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Taija Mäkinen · SciRah

Researcher profile · Semantic Scholar

Taija Mäkinen

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Taija Mäkinen — researcher profile on SciRah

h-index: 41
Works: 82
Citations: 10K

Most-cited papers

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
Ying-Di Wang, Masanori Nakayama, M. Pitulescu, T. S. Schmidt +11 more
2010Nature1,268 citations
Semantic Scholar
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3
Taija Mäkinen, Tanja Veikkola, S. Mustjoki, Terhi Karpanen +9 more
2001EMBO Journal877 citations Open access
Semantic Scholar
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
Taija Mäkinen, Lotta Jussila, Tanja Veikkola, Terhi Karpanen +8 more
2001Nature Medicine821 citations
Semantic Scholar
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox‐1 homeobox transcription factor
T. Petrova, Taija Mäkinen, T. Mäkelä, J. Saarela +6 more
2002EMBO Journal672 citations Open access
Semantic Scholar
Vascular heterogeneity and specialization in development and disease
M. Potente, Taija Mäkinen
2017Nature reviews. Molecular cell biology588 citations Open access
Semantic Scholar
Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
Hsei-Wei Wang, M. Trotter, D. Lagos, D. Bourboulia +6 more
2004Nature Genetics492 citations
Semantic Scholar
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.
Taija Mäkinen, R. Adams, J. Bailey, Qiang Lu +4 more
2005Genes & Development474 citations Open access
Semantic Scholar
Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.
A. Sabine, Yan Agalarov, Hélène Maby-El Hajjami, M. Jaquet +12 more
2012Developmental Cell397 citations Open access
Semantic Scholar
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
T. Tammela, G. Zarkada, H. Nurmi, Lars Jakobsson +14 more
2011Nature Cell Biology327 citations Open access
Semantic Scholar
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea
H. Kubo, Ren-Hai Cao, Ebba Bräkenhielm, Taija Mäkinen +2 more
2002Proceedings of the National Academy of Sciences of the United States of America322 citations Open access
Semantic Scholar
Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites*
Johan Dixelius, Taija Mäkinen, Maria Wirzenius, Marika J. Karkkainen +3 more
2003Journal of Biological Chemistry301 citations Open access
Semantic Scholar
Lymphatic endothelium: a new frontier of metastasis research
Marika J. Karkkainen, Taija Mäkinen, K. Alitalo
2002Nature Cell Biology247 citations
Semantic Scholar
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.
L. Stanczuk, I. Martinez-Corral, Maria H. Ulvmar, Yang Zhang +9 more
2015Cell Reports226 citations Open access
Semantic Scholar
FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature.
A. Sabine, E. Bovay, Cansaran Saygili Demir, Wataru Kimura +16 more
2015Journal of Clinical Investigation221 citations Open access
Semantic Scholar
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
Aleksanteri Aspelund, T. Tammela, Salli Antila, H. Nurmi +8 more
2014Journal of Clinical Investigation218 citations Open access
Semantic Scholar
Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies.
Taija Mäkinen, L. Boon, M. Vikkula, K. Alitalo
2021Circulation Research180 citations Open access
Semantic Scholar
Lymphangiogenesis guidance by paracrine and pericellular factors
Kari Vaahtomeri, S. Karaman, Taija Mäkinen, K. Alitalo
2017Genes & Development166 citations Open access
Semantic Scholar
Heterogeneity in the lymphatic vascular system and its origin
Maria H. Ulvmar, Taija Mäkinen
2016Cardiovascular Research156 citations Open access
Semantic Scholar
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.
Terhi Karpanen, Maria Wirzenius, Taija Mäkinen, Tanja Veikkola +6 more
2006American Journal of Pathology154 citations Open access
Semantic Scholar
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
Maike Frye, Andrea Taddei, Cathrin Dierkes, I. Martinez-Corral +10 more
2018Nature Communications147 citations Open access
Semantic Scholar
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction
S. Rouhani, Jacob D. Eccles, P. Riccardi, J. Peske +5 more
2015Nature Communications143 citations Open access
Semantic Scholar
Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages
Sang-He-On Suh, K. Choe, S. Hong, Seung-hwan Jeong +6 more
2019EMBO Reports128 citations Open access
Semantic Scholar
Molecular anatomy of adult mouse leptomeninges.
R. Pietilä, F. Del Gaudio, Li-Qun He, E. Vázquez-Liébanas +29 more
2023Neuron126 citations Open access
Semantic Scholar
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19
Li-Qun He, M. Mäe, L. Muhl, Ying Sun +28 more
2020bioRxiv122 citations Open access
Semantic Scholar
Vegfc is required for vascular development and endoderm morphogenesis in zebrafish
E. Ober, B. Olofsson, Taija Mäkinen, Suk-Won Jin +4 more
2004EMBO Reports122 citations Open access
Semantic Scholar
Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
I. Martinez-Corral, Yan Zhang, M. Petkova, H. Ortsäter +10 more
2020Nature Communications92 citations Open access
Semantic Scholar
YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis
H. Cho, Jaeryung Kim, J. Ahn, Young-Kwon Hong +3 more
2019Circulation Research85 citations Open access
Semantic Scholar
Lymphatic Dysfunction, Not Aplasia, Underlies Milroy Disease
R. Mellor, Charlotte Hubert, A. Stanton, Naomi Tate +7 more
2010Microcirculation85 citations
Semantic Scholar
Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function
Tanja Veikkola, Marja Lohela, K. Ikenberg, Taija Mäkinen +6 more
2003The FASEB Journal83 citations
Semantic Scholar
Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression
Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, A. Anisimov +19 more
2022Journal of Clinical Investigation79 citations Open access
Semantic Scholar
Homeostatic maintenance of the lymphatic vasculature.
Simon Stritt, K. Koltowska, Taija Mäkinen
2021Trends in Molecular Medicine75 citations Open access
Semantic Scholar
Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation
M. Petkova, Marle Kraft, Simon Stritt, I. Martinez-Corral +8 more
2023Journal of Experimental Medicine74 citations Open access
Semantic Scholar
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms
Yan Zhang, Maria H. Ulvmar, L. Stanczuk, I. Martinez-Corral +3 more
2018Nature Communications71 citations Open access
Semantic Scholar
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research
L. Muhl, Li-Qun He, Ying Sun, Maarja Andaloussi Mäe +24 more
2022Stem Cell Reports64 citations Open access
Semantic Scholar
Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity
Yixin Wang, Yi Jin, M. Mäe, Yang Zhang +4 more
2017Development61 citations Open access
Semantic Scholar
EphB Receptors and Ephrin-B3 Regulate Axon Guidance at the Ventral Midline of the Embryonic Mouse Spinal Cord
Stephanie R. Kadison, Taija Mäkinen, R. Klein, M. Henkemeyer +1 more
2006Journal of Neuroscience58 citations Open access
Semantic Scholar
Specialized post-arterial capillaries facilitate adult bone remodelling
V. Mohanakrishnan, K. Sivaraj, H. Jeong, Esther Bovay +17 more
2024Nature Cell Biology50 citations Open access
Semantic Scholar
Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth
S. Urner, Lara Planas-Paz, Laura Sophie Hilger, Carina Henning +8 more
2018EMBO Journal50 citations Open access
Semantic Scholar
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity
Maike Frye, Simon Stritt, H. Ortsäter, Magda N. Hernández Vásquez +7 more
2020eLife47 citations Open access
Semantic Scholar
A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research
R. Bianchi, Á. Teijeira, S. Proulx, A. Christiansen +6 more
2015PLoS ONE47 citations Open access
Semantic Scholar
Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling.
Terhi Karpanen, Taija Mäkinen
2006Experimental Cell Research46 citations
Semantic Scholar
Dachsous1–Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis—Brief Report
F. Pujol, Tina Hodgson, I. Martinez-Corral, A. Prats +7 more
2017Arteriosclerosis, Thrombosis and Vascular Biology40 citations Open access
Semantic Scholar
Mutations in FOXC2 in Humans (Lymphoedema Distichiasis Syndrome) Cause Lymphatic Dysfunction on Dependency
R. Mellor, Naomi Tate, A. Stanton, Charlotte Hubert +6 more
2011Journal of Vascular Research38 citations
Semantic Scholar
PROX1 is a transcriptional regulator of MMP14
Silvia Gramolelli, Jian-Ping Cheng, I. Martinez-Corral, M. Vähä-Koskela +12 more
2018Scientific Reports33 citations Open access
Semantic Scholar
Pdgfrb‐Cre targets lymphatic endothelial cells of both venous and non‐venous origins
Maria H. Ulvmar, I. Martinez-Corral, L. Stanczuk, Taija Mäkinen
2016Genesis33 citations Open access
Semantic Scholar
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium
Hans Schoofs, N. Daubel, Sarah Schnabellehner, Max L. B. Grönloh +18 more
2025Nature32 citations Open access
Semantic Scholar
APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis
Simon Stritt, P. Nurden, A. Nurden, J. Schved +6 more
2022Haematologica32 citations Open access
Semantic Scholar
Lymphatic malformations: mechanistic insights and evolving therapeutic frontiers
Milena Petkova, Ingvar Ferby, Taija Mäkinen
2024Journal of Clinical Investigation27 citations Open access
Semantic Scholar
Transcription factor FOXP2 is a flow‐induced regulator of collecting lymphatic vessels
Magda N. Hernández Vásquez, Maria H. Ulvmar, A. González-Loyola, I. Kritikos +5 more
2021EMBO Journal27 citations Open access
Semantic Scholar
Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema
Leonid Nikitenko, T. Shimosawa, S. Henderson, Taija Mäkinen +6 more
2013Journal of Investigative Dermatology24 citations Open access
Semantic Scholar

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K. Alitalo×23
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K. Alitalo — researcher profile on SciRah
I. Martinez-Corral×9
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I. Martinez-Corral — researcher profile on SciRah
Simon Stritt×7
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Simon Stritt — researcher profile on SciRah
L. Stanczuk×6
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L. Stanczuk — researcher profile on SciRah

Maria H. Ulvmar

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Maria H. Ulvmar — researcher profile on SciRah

C. Betsholtz×5

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H. Ortsäter×5

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Li-Qun He — researcher profile on SciRah

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R. Adams — researcher profile on SciRah

Tanja Veikkola×4

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Tanja Veikkola — researcher profile on SciRah

Terhi Karpanen×4

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S. Ylä-Herttuala×4

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