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J. Ruan · SciRah

Researcher profile · Semantic Scholar

J. Ruan

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J. Ruan — researcher profile on SciRah

h-index: 27
Works: 54
Citations: 9,877

Most-cited papers

Inflammasome - activated gasdermin D causes pyroptosis by forming membrane pores
Xing Liu, Zhi-Bin Zhang, J. Ruan, You-Dong Pan +3 more
2016Nature2,940 citations Open access
Semantic Scholar
Unified Polymerization Mechanism for the Assembly of ASC-dependent Inflammasomes
A. Lu, V. Magupalli, J. Ruan, Q. Yin +6 more
2014Cell1,282 citations Open access
Semantic Scholar
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
J. Hu, Xing Liu, S. Xia, Zhi-Bin Zhang +14 more
2020Nature Immunology1,028 citations Open access
Semantic Scholar
The pore forming protein gasdermin D regulates interleukin-1 secretion from living macrophages
C. Evavold, J. Ruan, Yun-Hao Tan, S. Xia +2 more
2017Immunity1,023 citations Open access
Semantic Scholar
Gasdermin D pore structure reveals preferential release of mature interleukin-1
S. Xia, Zhi-Bin Zhang, V. Magupalli, J. Pablo +9 more
2021Nature568 citations Open access
Semantic Scholar
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
I. Zanoni, Yun-Hao Tan, Marco di Gioia, A. Broggi +7 more
2016Science541 citations Open access
Semantic Scholar
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
Li-Man Zhang, Shuobing Chen, J. Ruan, Jiayi Wu +11 more
2015Science380 citations Open access
Semantic Scholar
Cryo-EM structure of the gasdermin A3 membrane pore
J. Ruan, S. Xia, Xing Liu, J. Lieberman +1 more
2018Nature367 citations Open access
Semantic Scholar
Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
C. Bian, Chao Xu, J. Ruan, Kenneth K. Lee +15 more
2011EMBO Journal265 citations Open access
Semantic Scholar
A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
F. Schmidt, A. Lu, Jeff W. Chen, J. Ruan +3 more
2016Journal of Experimental Medicine164 citations Open access
Semantic Scholar
INAUGURAL ARTICLE by a Recently Elected Academy Member:Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1
Yang Li, T. Fu, A. Lu, K. Witt +3 more
2018140 citations Open access
Semantic Scholar
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
Alessandro Annibaldi, Sidonie Wicky John, Tom Vanden Berghe, Kirby N. Swatek +12 more
2018Molecules and Cells139 citations Open access
Semantic Scholar
SERPINB1-mediated checkpoint of inflammatory caspase activation
Younho Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen +7 more
2019Nature Immunology128 citations Open access
Semantic Scholar
Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin
Ashley J. Russo, Swathy O. Vasudevan, S. Méndez-Huergo, P. Kumari +19 more
2021Nature Immunology118 citations Open access
Semantic Scholar
Molecular mechanism for NLRP6 inflammasome assembly and activation
Chen Shen, A. Lu, Wen-Jun Xie, J. Ruan +4 more
2019Proceedings of the National Academy of Sciences of the United States of America110 citations Open access
Semantic Scholar
Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
A. Lu, Yang Li, Q. Yin, J. Ruan +3 more
2015Cell Discovery93 citations Open access
Semantic Scholar
Structural basis for GSDMB pore formation and its targeting by IpaH7.8
Cheng-Liang Wang, Sonia Shivcharan, T. Tian, Skylar S. Wright +7 more
2023Nature86 citations Open access
Semantic Scholar
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
L. R. Hollingsworth, L. David, Yang Li, A. R. Griswold +7 more
2021Nature Communications69 citations Open access
Semantic Scholar
Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death.
J. Ruan
2019Advances in Experimental Medicine and Biology68 citations
Semantic Scholar
Mechanistic insights into gasdermin pore formation and regulation in pyroptosis
Cheng-Liang Wang, J. Ruan
2021Journal of Molecular Biology60 citations Open access
Semantic Scholar
Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors
X. Xiong, Songhai Tian, Pan Yang, F. Lebreton +14 more
2022Cell51 citations Open access
Semantic Scholar
Structural Basis for Specific Binding of Human MPP8 Chromodomain to Histone H3 Methylated at Lysine 9
Jing Li, Zhihong Li, J. Ruan, Chao Xu +6 more
2011PLoS ONE48 citations Open access
Semantic Scholar
Structural Analysis of Shu Proteins Reveals a DNA Binding Role Essential for Resisting Damage*
Yuyong Tao, Xu Li, Yiwei Liu, J. Ruan +3 more
2012Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1
J. Ruan, Chao Xu, C. Bian, R. Lam +4 more
2012FEBS Letters37 citations
Semantic Scholar
Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D
J. Hu, Xing Liu, Jing-Xia Zhao, S. Xia +5 more
2018bioRxiv33 citations Open access
Semantic Scholar
Structural Basis of the Chromodomain of Cbx3 Bound to Methylated Peptides from Histone H1 and G9a
J. Ruan, Hui Ouyang, M. Amaya, M. Ravichandran +3 more
2012PLoS ONE30 citations Open access
Semantic Scholar
Shiga toxin suppresses noncanonical inflammasome responses to cytosolic LPS
Morena S. Havira, Atri Ta, P. Kumari, Cheng-Liang Wang +4 more
2020Science immunology29 citations Open access
Semantic Scholar
Monitoring gasdermin pore formation in vitro
S. Xia, J. Ruan, Hao Wu
2019Methods in Enzymology23 citations Open access
Semantic Scholar
Nexinhib20 inhibits neutrophil adhesion and β2 integrin activation by antagonizing Rac-1-GTP interaction
Wei Liu, Chunxia G. Cronin, Zi-peng Cao, Cheng-Liang Wang +10 more
2022Journal of Immunology14 citations Open access
Semantic Scholar
An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis
Cheng-Liang Wang, J. Ruan
2023PLoS Biology6 citations Open access
Semantic Scholar
Cloning, purification, crystallization and preliminary crystallographic analysis of the tandem tudor domain of Sgf29 from Saccharomyces cerevisiae.
Jing Li, X. Xue, J. Ruan, Minhao Wu +2 more
2010Acta Crystallographica. Section F : Structural Biology and Crystallization Communications6 citations Open access
Semantic Scholar
Novel mode of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes
L. R. Hollingsworth, L. David, Yang Li, A. R. Griswold +6 more
2020bioRxiv5 citations Open access
Semantic Scholar
Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation
Younho Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen +7 more
2019Nature Immunology4 citations Open access
Semantic Scholar
Inflammasomes.
J. Ruan
2020Molecular Aspects of Medicine3 citations
Semantic Scholar
Cloning, purification, crystallization and preliminary crystallographic analysis of a ribokinase from Staphylococcus aureus.
Lin Wang, Haipeng Wang, J. Ruan, Chang-Lin Tian +2 more
2009Acta Crystallographica. Section F : Structural Biology and Crystallization Communications3 citations Open access
Semantic Scholar
Regulating GSDMB pore formation: to ignite or inhibit?
J. Ruan
2023Cell Death and Differentiation2 citations Open access
Semantic Scholar
Nexinhib20 prevents myocardial ischemia‐reperfusion injury by inhibiting neutrophil adhesion and β2 integrin activation
Zhi-Chao Fan, Wei Liu, Chunxia G. Cronin, Cheng-Liang Wang +9 more
2022The FASEB Journal1 citations
Semantic Scholar
Insights into gasdermin pore formation from the structure of a pre‐pore
S. Xia, J. Ruan, T. Fu, Hao Wu
2019The FASEB Journal1 citations
Semantic Scholar
The crystal structure of MPP8
Z. Li, J. Ruan, C. Xu, Y. Tong +5 more
20101 citations
Semantic Scholar
A Multifunctional Mxene Array Interface Coating for High-Rate and Stable Zn Metal Batteries
J. Ruan, Ding-Tao Ma, Kefeng Ouyang, Ming Yang +6 more
2022Social Science Research Network0 citations
Semantic Scholar
Nexinhib20 inhibits neutrophil adhesion and β2 integrin activation to prevent myocardial ischemia-reperfusion injury
Zhi-Chao Fan, Wei Liu, Chunxia G. Cronin, Cheng-Liang Wang +9 more
2022Journal of Immunology0 citations
Semantic Scholar
Pore-forming protein
S. Xia, J. Ruan, Hao Wu
20210 citations
Semantic Scholar
Pore Formation Mechanism of Human Gasdermin D
S. Xia, J. Ruan, Juan Lorenzo Pablo, Zhibin Zhang +5 more
20200 citations Open access
Semantic Scholar
Abstract A132: Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D
J. Hu, Xing Liu, Jing-Xia Zhao, S. Xia +5 more
2019Maintenance of Immune Balance: Effects of Targeted and Immune Therapies0 citations
Semantic Scholar
Crystal structure of an ASC binding nanobody
A. Lu, F. Schmidt, J. Ruan, C. Tang +2 more
20160 citations
Semantic Scholar
Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC
A. Lu, F. Schmidt, J. Ruan, C. Tang +2 more
20160 citations
Semantic Scholar
Abstract B134:Cryo-EMstructure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
Li-Man Zhang, Shuobing Chen, J. Ruan, L. David +2 more
20160 citations
Semantic Scholar
Unified assembly mechanism of ASC-dependent inflammasomes
A. Lu, V. Magupalli, J. Ruan, Q. Yin +6 more
20140 citations
Semantic Scholar
Complex structure of Sgf29 and trimethylated H3K4
J. Li, J. Ruan, M. Wu, X. Xue +1 more
20110 citations
Semantic Scholar
Crystal structure of Sgf29 tudor domain
J. Li, M. Wu, J. Ruan, J. Zang
20110 citations
Semantic Scholar

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Cheng-Liang Wang

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