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C. Hierholzer · SciRah

Researcher profile · Semantic Scholar

C. Hierholzer

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C. Hierholzer — researcher profile on SciRah

h-index: 34
Works: 90
Citations: 3,304

Most-cited papers

Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock
C. Hierholzer, B. Harbrecht, J. Menezes, J. Kane +5 more
1998Journal of Experimental Medicine502 citations Open access
Semantic Scholar
Biphasic response to gut manipulation and temporal correlation of cellular infiltrates and muscle dysfunction in rat.
J. Kalff, B. Buchholz, M. Eskandari, C. Hierholzer +3 more
1999Surgery181 citations
Semantic Scholar
Plate fixation of ununited humeral shaft fractures: effect of type of bone graft on healing.
C. Hierholzer, D. Samà, Jose B. Toro, M. Peterson +1 more
2006Journal of Bone and Joint Surgery. American volume171 citations
Semantic Scholar
Molecular mechanisms in the early phase of hemorrhagic shock
C. Hierholzer, T. Billiar
2001Langenbeck's archives of surgery (Print)147 citations Open access
Semantic Scholar
Outcome analysis of retrograde nailing and less invasive stabilization system in distal femoral fractures: A retrospective analysis
C. Hierholzer, C. von Rüden, T. Pötzel, A. Woltmann +1 more
2011Indian Journal of Orthopaedics120 citations Open access
Semantic Scholar
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury.
C. Hierholzer, J. Kalff, L. Omert, K. Tsukada +4 more
1998American Journal of Physiology - Lung cellular and Molecular Physiology118 citations
Semantic Scholar
Molecular and functional contractile sequelae of rat intestinal ischemia/reperfusion injury.
C. Hierholzer, Jörg C. Kalff, G. Audolfsson, T. Billiar +2 more
1999Transplantation117 citations Open access
Semantic Scholar
Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress.
S. Wehner, N. Schwarz, R. Hundsdoerfer, C. Hierholzer +4 more
2005Surgery101 citations
Semantic Scholar
Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock.
C. Hierholzer, J. Kalff, T. Billiar, A. Bauer +2 more
2004American Journal of Physiology - Gastrointestinal and Liver Physiology95 citations
Semantic Scholar
Association between a single-pass whole-body computed tomography policy and survival after blunt major trauma: a retrospective cohort study
Martin Hutter, A. Woltmann, C. Hierholzer, Christiane Gärtner +2 more
2011Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine87 citations Open access
Semantic Scholar
A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock.
J. Menezes, C. Hierholzer, Simon C Watkins, V. Lyons +4 more
1999American Journal of Physiology84 citations
Semantic Scholar
Breakage of cephalomedullary nailing in operative treatment of trochanteric and subtrochanteric femoral fractures
C. von Rüden, S. Hungerer, P. Augat, O. Trapp +2 more
2015Archives of Orthopaedic and Trauma Surgery80 citations
Semantic Scholar
Characterization of the Expression of Inducible Nitric Oxide Synthase in Rat and Human Liver During Hemorrhagic Shock
Joy L. Collins, Y. Vodovotz, C. Hierholzer, R. T. Villavicencio +10 more
2003Shock70 citations Open access
Semantic Scholar
Inhibition of Protein Synthesis by Nitric Oxide Correlates with Cytostatic Activity: Nitric Oxide Induces Phosphorylation of Initiation Factor eIF-2α
Young-Myeong Kim, K. Son, S. Hong, A. Green +4 more
1998Molecular Medicine70 citations Open access
Semantic Scholar
Chronic hepatitis C virus infection in humans: induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis.
J. Kane, L. Shears, C. Hierholzer, S. Ambs +2 more
1997Journal of Surgical Research70 citations
Semantic Scholar
Reamed intramedullary exchange nailing: treatment of choice of aseptic femoral shaft nonunion
C. Hierholzer, C. Glowalla, Michael Herrler, C. von Rüden +3 more
2014Journal of Orthopaedic Surgery and Research67 citations Open access
Semantic Scholar
Open reduction and internal fixation of distal femoral nonunions: long-term functional outcomes following a treatment protocol.
M. Gardner, Jose B. Toro-Arbelaez, M. Harrison, C. Hierholzer +2 more
2008Journal of Trauma65 citations
Semantic Scholar
G‐CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia
C. Hierholzer, E. Kelly, V. Lyons, Eva Roedling +3 more
1998Journal of Leukocyte Biology65 citations
Semantic Scholar
Outcome after severe multiple trauma: a retrospective analysis
C. von Rüden, A. Woltmann, M. Röse, S. Wurm +3 more
2013Journal of Trauma Management & Outcomes57 citations Open access
Semantic Scholar
The Modulation of Hepatic Injury and Heat Shock Expression by Inhibition of Inducible Nitric Oxide Synthase After Hemorrhagic Shock
J. Menezes, C. Hierholzer, Simon C Watkins, T. Billiar +2 more
2002Shock52 citations Open access
Semantic Scholar
Procalcitonin ratio as a predictor of successful surgical treatment of severe necrotizing soft tissue infections.
J. Friederichs, Martin Hutter, C. Hierholzer, A. Novotny +3 more
2013American Journal of Surgery49 citations
Semantic Scholar
Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock
C. Hierholzer, B. Harbrecht, T. Billiar, D. Tweardy
2001Archives of Orthopaedic and Trauma Surgery49 citations
Semantic Scholar
Hepatocyte nitric oxide biosynthesis inhibits glucose output and competes with urea synthesis for L-arginine.
J. Stadler, D. Barton, H. Beil-Moeller, S. Diekmann +3 more
1995American Journal of Physiology49 citations
Semantic Scholar
Acetabular fractures in the elderly.
Jose B. Toro, C. Hierholzer, D. Helfet
2004Bulletin (Hospital for Joint Diseases (New York, N.Y.))48 citations Open access
Semantic Scholar
Hemorrhagic shock induces G-CSF expression in bronchial epithelium.
C. Hierholzer, E. Kelly, K. Tsukada, E. Loeffert +3 more
1997American Journal of Physiology - Lung cellular and Molecular Physiology46 citations
Semantic Scholar
Impaired Gut Contractility Following Hemorrhagic Shock is Accompanied by IL-6 and G-CSF Production and Neutrophil Infiltration
C. Hierholzer, J. Kalff, A. Chakraborty, Simon C Watkins +3 more
2001Digestive Diseases and Sciences43 citations
Semantic Scholar
A Nitric Oxide Scavenger Protects Against Pulmonary Inflammation Following Hemorrhagic Shock
C. Hierholzer, J. Menezes, A. Ungeheuer, T. Billiar +2 more
2002Shock42 citations Open access
Semantic Scholar
Operative management of periarticular medial clavicle fractures—Report of ten cases
Keisuke Oe, Leander Gaul, C. Hierholzer, A. Woltmann +3 more
2012Journal of Trauma and Acute Care Surgery41 citations
Semantic Scholar
Reamed intramedullary exchange nailing in the operative treatment of aseptic tibial shaft nonunion
C. Hierholzer, J. Friederichs, C. Glowalla, A. Woltmann +2 more
2017International Orthopaedics40 citations Open access
Semantic Scholar
The missing effect of human recombinant Bone Morphogenetic Proteins BMP-2 and BMP-7 in surgical treatment of aseptic forearm nonunion.
C. von Rüden, M. Morgenstern, C. Hierholzer, S. Hackl +4 more
2016Injury40 citations Open access
Semantic Scholar
Hemorrhagic shock results in intestinal muscularis intercellular adhesion molecule (ICAM-1) expression, neutrophil infiltration, and smooth muscle dysfunction
Jörg C. Kalff, C. Hierholzer, K. Tsukada, T. Billiar +1 more
1999Archives of Orthopaedic and Trauma Surgery38 citations
Semantic Scholar
The effect of geriatric comanagement (GC) in geriatric trauma patients treated in a level 1 trauma setting: A comparison of data before and after the implementation of a certified geriatric trauma center
Sacha Halvachizadeh, L. Gröbli, T. Berk, K. Jensen +4 more
2021PLoS ONE35 citations Open access
Semantic Scholar
The unstable thoracic cage injury: The concomitant sternal fracture indicates a severe thoracic spine fracture.
M. Morgenstern, C. von Rüden, Hauke Callsen, J. Friederichs +4 more
2016Injury35 citations Open access
Semantic Scholar
The role of low-grade infection in the pathogenesis of apparently aseptic tibial shaft nonunion.
S. Hackl, L. Keppler, C. von Rüden, J. Friederichs +2 more
2021Injury34 citations
Semantic Scholar
Long-term outcome following additional rhBMP-7 application in revision surgery of aseptic humeral, femoral, and tibial shaft nonunion
S. Hackl, C. Hierholzer, J. Friederichs, A. Woltmann +2 more
2017BMC Musculoskeletal Disorders31 citations Open access
Semantic Scholar
Traumatic disruption of pubis symphysis with accompanying posterior pelvic injury after natural childbirth.
C. Hierholzer, Arif Ali, Jose B. Toro-Arbelaez, M. Suk +1 more
2007American journal of orthopedics28 citations
Semantic Scholar
Long-term consequences of pelvic trauma patients with thromboembolic disease treated with inferior vena caval filters.
Jose B. Toro, M. Gardner, C. Hierholzer, D. Samà +3 more
2008Journal of Trauma23 citations
Semantic Scholar
Neutrophil accumulation and damage to the gastric mucosa in resuscitated hemorrhagic shock is independent of inducible nitric oxide synthase.
K. Tsukada, L. Omert, J. Menezes, B. Harbrecht +3 more
1999Shock20 citations Open access
Semantic Scholar
Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock
C. Hierholzer, Jörg C. Kalff, T. Billiar, D. Tweardy
1998Archives of Orthopaedic and Trauma Surgery19 citations
Semantic Scholar
Surgical treatment of ipsilateral multi-level femoral fractures
C. von Rüden, M. Tauber, A. Woltmann, J. Friederichs +3 more
2015Journal of Orthopaedic Surgery and Research17 citations Open access
Semantic Scholar
[Intramedullary nailing vs. locking plate osteosynthesis in proximal humeral fractures: Long-term outcome].
C. von Rüden, O. Trapp, C. Hierholzer, S. Prohaska +2 more
2015Der Unfallchirurg17 citations
Semantic Scholar
Comparative study suggests that human bone morphogenetic proteins have no influence on the outcome of operative treatment of aseptic clavicle non-unions
C. von Rüden, M. Morgenstern, J. Friederichs, P. Augat +4 more
2016International Orthopaedics16 citations Open access
Semantic Scholar
Rapid and simultaneous activation of Stat3 and production of interleukin 6 in resuscitated hemorrhagic shock
C. Hierholzer, J. Kalff, B. Bednarski, F. Memarzadeh +3 more
1999Archives of Orthopaedic and Trauma Surgery16 citations
Semantic Scholar
A ROLE OF NEUTROPHILS IN THE DOWN‐REGULATION OF IL‐6 AND CD14 FOLLOWING HEMORRHAGIC SHOCK
L. Omert, K. Tsukada, C. Hierholzer, V. Lyons +3 more
1998Shock16 citations
Semantic Scholar
Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase
C. Hierholzer, E. Kelly, T. Billiar, D. Tweardy
2004Archives of Orthopaedic and Trauma Surgery15 citations
Semantic Scholar
The pivotal role of the intermediate fragment in initial operative treatment of olecranon fractures
C. von Rüden, A. Woltmann, C. Hierholzer, O. Trentz +1 more
2011Journal of Orthopaedic Surgery and Research13 citations Open access
Semantic Scholar
Operative Timing and Management of Spinal Injuries in Multiply Injured Patients
C. Hierholzer, V. Bühren, A. Woltmann
2007European Journal of Trauma and Emergency Surgery13 citations Open access
Semantic Scholar
Management of persistent postpartum pelvic pain.
Y. Weil, C. Hierholzer, D. Samà, C. Wright +3 more
2008American journal of orthopedics12 citations
Semantic Scholar
Stent placement in short unilateral iliac occlusion: Technique and 24-month results
H. Steinkamp, M. Werk, C. Wissgott, U. Settmacher +3 more
2001Acta Radiologica12 citations
Semantic Scholar
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury
C. Hierholzer, J. Kalff, L. Omert, K. Tsukada +4 more
199811 citations
Semantic Scholar

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T. Billiar×19
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T. Billiar — researcher profile on SciRah
D. Tweardy×15
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V. Bühren×15
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C. von Rüden×13
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A. Woltmann — researcher profile on SciRah

J. Friederichs×9

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B. Harbrecht×7

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Simon C Watkins×7

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D. Helfet — researcher profile on SciRah

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K. Tsukada — researcher profile on SciRah

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J. Menezes — researcher profile on SciRah

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