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P. Kavathas · SciRah

Researcher profile · Semantic Scholar

P. Kavathas

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P. Kavathas — researcher profile on SciRah

h-index: 30
Works: 83
Citations: 3,874

Most-cited papers

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
S. Gettinger, Jungmin Choi, K. Hastings, A. Truini +22 more
2017Cancer Discovery698 citations Open access
Semantic Scholar
Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase
A. Shaw, J. Chalupny, J. Whitney, Craig Hammond +4 more
1990Molecular and Cellular Biology259 citations Open access
Semantic Scholar
Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cells.
P. Kavathas, F. Bach, R. Demars
1980Proceedings of the National Academy of Sciences of the United States of America245 citations Open access
Semantic Scholar
CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation.
Mark A Daniels, L. Devine, Joseph D. Miller, Janice M. Moser +5 more
2001Immunity205 citations Open access
Semantic Scholar
Family studies define a new histocompatibility locus, SB, between HLA-DR and GLO
S. Shaw, P. Kavathas, M. Pollack, D. Charmot +1 more
1981Nature143 citations
Semantic Scholar
Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells
R. Margolskee, P. Kavathas, Paul Berg
1988Molecular and Cellular Biology134 citations Open access
Semantic Scholar
Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene
J. Hambor, J. Mennone, M. E. Coon, J. Hanke +1 more
1993Molecular and Cellular Biology132 citations Open access
Semantic Scholar
The Golgi-associated Protein p115 Mediates the Secretion of Macrophage Migration Inhibitory Factor (MIF)
M. Merk, J. Baugh, S. Zierow, L. Leng +10 more
2009Journal of Immunology128 citations Open access
Semantic Scholar
Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non–Small Cell Lung Cancer
S. Gettinger, A. Wurtz, S. Goldberg, D. Rimm +8 more
2018Journal of Thoracic Oncology120 citations Open access
Semantic Scholar
A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast
Melissa J. Mulla, J. Salmon, L. Chamley, J. Brosens +3 more
2013PLoS ONE116 citations Open access
Semantic Scholar
Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting.
P. Kavathas, L. Herzenberg
1983Proceedings of the National Academy of Sciences of the United States of America114 citations Open access
Semantic Scholar
Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the alpha 2 and alpha 3 domains of MHC class I
Jiaren Sun, Daniel J. Leahy, P. Kavathas
1995Journal of Experimental Medicine109 citations Open access
Semantic Scholar
Interplay between TCR Affinity and Necessity of Coreceptor Ligation: High-Affinity Peptide-MHC/TCR Interaction Overcomes Lack of CD8 Engagement 1
S. Kerry, Jennifer Buslepp, Lorraine A. Cramer, R. Maile +6 more
2003Journal of Immunology104 citations Open access
Semantic Scholar
Severe Tryptophan Starvation Blocks Onset of Conventional Persistence and Reduces Reactivation of Chlamydia trachomatis
Ralf M. Leonhardt, Seung-Joon Lee, P. Kavathas, P. Cresswell
2007Infection and Immunity93 citations Open access
Semantic Scholar
Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.
P. Kavathas, V. Sukhatme, L. Herzenberg, J. Parnes
1984Proceedings of the National Academy of Sciences of the United States of America88 citations Open access
Semantic Scholar
SB: a new HLA-linked human histocompatibility gene defined using HLA-mutant cell lines
P. Kavathas, R. Demars, F. Bach, S. Shaw
1981Nature85 citations
Semantic Scholar
Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions.
H. Nakauchi, G. Nolan, Charles Hsu, H.-S. Huang +2 more
1985Proceedings of the National Academy of Sciences of the United States of America83 citations Open access
Semantic Scholar
Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex
H. Orr, F. Bach, H. Ploegh, J. Strominger +2 more
1982Nature72 citations
Semantic Scholar
Direct Detection and Magnetic Isolation of Chlamydia trachomatis Major Outer Membrane Protein-Specific CD8+ CTLs with HLA Class I Tetramers1
Seon-Kyeong Kim, L. Devine, M. Angevine, R. Demars +1 more
2000Journal of Immunology67 citations
Semantic Scholar
Transfer of cloned human class I major histocompatibility complex genes into HLA mutant human lymphoblastoid cells
Yoji Shimizu, B. H. Koller, D. Geraghty, H. Orr +3 more
1986Molecular and Cellular Biology62 citations Open access
Semantic Scholar
Mutation in EGFP domain of LRP6 impairs cellular LDL Clearance
Wen-Zhong Liu, Sheida Mani, N. R. Davis, N. Sarrafzadegan +2 more
2008Circulation Research51 citations Open access
Semantic Scholar
A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.
P. Giblin, J. Ledbetter, P. Kavathas
1989Proceedings of the National Academy of Sciences of the United States of America50 citations Open access
Semantic Scholar
Chlamydia trachomatis infection modulates trophoblast cytokine/chemokine production
E. de la Torre, Melissa J. Mulla, Andrew G. Yu, Seung-Joon Lee +2 more
2009Journal of Immunology42 citations Open access
Semantic Scholar
Amplification of a gene coding for human T-cell differentiation antigen
P. Kavathas, L. Herzenberg
1983Nature41 citations
Semantic Scholar
Identification of a Candidate Regulatory Region in the Human CD8 Gene Complex by Colocalization of DNase I Hypersensitive Sites and Matrix Attachment Regions Which Bind SATB1 and GATA-31
L. Kieffer, J. Greally, I. Landres, Shanta Nag +3 more
2002Journal of Immunology40 citations Open access
Semantic Scholar
RepetitiveAluElements form a Cruciform Structure that Regulates the Function of the Human CD8α T Cell-specific En hancer
J. Hanke, J. Hambor, P. Kavathas
199540 citations Open access
Semantic Scholar
Orientation of the Ig Domains of CD8αβ Relative to MHC Class I
L. Devine, Jiaren Sun, M. R. Barr, P. Kavathas
1999Journal of Immunology38 citations Open access
Semantic Scholar
The Complementarity-Determining Region-Like Loops of CD8α Interact Differently with β2-Microglobulin of the Class I Molecules H-2Kb and Thymic Leukemia Antigen, While Similarly with Their α3 Domains1
L. Devine, L. Rogozinski, O. Naidenko, H. Cheroutre +1 more
2002Journal of Immunology33 citations Open access
Semantic Scholar
Cell-surface antigens expressed on L-cells transfected with whole DNA from non-expressing and expressing cells
Charles Hsu, P. Kavathas, L. Herzenberg
1984Nature33 citations
Semantic Scholar
Human CD8β, But Not Mouse CD8β, Can Be Expressed in the Absence of CD8α as a ββ Homodimer1
L. Devine, L. Kieffer, V. Aitken, P. Kavathas
2000Journal of Immunology32 citations Open access
Semantic Scholar
Spatial analysis and clinical significance of HLA class-I and class-II subunit expression in non-small cell lung cancer
I. Datar, Sacha C. Hauc, Shruti S. Desai, Nicole Gianino +7 more
2021Clinical Cancer Research29 citations Open access
Semantic Scholar
Molecular Basis for the High Affinity Interaction between the Thymic Leukemia Antigen and the CD8αα Molecule1
A. Attinger, L. Devine, Yiran Wang-Zhu, D. Martin +5 more
2005Journal of Immunology29 citations
Semantic Scholar
Functional importance of the cyclic AMP response element-like decamer motif in the CD8 alpha promoter.
Meiyan Gao, P. Kavathas
1993Journal of Immunology29 citations
Semantic Scholar
Repetitive Alu elements form a cruciform structure that regulates the function of the human CD8 alpha T cell-specific enhancer.
J. Hanke, J. Hambor, P. Kavathas
1995Journal of Molecular Biology27 citations
Semantic Scholar
Location of the epitope for an anti-CD8alpha antibody 53.6.7 which enhances CD8alpha-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation.
L. Devine, M. Hodsdon, M. Daniels, S. Jameson +1 more
2004Immunology Letters24 citations
Semantic Scholar
Fluorescence-activated cell sorting of mouse-human hybrid cells aids in locating the gene for the Leu 7 (HNK-1) antigen to human chromosome 11.
J. Schröder, B. Nikinmaa, P. Kavathas, L. A. Herzenberg
1983Proceedings of the National Academy of Sciences of the United States of America24 citations Open access
Semantic Scholar
A non-class I MHC intestinal epithelial surface glycoprotein, gp180, binds to CD8.
N. Campbell, M. Park, L. Toy, X. Yio +3 more
2002Clinical Immunology23 citations
Semantic Scholar
Hemizygous HLA mutants of lymphoblastoid cells: a new cell type for histocompatibility testing.
P. Kavathas, R. Demars, F. H. Bach
1980Human Immunology23 citations
Semantic Scholar
Mapping the Binding Site on CD8β for MHC Class I Reveals Mutants with Enhanced Binding1
L. Devine, Deepshi Thakral, Shanta Nag, J. Dobbins +2 more
2006Journal of Immunology21 citations Open access
Semantic Scholar
Activation of T cells by H-2 factors in the graft-vs-host reaction.
W. Elkins, P. Kavathas, F. Bach
1973Transplantation Proceedings19 citations
Semantic Scholar
Differential Expression of the Human CD8β Splice Variants and Regulation of the M-2 Isoform by Ubiquitination1
Deepshi Thakral, J. Dobbins, L. Devine, P. Kavathas
2008Journal of Immunology18 citations Open access
Semantic Scholar
Human CD8α expression in NK cells but not cytotoxic T cells of transgenic mice
L. Kieffer, J. Bennett, A. Cunningham, R. Gladue +3 more
199618 citations
Semantic Scholar
Lymphocyte subsets in Sjogren's syndrome: a quantitative analysis using monoclonal antibodies and the fluorescence-activated cell sorter.
A. Bakhshi, N. Miyasaka, P. Kavathas, T. Daniels +3 more
1983Journal of clinical & laboratory immunology18 citations
Semantic Scholar
Human CD8 beta, but not mouse CD8 beta, can be expressed in the absence of CD8 alpha as a beta beta homodimer.
L. Devine, L. Kieffer, V. Aitken, P. Kavathas
2000Journal of Immunology15 citations
Semantic Scholar
Post-transcriptional regulation associated with control of human CD8A expression of CD4+ T cells
M.-H. Gao, M. Walz, P. Kavathas
1996Immunogenetics13 citations
Semantic Scholar
Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule.
A. Attinger, L. Devine, Yiran Wang-Zhu, D. Martin +5 more
2005Journal of Immunology11 citations
Semantic Scholar
The complementarity-determining region-like loops of CD8 alpha interact differently with beta 2-microglobulin of the class I molecules H-2Kb and thymic leukemia antigen, while similarly with their alpha 3 domains.
L. Devine, L. Rogozinski, O. Naidenko, H. Cheroutre +1 more
2002Journal of Immunology11 citations
Semantic Scholar
Orientation of the Ig domains of CD8 alpha beta relative to MHC class I.
L. Devine, J. Sun, M. R. Barr, P. Kavathas
1999Journal of Immunology10 citations
Semantic Scholar
A new variant glyoxalase I allele that is readily detectable in stimulated lymphocytes and lymphoblastoid cell lines but not in circulating lymphocytes or erythrocytes.
P. Kavathas, R. Demars
1981American Journal of Human Genetics9 citations
Semantic Scholar
Immunoepidemiology
P. Krause, P. Kavathas, N. Ruddle
20197 citations
Semantic Scholar

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K. Schalper — researcher profile on SciRah

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S. Gettinger — researcher profile on SciRah