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E. Affar · SciRah

Researcher profile · Semantic Scholar

E. Affar

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E. Affar — researcher profile on SciRah

h-index: 37
Works: 88
Citations: 7,538

Most-cited papers

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
Guang-Chao Sui, Christina Y. Soohoo, E. Affar, F. Gay +3 more
2002Proceedings of the National Academy of Sciences of the United States of America1,184 citations Open access
Semantic Scholar
Coordinated histone modifications mediated by a CtBP co-repressor complex
Yu-Jiang Shi, J. Sawada, Guang-Chao Sui, E. Affar +6 more
2003Nature826 citations
Semantic Scholar
Cleavage of Automodified Poly(ADP-ribose) Polymerase during Apoptosis
Marc Germain, E. Affar, D. D'Amours, V. Dixit +2 more
1999Journal of Biological Chemistry467 citations Open access
Semantic Scholar
Yin Yang 1 is a negative regulator of p53.
Guang-Chao Sui, E. Affar, Y. Shi, C. Brignone +7 more
2004Cell458 citations Open access
Semantic Scholar
BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
A. Bononi, C. Giorgi, S. Patergnani, D. Larson +21 more
2017Nature374 citations Open access
Semantic Scholar
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair
Helen Yu, Helen Pak, Ian Hammond-Martel, Mehdi Ghram +9 more
2013Proceedings of the National Academy of Sciences of the United States of America370 citations Open access
Semantic Scholar
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.
L. Davidovic, M. Vodenicharov, E. Affar, G. Poirier
2001Experimental Cell Research350 citations
Semantic Scholar
The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression
Helen Yu, N. Mashtalir, Salima Daou, Ian Hammond-Martel +8 more
2010Molecular and Cellular Biology277 citations Open access
Semantic Scholar
Essential Dosage-Dependent Functions of the Transcription Factor Yin Yang 1 in Late Embryonic Development and Cell Cycle Progression
E. Affar, F. Gay, Y. Shi, Huifei Liu +5 more
2006Molecular and Cellular Biology191 citations
Semantic Scholar
Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.
N. Mashtalir, Salima Daou, Haithem Barbour, Nadine N. Sen +5 more
2014Molecules and Cells190 citations Open access
Semantic Scholar
Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis
Hong-Liu Ding, D. Schwarz, Alex C. Keene, E. Affar +5 more
2003Aging Cell181 citations
Semantic Scholar
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression
Louis Masclef, Oumaima Ahmed, Benjamin Estavoyer, B. Larrivée +3 more
2021Cell Death and Differentiation152 citations Open access
Semantic Scholar
Par-4 links dopamine signaling and depression.
Sang Ki Park, M. Nguyen, A. Fischer, Margaret Po-shan Luke +5 more
2005Cell146 citations Open access
Semantic Scholar
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
Haithem Barbour, Salima Daou, Michael J Hendzel, E. Affar
2020Nature Communications135 citations Open access
Semantic Scholar
The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer*♦
Salima Daou, Ian Hammond-Martel, N. Mashtalir, Haithem Barbour +11 more
2015Journal of Biological Chemistry132 citations Open access
Semantic Scholar
Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis*
E. Affar, Marc Germain, E. Winstall, M. Vodenicharov +3 more
2001Journal of Biological Chemistry130 citations Open access
Semantic Scholar
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90
Alexandre Orthwein, Anne-Marie Patenaude, E. Affar, A. Lamarre +2 more
2010Journal of Experimental Medicine107 citations Open access
Semantic Scholar
Roles of ubiquitin signaling in transcription regulation.
Ian Hammond-Martel, Helen Yu, E. Affar
2012Cellular Signalling101 citations
Semantic Scholar
Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway
Salima Daou, N. Mashtalir, Ian Hammond-Martel, Helen Pak +5 more
2011Proceedings of the National Academy of Sciences of the United States of America99 citations Open access
Semantic Scholar
ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells
Yannick Auclair, R. Rouget, E. Affar, E. Drobetsky
2008Proceedings of the National Academy of Sciences of the United States of America98 citations Open access
Semantic Scholar
Targeting of AMSH to Endosomes Is Required for Epidermal Growth Factor Receptor Degradation*
Yu May Ma, Emmanuel Boucrot, J. Villén, E. Affar +3 more
2007Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Ikaros and GATA-1 Combinatorial Effect Is Required for Silencing of Human γ-Globin Genes
S. Bottardi, Julie Ross, Vincent Bourgoin, N. Fotouhi‐Ardakani +3 more
2008Molecular and Cellular Biology73 citations Open access
Semantic Scholar
Electron transfer dissociation (ETD): The mass spectrometric breakthrough essential for O-GlcNAc protein site assignments – A study of the O-GlcNAcylated protein Host Cell Factor C1
Samuel A. Myers, Salima Daou, E. Affar, A. L. Burlingame
2013Proteomics70 citations Open access
Semantic Scholar
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis
Maxime Uriarte, Nadine Sen Nkwe, Roch Tremblay, Oumaima Ahmed +23 more
2021Nature Communications69 citations Open access
Semantic Scholar
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Parasvi S. Patel, K. Abraham, K. K. N. Guturi, M. Halaby +23 more
2021Journal of Clinical Investigation64 citations Open access
Semantic Scholar
BAP1 regulates different mechanisms of cell death
E. Affar, M. Carbone
2018Cell Death and Disease61 citations Open access
Semantic Scholar
An inventory of crosstalk between ubiquitination and other post-translational modifications in orchestrating cellular processes
Haithem Barbour, Nadine Sen Nkwe, Benjamin Estavoyer, Clémence Messmer +10 more
2023iScience60 citations Open access
Semantic Scholar
Immunological determination and size characterization of poly(ADP-ribose) synthesized in vitro and in vivo.
E. Affar, Patrick Duriez, R. Shah, E. Winstall +5 more
1999Biochimica et Biophysica Acta58 citations
Semantic Scholar
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Salima Daou, Haithem Barbour, Oumaima Ahmed, Louis Masclef +15 more
2018Nature Communications57 citations Open access
Semantic Scholar
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
Andrew A. Horwitz, E. Affar, George F. Heine, Yang Shi +1 more
2007Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage
E. Affar, R. Shah, Annie-Karine Dallaire, V. Castonguay +1 more
2001Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Preferential perinuclear localization of poly(ADP-ribose) glycohydrolase.
E. Winstall, E. Affar, R. Shah, S. Bourassa +2 more
1999Experimental Cell Research53 citations
Semantic Scholar
Immunodot blot method for the detection of poly(ADP-ribose) synthesized in vitro and in vivo.
E. Affar, Patrick J. Duriez, R. Shah, Frédéric R. Sallmann +4 more
1998Analytical Biochemistry52 citations
Semantic Scholar
Isolation, purification and partial characterization of chloragocytes from the earthworm species Lumbricus terrestris
E. Affar, M. Dufour, G. Poirier, D. Nadeau
1998Molecular and Cellular Biochemistry51 citations
Semantic Scholar
Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression
Hassan Nassour, Zhiqiang Wang, Amine Saad, Arturo Papaluca +4 more
2016Scientific Reports46 citations Open access
Semantic Scholar
The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis
S. Bottardi, Lionel O Mavoungou, Helen Pak, Salima Daou +4 more
2014PLoS Genetics45 citations Open access
Semantic Scholar
Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1
M. Ghodgaonkar, R. Shah, F. Kandan-Kulangara, E. Affar +3 more
2009Cell Death and Differentiation44 citations
Semantic Scholar
Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110-kDa protein.
Eric Winstall, E. Affar, R. Shah, Sylvie Bourassa +2 more
1999Experimental Cell Research37 citations
Semantic Scholar
A Sensitive Flow Cytometry-based Nucleotide Excision Repair Assay Unexpectedly Reveals That Mitogen-activated Protein Kinase Signaling Does Not Regulate the Removal of UV-induced DNA Damage in Human Cells*
R. Rouget, Yannick Auclair, M. Loignon, E. Affar +1 more
2008Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases
Benjamin Estavoyer, Clémence Messmer, Mohamed Echbicheb, C. Rudd +2 more
2022Journal of Biological Chemistry33 citations Open access
Semantic Scholar
The LMO2 oncogene regulates DNA replication in hematopoietic cells
Marie-Claude Sincennes, M. Humbert, B. Grondin, V. Lisi +7 more
2016Proceedings of the National Academy of Sciences of the United States of America33 citations Open access
Semantic Scholar
Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis
Li Li, K. K. N. Guturi, Brandon Gautreau, Parasvi S. Patel +19 more
2018Journal of Clinical Investigation32 citations Open access
Semantic Scholar
Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine
M. Carbone, I. Amelio, E. Affar, J. Brugarolas +24 more
2018Cell Death and Differentiation32 citations Open access
Semantic Scholar
Limiting the DNA Double-Strand Break Resectosome for Genome Protection.
Daryl A. Ronato, Sofiane Y. Mersaoui, F. F. Busatto, E. Affar +2 more
2020TIBS -Trends in Biochemical Sciences. Regular ed31 citations
Semantic Scholar
Undetectable histone O-GlcNAcylation in mammalian cells
Jessica K. Gagnon, Salima Daou, Natalia Zamorano, Nicholas Iannantuono +6 more
2015Epigenetics31 citations Open access
Semantic Scholar
DNA vector-based RNAi approach for stable depletion of poly(ADP-ribose) polymerase-1.
R. Shah, M. Ghodgaonkar, E. Affar, G. Shah
2005Biochemical and Biophysical Research Communications - BBRC26 citations
Semantic Scholar
Live single-cell laser tag
Loïc Binan, J. Mazzaferri, K. Choquet, Louis-Étienne Lorenzo +6 more
2016Nature Communications23 citations Open access
Semantic Scholar
Approaches to detect PARP-1 activation in vivo, in situ, and in vitro.
G. Shah, F. Kandan-Kulangara, Alicia Montoni, R. Shah +3 more
2011Methods in molecular biology23 citations
Semantic Scholar
Direct Protein Interactions Are Responsible for Ikaros-GATA and Ikaros-Cdk9 Cooperativeness in Hematopoietic Cells
S. Bottardi, Lionel O Mavoungou, Vincent Bourgoin, N. Mashtalir +2 more
2013Molecular and Cellular Biology21 citations Open access
Semantic Scholar
A potent nuclear export mechanism imposes USP16 cytoplasmic localization during interphase
Nadine Sen Nkwe, Salima Daou, Maxime Uriarte, Jessica K. Gagnon +15 more
2020Journal of Cell Science20 citations Open access
Semantic Scholar

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