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O. Saavedra · SciRah

Researcher profile · Semantic Scholar

O. Saavedra

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O. Saavedra — researcher profile on SciRah

h-index: 15
Works: 35
Citations: 570

Most-cited papers

Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.
S. Claridge, F. Raeppel, Marie-Claude Granger, Naomy Bernstein +23 more
2008Bioorganic & Medicinal Chemistry Letters63 citations Open access
Semantic Scholar
SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes.
O. Saavedra, L. Isakovic, David B. Llewellyn, Lijie Zhan +12 more
2009Bioorganic & Medicinal Chemistry Letters57 citations Open access
Semantic Scholar
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors.
L. Isakovic, O. Saavedra, David B. Llewellyn, S. Claridge +12 more
2009Bioorganic & Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
M. Mannion, S. Raeppel, S. Claridge, N. Zhou +20 more
2009Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
Chemical Synthesis of beta-Homonojirimycin, of Its N-Butyl Derivative, and of "Methyl Homoazacellobioside"
O. Saavedra, O. Martin
1996Journal of Organic Chemistry35 citations
Semantic Scholar
N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
S. Raeppel, S. Claridge, O. Saavedra, F. Gaudette +20 more
2009Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
α- and β-Homogalactonojirimycins (α- and β-Homogalactostatins): synthesis and further biological evaluation
O. Martin, O. Saavedra, F. Xie, Li Liu +4 more
200133 citations Open access
Semantic Scholar
Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors.
I. Paquin, S. Raeppel, S. Leit, F. Gaudette +21 more
2008Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Practical syntheses of B disaccharide and linear B type 2 trisaccharide—non-primate epitope markers recognized by human anti-α-Gal antibodies causing hyperacute rejection of xenotransplants
S. Hanessian, O. Saavedra, V. Mascitti, W. Marterer +2 more
200131 citations
Semantic Scholar
Concise chemical synthesis of β-homonojirimycin and related compounds
O. Martin, O. Saavedra
199526 citations
Semantic Scholar
N3-arylmalonamides: a new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases.
O. Saavedra, S. Claridge, Lijie Zhan, F. Raeppel +16 more
2009Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Identification of a novel series of potent RON receptor tyrosine kinase inhibitors.
S. Raeppel, F. Gaudette, M. Mannion, S. Claridge +12 more
2010Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4′-deoxy-4′-fluoro neomycin analogs
S. Hanessian, O. Saavedra, M. Vilchis-Reyes, J. Maianti +5 more
201417 citations
Semantic Scholar
Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue.
S. Hanessian, A. Giguère, J. Grzyb, J. Maianti +11 more
2011ACS Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells.
S. Hanessian, Lijie Zhan, R. Bovey, O. Saavedra +1 more
2003Journal of Medicinal Chemistry16 citations
Semantic Scholar
Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines.
Stephen Hanessian, O. Saavedra, F. Xie, Nadia Amboldi +1 more
2000Bioorganic & Medicinal Chemistry Letters14 citations
Semantic Scholar
Short step synthesis of (22E, 24R)-5α-ergosta-2,22-dien-6-one, a key intermediate for the preparation of 24-epibrassinolide
J. Ferrer, Rubén Lalueza, O. Saavedra, C. Brosa
199011 citations
Semantic Scholar
Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT6 receptor ligands with significant selectivity for D3 over D2 receptors.
O. Saavedra, D. Karila, D. Brossard, A. Rojas +6 more
2017Bioorganic & Medicinal Chemistry8 citations Open access
Semantic Scholar
Synthesis of 4′-deoxy-4′-fluoro neamine and 4′-deoxy-4′-fluoro 4′-epi neamine
S. Hanessian, O. Saavedra, M. Vilchis-Reyes, Ana M. Llaguno-Rueda
20146 citations
Semantic Scholar
Design and synthesis of bridged piperidine and piperazine isosteres.
G. Maertens, O. Saavedra, V. Vece, Miguel A. Vilchis Reyes +7 more
2018Bioorganic & Medicinal Chemistry Letters5 citations
Semantic Scholar
Abstract 930: Preclinical characterization of MG516, a novel inhibitor of receptor tyrosine kinases involved in resistance to targeted therapies.
N. Beaulieu, H. Sainte-Croix, C. Bonfils, M. Mannion +10 more
20135 citations
Semantic Scholar
Fluorinated aminoglycosides
O. Saavedra, M. Vilchis-Reyes
2019ARKIVOC3 citations Open access
Semantic Scholar
Structure‐Based Design of a Eukaryote‐Selective Antiprotozoal Fluorinated Aminoglycoside
H. Kanazawa, O. Saavedra, J. Maianti, S. Young +4 more
2018ChemMedChem3 citations Open access
Semantic Scholar
Abstract 3612: Potent preclinical anti-tumor activity of MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, in combination with an EGFR inhibitor
M. Fournel, I. Dupont, C. Bonfils, M. Dubay +15 more
20103 citations
Semantic Scholar
Inhibitors of the VEGF receptor and the HGF receptor signaling
O. Saavedra, S. Claridge, Lijie Zhan, F. Raeppel +6 more
20062 citations
Semantic Scholar
Practical Syntheses of B Disaccharide (I) and Linear B Type 2 Trisaccharide (II) — Non-Primate Epitope Markers Recognized by Human Anti-α-Gal Antibodies Causing Hyperacute Rejection of Xenotransplants.
S. Hanessian, O. Saavedra, V. Mascitti, W. Marterer +2 more
20011 citations
Semantic Scholar
Corrigendum to “Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines” [Bioorg. Med. Chem. Lett. 10 (2000) 439]†
S. Hanessian, O. Saavedra, F. Xie, N. Amboldi +1 more
20001 citations
Semantic Scholar
Chemical Synthesis of β-Homonojirimycin, of Its N-Butyl Derivative, and of “Methyl Homoazacellobioside”.
O. Saavedra, O. Martin
19971 citations
Semantic Scholar
Concise Chemical Synthesis of β-Homonojirimycin and Related Compounds.
O. Martin, O. Saavedra
19951 citations
Semantic Scholar
Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog
S. Hanessian, O. Saavedra, M. Vilchis-Reyes, J. Maianti +5 more
20150 citations
Semantic Scholar
Abstract 3609: MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, potently inhibits clinically relevant Met mutants
N. Beaulieu, I. Dupont, C. Bonfils, M. Dubay +10 more
20100 citations
Semantic Scholar
Activity inhibitors of protein tyrosine kinase
S. Claridge, L. Isakovic, M. Mannion, S. Raeppel +8 more
20080 citations
Semantic Scholar
Evaluation of antitumor activity, anti-angiogenic activity and pharmacodynamic end points for orally active multi-targeted anti-angiogenic kinase inhibitors targeting c-MET, ron, VEGF and Tie-2 receptors
Hannah Nguyen, N. Beaulieu, Annie Barsalou, Carole Beaulieu +20 more
20060 citations
Semantic Scholar
410 POSTER Identification and characterization of novel, orally active inhibitors of c-MET and Ron receptor tyrosine kinases
R. Macleod, N. Beaulieu, L. Isakovic, Hannah Nguyen +6 more
20060 citations
Semantic Scholar
alpha- and beta-homogalactonojirimycins (alpha- and beta-homogalactostatins): synthesis and further biological evaluation.
O. Martin, O. Saavedra, F. Xie, L. Liu +4 more
2001Bioorganic & Medicinal Chemistry0 citations
Semantic Scholar

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