
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.
Bennett M. Kaufman, O. Scharf, J. Arbeit, M. Ashcroft +22 more
2004Cancer Research37 citations Open access
Semantic Scholar
A phase 3, randomized, open-label study of first-line durvalumab (MEDI4736) ± tremelimumab versus standard of care (SoC; EXTREME regimen) in recurrent/metastatic (R/M) SCCHN: KESTREL.
T. Seiwert, J. Weiss, S. Baxi, M. Ahn +10 more
201634 citations
Semantic Scholar
Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome.
A. Tandle, Maura Calvani, B. Uranchimeg, D. Zahavi +2 more
2009Experimental Cell Research30 citations Open access
Semantic Scholar
A Phase I Trial of UCN-01 and Prednisone in Patients With Refractory Solid Tumors and Lymphomas
S. Kummar, M. Gutierrez, E. Gardner, W. Figg +6 more
2009Cancer Chemotherapy and Pharmacology30 citations Open access
Semantic Scholar
1042ODurvalumab for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): Preliminary results from a single-arm, phase 2 study
D. Zandberg, A. Algazi, A. Jimeno, J. Good +10 more
201728 citations Open access
Semantic Scholar
Antiangiogenic agents and HIF-1 inhibitors meet at the crossroads
A. Rapisarda, R. Shoemaker, G. Melillo
2009Cell Cycle28 citations Open access
Semantic Scholar
Related citationsHypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells.
Maura Calvani, A. Rapisarda, B. Uranchimeg, R. Shoemaker +1 more
200628 citations
Semantic Scholar
Weekly EZN-2208 (PEGylated SN-38) in combination with bevacizumab in patients with refractory solid tumors
W. Jeong, S. Park, A. Rapisarda, Nicole Fer +8 more
2013Investigational new drugs27 citations Open access
Semantic Scholar
Induction of Apoptosis by Flavopiridol in Human Neuroblastoma Cells Is Enhanced under Hypoxia and Associated With N-myc Proto-oncogene Down-Regulation
M. Puppo, S. Pastorino, G. Melillo, A. Pezzolo +2 more
2004Clinical Cancer Research25 citations Open access
Semantic Scholar
Meeting report: exploiting the tumor microenvironment for therapeutics.
G. Melillo, G. Semenza
2006Cancer Research24 citations Open access
Semantic Scholar
Identification of a new natural camptothecin analogue in targeted screening for HIF-1alpha inhibitors.
Paul Klausmeyer, T. McCloud, G. Melillo, D. Scudiero +2 more
2006Planta Medica23 citations
Semantic Scholar
Phase I Trial of Vandetanib and Bevacizumab Evaluating the VEGF and EGF Signal Transduction Pathways in Adults With Solid Tumours and Lymphomas
S. Kummar, M. Gutierrez, Alice P. Chen, I. Turkbey +13 more
2011European Journal of Cancer22 citations Open access
Semantic Scholar
Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.
Paul Klausmeyer, Qin Zhou, D. Scudiero, B. Uranchimeg +5 more
2009Journal of Natural Products22 citations Open access
Semantic Scholar
Hypoxia: jump-starting inflammation.
G. Melillo
2011Blood21 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

A. Rapisarda×17
Invite
A. Rapisarda — researcher profile on SciRah
R. Shoemaker×10
Invite
R. Shoemaker — researcher profile on SciRah
J. Doroshow×9
Invite
J. Doroshow — researcher profile on SciRah
S. Kummar×8
Invite
S. Kummar — researcher profile on SciRah

×8

Invite

B. Uranchimeg — researcher profile on SciRah

Invite

A. Murgo — researcher profile on SciRah

J. Cardellina×6

Invite

J. Cardellina — researcher profile on SciRah

Invite

W. Figg — researcher profile on SciRah

Alice P. Chen×5

Invite

Alice P. Chen — researcher profile on SciRah

Maura Calvani×4

Invite

Maura Calvani — researcher profile on SciRah

Invite

J. Fayette — researcher profile on SciRah

Invite

R. Kinders — researcher profile on SciRah