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D. Tweardy · SciRah

Researcher profile · Semantic Scholar

D. Tweardy

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D. Tweardy — researcher profile on SciRah

h-index: 64
Works: 299
Citations: 15K

Most-cited papers

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
U. Bharadwaj, M. Kasembeli, P. Robinson, D. Tweardy
2020Pharmacological Reviews282 citations Open access
Semantic Scholar
Stat3 Activation links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass
Li-Ping Zhang, Jenny Pan, Yan-Jun Dong, D. Tweardy +3 more
2013Cell Metabolism256 citations Open access
Semantic Scholar
Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor.
M. Redell, M. J. Ruiz, T. Alonzo, R. Gerbing +1 more
2011Blood239 citations Open access
Semantic Scholar
Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia*
K. Silva, Jiangling Dong, Yan-Jun Dong, Yan-Lan Dong +4 more
2015Journal of Biological Chemistry204 citations Open access
Semantic Scholar
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
M. Kasembeli, U. Bharadwaj, P. Robinson, D. Tweardy
2018International Journal of Molecular Sciences183 citations Open access
Semantic Scholar
STAT‐3 contributes to pulmonary fibrosis through epithelial injury and fibroblast‐myofibroblast differentiation
Mesias Pedroza, Thuy T. Le, Katherine Lewis, H. Karmouty-quintana +5 more
2016The FASEB Journal182 citations Open access
Semantic Scholar
Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy
Meenu Sharma, H. Khong, F. Fa'ak, S. Bentebibel +27 more
2020Nature Communications155 citations Open access
Semantic Scholar
DRUG-REPOSITIONING SCREENING IDENTIFIED PIPERLONGUMINE AS A DIRECT STAT3 INHIBITOR WITH POTENT ACTIVITY AGAINST BREAST CANCER
U. Bharadwaj, T. K. Eckols, Mikhail I Kolosov, M. Kasembeli +12 more
2014Oncogene149 citations Open access
Semantic Scholar
STAT3 Signaling Is Activated Preferentially in Tumor‐Initiating Cells in Claudin‐Low Models of Human Breast Cancer
Wei Wei, D. Tweardy, Mei Zhang, Xiao-Mei Zhang +7 more
2014Stem Cells113 citations Open access
Semantic Scholar
Estrogen Replacement Reduces Risk and Increases Survival Times of Women With Hepatocellular Carcinoma
Manal M. Hassan, G. Botrus, Reham Abdel-Wahab, R. Wolff +20 more
2017Clinical Gastroenterology and Hepatology112 citations Open access
Semantic Scholar
STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model
A. C. Gavino, Karen Nahmod, U. Bharadwaj, George Makedonas +1 more
2016Allergy. European Journal of Allergy and Clinical Immunology109 citations
Semantic Scholar
Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin
M. Kasembeli, W. Lau, S. Roh, T. K. Eckols +3 more
2014PLoS Biology101 citations Open access
Semantic Scholar
Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
Manisha Singh, Christina Vianden, M. Cantwell, Zhi-Min Dai +14 more
2017Nature Communications81 citations Open access
Semantic Scholar
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis
S. Roh, M. Kasembeli, Deenadayalan Bakthavatsalam, W. Chiu +1 more
2015International Journal of Molecular Sciences78 citations Open access
Semantic Scholar
Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model
B. Dave, M. Landis, L. Dobrolecki, Meng-Fen Wu +7 more
2012PLoS ONE74 citations Open access
Semantic Scholar
Role of STAT3 in skin fibrosis and transforming growth factor beta signalling
Mesias Pedroza, Sarah To, S. Assassi, Ming-Hua Wu +2 more
2018Rheumatology71 citations Open access
Semantic Scholar
BACTERIOPHAGES ARE SYNERGISTIC WITH BACTERIAL INTERFERENCE FOR THE PREVENTION OF PSEUDOMONAS AERUGINOSA BIOFILM FORMATION ON URINARY CATHETERS
Kershena Liao, S. Lehman, D. Tweardy, R. Donlan +1 more
2012Journal of Applied Microbiology71 citations Open access
Semantic Scholar
Association Between Hepatitis C Virus and Head and Neck Cancers.
Parag Mahale, E. Sturgis, D. Tweardy, E. Ariza-Heredia +1 more
2016Journal of the National Cancer Institute68 citations Open access
Semantic Scholar
Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance
P. Robinson, M. Kasembeli, U. Bharadwaj, Nikita Engineer +2 more
2016BioMed Research International61 citations Open access
Semantic Scholar
Diminution of STAT3 signaling inhibits vascular permeability and anaphylaxis
V. Hox, M. O'Connell, Jonathan J. Lyons, P. Sackstein +10 more
2016Journal of Allergy and Clinical Immunology56 citations Open access
Semantic Scholar
PARP inhibition suppresses growth of EGFR-mutant cancers by targeting nuclear PKM2
Nan Li, Lin Feng, Hui Liu, Jiadong Wang +5 more
2016Cell Reports55 citations Open access
Semantic Scholar
Substance P Causes Seizures in Neurocysticercosis
P. Robinson, A. Garza, J. Weinstock, José A. Serpa +4 more
2012PLoS Pathogens54 citations Open access
Semantic Scholar
Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy
S. Haricharan, Jie Dong, Sarah M. Hein, J. Reddy +15 more
2013eLife49 citations Open access
Semantic Scholar
The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma
Hai-Feng Zhang, Ye Chen, Chengsheng Wu, Zhi-Yong Wu +12 more
2015Clinical Cancer Research47 citations
Semantic Scholar
Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40.
Li-Ping Zhang, Zihong Chen, Ying Wang, D. Tweardy +1 more
2020American Journal of Physiology. Endocrinology and Metabolism43 citations Open access
Semantic Scholar
TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain
M. Kasembeli, Pooja Singhmar, Jiacheng Ma, Jules D. Edralin +5 more
2021Biochemical Pharmacology40 citations Open access
Semantic Scholar
Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease
Jing-Jing Jiao, Jessica I. Sanchez, Omar A. Saldarriaga, L. Solis +4 more
2022JHEP Reports38 citations Open access
Semantic Scholar
Rhodium(II) proximity-labeling identifies a novel target site on STAT3 for inhibitors with potent anti-leukemia activity
Matthew B. Minus, Wei Liu, Farrukh Vohidov, M. Kasembeli +8 more
2015Angewandte Chemie36 citations Open access
Semantic Scholar
FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report.
M. Redell, M. J. Ruiz, R. Gerbing, T. Alonzo +3 more
2013Blood36 citations Open access
Semantic Scholar
Lethal human neutropenic entercolitis caused by Clostridium chauvoei in the United States: tip of the iceberg?
J. Weatherhead, D. Tweardy
2012Journal of Infection33 citations
Semantic Scholar
Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome.
C. Bocchini, Karen Nahmod, Panagiotis Katsonis, Sang Kim +5 more
2016Blood30 citations Open access
Semantic Scholar
Contribution of chaperones to STAT pathway signaling.
C. Bocchini, M. Kasembeli, S. Roh, D. Tweardy
2014JAK-STAT30 citations Open access
Semantic Scholar
Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO*
S. Roh, M. Kasembeli, Jesús G. Galaz-Montoya, M. Trnka +4 more
2015Journal of Biological Chemistry29 citations Open access
Semantic Scholar
NANOSCALE SURFACE MODIFICATION FAVORS BENIGN BIOFILM FORMATION AND IMPEDES ADHERENCE BY PATHOGENS
B. Trautner, Analette I. Lopez, Amit Kumar, D. Siddiq +4 more
2011Nanomedicine: Nanotechnology, Biology and Medicine26 citations Open access
Semantic Scholar
Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.
J. Qiu, Xiao-Xi Lu, B. Zeisig, Zhi-Gui Ma +6 more
2010Blood25 citations
Semantic Scholar
Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers
M. Kasembeli, E. Kaparos, U. Bharadwaj, Ahmad B. Allaw +3 more
2022Blood23 citations Open access
Semantic Scholar
STAT3 Inhibitors in Cancer: A Comprehensive Update
U. Bharadwaj, M. Kasembeli, D. Tweardy
201623 citations
Semantic Scholar
A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance
Hanan S. Elsarraj, Yan Hong, K. Valdez, Martha Z. Carletti +8 more
2013Journal of Cell Science23 citations Open access
Semantic Scholar
Novel STAT3 Small-Molecule Inhibitors Identified by Structure-Based Virtual Ligand Screening Incorporating SH2 Domain Flexibility
Ren Kong, U. Bharadwaj, T. K. Eckols, Mikhail I Kolosov +8 more
2021Pharmacological Research22 citations Open access
Semantic Scholar
Pharmacokinetics (PK) and pharmacodynamics (PD) of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease.
Li-Ping Zhang, Ying Wang, Yan-Lan Dong, Zihong Chen +4 more
2020AJP - Renal Physiology22 citations Open access
Semantic Scholar
Severe pulmonary involvement in a case attributed to domestically acquired Seoul hantavirus in the United States.
Ingrid L Roig, D. Musher, D. Tweardy
2012Clinical Infectious Diseases21 citations
Semantic Scholar
Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer
U. Bharadwaj, M. Kasembeli, T. K. Eckols, Mikhail I Kolosov +4 more
2014Cancers19 citations Open access
Semantic Scholar
Modulation of the Unfolded Protein Response During Hepatocyte and Cardiomyocyte Apoptosis In Trauma/Hemorrhagic Shock
Stephen A. Thacker, P. Robinson, A. Abel, D. Tweardy
2013Scientific Reports19 citations Open access
Semantic Scholar
Stat5: from breast development to cancer prognosis, prediction, and progression.
D. Tweardy, Jenny C. Chang
2011Journal of Clinical Oncology19 citations Open access
Semantic Scholar
Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy
K. Hoffman, M. J. Villar, Cristina Poveda, M. Bottazzi +3 more
2021Frontiers in Cellular and Infection Microbiology18 citations Open access
Semantic Scholar
First Description of Oral Cryptococcus neoformans Causing Osteomyelitis of the Mandible, Manubrium and Third Rib with Associated Soft Tissue Abscesses in an Immunocompetent Host
A. DiNardo, D. Schmidt, A. Mitchell, Yoav Kaufman +1 more
2015Clinical microbiology & case reports18 citations
Semantic Scholar
Impact of epidural analgesia on the systemic biomarker response after hepatic resection
D. Vicente, M. Patiño, Rebecca Marcus, Heather Lillmoe +10 more
2019OncoTarget17 citations Open access
Semantic Scholar
Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†
Heng-Jie Yuan, Katie L. L. Houck, Ye Tian, U. Bharadwaj +10 more
2015PLoS ONE17 citations Open access
Semantic Scholar
INCREASED APOPTOSIS OF PERIPHERAL BLOOD NEUTROPHILS IS ASSOCIATED WITH REDUCED INCIDENCE OF INFECTION IN TRAUMA PATIENTS WITH HEMORRHAGIC SHOCK
C. A. Morrison, A. Moran, Shruti B. Patel, Maria del Pilar Huby Vidaurre +2 more
2012Journal of Infection15 citations Open access
Semantic Scholar
Stat 3 signaling in acute myeloid leukemia : ligand-dependent and-independent activation and induction of apoptosis by a novel small-molecule Stat 3 inhibitor
M. Redell, M. J. Ruiz, T. Alonzo, R. Gerbing +1 more
201114 citations
Semantic Scholar

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