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C. Deben · SciRah

Researcher profile · Semantic Scholar

C. Deben

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C. Deben — researcher profile on SciRah

h-index: 24
Works: 86
Citations: 2,096

Most-cited papers

The potential and controversy of targeting STAT family members in cancer.
Y. Verhoeven, Sam Tilborghs, J. Jacobs, J. De Waele +9 more
2020Seminars in Cancer Biology322 citations Open access
Semantic Scholar
Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer Cells
J. Van Loenhout, T. Flieswasser, Laurie Freire Boullosa, J. De Waele +12 more
2019Cancers105 citations Open access
Semantic Scholar
Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer
Laurie Freire Boullosa, J. Van Loenhout, T. Flieswasser, J. De Waele +10 more
2021Redox Biology99 citations Open access
Semantic Scholar
Oxidative Stress-Inducing Anticancer Therapies: Taking a Closer Look at Their Immunomodulating Effects
J. Van Loenhout, M. Peeters, A. Bogaerts, E. Smits +1 more
2020Antioxidants98 citations Open access
Semantic Scholar
The Influence of Cell Type and Culture Medium on Determining Cancer Selectivity of Cold Atmospheric Plasma Treatment
Eline Biscop, A. Lin, W. Van Boxem, J. Van Loenhout +5 more
2019Cancers97 citations Open access
Semantic Scholar
IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts
Astrid Van Den Eynde, Laura Gehrcken, Tias Verhezen, Ho-Wa Lau +23 more
2024Journal of Hematology & Oncology95 citations Open access
Semantic Scholar
Cellular senescence in cancer: clinical detection and prognostic implications
A. Domen, C. Deben, Jasper Verswyvel, T. Flieswasser +4 more
2022Journal of experimental & clinical cancer research : CR88 citations Open access
Semantic Scholar
TP53 and MDM2 genetic alterations in non-small cell lung cancer: Evaluating their prognostic and predictive value.
C. Deben, V. Deschoolmeester, F. Lardon, C. Rolfo +1 more
2016Critical reviews in oncology/hematology87 citations
Semantic Scholar
OrBITS: label-free and time-lapse monitoring of patient derived organoids for advanced drug screening
C. Deben, Edgar Cardenas De La Hoz, Maxim Le Compte, P. V. Van Schil +10 more
2021bioRxiv71 citations Open access
Semantic Scholar
Urine biomarkers in cancer detection: A systematic review of preanalytical parameters and applied methods
S. Jordaens, K. Zwaenepoel, W. Tjalma, C. Deben +4 more
2023International Journal of Cancer67 citations Open access
Semantic Scholar
Auranofin and Cold Atmospheric Plasma Synergize to Trigger Distinct Cell Death Mechanisms and Immunogenic Responses in Glioblastoma
J. Van Loenhout, Laurie Freire Boullosa, D. Quatannens, J. De Waele +10 more
2021Cells66 citations Open access
Semantic Scholar
The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer
C. Deben, A. Wouters, K. O. de Beeck, J. Van den Bossche +8 more
2015OncoTarget65 citations Open access
Semantic Scholar
STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy
Laura Gehrcken, C. Deben, E. Smits, J. V. Van Audenaerde
2025Advancement of science59 citations Open access
Semantic Scholar
Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation
J. Jacobs, V. Deschoolmeester, K. Zwaenepoel, T. Flieswasser +10 more
2018Oncoimmunology59 citations Open access
Semantic Scholar
APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines.
C. Deben, F. Lardon, A. Wouters, Ken Op de Beeck +7 more
2016Cancer Letters59 citations
Semantic Scholar
Unlocking the potential of CD70 as a novel immunotherapeutic target for non-small cell lung cancer
J. Jacobs, K. Zwaenepoel, C. Rolfo, J. Van den Bossche +8 more
2015OncoTarget58 citations Open access
Semantic Scholar
Cancer-Associated Fibroblasts as a Common Orchestrator of Therapy Resistance in Lung and Pancreatic Cancer
A. Domen, D. Quatannens, S. Zanivan, C. Deben +11 more
2021Cancers55 citations Open access
Semantic Scholar
Hypoxia-Induced Cisplatin Resistance in Non-Small Cell Lung Cancer Cells Is Mediated by HIF-1α and Mutant p53 and Can Be Overcome by Induction of Oxidative Stress
C. Deben, V. Deschoolmeester, J. De Waele, J. Jacobs +7 more
2018Cancers55 citations Open access
Semantic Scholar
Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade
J. De Waele, E. Marcq, J. V. Van Audenaerde, J. Van Loenhout +13 more
2018Oncoimmunology42 citations Open access
Semantic Scholar
Single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer
Maxim Le Compte, Edgar Cardenas De La Hoz, Sofía Peeters, Felicia Rodrigues Fortes +12 more
2023npj Precision Oncology39 citations Open access
Semantic Scholar
Prognostic implications of cellular senescence in resected non-small cell lung cancer
A. Domen, C. Deben, I. De Pauw, Christophe Hermans +15 more
2021Translational Lung Cancer Research36 citations Open access
Semantic Scholar
Expression Analysis on Archival Material Revisited: Isolation and Quantification of RNA Extracted From FFPE Samples
C. Deben, K. Zwaenepoel, Carolien Boeckx, A. Wouters +5 more
2013Diagnostic molecular pathology (Print)32 citations
Semantic Scholar
Deep sequencing of the TP53 gene reveals a potential risk allele for non–small cell lung cancer and supports the negative prognostic value of TP53 variants
C. Deben, J. Van den Bossche, N. Van Der Steen, F. Lardon +9 more
2017Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine29 citations Open access
Semantic Scholar
Auranofin Synergizes with the PARP Inhibitor Olaparib to Induce ROS-Mediated Cell Death in Mutant p53 Cancers
Laurie Freire Boullosa, J. Van Loenhout, T. Flieswasser, Christophe Hermans +8 more
2023Antioxidants26 citations Open access
Semantic Scholar
In vitro study of the Polo‐like kinase 1 inhibitor volasertib in non‐small‐cell lung cancer reveals a role for the tumor suppressor p53
J. Van den Bossche, C. Deben, I. De Pauw, H. Lambrechts +9 more
2019Molecular Oncology26 citations Open access
Semantic Scholar
Development and validation of the Normalized Organoid Growth Rate (NOGR) metric in brightfield imaging-based assays
C. Deben, Edgar Cardenas De La Hoz, Felicia Rodrigues Fortes, Maxim Le Compte +11 more
2024Communications Biology22 citations Open access
Semantic Scholar
Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition
C. Deben, L. F. Boullosa, Felicia Rodrigues Fortes, Edgar Cardenas De La Hoz +12 more
2024Journal of experimental & clinical cancer research : CR21 citations Open access
Semantic Scholar
Mass Spectrometry Imaging Reveals Neutrophil Defensins as Additional Biomarkers for Anti-PD-(L)1 Immunotherapy Response in NSCLC Patients
Eline Berghmans, J. Jacobs, C. Deben, Christophe Hermans +6 more
2020Cancers21 citations Open access
Semantic Scholar
Functional Validation of the Putative Oncogenic Activity of PLAU
Federica Sarno, Désiréé Goubert, Emilie Logie, M. Rutten +8 more
2022Biomedicines17 citations Open access
Semantic Scholar
Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis.
Maxim Le Compte, Edgar Cardenas De La Hoz, Sofía Peeters, E. Smits +7 more
2022Journal of Visualized Experiments17 citations
Semantic Scholar
Radiosensitization of Non-Small Cell Lung Cancer Cells by the Plk1 Inhibitor Volasertib Is Dependent on the p53 Status
J. Van den Bossche, A. Domen, M. Peeters, C. Deben +8 more
2019Cancers16 citations Open access
Semantic Scholar
Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy
J. Jacobs, V. Deschoolmeester, C. Rolfo, K. Zwaenepoel +10 more
2017OncoTarget14 citations Open access
Semantic Scholar
Capturing the Heterogeneity of the PDAC Tumor Microenvironment: Novel Triple Co-Culture Spheroids for Drug Screening and Angiogenic Evaluation
Ruben Verloy, A. Privat-Maldonado, J. V. Van Audenaerde, Sophie Rovers +8 more
2025Cells12 citations Open access
Semantic Scholar
Towards Prognostic Profiling of Non-Small Cell Lung Cancer: New Perspectives on the Relevance of Polo-Like Kinase 1 Expression, the TP53 Mutation Status and Hypoxia
J. Van den Bossche, C. Deben, Ken Op de Beeck, V. Deschoolmeester +9 more
2017Journal of Cancer12 citations Open access
Semantic Scholar
CRISPR/Cas9-edited ROS1 + non-small cell lung cancer cell lines highlight differential drug sensitivity in 2D vs 3D cultures while reflecting established resistance profiles
Marc Terrones, C. Deben, Felicia Rodrigues-Fortes, A. Schepers +3 more
2024Journal of Translational Medicine11 citations Open access
Semantic Scholar
A Systematic Review of Patient-derived Tumor Organoids Generation from Malignant Effusions.
Sofie Seghers, Maxim Le Compte, Jeroen M. H. Hendriks, P. V. Van Schil +5 more
2024Critical reviews in oncology/hematology11 citations
Semantic Scholar
Characterization of acquired nutlin-3 resistant non-small cell lung cancer cells
C. Deben, L. F. Boullosa, A. Domen, A. Wouters +4 more
2020Cancer Drug Resistance11 citations Open access
Semantic Scholar
Better to be alone than in bad company: The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer
N. Van Der Steen, C. Deben, V. Deschoolmeester, A. Wouters +6 more
2016World Journal of Clinical Oncology11 citations Open access
Semantic Scholar
Advancements in Research and Treatment Applications of Patient-Derived Tumor Organoids in Colorectal Cancer
D. van der Graaff, Sofie Seghers, P. Vanclooster, C. Deben +2 more
2024Cancers9 citations Open access
Semantic Scholar
Expression of SARS-CoV-2-Related Surface Proteins in Non-Small-Cell Lung Cancer Patients and the Influence of Standard of Care Therapy
C. Deben, Maxim Le Compte, V. Siozopoulou, H. Lambrechts +10 more
2022Cancers8 citations Open access
Semantic Scholar
Optimization of the Solvent and In Vivo Administration Route of Auranofin in a Syngeneic Non-Small Cell Lung Cancer and Glioblastoma Mouse Model
Laurie Freire Boullosa, J. Van Loenhout, Christophe Hermans, Ho-Wa Lau +8 more
2022Pharmaceutics8 citations Open access
Semantic Scholar
UAS™—A Urine Preservative for Oncology Applications
S. Jordaens, Amit Arora, Kyle Macdonald, Cameron Wood +7 more
2023Cancers7 citations Open access
Semantic Scholar
Patient-derived organoids as individual patient models for chemoradiation response prediction in gastrointestinal malignancies.
Maxim Le Compte, Niels Komen, I. Joye, M. Peeters +4 more
2020Critical reviews in oncology/hematology7 citations Open access
Semantic Scholar
"Keep on ROCKIn": Repurposed ROCK inhibitors to boost corneal endothelial regeneration.
Hendrik Vercammen, Martin Ondra, Jana Kotulová, Edgar Cardenas De La Hoz +8 more
2024Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie6 citations Open access
Semantic Scholar
Phototoxicity and cell passage affect intracellular reactive oxygen species levels and sensitivity towards non-thermal plasma treatment in fluorescently-labeled cancer cells
Hanne Verswyvel, C. Deben, A. Wouters, F. Lardon +3 more
2023Journal of Physics D: Applied Physics6 citations Open access
Semantic Scholar
MDM2 SNP309 and SNP285 Act as Negative Prognostic Markers for Non-small Cell Lung Cancer Adenocarcinoma Patients
C. Deben, Ken Op de Beeck, J. Van den Bossche, J. Jacobs +7 more
2017Journal of Cancer4 citations Open access
Semantic Scholar
Deep sequencing of the TP 53 gene reveals a potential risk allele for non – small cell lung cancer and supports the negative prognostic value of TP 53 variants
C. Deben, J. Van den Bossche, N. Van Der Steen, F. Lardon +9 more
20174 citations
Semantic Scholar
Protein accumulation and rumen stability of wheat γ-gliadin fusion proteins in tobacco and alfalfa.
Xiao-Dong Sun, C. Chi-Ham, T. Cohen-Davidyan, C. Deben +4 more
2015Plant Biotechnology Journal4 citations Open access
Semantic Scholar
DRP1 depletion protects NK cells from hypoxia-induced dysfunction
Tias Verhezen, Astrid Van Den Eynde, P. Verstraelen, Laura Gehrcken +20 more
2026Redox Report3 citations Open access
Semantic Scholar
Immunogenic Potential Of Cold Atmospheric Plasma For The Treatment Of Pancreatic Cancer
J. Van Loenhout, C. Deben, J. Jacobs, J. De Waele +5 more
20183 citations
Semantic Scholar

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