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Yukako Ito · SciRah

Researcher profile · Semantic Scholar

Yukako Ito

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Yukako Ito — researcher profile on SciRah

h-index: 31
Works: 121
Citations: 2,962

Most-cited papers

Two-Layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs in Rats
Keizo Fukushima, A. Ise, Hiromi Morita, Ryo Hasegawa +3 more
2010Pharmaceutical Research176 citations
Semantic Scholar
Two-layered dissolving microneedles formulated with intermediate-acting insulin.
Yukako Ito, Muneyuki Hirono, Keizo Fukushima, N. Sugioka +1 more
2012International journal of pharmaceutics93 citations
Semantic Scholar
Evaluation of self-dissolving needles containing low molecular weight heparin (LMWH) in rats.
Yukako Ito, Aiko Murakami, T. Maeda, N. Sugioka +1 more
2008International journal of pharmaceutics66 citations
Semantic Scholar
Antigen-loaded dissolving microneedle array as a novel tool for percutaneous vaccination.
S. Naito, Yukako Ito, T. Kiyohara, M. Kataoka +2 more
2012Vaccine60 citations
Semantic Scholar
Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles.
Yukako Ito, H. Murano, N. Hamasaki, Keizo Fukushima +1 more
2011International journal of pharmaceutics58 citations
Semantic Scholar
Therapeutic Drug Monitoring of Vancomycin in Dermal Interstitial Fluid Using Dissolving Microneedles
Yukako Ito, Yuto Inagaki, Shinji Kobuchi, K. Takada +1 more
2016International Journal of Medical Sciences57 citations Open access
Semantic Scholar
Two-layered dissolving microneedles for percutaneous delivery of sumatriptan in rats
Yukako Ito, Sumie Kashiwara, Keizo Fukushima, K. Takada
2011Drug Development and Industrial Pharmacy50 citations
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Evaluation of Insulin Dissolving Microneedles in Dogs
Keizo Fukushima, Takenao Yamazaki, Ryo Hasegawa, Yukako Ito +2 more
2010Diabetes Technology & Therapeutics49 citations
Semantic Scholar
Self-dissolving micropile array tips for percutaneous administration of insulin
Yukako Ito, Takenao Yamazaki, N. Sugioka, K. Takada
2010Journal of materials science. Materials in medicine43 citations
Semantic Scholar
Pharmaceutical approach to HIV protease inhibitor atazanavir for bioavailability enhancement based on solid dispersion system.
Keizo Fukushima, Shuichi Terasaka, K. Haraya, S. Kodera +6 more
2007Biological and Pharmaceutical Bulletin43 citations Open access
Semantic Scholar
Effect of lipophilicity on the bioavailability of drugs after percutaneous administration by dissolving microneedles.
Yukako Ito, M. Yoshimura, Tsutomu Tanaka, K. Takada
2012Journal of Pharmacy and Science40 citations
Semantic Scholar
A validated LC-MS/MS method for the determination of canagliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, in a lower volume of rat plasma: application to pharmacokinetic studies in rats.
Shinji Kobuchi, K. Yano, Yukako Ito, T. Sakaeda
2016Biomedical chromotography39 citations
Semantic Scholar
Transdermal Insulin Application System with Dissolving Microneedles
Yukako Ito, T. Nakahigashi, N. Yoshimoto, Yuriko Ueda +2 more
2012Diabetes Technology & Therapeutics37 citations
Semantic Scholar
Percutaneous absorption of interferon-α by self-dissolving micropiles
Yukako Ito, Atsushi Saeki, Keiji Shiroyama, N. Sugioka +1 more
200835 citations
Semantic Scholar
Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors
T. Sakaeda, Shinji Kobuchi, Ryosuke Yoshioka, M. Haruna +9 more
2018International Journal of Medical Sciences33 citations Open access
Semantic Scholar
Self-dissolving micropile array chip as percutaneous delivery system of protein drug.
Yukako Ito, Ryo Hasegawa, Keizo Fukushima, N. Sugioka +1 more
2010Biological and Pharmaceutical Bulletin32 citations Open access
Semantic Scholar
Antihyperglycemic effect of insulin from self-dissolving micropiles in dogs.
Yukako Ito, Y. Ohashi, Atsushi Saeki, N. Sugioka +1 more
2008Chemical and pharmaceutical bulletin32 citations Open access
Semantic Scholar
Self-dissolving micropiles for the percutaneous absorption of recombinant human growth hormone in rats.
Yukako Ito, Y. Ohashi, Keiji Shiroyama, N. Sugioka +1 more
2008Biological and Pharmaceutical Bulletin31 citations Open access
Semantic Scholar
Dissolving microneedles to obtain rapid local anesthetic effect of lidocaine at skin tissue
Yukako Ito, Jun-ichi Ohta, Kazuki Imada, S. Akamatsu +4 more
2013Journal of drug targeting (Print)30 citations
Semantic Scholar
Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats
Shinji Kobuchi, Y. Yazaki, Yukako Ito, T. Sakaeda
2018European Journal of Pharmaceutical Sciences25 citations
Semantic Scholar
Application of Pharmacometrics of 5-Fluorouracil to Personalized Medicine: A Tool for Predicting Pharmacokinetic–Pharmacodynamic/Toxicodynamic Responses
Shinji Kobuchi, Yukako Ito
2020Anticancer Research22 citations Open access
Semantic Scholar
Pharmacokinetics of Macrolide Antibiotics and Transport into the Interstitial Fluid: Comparison among Erythromycin, Clarithromycin, and Azithromycin
Shinji Kobuchi, T. Kabata, K. Maeda, Yukako Ito +1 more
2020Antibiotics22 citations Open access
Semantic Scholar
Dissolving Microneedles as Skin Allergy Test Device.
Yukako Ito, Kengo Matsumoto, Noriyuki Osakama, Ryosuke Yoshioka +3 more
2017Biological and Pharmaceutical Bulletin19 citations Open access
Semantic Scholar
Application of dissolving microneedles to glucose monitoring through dermal interstitial fluid.
Yukako Ito, Mayu Taniguchi, Asuka Hayashi, Miku Anai +7 more
2014Biological and Pharmaceutical Bulletin19 citations Open access
Semantic Scholar
Permeation enhancement of ascorbic acid by self-dissolving micropile array tip through rat skin.
Yukako Ito, T. Maeda, Keizo Fukushima, N. Sugioka +1 more
2010Chemical and pharmaceutical bulletin19 citations Open access
Semantic Scholar
Pharmacokinetics of clomipramine, an antidepressant, in poloxamer 407‐induced hyperlipidaemic model rats
Shinji Kobuchi, Keizo Fukushima, Masakazu Shibata, Yukako Ito +2 more
2011The Journal of pharmacy and pharmacology18 citations
Semantic Scholar
Effects of obesity induced by high‐fat diet on the pharmacokinetics of nelfinavir, a HIV protease inhibitor, in laboratory rats
N. Sugioka, K. Haraya, Keizo Fukushima, Yukako Ito +1 more
2009Biopharmaceutics & drug disposition18 citations
Semantic Scholar
A quantitative LC-MS/MS method for determining ipragliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, and its application to a pharmacokinetic study in rats.
Shinji Kobuchi, Yukako Ito, K. Yano, T. Sakaeda
2015Journal of chromatography. B, Analytical technologies in the biomedical and life sciences15 citations
Semantic Scholar
Molecular weight dependence on bioavailability of FITC-dextran after administration of self-dissolving micropile to rat skin
Yukako Ito, A. Ise, N. Sugioka, K. Takada
2010Drug Development and Industrial Pharmacy15 citations
Semantic Scholar
Long-term pharmacokinetic efficacy and safety of low-dose ritonavir as a booster and atazanavir pharmaceutical formulation based on solid dispersion system in rats.
Keizo Fukushima, K. Haraya, Shuichi Terasaka, Yukako Ito +2 more
2008Biological and Pharmaceutical Bulletin15 citations Open access
Semantic Scholar
Circadian variations in the pharmacokinetics of the oral anticancer agent tegafur‐uracil (UFT) and its metabolites in rats
Shinji Kobuchi, Yukako Ito, Daiki Takamatsu, T. Sakaeda
2018European Journal of Pharmaceutical Sciences14 citations
Semantic Scholar
Dissolving microneedles for enhanced local delivery of capsaicin to rat skin tissue
Yukako Ito, Shinji Kobuchi, Genta Inoue, Eisaku Kakumu +3 more
2017Journal of drug targeting (Print)14 citations
Semantic Scholar
Mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of oxaliplatin for hematological toxicity in rats
Shinji Kobuchi, Y. Katsuyama, Yukako Ito
2019Xenobiotica; the fate of foreign compounds in biological systems13 citations
Semantic Scholar
Pharmacokinetic/pharmacodynamic modeling of 5-fluorouracil by using a biomarker to predict tumor growth in a rat model of colorectal cancer.
Shinji Kobuchi, Yukako Ito, K. Okada, K. Imoto +2 more
2013Journal of Pharmacy and Science13 citations
Semantic Scholar
Pharmacokinetic and toxicodynamic evaluation of oxaliplatin-induced neuropathy and hematological toxicity in rats
Yukako Ito, Shinji Kobuchi, Risa Shimizu, Y. Katsuyama
2017Cancer Chemotherapy and Pharmacology12 citations
Semantic Scholar
Semi-physiological pharmacokinetic–pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil and lymphocyte counts in rats
Shinji Kobuchi, Yukako Ito, Taro Hayakawa, S. Kuwano +5 more
2014Xenobiotica; the fate of foreign compounds in biological systems12 citations
Semantic Scholar
Pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation of 5-fluorouracil for erythropenia in rats.
Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Asako Nishimura +3 more
2014Journal of pharmacological and toxicological methods12 citations
Semantic Scholar
Method to increase the systemically delivered amount of drug from dissolving microneedles.
Yukako Ito, N. Hamasaki, H. Higashino, Y. Murakami +2 more
2013Chemical and pharmaceutical bulletin12 citations Open access
Semantic Scholar
Three-layered microcapsules as a long-term sustained release injection preparation.
Yukako Ito, Yuya Ochii, Keizo Fukushima, N. Sugioka +1 more
2010International journal of pharmaceutics12 citations
Semantic Scholar
Pharmacokinetics and lung distribution of macrolide antibiotics in sepsis model rats
Shinji Kobuchi, Akihiro Fujita, Akihito Kato, H. Kobayashi +2 more
2020Xenobiotica; the fate of foreign compounds in biological systems11 citations
Semantic Scholar
Population pharmacokinetic modelling and simulation of 5-fluorouracil incorporating a circadian rhythm in rats
Shinji Kobuchi, Yukako Ito, Yuya Nakano, T. Sakaeda
2016Xenobiotica; the fate of foreign compounds in biological systems11 citations
Semantic Scholar
Pre-therapeutic assessment of plasma dihydrouracil/uracil ratio for predicting the pharmacokinetic parameters of 5-fluorouracil and tumor growth in a rat model of colorectal cancer.
Shinji Kobuchi, Yukako Ito, K. Okada, K. Imoto +2 more
2013Biological and Pharmaceutical Bulletin11 citations Open access
Semantic Scholar
Development and validation of an LC-MS/MS method for the determination of tofogliflozin in plasma and its application to a pharmacokinetic study in rats.
Shinji Kobuchi, Megumi Matsuno, Etsuko Fukuda, Yukako Ito +1 more
2016Journal of chromatography. B, Analytical technologies in the biomedical and life sciences10 citations
Semantic Scholar
A predictive biomarker for altered 5‐fluorouracil pharmacokinetics following repeated administration in a rat model of colorectal cancer
Shinji Kobuchi, S. Kuwano, K. Imoto, K. Okada +4 more
2013Biopharmaceutics & drug disposition10 citations
Semantic Scholar
Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats
Shinji Kobuchi, Yukako Ito, K. Okada, K. Imoto +1 more
2012European journal of drug metabolism and pharmacokinetics10 citations
Semantic Scholar
Two- and Three-Layered Dissolving Microneedles for Transcutaneous Delivery of Model Vaccine Antigen in Rats
A. Ikejiri, Yukako Ito, S. Naito, K. Takada
20129 citations Open access
Semantic Scholar
Effect of streptozotocin‐induced diabetes mellitus on the pharmacokinetics of nelfinavir in rats
N. Sugioka, Kenji Sato, K. Haraya, Yu Maeda +4 more
2008Biopharmaceutics & drug disposition9 citations
Semantic Scholar
Assessment of Oxaliplatin-induced Chronic Neuropathy and Anticancer Efficacy Through Pharmacokinetic and Toxicodynamic Evaluation of a Rat Model of Colorectal Cancer
Yukako Ito, Shinji Kobuchi, Takesada Waki, Chiharu Takahashi
2019Anticancer Research8 citations Open access
Semantic Scholar
Transport of Azithromycin into Extravascular Space in Rats
Shinji Kobuchi, Miki Aoki, Chiaki Inoue, Hiroyuki Murakami +6 more
2016Antimicrobial Agents and Chemotherapy8 citations Open access
Semantic Scholar
Population Pharmacokinetic–Pharmacodynamic Modeling of 5-Fluorouracil for Toxicities in Rats
Shinji Kobuchi, Yukako Ito, T. Sakaeda
2016European journal of drug metabolism and pharmacokinetics8 citations
Semantic Scholar

Frequent co-authors

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K. Takada×36
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K. Takada — researcher profile on SciRah
Shinji Kobuchi×26
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Shinji Kobuchi — researcher profile on SciRah
N. Sugioka×17
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N. Sugioka — researcher profile on SciRah
T. Sakaeda×16
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Keizo Fukushima

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Keizo Fukushima — researcher profile on SciRah

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K. Haraya — researcher profile on SciRah

Nobuhito Shibata×4

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K. Okada — researcher profile on SciRah

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K. Imoto — researcher profile on SciRah

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S. Kuwano — researcher profile on SciRah

Ryo Hasegawa×3

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N. Hamasaki — researcher profile on SciRah