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R. Sundaram · SciRah

Researcher profile · Semantic Scholar

R. Sundaram

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R. Sundaram — researcher profile on SciRah

h-index: 24
Works: 104
Citations: 2,590

Most-cited papers

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
Parker L. Sulkowski, C. Corso, Nathaniel D. Robinson, Susan E. Scanlon +17 more
2017Science Translational Medicine499 citations Open access
Semantic Scholar
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination
Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head +24 more
2017Cell Reports177 citations Open access
Semantic Scholar
Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma.
J. Richter, N. Neparidze, Lin Zhang, Shiny Nair +5 more
2013Blood167 citations Open access
Semantic Scholar
Krebs Cycle-Deficient Hereditary Cancer Syndromes are Defined by Homologous Recombination DNA Repair Defects
Parker L. Sulkowski, R. Sundaram, S. Oeck, C. Corso +11 more
2018Nature Genetics152 citations Open access
Semantic Scholar
Prospective analysis of antigen-specific immunity, stem-cell antigens, and immune checkpoints in monoclonal gammopathy.
M. Dhodapkar, R. Sexton, Rituparna Das, K. Dhodapkar +6 more
2015Blood121 citations Open access
Semantic Scholar
Mechanism-based design of agents that selectively target drug-resistant glioma
Kingson Lin, S. Gueble, R. Sundaram, Eric D. Huseman +2 more
2022Science103 citations Open access
Semantic Scholar
Genetic transformation of a Corynebacterial symbiont from the Chagas disease vector Triatoma infestans.
R. Durvasula, R. Sundaram, P. Kirsch, I. Hurwitz +3 more
2008Experimental parasitology72 citations Open access
Semantic Scholar
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
N. Fons, R. Sundaram, G. Breuer, S. Peng +11 more
2019Nature Communications69 citations Open access
Semantic Scholar
Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors
Christopher B. Jackson, Seth I. Noorbakhsh, R. Sundaram, A. Kalathil +7 more
2019Cancer Research59 citations Open access
Semantic Scholar
Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) Nanoparticles for Enhanced and Sustained Drug Delivery to Treat Brain Tumors
E. Chen, Amanda Quijano, Young-Eun Seo, C. Jackson +8 more
2018Biomaterials58 citations Open access
Semantic Scholar
Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay
Y. Surovtseva, V. Jairam, A. Salem, R. Sundaram +2 more
2016Journal of the American Chemical Society50 citations Open access
Semantic Scholar
Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.
S. Koduru, E. Wong, T. Strowig, R. Sundaram +6 more
2012Blood50 citations Open access
Semantic Scholar
Differential trafficking of the Niemann‐Pick C1 and 2 proteins highlights distinct roles in late endocytic lipid trafficking
M. Zhang, M. Sun, N. Dwyer, M. Comly +4 more
2003Acta paediatrica49 citations
Semantic Scholar
Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
Jennifer Garbarino, Jillian Eckroate, R. Sundaram, R. B. Jensen +1 more
2021Translational Oncology43 citations Open access
Semantic Scholar
TOP1-DNA trapping by exatecan and combination therapy with ATR inhibitor
U. Jo, Yasuhisa Murai, K. Agama, Yi-Lun Sun +12 more
2022Molecular Cancer Therapeutics40 citations Open access
Semantic Scholar
Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors
A. Goglia, R. Delsite, A. Luz, D. Shahbazian +10 more
2014Molecular Cancer Therapeutics37 citations Open access
Semantic Scholar
Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity
Sophia Gayle, R. Aiello, N. Leelatian, J. Beckta +20 more
2021NAR Cancer30 citations Open access
Semantic Scholar
Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors
Amrita Sule, Jinny Van Doorn, R. Sundaram, Sachita Ganesa +2 more
2021NAR Cancer29 citations Open access
Semantic Scholar
Immunocytochemical localization of apolipoprotein D in oligodendrocyte precursor-like cells, perivascular cells, and pericytes in the human cerebral cortex
Chang-Yong Hu, W. Ong, R. Sundaram, C. Chan +1 more
2001Journal of Neurocytology29 citations
Semantic Scholar
Neuronal localization and association of Niemann Pick C2 protein (HE1/NPC2) with the postsynaptic density.
Wei-Yi Ong, R. Sundaram, E. Huang, S. Ghoshal +3 more
2004Neuroscience28 citations
Semantic Scholar
In Vivo Anti-Tumor Effect of PARP Inhibition in IDH1/2 Mutant MDS/AML Resistant to Targeted Inhibitors of Mutant IDH1/2
R. Gbyli, Yuan-Bin Song, W. Liu, Yimeng Gao +13 more
2022Leukemia26 citations Open access
Semantic Scholar
Local DNA repair inhibition for sustained radiosensitization of high grade gliomas
Amanda R. King, C. Corso, E. Chen, E. Song +5 more
2017Molecular Cancer Therapeutics26 citations Open access
Semantic Scholar
Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma
Sachita Ganesa, Amrita Sule, R. Sundaram, R. Bindra
2022Scientific Reports22 citations Open access
Semantic Scholar
Novel Detox Gel Depot sequesters β-Amyloid Peptides in a mouse model of Alzheimer’s Disease
R. Sundaram, C. Kasinathan, S. Stein, P. Sundaram
2011International Journal of Peptide Research and Therapeutics16 citations Open access
Semantic Scholar
Development of a novel method to create double-strand break repair fingerprints using next-generation sequencing.
C. Soong, G. Breuer, Ryan A. Hannon, Savina D Kim +7 more
2015DNA Repair14 citations
Semantic Scholar
Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy
Daiki Ueno, Juan C. Vasquez, Amrita Sule, Jia-Yu Liang +14 more
2022OncoTarget13 citations Open access
Semantic Scholar
Expression of a functional single-chain antibody via Corynebacterium pseudodiphtheriticum
R. Sundaram, Ivy Hurwitz, Scott Matthews, E. Hoy +4 more
2008European Journal of Clinical Microbiology and Infectious Diseases12 citations
Semantic Scholar
Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers
Eric D. Huseman, Anna Lo, Olga Fedorova, J. Elia +14 more
2024Journal of the American Chemical Society11 citations
Semantic Scholar
Protein stains and applications.
R. Sundaram, N. Balasubramaniyan, P. Sundaram
2012Methods in molecular biology9 citations
Semantic Scholar
Detoxification Depot for β -Amyloid Peptides
P. Sundaram, R. Sundaram, C. Kasinathan, S. Stein
20089 citations
Semantic Scholar
NAPRT silencing in FH-deficient renal cell carcinoma confers therapeutic vulnerabilities via NAD+ depletion
Katelyn J. Noronha, Karlie N. Lucas, Sateja Paradkar, Joseph Edmonds +13 more
2024Molecular Cancer Research8 citations Open access
Semantic Scholar
PARG inhibition induces nuclear aggregation of PARylated PARP1
Sateja Paradkar, Julia Purcell, Annie Cui, Sam Friedman +5 more
2023bioRxiv6 citations Open access
Semantic Scholar
PARP Inhibitors Are Effective in IDH1/2 Mutant MDS and AML Resistant to Targeted IDH Inhibitors
R. Gbyli, Yuan-Bin Song, Wei Liu, Yimeng Gao +15 more
2019Blood6 citations Open access
Semantic Scholar
Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors
Matthew A. Murray, Katelyn J. Noronha, Yazheng Wang, Anna P Friedman +6 more
2024Molecular Cancer Therapeutics5 citations Open access
Semantic Scholar
Detoxification depot for beta-amyloid peptides.
R. Sundaram, C. Kasinathan, S. Stein, P. Sundaram
2008Current Alzheimer Research4 citations
Semantic Scholar
Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes
Collin D. Heer, James L. Elia, Vijay Menon, Spenser S. Johnson +7 more
2026NAR Cancer3 citations Open access
Semantic Scholar
Development of Syngeneic Murine Glioma Models with Somatic Mismatch Repair Deficiency to Study Therapeutic Responses to Alkylating Agents and Immunotherapy
Deepti Bhatt, R. Sundaram, Karla S. Lugo López, Teresa Lee +2 more
2025Current Protocols3 citations
Semantic Scholar
Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore
Sateja Paradkar, J. Herrington, Adam W. Hendricson, P. Hewawasam +5 more
2021OncoTarget3 citations Open access
Semantic Scholar
Prospects for paratransgenic applications to commercial mariculture using genetically engineered algae.
R. Durvasula, R. Sundaram, Scott Matthews, P. Sundaram +2 more
20063 citations
Semantic Scholar
DNA damage response profile distinguishes poor-acting gliomas with shared methylome signatures
N. Leelatian, C. Singh, R. Bouffard, R. Sundaram +8 more
2025Neuro-Oncology2 citations Open access
Semantic Scholar
Abstract 1389: Exploiting inherent DNA damage repair defects in IDH1/2 mutated gliomas with the CNS penetrant PARP inhibitor, pamiparib
Christopher S. Hong, Amrita Sule, J. Beckta, R. Sundaram +1 more
2020Molecular and Cellular Biology / Genetics2 citations
Semantic Scholar
Unlocking PARP inhibitor efficacy for HRD-negative cancers using the alphalex tumor targeting platform inhibitor efficacy for HRD-negative cancers using the alphalex tumor targeting platform.
R. Bindra, R. Sundaram, R. Aiello, D. Marshall +11 more
2019Journal of Clinical Oncology2 citations
Semantic Scholar
NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibition
Angela Kim, Prateek Bhardwaj, Collin D. Heer, Sophia J. Zhao +22 more
2025bioRxiv1 citations
Semantic Scholar
Abstract A081 Biomarker-driven targeting of NAD metabolism in rhabdomyosarcoma
Juan C. Vasquez, Prateek Bhardwaj, Sophia J. Zhao, Katelyn J. Noronha +6 more
2024Cancer Research1 citations
Semantic Scholar
MODL-02. DEVELOPMENT OF RODENT GLIOBLASTOMA MODELS OF MGMT-MEDIATED TEMOZOLOMIDE RESISTANCE
Teresa Lee, Deepti Bhatt, R. Sundaram, W. M. Saltzman +2 more
2023Neuro-Oncology1 citations Open access
Semantic Scholar
Abstract 1568: Mechanistic studies of KL-50, a novel imidazotetrazine for the treatment of MGMT-/MMR- gliomas and glioblastoma
Eric D. Huseman, Anna Lo, O. Fedorova, Kingson Lin +5 more
2023Cancer Research1 citations
Semantic Scholar
CRISPR screening identifies novel PARP inhibitor classification based on
G. Breuer, Jonathan Bezney, N. Fons, R. Sundaram +4 more
20211 citations
Semantic Scholar
Correction to ‘Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity’
Sophia Gayle, R. Aiello, N. Leelatian, J. Beckta +20 more
2021NAR Cancer1 citations Open access
Semantic Scholar
Abstract P258: CBX-12 (alphalexTM-exatecan) sensitizes tumors to immune checkpoint blockade in an antigen agnostic manner by immune activation
Sophia Gayle, Juan C. Vasquez, T. Paradis, Kelli Jones +6 more
2021Poster Presentations - Proffered Abstracts1 citations
Semantic Scholar
Targeted DNA Damage Repair CRISPR/Cas9 Knockout Screen Identifies Novel Classification of Poly-ADP Ribose Polymerase Inhibitors Based on Key Base Excision Repair Proteins
G. Breuer, Jonathan Bezney, N. Fons, R. Sundaram +3 more
2020bioRxiv1 citations Open access
Semantic Scholar

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